Neuro-Immune-Stromal Interactions in Itch, Pain, and other Symptoms.
Neuro-Immune-Stromal Interactions in Itch, Pain, and other Symptoms.
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Our previous findings have demonstrated that immune cells and stromal cells can directly activate peripheral sensory neurons to elicit itch (Science Translational Medicine 2021, Science Advance 2022, Journal of Investigative Dermatology 2022a). The inflammatory mediators released from immune and stromal cells also mutually interact with each others, leading to the development of chronic inflammation, exaggerating itch and pain (Journal of Investigative Dermatology, 2022b). We aim to dissect these intercellular signaling networks using integrated single-cell RNA-sequencing analysis, and to discover novel druggable targets contributing chronic itch and chronic pain. We create an interactive browser to visualize these neuro-immune-stromal signaling networks in the skin.
Transcriptional Reprograming of Sensory Neurons Underlie Chronic Inflammatory Symptoms.
Transcriptional Reprograming of Sensory Neurons Underlie Chronic Inflammatory Symptoms.
Emerging evidence suggests that sensory neurons can undergo transcriptional reprogramming in response to chronic inflammation or nerve injury. This reprogramming leads to the upregulation of transcriptional factors, pro-nociceptive peptides, ion channels, and receptors. Through a series of transcriptomic analyses of sensory neurons under pain or itch conditions, we discovered that chronic itch also alters the transcriptional landscape of these neurons, preferentially increasing the expression of itch-related receptors and neuropeptides, particularly Natriuretic Peptide B (NPPB) (PAIN, 2025). We developed a R Shiny application that allows users to easily compare pain and itch transcriptomes in peripheral sensory neurons.
https://tseng.shinyapps.io/DRGene
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