研究成果 (Publications)
原著論文(Original Paper)
026. Morimoto K, Suzuki H, Kuno A, Daitoku Y, Tanimoto Y, Kato K, Murata K, Sugiyama F, Mizuno S. “Regional random mutagenesis driven by multiple sgRNAs and diverse on-target genome editing events to identify functionally important elements in non-coding regions.” Open Biol. 14(4):240007. (2024) PMID: 38565160
025. Mikami N, Nguyen CLK, Osawa Y, Kato K, Ishida M, Tanimoto Y, Morimoto K, Murata K, Kang W, Sugiyama F, Ema M, Takahasi S, Mizuno S. “Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice.” Exp. Anim. (2024) PMID: 38325858
024. Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H, Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H. “Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function.” Cell Rep. 42(8):112914. (2023) PMID: 37557182
023. Hashimoto M, Takeichi K, Murata K, Kozakai A, Yagi A, Ishikawa K, Suzuki-Nakagawa C, Kasuya Y, Fukamizu A, Nakagawa T. “Regulation of neural stem cell proliferation and survival by protein arginine methyltransferase 1” Front. Neurosci. 16:948517. (2022) PMID: 36440275
022. Shinga K, Iwata T, Murata K, Daitoku Y, Michibata J, Arafiles JVV, Sakamoto K, Akishiba M, Takatani-Nakase T, Mizuno S, Sugiyama F, Imanishi M, Futaki S. “L17ER4: A cell-permeable attenuated cationic amphiphilic lytic peptide.” Bioorg. Med. Chem. 61:116728. (2022) PMID: 35395514
021. Kuno A, Ikeda Y, Ayabe S, Kato K, Sakamoto K, Suzuki SR, Morimoto K, Wakimoto A, Mikami N, Ishida M, Iki N, Hamada Y, Takemura M, Daitoku Y, Tanimoto Y, Dinh TTH, Murata K, Hamada M, Muratani M, Yoshiki A, Sugiyama F, Takahashi S, Mizuno S. “DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes.” PLoS Biol. 20(1):e3001507. (2022) PMID: 35041655
020. Murata K*, Mimura A, Suzuki H, Mikami N, Hamada Y, Kato K, Iki N, Ishida M, Daitoku Y, Tanimoto Y, Okiyoneda T, Fujiyama T, Dinh TTH, Mizuno S, Sugiyama F. “Efficient induction of proximity-dependent labeling by biotin feeding in BMAL1-BioID knock-in mice.” J. Biochem. 170(4):453-461. (2021) PMID: 33982090 *Corresponding author (2022 年 JB 論文賞 受賞)
019. Osawa Y*, Murata K*, Usui M, Kuba Y, Le HT, Mikami N, Nakagawa T, Daitoku Y, Kato K, Shawki HH, Ikeda Y, Kuno A, Morimoto K, Tanimoto Y, Dinh TTH, Yagami KI, Ema M, Yoshida S, Takahashi S, Mizuno S, Sugiyama F. “EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice.” eLife. 10:e59759. (2021) PMID: 33973520 *Contributed equally
018. Dinh TTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami KI, Wilson V, Arkell RM, Sugiyama F. “Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 expression and enhanced p53 pathway.” eLife. 10:e50346. (2021) PMID: 33949947
017. Matsuda S, Kim JD, Sugiyama F, Matsuo Y, Ishida J, Murata K, Nakamura K, Namiki K, Sudo T, Kuwaki T, Hatano M, Tatsumi K, Fukamizu A, Kasuya Y. “Transcriptomic Evaluation of Pulmonary Fibrosis-Related Genes: Utilization of Transgenic Mice with Modifying p38 Signal in the Lungs.” Int. J. Mol. Sci. 21(18):6746. (2020) PMID: 32937976
016. Hashimoto M, Kumabe A, Kim JD, Murata K, Sekizar S, Williams A, Lu W, Ishida J, Nakagawa T, Endo M, Minami Y, Fukamizu A. “Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development.” J. Neurochem. 156(6):834-847. (2020) PMID: 33460120
015. Hasan ASH, Dinh TTH, Le HT, Mizuno-Iijima S, Daitoku Y, Ishida M, Tanimoto Y, Kato K, Yoshiki A, Murata K, Mizuno S, Sugiyama F. “Characterization of a bicistronic knock-in reporter mouse model for investigating the role of Cables2 in vivo” Exp. Anim. 70(1):22-30. (2020) PMID: 32779618
014. Sakamoto K, Akishiba M, Iwata T, Murata K, Mizuno S, Kawano K, Imanishi M, Sugiyama F, Futaki S. “Optimizing charge switching in membrane lytic peptides for endosomal release of biomacromolecules.” Angew. Chem. Int. Ed. Engl. 59(45):19990-19998. (2020) PMID: 32557993
013. Morimoto K, Numata K, Daitoku Y, Hamada Y, Kobayashi K, Kato K, Suzuki H, Ayabe S, Yoshiki A, Takahashi S, Murata K, Mizuno S, Sugiyama F. “Reverse Genetics Reveals Single Gene of Every Candidate on Hybrid Sterility, X Chromosome QTL 2 (Hstx2) Are Dispensable for Spermatogenesis” Sci. Rep. 10(1):9060, (2020) PMID: 32493902
012. Mizuno-Iijima S, Ayabe S, Kato K, Matoba S, Ikeda Y, Dinh TTH, Le HT, Suzuki H, Nakashima K, Hasegawa Y, Hamada Y, Tanimoto Y, Daitoku Y, Iki N, Ishida M, Elsayed Ibrahim Elzeftawy A, Nakashiba T, Hamada M, Murata K, Miwa Y, Okada-Iwabu M, Iwabu M, Yagami KI, Ogura A, Obata Y, Takahashi S, Mizuno S, Yoshiki A, Sugiyama F. “Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes” Methods. pii: S1046-2023(19)30328-7 (2020) PMID: 32334080
011. Le HT, Hasegawa Y, Daitoku Y, Kato K, Miznuo-Iijima S, Dinh TTH, Kuba Y, Osawa Y, Mikami N, Morimoto K, Ayabe S, Tanimoto Y, Murata K, Yagami KI, Takahashi S, Mizuno S, Sugiyama F. “Generation of B6-Ddx4em1(CreERT2)Utr, a novel CreERT2 knock-in line, for germ cell lineage by CRISPR/Cas9” Genesis. e23367 (2020) PMID: 32293787
010. Suzuki H, Dinh TTH, Daitoku Y, Tanimoto Y, Kato K, Azami T, Ema M, Murata K, Mizuno S, Sugiyama F. “Generation of bicistronic reporter knockin mice for visualizing germ layers” Exp. Anim. 6;68(4):499-509. (2019) PMID: 31189761
009. Murata K, Lu W, Hashimoto M, Ono N, Muratani M, Nishikata K, Kim JD, Ebihara S, Ishida J, Fukamizu A. "PRMT1 deficiency in mouse juvenile heart induces dilated cardiomyopathy and reveals cryptic alternative splicing products" iScience. 8, 200-213. (2018) PMID: 30321814
008. Murata K, Ishida J, Ishimaru T, Mizukami H, Hamada J, Saito C, Fukamizu A. “Lactation is a risk factor of postpartum heart failure in mice with cardiomyocyte-specific APJ overexpression” J. Biol. Chem. 291, 11241-11251, (2016) PMID: 27033703
007. Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami K, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang Y, Ito T, Kokubu Y, Noguchi T, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S. “Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies.” Exp. Anim. 65, 175-187, (2016) PMID: 26822934
006. Hashimoto M, Murata K, Ishida J, Kanou A, Kasuya Y, Fukamizu A. “Severe hypomyelination and developmental defects are caused in mice lacking protein arginine methyltransferase 1 (PRMT1) in the central nervous system.” J. Biol. Chem. 291, 2080-2086, (2016) PMID: 26637354
005. Murata K, Baasanjav A, Kwon C, Hashimoto M, Ishida J, Fukamizu A. “Angiotensin II accelerates mammary gland development independently of high blood pressure in pregnancy-associated hypertensive mice.” Physiol. Rep. 3, e12542, (2015) PMID: 26341998
004. Hamada J, Baasanjav A, Ono N, Murata K, Kako K, Ishida J, Fukamizu A. “Possible involvement of downregulation of the apelin-APJ system in doxorubicin-induced cardiotoxicity.” Am. J. Physiol. Heart Circ. Physiol. 308, H931-H941, (2015) PMID: 25681427
003. Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y. “p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.” J. Recept. Signal Transduct. 34, 299-306, (2014) PMID: 24593255
002. Murata K, Saito C, Ishida J, Hamada J, Sugiyama F, Yagami K, Fukamizu A. “Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice.” Endocrinology 154, 597-602, (2013) PMID: 23254193
001. Namiki K, Matsunaga H, Yoshioka K, Tanaka K, Murata K, Ishida J, Sakairi A, Kim J, Tokuhara N, Shibakawa N, Shimizu M, Wada Y, Tokunaga Y, Shigetomi M, Hagihara M, Kimura S, Sudo T, Fukamizu A, Kasuya Y. “Mechanism for p38α-mediated experimental autoimmune encephalomyelitis.” J. Biol. Chem. 287, 24228-24238, (2012) PMID: 22637476