Lack of interactions between prenatal immune activation and Δ9-tetrahydrocannabinol exposure during adolescence in behaviours relevant to symptom dimensions of schizophrenia in rats. Mario Moreno-Fernández, Marcos Ucha, Raquel Reis-de-Paiva, Alberto Marcos, Emilio Ambrosio, Alejandro Higuera-Matas. Progress in Neuropsychopharmacology and Biological Psychiatry. 2023 Oct 31;129:110889. doi: 10.1016/j.pnpbp.2023.110889.
Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome. Capellán, R., Orihuel, J., Marcos, A., Ucha, M., Moreno-Fernández, M., Casquero-Veiga, M., Soto-Montenegro, M. L., Desco, M., Oteo-Vives, M., Ibáñez-Moragues, M., Magro-Calvo, N., Morcillo, M. Á., Ambrosio, E., & Higuera-Matas, A. Translational Psychiatry. 2023. Mar 8;13(1):84. doi: 10.1038/s41398-023-02378-6.
Editorial: Neurobehavioral Mechanisms of Reward: Theoretical and Technical Perspectives and Their Implications for Psychopathology. Panagis G, Vlachou S, Higuera-Matas A, Simon MJ. Front Behav Neurosci. 2022 Jul 5;16:967922. doi: 10.3389/fnbeh.2022.967922.
Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats. Ucha M, Roura-Martínez D, Santos-Toscano R, Capellán R, Ambrosio E, Higuera-Matas A. Psychopharmacology (Berl). 2022 Aug;239(8):2559-2571. doi: 10.1007/s00213-022-06144-2.
The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats. Marcos A, Ballesteros-Yáñez I, Castillo-Sarmiento CA, Pardo F, Roura-Martínez D, Muñoz-Rodríguez JR, Higuera-Matas A, Ambrosio E. Neuropharmacology. 2022 Mar 15;206:108937. doi: 10.1016/j.neuropharm.2021.108937.
Δ 9-tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner. Javier Orihuel, Roberto Capellán, David Roura-Martínez, Marcos Ucha, Emilio Ambrosio, Alejandro Higuera-Matas. Int J Neuropsychopharmacol. 2021 Aug 26:pyab058. doi: 10.1093/ijnp/pyab058.
Cocaine-induced Fos expression in the rat brain: Modulation by prior Δ9-tetrahydrocannabinol exposure during adolescence and sex-specific effects. Javier Orihuel, Laura Gómez-Rubio, Claudia Valverde, Roberto Capellán, David Roura-Martínez, Marcos Ucha, Emilio Ambrosio, Alejandro Higuera-Matas. Brain Research. 2021. 1;1764:147480. doi: 10.1016/j.brainres.2021.147480.
The Basolateral Amygdala to Nucleus Accumbens Core Circuit Mediates the Conditioned Reinforcing Effects of Cocaine-Paired Cues on Cocaine Seeking. Puaud M, Higuera-Matas A, Brunault P, Everitt BJ, Belin D. Biol Psychiatry. 2020 Aug 5:S0006-3223(20)31808-4.
Modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration. Roura-Martínez D, Díaz-Bejarano P, Ucha M, Paiva RR, Ambrosio E, Higuera-Matas A. Neuropharmacology. 2020 Dec 1;180:108290. doi: 10.1016/j.neuropharm.2020.108290. Epub 2020 Sep 1.
The role of the mTOR pathway in models of drug-induced reward and the behavioural constituents of addiction. Ucha M, Roura-Martínez D, Ambrosio E, Higuera-Matas A. J Psychopharmacol. 2020 Nov;34(11):1176-1199. doi: 10.1177/0269881120944159. Epub 2020 Aug 27.
Maternal immune activation is associated with a lower number of dopamine receptor 3-expressing granulocytes with no alterations in cocaine reward, resistance to extinction or cue-induced reinstatement. Santos-Toscano R, Ucha M, Borcel É, Ambrosio E, Higuera-Matas A. Pharmacol Biochem Behav. 2020 Jun;193:172930.
The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats. Marcos A, Moreno M, Orihuel J, Ucha M, Mª de Paz A, Higuera-Matas A, Capellán R, Crego AL, Martínez-Larrañaga MR, Ambrosio E, Anadón A. PLoS One. 2020 Mar 23;15(3):e0227044.
Ex vivo 1H-MRS brain metabolic profiling in a two-hit model of neurodevelopmental disorders: Prenatal immune activation and peripubertal stress. Capellán R, Moreno-Fernández M, Orihuel J, Roura-Martínez D, Ucha M, Ambrosio E, Higuera-Matas A. Schizophr Res. 2019 Nov 28:S0920-9964(19)30505-5.
Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats. Ucha M, Coria SM, Núñez AE, Santos-Toscano R, Roura-Martínez D, Fernández-Ruiz J, Higuera-Matas A, Ambrosio E. J Psychopharmacol. 2019 Jul;33(7):882-893.
Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABAA Receptor Alfa 1 Subunit and the CB1 Receptor in the Lateral and Medial Orbitofrontal Cortices. Ucha M, Roura-Martínez D, Contreras A, Pinto-Rivero S, Orihuel J, Ambrosio E, Higuera-Matas A. Front Behav Neurosci. 2019 Feb 20;13:22.
Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking. Roura-Martínez D, Ucha M, Orihuel J, Ballesteros-Yáñez I, Castillo CA, Marcos A, Ambrosio E, Higuera-Matas A. Addict Biol. 2020 Mar;25(2):e12706.
MouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice. Bello-Arroyo E, Roque H, Marcos A, Orihuel J, Higuera-Matas A, Desco M, Caiolfa VR, Ambrosio E, Lara-Pezzi E, Gómez-Gaviro MV. Front Behav Neurosci. 2018 Sep 7;12:201.
Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum. Fernández-Cabrera MR, Higuera-Matas A, Fernaud-Espinosa I, DeFelipe J, Ambrosio E, Miguéns M. PLoS One. 2018 Jul 26;13(7):e0200950.
Mu-Opioid Receptors in Ganglia, But Not in Muscle, Mediate Peripheral Analgesia in Rat Muscle Pain. Bagues A, Martín MI, Higuera-Matas A, Esteban-Hernández J, Ambrosio E, Sánchez-Robles EM. Anesth Analg. 2018 Apr;126(4):1369-1376.
Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown. Gonçalves J, Leitão RA, Higuera-Matas A, Assis MA, Coria SM, Fontes-Ribeiro C, Ambrosio E, Silva AP. Brain Behav Immun. 2017 May;62:306-317
Parafascicular thalamic nucleus deep brain stimulation decreases NMDA receptor GluN1 subunit gene expression in the prefrontal cortex. Fernández-Cabrera MR, Selvas A, Miguéns M, Higuera-Matas A, Vale-Martínez A, Ambrosio E, Martí-Nicolovius M, Guillazo-Blanch G. Neuroscience. 2017 Apr 21;348:73-82.
Unaltered cocaine self-administration in the prenatal LPS rat model of schizophrenia. Santos-Toscano R, Borcel É, Ucha M, Orihuel J, Capellán R, Roura-Martínez D, Ambrosio E, Higuera-Matas A. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Aug 1;69:38-48.
Changes in D1 but not D2 dopamine or mu-opioid receptor expression in limbic and motor structures after lateral hypothalamus electrical self-stimulation: A quantitative autoradiographic study. Simon MJ, Higuera-Matas A, Roura-Martinez D, Ucha M, Santos-Toscano R, Garcia-Lecumberri C, Ambrosio E, Puerto A. Neurobiol Learn Mem. 2016 Jan;127:17-26.
Long-term consequences of perinatal and adolescent cannabinoid exposure on neural and psychological processes. Higuera-Matas A, Ucha M, Ambrosio E. Neurosci Biobehav Rev. 2015 Aug;55:119-46.