Hyun Bin Lee

MS/PH.D candidate (2022. 03 - present)

Research Interests

Protein engineering, Immunotherapy, T cell, Antibody

1. Kim, H. J.,* Jun, H., Lee, H. B., Eom, S., Kim, J., Jeon, J. P., Park, S. H., and Kang, S.,* Leukemia-Targeting NK cell Nanoengagers Effectively Promote Robust NK Activation and Potent Anti-Acute Myeloid Leukemia Response. J. Nanobiotechnology, 2026, 24, 346.

2. Eom, S., Park, S. G., Jun, H., Kim, Y., Lee, H. B., and Kang, S.,* Effective in vivo delivery of diphtheria toxin using protein cage nanoparticles for targeted cancer therapy. Acta Biomater., 2025, 202, 517-528.

3. Lee, H. B., Park, S. G., Kim, H. J., Jeon, J. P., Oh, S., Lee, S., Park, S. H., and Kang, S.,* CD7-Targeted Cytotoxic Potency of Diphtheria Toxin- and Ricin-based Immunotoxins in Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia. Mol. Pharm., 2025, 22, 3255-3267.

4. Kim, Y.,* Kim, J., Eom, S., Jun, H., Lee, H. B., Jeong, D., and Kang, S.,* Protein Nanoparticles Simultaneously Displaying TRAIL and EGFR-Binding Ligands Effectively Induce Apoptotic Cancer Cell Death and Overcome EGFR-TKI Resistance in Lung Cancer. ACS Appl. Mater. Interfaces, 2025, 17, 25239-25151.

5. Park, S. G.,# Lee, H. B.,# and Kang, S.* Development of plug-and-deliverable intracellular protein delivery platforms based on botulinum neurotoxin. Int. J. Biol. Macromol., 2024, 261, 129622.

# Equal contribution

6. Park, S. G., Kim, H. J., Lee, H. B., Eom, S., Jun, H., Jang, Y., Park, S. H.* and Kang, S.* Protein cage nanoparticle-based NK cell-engaging nanodrones (NKeNDs) effectively recruit NK cells to target tumor sites and suppress tumor growth. Nano Today, 2024, 54, 102075.