青年學者獎
李鎮源教授醫學研究青年學者獎 實施辦法
(93.10.27 九十三年度第二次董事會議通過)
(94.04.27 九十四年度第一次董事會議修正)
(98.09.07 九十八年度第一次董事會議修正)
(101.04.17 一O一年度第 二次董事會議修正)
(108.09.27 一O八年度第十二屆第二次董事會議修正)
一、為鼓勵國內生物醫學學術研究風氣，並提昇其水準，特設此獎。
二、申請資格：國內學者年齡未滿四十歲 (申請當年12月31日前未滿40歲) 之中華民國國民，於申請年度及前一年度內在國際性期刊發表生物醫學相關之原著論文，該論文為在國內完成且未接受其他單位獎助者。申請人必須為該論文之第一作者。評分比重主論文佔70%，近三年著作發表成果佔30%。
三、每年遴選一名，獎金 10 萬元，申請時間為每年六月底發文起至七月底截止，並於當年臺灣醫學會年會時頒獎。
四、由財團法人李鎮源教授學術基金會聘請領域相關之委員進行初審，並由董事會複審決定當選。
2023李巧玲 / 台灣大學醫學院 博士後研究員
Chiao-Ling Li, Chia-Lang Hsu, You-Yu Lin, Ming-Chih Ho, Ray-Heng Hu, Chi-Ling Chen, Tung-Ching Ho, Yung-Feng Lin, Shih-Feng Tsai, Sheng-Tai Tzeng, Chin-Fang Huang, Ya-Chun Wang, Shiou-Hwei Yeh, Pei-Jer Chen. HBV DNA Integration into Telomerase or MLL4 Genes and TERT Promoter Point Mutation as Three Independent Signatures in Subgrouping HBV-related HCC with Distinct Features. Liver Cancer. 2023. In Press. DOI: 10.1159/000530699.
2022 葉志凡主治醫師 / 台灣大學醫學院附設醫院
Yeh CF, Cheng SH, Lin YS, Shentu TP, Huang RT, Zhu J, Chen YT, Kumar S, Lin MS, Kao HL, Huang PH, Rosello-Sastre E, Garcia F, Jo H, Fang Y, Yang KC.
Targeting mechano-sensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo.
Sci Adv. 2022 Jan 21;8(3):eabl8096.
2021 師範大學生命科學系 王麗婷助理教授
Li-Ting Wang#, Ming-Hong Lin#, Kwei-Yan Liu, Shyh-Shin Chiou, Shen-Nien Wang, Chee-Yin Chai, Li-Wen Tseng, Hsin-Ying Clair Chiou, Hsueh-Chun Wang, Kazunari K. Yokoyama, Shih-Hsien Hsu*, Shau-Ku Huang*.
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Autophagy. 2021 Apr 14:1-16
2020 中央研究院生物醫學科學研究所 胡哲銘 副研究員
Chattopadhyay S, Liu Y-H, Fang Z-S, Lin C-L, Lin J-C, Yao B-Y, Hu C-M*.
Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo immunotherapy.
Nano Letters, 2020, 20, 4, 2246-2256.
2019 國立成功大學生理學科所 許佩玲 博士
Pei-Ling Hsu, Jheng-Sin Chen, Chin-Yung Wang, Hua-Lin Wu, Fan-E Mo.
Shear-induced CCN1 promotes atheroprone endothelial phenotypes and atherosclerosis.
Circulation. 2019; 139(25):2877-2891.
2018 財團法人國家衛生研究院免疫醫學研究中心 莊懷佳 助研究員
Chuang HC, Tsai CY, Hsueh CH, and Tan TH.
GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease.
Science Advances. 2018; 4 : eaat5401
2017 中央研究院 蔡怡陞 助研究員
VL Hunt†, IJ Tsai†, A Coghlan†, AJ Reid†, N Holroyd, BJ Foth, A Tracey, JA Cotton, EJ Stanley, H Beasley, H Bennett, K Brooks, B Harsha, R Kajitani, A Kulkarni, D Harbecke, E Nagayasu, S Nichol, Y Ogura, MA Quail, N Randle, DM Ribeiro, A Sanchez-Flores, T Hayashi, T Itoh, DR Denver, W Grant, JD Stoltzfus, JB Lok, H Murayama, J Wastling, A Streit, T Kikuchi, M Viney and M Berriman
The Genomic Basis of Parasitism in the Strongyloides Clade 1 of Nematodes
Nat Genet. 2016 Mar;48(3):299-307.
2016 中國醫藥大學 沈明毅 助理教授
Ming-Yi Shen, Fang-Yu Chen, Jing-Fang Hsu, Ru-Huei Fu, Chia-Ming Chang, et al.
Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.
BLOOD 2016, 127(10):1336-1345.
2015 中央研究院細胞與個體生物學研究所 吳建勳 博士後研究人員
Wu, C.H., Kuo, Y.H., Hong, R.L., and Wu, H.C.
α-Enolase-binding peptide enhances drug delivery efficiency and therapeutic efficacy against colorectal cancer.
J Sci Transl Med 2015, 7:290ra291.
2014 台北榮民總醫院神經醫學中心--廖翊筑 主治醫師
Liao YC, Wang YS, Guo YC, Lin WL, Chang MH, Hank Juo SH.
Let-7g Improves Multiple Endothelial Functions Through Targeting Transforming Growth Factor-Beta and SIRT-1 Signaling.
J Am Coll Cardiol. 2014; 63(16):1685-94.
2013 國立臺灣大學醫學院 口腔生物科學研究所 - 張正琪 副教授
Chang CC, Hsu WH, Wang CC, Chou CH, Kuo MY, Lin BR, Chen ST, Tai SK, Kuo ML, Yang MH.
Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells.
Cancer Res. 2013 Jul 1;73(13):4147-57.
2012 國立成功大學醫學院 醫學檢驗生物技術學系-陳百昇 助理教授
Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HC, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Hsiao M, Chang YW, Chen JS, Yang PC, Kuo ML.
MiR-107 Promotes Tumor Progression by Targeting the Let-7 MicroRNA in Mice and Humans.
J Clin Invest. 2011 Sep;121(9):3442-55.
2011 臺北醫學大學- 林若凱 助理教授
Lin RK, Hsieh YS, Lin P, Hsu HS, Chen CY, Tang YA, Lee CF, Wang YC.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
J Clin Invest. 2010 Feb 1;120(2):521-32. Epub 2010 Jan 19.
2010 長庚大學- 陳立強 博士
L-C Chen, I-C Chung, C Hsueh, N-M Tsang, L-M Chi, Y Liang, C-C Chen, L-J Wang, Y-S Chang
The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients
Cell Death and Differentiation 17, 1463-1473 (12 March 2010)
2009 中國醫藥大學-許晉銓 助理教授
Sheu JJ, Hua CH, Wan L, Lin YJ, Lai MT, Tseng HC, Jinawath N, Tsai MH, Chang NW, Lin CF, Lin CC, Hsieh LJ, Wang TL, Shih IeM, Tsai FJ.
Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma.
Cancer Research 2009 Mar 15; 69 (6): 2568-76. Epub 2009 Mar 10.
2008 中國醫藥大學醫學系藥理學科 - 湯智昕 助理教授
Tang CH, Chiu YC, Tan TW, Yang RS, Fu WM.
Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway.
J Immunol. 2007 Oct 15;179 (8):5483-92.
2007 美國德州大學安德森癌症研究中心 - 黃偉謙 博士後研究員
Huang WC, Ju TK, Hung MC, Chen CC.
Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
Mol Cell. 2007 Apr 13;26(1):75-87.
2006 中國醫藥大學 醫學研究所 - 蘇振良 助理教授
Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY, Chou CH, Jeng YM, Wang MY, Chang KJ, Hung MC, Kuo ML.
The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells.
Cancer Cell. 2006 Mar;9(3):209-23.
2005 長庚醫院皮膚科 - 鐘文宏 醫師
Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT. Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004 Apr 1;428(6982):486.
Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, Lin YL, Lan JL, Yang LC, Hong HS, Chen MJ, Lai PC, Wu MS, Chu CY, Wang KH, Chen CH, Fann CS, Wu JY, Chen YT. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9. Epub 2005 Mar 2.
2004 臺北醫學大學細胞及分子生物研究所 - 葉添順 助理教授
Yeh TS, Lin YM, Hsieh RH, Tseng MJ. Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch. J Biol Chem. 2003 Oct 24;278(43):41963-9. Epub 2003 Aug 11.
Yeh TS, Hsieh RH, Shen SC, Wang SH, Tseng MJ, Shih CM, Lin JJ. Nuclear betaII-tubulin associates with the activated notch receptor to modulate notch signaling. Cancer Res. 2004 Nov 15;64(22):8334-40.