Past and Present Research Projects

Research Projects as Principal Investigator

1)   “Design and Development of Tissue Selective Antiestrogens” (File No. SR/FTP/CSA-05/2002) of worth Rs. eleven lakhs, DST, New Delhi (2003- 2006).

2)   “Design and Synthesis of Novel SERMs (Selective Estrogen Receptor Modulators) for the management of Osteoporosis and other estrogen related disorders” (File No. 58/1/2003-BMS) of Rs. seventeen lakhs, ICMR, New Delhi (2003-2006)- 58/1/2003-BMS.

3)   “Diversity Oriented Organic Synthesis of Small but Smart Molecules in Drug Discovery Research” (File No. SR/S1/OC-23/2005) of worth Rs. twenty lakhs, DST, New Delhi (2006-2009). 

4)   “Amino Acids as chiral Synthons: Development of new synthetic protocols for creating Natural Products and related diversity in quest for anticancer agent” (File No. SR/S1/OC-74/2009) of Rs. 35 lakhs, DST, New Delhi (2010-2013).

5)   Project Coordinator from CDRI on “Synthetic Biology (Metabolic Engineering of Vinca Alkaloid Pathway (Rs 81 lakhs) and Metabolic Engineering of Azadirachtin biosynthetic pathway (Rs 35 lakhs)” (2010-2013)

6)   “Design, synthesis and evaluation of new chemical entities against atypical mycobacterium, Mycobacterium fortuitum” of Rs. 40 lakhs, ICMR, New Delhi (2011-2013)- IRIS ID: 2009-04190. 

7)   “Quest for Corannulene based Polyfunctional Molecules in Nanobiotechnology and Nanomedicine: Transporting and Translocating properties of Corannulene derived carrier systems” (File No. SB/S1/OC-93 /2013) of Rs 53 lakhs, DST, New Delhi (2015-2018).

8)   Ligand and structure-based screening of designed and synthesized chemical library around Psammaplin A against DNA methyltransferase 1 (DNMT1) and Diversity oriented synthesis of Halimide & Phenylahistin related analogs as anticancer agents (File No. MoES/09-DS/3/201P5C –IV), of Rs 45 lakhs (2016-2019) from MoES, New Delhi.

9)   "Amino acids derived steroidal and non-steroidal Ligands as inhibitors of steroid 5-α-reductase in cancer" (File No. 3511410812018-BRNS/35032) of Rs 35 lakhs from BRNS (2018-2021)

10) “Inhibition of ATP synthase enzyme of drug-resistant Mycobacterium tuberculosis through chemical library of Asymmetric Tri and Tetrasubstituted methanes (TRSMs) and ethanes (TRSEs)” (File No. SERB/F/8968/2019-2020) of Rs 45 lakhs from DST approved (2020-todate)

11) Cost Effective Route of Nitisinone for Alkaptonuria and Hereditary Tyrosinemia-1 (HT-1) from DST (GAP 0431) ongoing (27.03.2023-todate)

12) Process for Acyclovir and Sulbactam from DST (GAP 0439) ongoing (27.03.2023-todate)

13) Stereoselective Construction of 3-(aminoalkylidene)Oxindoles in One Pot: Quick Access of a Novel, Robust Chemical Library around Nintedanib, Hesperadin targeting VEGFR-2  in Cancer  Therapy, Submitted to DST with Regensburg Univ, Germany

14) Cost Effective Import Substitution of Nintedanib, Sunitinib and Alectinib, Ongoing API mission of CSIR (HCP 0050)

Research Projects as Team Member

Ongoing Project Title as significant member

1)   "Making cancer care affordable; Empowering Women’s Health: Focusing on Breast and Gynaecological Cancers of Indian Relevance" by PAN-CSIR Cancer Program

2)   “Novel and integrative approaches towards discovery of small molecule therapeutics for healthy ageing (NISTHA)" by in house CSIR project

3)   “Investigating the host-parasite determinants of survival, virulence and immunity in Malaria" by CSIR network project

4)   "Molecules for Anti Mycobacterial Resistance (AMR)" by CSIR

5)   Chemical biology approaches towards dissecting non-canonical protein functions and novel targets in the Malaria, Leishmania and Filaria parasites (MLP 2031--NCP)

6)   Bucky-Bowl Based Small Peptides-Doxorubicin Co-assembly for tumor cell treatment (CII7063)

7) “Development of First-in-class EZH2-EGFR Dual Inhibitor against Triple Negative Breast Cancer (TNBC)”. 96 lakhs from ICMR  (IIRPIG-2025-01-00527) from ICMR