Praveen Deepak

Research Interest

My focal research interest is to understand the role of Th2-type cytokines in particular IL-13 and IL-17 in different pathophysiological conditions, like cancer and autoimmune diseases, and its possible application in translational medicine. In extension, my future endeavor will be to focus its role in a quite unexplored area of Immunology such as the involvement of these cytokines in lineage determination of B and T cells specific to certain immune responses and how it might affect and/or regulate the molecular mechanism of generation of antigen-specific paratope specifically in the case of certain infection and malignancy. At present, my focus is decipher the role of natural products in cancer and rheumatoid arthritis and their implication in translational medicine.

Biographical Sketch

Praveen Deepak is an Assistant Professor in Zoology at Magadh University, Bodhgaya. He received his B.Sc. and M.Sc. degrees from Tilka Manjhi Bhagalpur University, Bhagalpur, and thereafter, he joined the Department of Zoology, Banaras Hindu University, Varanasi as Junior Research Fellow and later, as a Senior Research Fellow where he has worked on the role of interleukin – 13, a Th2 type cytokine, in modulating both innate as well as adaptive or acquired immunity in tumor-bearing host using BALB/c mice as an experimental model. At present, he is primarily focusing on teaching and establishing a niche in his research interest comprising the role of small molecules and natural products in the therapeutic application in cancer and rheumatoid arthritis.

Awards & Fellowship

• Senior Research Fellow (SRF), UGC, New Delhi.

•  Junior Research Fellow (JRF), UGC, New Delhi.

Membership of society

• Member of The Science Advisory Board, Membership No. 88976.

• Life member of the Indian Immunology Society, Membership No. 159/10/11

• Member of the International Society of Exercise and Immunology (www.isei.dk).

• Life member of the Indian Science Congress Association

Research Experience

• Doing Ph.D. on the topic “Studies on the role of interleukin–13 in innate and adaptive immune response in tumor–bearing hosts”.

• Dissertation work entitled “Histochemical localization of PAS–positive glands in the intestine of Channa punctatus”.

• Field work cum study on the topic “A study of Biodiversity and Systematics of local insectan fauna of Bhagalpur region of Bihar including their study of distribution and abundance”.

Conferences/Seminar/Symposia/Workshops 

• National Symposia on Aquatic Biodiversity of India, Tilka Manjhi Bhagalpur University, Bhagalpur, Bihar, India, 2003

• National Symposium and Brainstorming Meeting on Advances in Neuroendocrinology, Banaras Hindu University, Varanasi, Uttar Pradesh, February 14–15, 2011. 

• 6th Biyani’s International Conference – 2011 (BIOCON–11) on Innovations in the Latest Healthcare Issues, Faculty of Science and Department of Nursing, Biyani Girls College, Jaipur, September 19–21, 2011.

• International Symposium on Cancer Biology, National Institute of Immunology, New Delhi, November 14–16, 2011.

• National Conference on Frontiers in Biological Sciences, Department of Biotechnology, VBS Purvanchal University, Jaunpur, December 4–5, 2011.

• 22nd All India Congress of Zoology & National Seminar on Recent Advanes in Biological Sciences: Biodiversity and human welfare, Department of Zoology, Lucknow University, Lucknow, December 29–31, 2011.

• International Conference on Cancer Prevention, Diagnosis and Treatment, Rajasthan University, Jaipur, January 21–22, 2012.

• International Symposium on Recent Advances in Cancer Research Therapeutics to Chemoprevention. Central University of Gujarat, Gandhinagar, February 8–9, 2012.

• 39th Annual Conference of Indian Immunology Society, Institute of Medical Sciences, Banaras Hindu University, Varanasi, November 9–11, 2012.

International Refereed Papers

• Deepak P, Kumar S, Acharya A. Heat shock proteins (HSPs): Future trend in cancer immunotherapy. Eur. J. Inflamm., 2006; 4(1): 1–10.

• Kumar S, Deepak P, Acharya A. Hsp70 modulates the enhanced production of reactive intermediate metabolites and a pro–inflammatory cytokine TNF–α expression in a T–cell lymphoma. Eur. J. Inflamm., 2006; 4(3): 157–169.

• Kumar S, Deepak P, Acharya A. Hsp70 induces Th1 polarization through tumor–associated macrophages in a T–cell lymphoma. Neoplasma, 2007; 54(2): 113–122.

• Deepak P, Kumar S, Acharya A. IL–13 neutralization modulates function of type II polarized macrophages in vivo in a murine T–cell lymphoma. Eur. J. Inflamm., 2007; 5(1): 29–37.

• Deepak P, Kumar S, Acharya A. IL–13 Rα2–mediated interleukin–13 neutralization represses in vivo progressive growth of a T–cell lymphoma. J. Exp. Clin. Cancer Res., 2007; 26(3): 347–352.

• Deepak P, Kumar S, Acharya A. Gender dichotomy in antibody response in a T–cell lymphoma: involvement of IL–13 and gonadal hormones.  Am. J. Reprod. Immunol., 2008; 59: 127–138.

• Deepak P, Kumar S, Acharya A. Gender variation in interleukin–13 production: a possible mechanism of differential in vivo growth of a T–cell lymphoma.  Scand. J. Immunol., 2008; 67: 581–588.

• Deepak P, Kumar S, Acharya A. Interleukin–13 neutralization modulates interleukin–13 induced suppression of reactive oxygen species production in peritoneal macrophages in a murine T–cell lymphoma. Cell. Immunol., 2008; 251: 72–77.

• Kumar S, Deepak P, Acharya A. Autologous Hsp70 immunization induces anti–tumor immunity and increases longevity and survival of tumor-bearing mice. Neoplasma, 2009; 56(3): 257–266.

• Deepak P, Kumar S, Acharya A. Over expression of interleukin–13 in a murine T–cell lymphoma: a possible factor of DL–induced immunosuppression and tumor progression. Cancer Invest., 2009; 27(6): 641–649.

• Kumar S, Deepak P, Kumar S, Jr., Kishore D, Acharya A. Autologous HSP70 Induces Antigen Specific Th1 Immune Responses in a Murine T–Cell Lymphoma. Immunol. Invest., 2009; 38: 449–465.

• Deepak P, Kumar S, Kishore D, Kumar S, Jr., Acharya A. Interleukin–13 from Th2 type cells suppresses induction of antigen specific cell–mediated immunity in a T–cell lymphoma. Int. Immunol., 2009; 22: 53–63.

• Deepak P, Acharya A. Anti–tumor immunity and mechanism of immunosuppression mediated by tumor cells: role of tumor–derived soluble factors and cytokines. Int. Rev. Immunol., 2010; 29(4): 421–458.

• Deepak P, Acharya A. Interleukin–13 T helper type 2 immune responses in OVA-immunized BALB/c mice bearing a T cell lymphoma. Scand. J. Immunol., 2012; 75(1): 85–95.

• Gautam PK, Deepak P, Kumar S, Acharya A. Role of macrophage in tumor microenvironment: Prospect in cancer immunotherapy. Euro. J. Inflamm., 2013; 11(1): 1–14.

• Gautam PK, Maurya BN, Kumar S, Deepak P, Kumar S Jr., Tomar MS, Acharya A. Progressive growth of a murine T cell lymphoma alters population kinetics and cell viability of macrophages in a tumor–bearing host. Tumour Biol., 2013; 34(2): 827–836.

• Gautam PK, Kumar S, Deepak P, Acharya A. Morphological effects of autologous hsp70 on peritoneal macrophages in a murine T cell lymphoma. Tumour Biol., 2013; 34(6): 3407–3415.

• Kumar S, Deepak P, Kumar S, Gautam PK, Acharya A. A benzophenanthridine alkaloid, chelerythrine induces apoptosis in vitro in a Dalton’s lymphoma. J. Cancer Res. Thera., 2013; 9(4): 693–700.

Book Chapters

• Deepak P, Kumar S, Acharya A. Immunobiology of tumor progression and therapeutic application of natural products. In: Yamini B. Tripathi (Ed.). Chronic Inflammatory Diseases and Neutraceuticals. Varanasi, India: BHU Press, 2005, pp. 64–105.

• Deepak P, Acharya A. Biological functions of IL–4/IL–13, signaling cascades and implication in growth and development of tumor. In: Shree R. Singh and Manoj K. Mishra (Eds.). Signaling, Gene Regulation and Cancer. New York, USA: Nova Science Publishers, 2013, pp. 317–362. ISBN: 978–1–61942–088–5.

Abstract

• Praveen Deepak, Sanjay Kumar, Sanjay Kumar Jr, et al. Different exercise paradigms-induced hsp70 enhances cell-mediated immunity in a T cell lymphoma murine model. Brainstorming Meeting on Advances in Neuroendocrinology, Banaras Hindu University, February 14–15, 2011.

• Pramod K. Gautam, Sanjay Kumar, Praveen Deepak, et al. Progressive growth of Dalton’s lymphoma induces early increase in polarized type II phagocytic cell population at the tumor microenvironment. 6th Biyani’s International Conference – 2011 (BIOCON–11) on Innovations in the Latest Healthcare Issues, Biyani Girls College, Jaipur, September 19–21, 2011.

• Sanjay Kumar, Praveen Deepak, Arbind Acharya, et al. Pharmacological inhibitor of protein kinase C, chelerythrine downregulates Bcl–2 and Bcl–xL expression in a murine T cell lymphoma. International Symposium on Cancer Biology, New Delhi, November 14–16, 2011.

• Sanjay Kumar, Praveen Deepak, Arbind Acharya, et al. Staurosporine, a PKC inhibitor, suppresses tumor growth and progression in a murine T cell lymphoma. National Conference on Frontiers in Biological Sciences, VBS Purvanchal University, Jaunpur, December 4–5, 2011.

• Pramod K. Gautam, Praveen Deepak, Sanjay Kumar, et al. Anti-sera pre-coating enhances adherence of myeloid-derived suppressor cells (MDSC) of monocytic lineage. 22nd All India Congress of Zoology & National Seminar on Recent Advances in Biological Sciences: Biodiversity and Human Welfare, Lucknow University, Lucknow, December 29–31, 2011.

• Sanjay Kumar, Praveen Deepak, Sanjay Kumar, et al. Protein kinase C inhibitor chelerythrine induces tumor cell apoptosis and growth delay of Dalton’s lymphoma in vivo. International Conference on Cancer Prevention, Diagnosis and Treatment, Rajasthan University, Jaipur, January 21–22, 2012.

• Sanjay Kumar Jr, Praveen Deepak, Sanjay Kumar, et al. Inhibition of protein kinase C induces apoptosis of tumor cell in a mice bearing T cell lymphoma. International Symposium on Recent Advances in Cancer Research Therapeutics to Chemoprevention. Central University of Gujarat, Gandhinagar, February 8–9, 2012.

• Praveen Deepak, Sanjay Kumar Jr, Sanjay Kumar, et al. Interleukin-13 enhances CD4+ T helper 2 cell polarization in hyperimmunized BALB/c mice. 5th Congress of the Federation of Immunological Societies of Asia Oceania (FIMSA 2012), New Delhi, March 14–17, 2012.

• Sanjay Kumar, Praveen Deepak, Sanjay Kumar Sr, et al. A benzophenanthridine alkaloid, chelerythrine induces apoptosis through Bax and Bcl–Xs dependent mechanism in a murine T cell lymphoma. 5th Congress of the Federation of Immunological Societies of Asia Oceania (FIMSA 2012), New Delhi, March 14–17, 2012.