Research

Pulsed Vibro-Acoustic Analysis 

Ultrasound-based vibroacoustic analysis has become an effective noninvasive approach for characterizing bone mechanical integrity. When an acoustic wave propagates through bone, its travel speed (speed of sound, SoS) and spectral content are altered by the bone’s microstructure, mineralization (calcification), porosity, and elastic properties. These wave–tissue interactions create measurable signatures in the received RF signals that can be leveraged as quantitative biomarkers for bone strength and quality assessment.

In our work, we estimate SoS and derive complementary frequency-domain biomarkers (e.g., peak frequency and spectral-shift measures) from ultrasound acquisitions to assess changes associated with bone calcification. SoS provides a physics-grounded measure linked to effective stiffness, while frequency-based features capture attenuation, scattering, and microstructural effects that are not fully described by speed alone. By combining propagation-based and spectral biomarkers, the framework increases sensitivity to subtle biomechanical changes and supports robust monitoring of bone health using ultrasound vibroacoustic measurements.