2025
Lee, J., Park, J., Hur, Y., Um, D., Choi, H.-S., Park, J., Kim, Y., Lee, J.-S., Choi, K., Kim, E., Park, Y.B., Choi, J.-M., Kim, T.-K. and Lee, Y. ETV5 reduces androgen receptor expression and induces neural stem-like properties during neuroendocrine prostate cancer development. PNAS 2025;122(12):e2420313122
Lee, Y. Principles and therapeutics of cancer. Molecules and Cells 2025;48(5):100201 (Editorial)
Lee, J. and Lee, Y. The role of transcription factors in prostate cancer progression. Molecules and Cells 2025;48(4):100193 (Minireview)
2024
Park, J., Kang, M., Kim, H.B., Hong, H., Lee, J., Song, Y., Hur, Y., Kim, S., Kim, T.-K. and Lee, Y. The capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression. Nature Communications 2024;15,10579
Song, Y. and Lee, Y. Brief guide to flow cytometry. Molecules and Cells 2024;47(11):100129 (MiniResource)
Kim, D.*, Lee, J.*, Seok, O.-H., Lee, Y.# and Hwang, C.-S.# (*co-first authors, #co-corresponding authors) Cytosolic N-terminal formyl-methionine deformylation derives cancer stem cell features and tumor progression. Scientific Reports 2024;14,14900
Park, J., Lee, J., Hur, Y., Kim, C.-J., Kim, H. B., Um, D., Kim, D. S., Lee, J.-Y., Park, S., Park, Y., Kim, T.-K., Im, S.-H., Kim, S. W., Kwak, S.-K. and Lee, Y. ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression. PNAS 2024;121(24):e2322009121
Yang, S., Golkaram, M., Oh, S., Oh, Y., Cho, Y., Yoe, J., Ju, S., Lalli, M. A., Park, S.-Y., Lee, Y. and Jang, J. ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification. Nature Cell Biology 2024;26,903–916
2023
Yang, J., Lee, Y. and Hwang, C.-S. The ubiquitin-proteasome system links NADPH metabolism to ferroptosis. Trends in Cell Biology 2023;S0962-8924(23)00136-8
Kim, Y.-J., Oh, J., Jung, S., Kim, C.J., Choi, J., Jeon, Y.K., Kim, H.J., Kim, J.-W., Suh, C.-H., Lee, Y., Im, S.-H., Crotty, S. and Choi, Y.S. The transcription factor Mef2d regulates B:T synapse-dependent GC-Tfh differentiation and IL-21-mediated humoral immunity. Science Immunology 2023;8(81):eadf2248
2022
Park, J., Park, G.-Y., Lee, J., Park, J., Kim, S., Kim, E., Park, S.-Y., Yoon, J.H. and Lee, Y. ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth. Frontiers in Molecular Biosciences 2022;9:1030725
Hong, H.# and Lee, Y.# (#co-corresponding authors) Generation of hematopoietic lineage cell-specific chimeric mice using retrovirus-transduced fetal liver cells. STAR Protocols 2022;3,101526
Nguyen, K.T., Mun, S.-H., Yang, J., Lee, J., Seok. O.-H., Kim, E., Kim, D., An, S.Y., Seo, D.-Y., Suh, J.-Y., Lee, Y.# and Hwang, C.-S.# (#co-corresponding authors) The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis. Nature Cell Biology 2022;24,1239-1251
Hong, H., Lee, J., Park, G.-Y., Kim, S., Park, J., Park, J.S., Song, Y., Lee, S., Kim, T.J., Lee, Y.J., Roh, T.-Y., Kwok, S.-K., Kim, S.W., Tan, Q. and Lee, Y. Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis. Cell Reports 2022;38(7):110386
2021
Kim, S., Park, G.-Y., Park, J.S., Park, J., Hong, H. and Lee, Y. Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua. eLife 2021;10:e71769
2020
Park, G.-Y., Lee, G.-W., Kim, S., Hong, H., Park, J.S., Cho, J.# and Lee, Y.# (#co-corresponding authors) Deletion timing of Cic alleles during hematopoiesis determines the degree of peripheral CD4+ T cell activation and proliferation. Immune Network 2020;20(5):e43
Lee, S.-H., Zhang, Y., Park, J., Kim, B., Kim, Y., Lee, S.H., Kim, G.H., Huh, Y.H., Lee, B., Kim, Y., Lee, Y., Kim, J.Y., Kang, H., Choi, S.-Y., Jang, S., Li, Y., Kim, S., Jin, C., Pang, K., Kim, E., Lee, Y., Kim, H., Kim, E., Choi, J., Kim, J.H., Lee , K.J.#, Choi, S.-Y.# and Han, K.# (#co-corresponding authors) Haploinsufficiency of Cyfip2 causes lithium-responsive prefrontal dysfunction. Annals of Neurology 2020;88(3):526-543
Lee, Y. Regulation and function of capicua in mammals. Experimental & Molecular Medicine 2020; 52:531-537 (Invited review article)
Yoe, J., Kim, D., Kim, S. and Lee, Y. Capicua restricts cancer stem cell-like properties in breast cancer cells. Oncogene 2020;39:3489-3506
Lee, J.-S.*, Kim, E.*, Lee, J.*, Kim, D., Kim, H., Kim, C.-J., Kim, S., Jeong, D.# and Lee, Y.# (*co-first authors, #co-corresponding authors) Capicua suppresses colorectal cancer progression via repression of ETV4 expression. Cancer Cell International 2020;20:42
2019
Park, S.#, Park, J., Kim, E. and Lee, Y.# (#co-corresponding authors) The Capicua/ETS translocation variant 5 axis regulates liver-resident memory CD8+ T-cell development and the pathogenesis of liver injury. Hepatology 2019;70(1):358-371
Islam, M.R., Kwak, J.-W., Lee, J.-S., Hong, S.-W., Khan, M.R.I., Lee, Y., Lee, Y., Lee, S.-W. and Hwang, I. Cost-effective production of tag-less recombinant protein in Nicotiana benthamiana. Plant Biotechnology Journal 2019;17(6):1094-1105
2018
Cho, H.*, Cho, H.S.*, Nam, H., Jo, H., Yoon, J., Park, C., Dang, T.V.T., Kim, E., Jeong, J., Park, S., Wallner, E.S., Youn, H., Park, J., Jeon, J., Ryu, H., Greb, T., Choi, K., Lee, Y., Jang, S.K., Ban, C. and Hwang, I. (*co-first authors) Translational control of phloem development by RNA G-quadruplex-JULGI determines plant sink strength. Nature Plants 2018;4(6):376-390
Kim, E., Kim, D., Lee, J.-S., Yoe, J., Park, J., Kim, C.-J., Jeong, D., Kim, S.# and Lee, Y.# (#co-corresponding authors) Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4-MMP1 axis. Hepatology 2018;67(6):2287-2301
Han, J., Perez, JT., Chen, C., Li, Y., Benitez, A., Kandasamy, M., Lee, Y., Andrade, J., tenOever, B. and Manicassamy, B. Genome-wide CRISPR/Cas9 screen identifies host factors essential for Influenza virus replication. Cell Reports 2018;23(2):596-607
2017
Bok, S., Kim, Y.-E., Woo, Y., Kim, S., Kang, S.-J., Lee, Y., Park, S.K., Weissman, I.L. and Ahn, G.-O. Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice. Oncotarget 2017;8(67):111508-111521
Park, S.*, Lee, S.*, Lee, C.-G.*, Park, G.Y., Hong, H., Lee, J.-S., Kim, Y.M., Lee, S.B., Hwang, D., Choi, Y.S., Fryer, J.D., Im, S.-H.#, Lee, S.-W.# and Lee, Y.# (*co-first authors, #co-corresponding authors) Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5. Nature Communications 2017;8,16037
Lu, H.C.*, Tan, Q.*, Rousseaux, M.W., Wang, W., Kim, J.Y., Richman, R., Wan, Y.W., Yeh, S.Y., Patel, J.M., Liu, X., Lin, T., Lee, Y., Fryer, J.D., Han, J., Chahrour, M., Finnell, R.H., Lei, Y., Zurita-Jimenez, M.E., Ahimaz, P., Anyane-Yeboa, K., Van Maldergem, L., Lehalle, D., Jean-Marcais, N., Mosca-Boidron, A.L., Thevenon, J., Cousin, M.A., Bro, D.E., Lanpher, B.C., Klee, E.W., Alexander, N., Bainbridge, M.N., Orr, H.T., Sillitoe, R.V., Ljungberg, M.C., Liu, Z, Schaaf, C.P. and Zoghbi, H.Y. (*co-first authors) Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nature Genetics 2017;49(4):527-536
2016
Lee, K., Kim, H., An, K., Kwon, O.B., Park, S., Cha, J.H., Kim, M.H., Lee, Y., Kim, J.H., Cho, K. and Kim, H.S. Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer’s Disease. Scientific Reports 2016;6,34433
2015
Seo, M., Seo, K., Hwang, W., Koo, H.J., Hahm, J.H., Yang, J.-S., Han, S.K., Hwang, D., Kim, S., Jang, S.K., Lee, Y., Nam, H.G.# and Lee, S.-J.V.# (#co-corresponding authors) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO signaling in C. elegans. PNAS 2015;112(31):E4246-55
Choi, N., Park, J., Lee, J.-S., Yoe, J., Park, G.Y., Kim, E., Jeon, H., Cho, Y.M., Roh, T.-Y. and Lee, Y. miR-93/miR-106b/miR-375-CIC-CRABP1: A novel regulatory axis in prostate cancer progression. Oncotarget 2015;6(27):23533-47
Kim, E., Park, S., Choi, N., Lee, J., Yoe, J., Kim, S., Jung, H.-Y., Kim, K.-T., Kang, H., Fryer, J.D., Zoghbi, H.Y., Hwang, D. and Lee, Y. Deficiency of Capicua disrupts bile acid homeostasis. Scientific Reports 2015;5,8272
2013
Park, J.*, Al-Ramahi, I.*, Tan, Q., Mollema, N., Diaz-Garcia, J.R., Gallego-Flores, T., Lu, H.-C., Lagalwar, S., Duvick, L., Kang, H., Lee, Y., Jafar-Nejad, P., Sayegh, L.S., Richman, R., Liu, X., Gao, Y., Shaw, C.A., Arthur, J.S.C., Orr, H.T.#, Westbrook, T.F.#, Botas, J.# and Zoghbi, H.Y.# (*co-first authors, #co-corresponding authors) RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature 2013;498:325-331
Kahle, J.J.*, Souroullas, G.P.*, Yu, P., Zohren, F., Lee, Y., Shaw, C.A.#, Zoghbi, H.Y.# and Goodell M.A.# (*co-first authors, #co-corresponding authors) Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery. PLoS Genetics 2013;9(3):e1003359.
Han, K.*, Gennarino, V.A.*, Lee, Y., Pang, K., Hashimoto-Torii, K., Choufani, S., Raju, C.S., Oldham, M.C., Weksberg, R., Rakic, P., Liu, Z. and Zoghbi, H.Y. (*co-first authors) Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p. Genes and Development 2013;27(5):485-490
2011
Lee, Y., Fryer, J.D., Kang, H., Crespo-Barreto, J., Bowman, A.B., Kahle, J.J., Gao, Y., Hong, J.S., Kheradmand, F., Orr, H.T., Finegold, M.J. and Zoghbi, H.Y. ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Developmental Cell 2011;21:746-57
~2010
Jin, H., Suh, M.R., Han, J., Yeom, K.-H., Lee, Y., Heo, I., Ha, M., Hyun, S. and Kim, V.N. Human UPF1 modulates small RNA-induced mRNA down-regulation. Molecular and Cellular Biology 2009;29(21):5789-99
Lee, Y., Samaco, R.C., Gatchel, J.R., Thaller, C., Orr, H.T. and Zoghbi, H.Y. miR-19, miR-101, and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nature Neuroscience 2008;11:1137-9
Lee, Y. and Kim, V.N. In vitro and in vivo assays for the activity of drosha complex. Methods in Enzymology 2007;427:87-106
Lee, Y., Han, J., Yeom, K.-H., Jin, H. and Kim, V.N. Drosha in primary microRNA processing. Cold Spring Harbor Symposia on Quantative Biology 2006;71:51-7
Yeom, K.-H., Lee, Y., Han, J., Suh, M.R. and Kim, V.N. Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Research 2006;34(16):4622-9
Han, J.*, Lee, Y.*, Yeom, K.-H.*, Nam, J.-W., Heo, I., Rhee, J.-K., Sohn, S.Y., Cho, Y., Zhang, B.-T., and Kim, V.N. (*co-first authors) Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 2006;125(5):887-901
Lee, Y.*, Hur, I.*, Park, S.-Y.*, Kim, Y.-K., Suh, M.R., and Kim, V.N. (*co-first authors) The role of PACT in the RNA silencing pathway. EMBO Journal 2006;25:522-532.
Nam, J.-W., Shin, KR., Han, J., Lee, Y., Kim, V.N., Zhang, BT. Human microRNA prediction through a probabilistic co-learning model of sequence and structure. Nucleic Acids Research 2005;33:3570.
Lee, Y. and Kim, V.N., Preparation and Characterization of Drosha. Methods in Molecular Biology 2005;309:17.
Kim, J., Jung, J.H., Reyes, J.L., Kim, Y.S., Kim, S.Y., Chung, K.S., Kim, J.A., Lee, M., Lee, Y., Kim, V.N., Chua, N.H. and Park, C.M. microRNA-directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems. Plant Journal 2005;42,84-94.
Han, J.*, Lee, Y.*, Yeom, K.-H., Kim, Y.-K., Jin, H., and Kim, V.N. (*co-first authors) The Drosha-DGCR8 complex in primary microRNA processing. Genes and Development 2004;18:3016-3027.
Lee, Y., Kim, M.J., Han, J., Yeom, K.-H., Lee, S.H., Baek, S.H. and Kim, V.N. MicoRNA genes are transcribed by RNA polymerase II. EMBO Journal 2004;23:4051-4060.
Suh, M.R., Lee, Y., Kim, J.Y., Kim, S.K., Moon, S.H., Lee, J.Y., Cha, K.Y., Chung, H.M., Yoon, H.S., Moon, S.Y., Kim, V.N.#, and Kim, K.S.# (#co-corresponding authors), Human embryonic stem cells express a unique set of microRNAs. Developmental Biology 2004;270:488-498.
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., and Kim, V.N., The Nuclear RNase III Drosha Initiates MicroRNA Processing. Nature 2003;425:415-419.
Lee, Y., Jeon, K.P., Lee, J.T., Kim, S and Kim, V.N., MicroRNA maturation: stepwise processing and subcellular localization. EMBO Journal 2002;21:4663-4670.