Michelangelo's Genesis on the ceiling of the Sistine Chapel depicts biblical stories and explores man's connection to divinity. Painted between 1508 and 1512, Michelangelo's meticulous process involved extensive planning, preliminary sketches, intense physical labor, and even injury to achieve the intricate details and profound expressions in the frescoes. Influenced by his detailed anatomical dissections, Michelangelo's pursuit of anatomical mastery is evident in works such as The Creation of Adam, where the silhouette of a brain frames God. Through this masterful series, Michelangelo has left an indelible mark on the history of art, elevating the fresco technique to unparalleled heights and inspiring countless generations.