Poget Laboratory

All cells require a membrane to separate them from their neighboring cells or the environment. While this compartmentalization is essential for life and its processes, it also poses problems: Not only do chemicals need to cross the barrier to get in and out of the cell, but communication also needs to take place between the cell and its environment. These transport and communication tasks are being carried out by proteins in the membrane that form transporters, pores, channels and signal transducers.

Research in Dr. Poget’s lab at the College of Staten Island, CUNY, focuses on understanding a few of these membrane proteins and their function on an atomic level of structural detail. We employ nuclear magnetic resonance spectroscopy (NMR) and a range of ancillary biophysical techniques to study these proteins. Significant effort is also devoted to the development and improvement of membrane protein expression, purification and reconstitution methods. Research is currently funded by NSF and NIH, and students interested in doing PhD or undergraduate research in the lab are encouraged to contact Sebastien Poget.

Affiliations:

• Department of Chemistry, College of Staten Island
• Program in Biochemistry, Graduate Center of CUNY
• Program in Chemistry, Graduate Center of CUNY
• Structural Biology Initiative, CUNY Advanced Science and Research Center