Biomolecules (such as proteins and RNAs) can gather together to form an independent phase in aqueous solution (like oil-water mixture). This behavior is observed not just in vitro, but also in cells, and cells utilize the phase behavior of biomolecules for various functions. We aim to understand the phase behavior at the molecular level and, based on this understanding, to design new cellular functions.

Biomolecules change their properties little by little as time evolves. This evolution process is shaped by factors such as how well organisms containing the molecules survive and how frequently the molecular mutations occur. We aim to analyze the diverse factors that contribute to the molecular evolution process and to predict how real molecules evolve in the given conditions.

In cells, biomolecules serve their functions by different interactions with each other. Sometimes two molecules stick together to form a rigid structure, and sometimes weak and transient interactions are used to toggle molecular states. We aim to analyze and quantify the interactions of biomolecules to eventually understand the molecular mechanisms of biomolecular activities.