RESEARCH INTERESTS
Metabolic dysregulation in cancer development and progression
Metabolism-associated mechanisms in neurodegenerative diseases
Functional role of nuclear TYRO3 signaling in colorectal carcinogenesis
PUBLICATIONS
A. Referred paper
1. You-Syuan Lou, Xu-Chen Liu, Chih-Cheng Cheng, Yi-Hsuan Yin, Tzu-Cheng Chien, Pei-Ling Hsu, Chu-Wan Lee, Hsin-Hsien Yu*, Bor-Chyuan Su*. (2025, May). Chemotherapy elevates cell surface PD-L1 and MHC-I expression in apoptotic gastric cancer cells. International Journal of Immunopathology and Pharmacology, 39:3946320251338662.
2. Luo-Yun Wu#, Bor-Chyuan Su#, Hsin-Hsien Yu, Chih-Cheng Cheng, Chia-Chi Tsai, Pei-Ling Hsu, Chu-Wan Lee*. # Equal Contribution. (2024, Dec). Antihypertensive agent losartan promotes tongue squamous cell carcinoma cell proliferation via EGFR/ERK1/2/cyclin D1 signaling axis. Journal of Oral Biosciences, 66(4):74-80.
3. Wei-Chen Yeh, Yun-Chieh Tu, Pei-Ling Hsu, Chu-Wan Lee, Hsin-Hsien Yu*, Bor-Chyuan Su*. (2024, Dec). Combination of vismodegib and paclitaxel enhances cytotoxicity via Bak-mediated mitochondrial damage in EGFR-mutant non-small cell lung cancer cells. Cell Biochemistry and Biophysics, 82(4):3499-3506.
4. Chi-Chen Huang, Sheng-Feng Tsai, Shu-Cheng Liu, Mei-Chen Yeh, Hao-Chang Hung, Chu-Wan Lee, Ching-Li Cheng, Pei-Ling Hsu*, Yu-Min Kuo*. (2024, Nov). Insulin mediates lipopolysaccharide-induced inflammatory responses and oxidative stress in BV2 microglia. Journal of Inflammation Research, 17:7993-8008.
5. Sheng-Feng Tsai#, Pei-Ling Hsu#, Mei-Chen Yeh, Hao-Chang Hung, Monica Meng-Chun Shih, Bon-Chu Chung, Chia-Yih Wang, Chih-Jen Chang, Yu-Min Kuo*. # Equal Contribution. (2024, Jul). High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice. Biomedical Journal, online ahead of print.
6. Wei-Chen Yeh#, Yun-Chieh Tu#, Tzu-Cheng Chien, Pei-Ling Hsu, Chu-Wan Lee, Shih-Ying Wu, Bo-Syong Pan, Hsin-Hsien Yu, Bor-Chyuan Su*. # Equal Contribution. (2024, May). Vismodegib potentiates marine antimicrobial peptide tilapia piscidin 4-induced cytotoxicity in human non-small cell lung cancer cells. Probiotics and Antimicrobial Proteins, online ahead of print.
7. Meng-Chieh Lin#, Guan-Yu Chen#, Hsin-Hsien Yu, Pei-Ling Hsu, Chu-Wan Lee, Chih-Cheng Cheng, Shih-Ying Wu, Bo-Syong Pan, Bor-Chyuan Su*. # Equal Contribution. (2024, Apr). Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function. Bone and Joint Research, 13(4):157-168.
8. Bor-Chyuan Su, Guan-Yu Chen, Chun-Ming Yang, Wei-Ting Chuang, Meng-Chieh Lin, Pei-Ling Hsu, Chu-Wan Lee, Chih-Cheng Cheng, Shih-Ying Wu, Bo-Syong Pan, Hsin-Hsien Yu*. (2024, Feb). Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins and PD-L1 expression in human gastric cancer cells. International Journal of Hyperthermia, 41(1):2310017.
9. Hsin Huang, Pei-Ling Hsu, Sheng-Feng Tsai, Yi-Hsiang Chuang, De-Quan Chen, Guo-Xuan Xu, Chien Chen, Yu-Min Kuo, Chih-Chung Huang*. (2023, Nov). High-spatiotemporal-resolution ultrasound flow imaging to determine cerebrovascular hemodynamics in Alzheimer's disease mice model. Advanced Science, 10(35):e2302345.
10. Hsin-Hsien Yu, Luo-Yun Wu, Pei-Ling Hsu, Chu-Wan Lee, Bor-Chyuan Su*.(2023, Jul). Marine antimicrobial peptide epinecidin-1 inhibits proliferation induced by lipoteichoic acid and causes cell death in non-small cell lung cancer cells via mitochondria damage. Probiotics and Antimicrobial Proteins, 16(5):1724-1733.
11. Pei-Ling Hsu, Chun-Wei Chien, Yen-An Tang, Bo-Wen Lin, Shih-Chieh Lin, Yi-Syuan Lin, Sih-Yu Chen, H Sunny Sun*, Shaw-Jenq Tsai*. (2023, Apr). Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Science Advances, 9(15):eade3422.
12. Hao-Chang Hung, Sheng-Feng Tsai, Hsuan-Wen Chou, Ming-Jun Tsai, Pei-Ling Hsu*, Yu-Min Kuo*. (2023, Apr). Dietary fatty acids differentially affect secretion of pro-inflammatory cytokines in human THP-1 monocytes. Scientific Reports, 13(1):5511.
13. Sheng-Feng Tsai, Pei-Ling Hsu, Yun-Wen Chen, Mohammad Shahadat Hossain, Pei-Chun Chen, Shun-Fen Tzeng, Po-See Chen, Yu-Min Kuo*. (2022, Sep). High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens. Molecular Psychiatry, 27(11):4372-4384.
14. Wan-Ning Li, Kuei-Yang Hsiao, Chu-An Wang, Ning Chang, Pei-Ling Hsu, Chung-Hsien Sun, Shang-Rung Wu, Meng-Hsing Wu*, Shaw-Jenq Tsai*. (2020, Oct). Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis. Proceedings of the National Academy of Sciences of the United States of America, 117(41), 25859-25868.
15. Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin, I-Chen Peng, Chia-Yih Wang, Shaw-Jenq Tsai*. (2020, May). Pathophysiological implications of hypoxia in human diseases. Journal of Biomedical Science, 27(1):63.
16. Chu-An Wang, I-Heng Chang, Pei-Chi Hou, Yu-Jing Tai, Wan-Ning Li, Pei-Ling Hsu, Shang-Rung Wu, Wen-Tai Chiu, Chien-Feng Li, Yan-Shen Shan, Shaw-Jenq Tsai*. (2020, Apr). DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination. Journal of Extracellular Vesicles, 9(1),1746529.
17. Fan-E Mo*, Pei-Ling Hsu. (2019, Nov). Response by Mo and Hsu to Letter Regarding Article, "Shear-induced CCN1 promotes atheroprone endothelial phenotypes and atherosclerosis". Circulation, 140(20):e768-e769.
18. Bor-Chyuan Su, Pei-Ling Hsu, Fan-E Mo*. (2019, Oct). CCN1 triggers adaptive autophagy in cardiomyocytes to curb its apoptotic activities. Journal of Cell Communication and Signaling, 14(1):93-100.
19. Pei-Ling Hsu, Jheng-Sin Chen, Chin-Yung Wang, Hua-Lin Wu, Fan-E Mo*. (2019, Mar). Shear-induced CCN1 promotes atheroprone endothelial phenotypes and atherosclerosis. Circulation, 139(25):2877-2891.
20. Pei-Ling Hsu, Jonathan Jou, and Shaw-Jenq Tsai*. (2019, Feb). TYRO3: A potential therapeutic target in cancer. Experimental Biology and Medicine (Maywood), 244(2):83-99.
21. Shih-Chieh Lin, Hsiu-Chi Lee, Ching-Ting Hsu, Yi-Han Huang, Wan-Ning Li, Pei-Ling Hsu, Meng-Hsing Wu, Shaw-Jenq Tsai*. (2019, Jan). Targeting anthrax toxin receptor 2 ameliorates endometriosis progression. Theranostics, 9(3), 620-632.
22. Pei-Ling Hsu, Yung-Ching Lin, Hao Ni, Fan-E Mo*. (2018, Apr). Ganoderma triterpenoids exert antiatherogenic effects in mice by alleviating disturbed flow-induced oxidative stress and inflammation. Oxidative Medicine and Cellular Longevity, 2018:3491703.
23. Pei-Ling Hsu, Fan-E Mo*. (2016, Jun). Matricellular protein CCN1 mediates doxorubicin-induced cardiomyopathy in mice. Oncotarget, 7(24), 36698-36710.
24. Qian-Yu Kuok, Chen-Yu Yeh, Bor-Chyuan Su, Pei-Ling Hsu, Hao Ni, Ming-Yie Liu, Fan-E Mo. (2013, Oct). The triterpenoids of Ganoderma tsugae prevent stress-induced myocardial injury in mice. Molecular Nutrition and Food Research, 57(10):1892-1896.
25. Pei-Ling Hsu#, Bor-Chyuan Su#, Qian-Yu Kuok, Fan-E Mo*. (2013, Apr). Extracellular matrix protein CCN1 regulates cardiomyocyte apoptosis in mice with stress-induced cardiac injury. Cardiovascular Research, 98(1):64-72. #Equal Contribution.
B. Conference paper
1. Pei-Ling Hsu*. (2024, Oct). TYRO3: the nuclear weapon driving colorectal cancer progression. 2024 Taiwan Digestive Disease Week.
2. Pei-Ling Hsu*. (2023, Mar). Operation nuclear storm: Blocking the “TYRO3” missile to ameliorate colon cancer malignancy. 2023 The 37th Joint Annual Conference of Biomedical Science.
3. Pei-Ling Hsu, Chun-Wei Chien, Yen-An Tang, Bo-Wen Lin, Sih-Yu Chen, H. Sunny Sun, Shaw-Jenq Tsai*. (2022, Nov). Intracellular MMP-2 drives nuclear TYRO3/BRD3-dependent colorectal cancer metastasis. 2022 ICCB & APOCB Joint Meeting, Humanities and Social Science Building (HSSB), Academia Sinica.
4. Chieh-Ting Fan, Pei-Ling Hsu, Shaw-Jenq Tsai*. (2022, Mar). Nuclear TYRO3 promotes colorectal cancer malignancy through BRD3. 2022 the 36th Joint Annual Conference of Biomedical Science.
5. Pei-Ling Hsu, Chun-Wei Chien, Bo-Wen Lin, Sih-Yu Chen, Shaw-Jenq Tsai*. (2022, Mar). Matrix metalloproteinase2-driven nuclear translocation of TYRO3 intracellular domain promotes colorectal cancer malignancy. 2022 the 36th Joint Annual Conference of Biomedical Science.
6. Pei-Ling Hsu, Fan-E Mo*. (2019, Jan). Shear-induced CCN1 promotes atheroprone endothelial phenotypes and atherosclerosis. The Vascular Cell Biology Gordon Research Conference.
7. Pei-Ling Hsu, Fan-E Mo*. (2018, Feb). CCN1 and its receptor integrin α6β1 instigate a vicious circle to accelerate disturbed flow-induced atherosclerosis. Keystone Symposia- Atherosclerosis: Lessons Learned and Concepts Challenged.
8. Pei-Ling Hsu, Fan-E Mo*. (2017, Apr). The extracellular matrix protein CCN1 mediates the endothelial dysfunction induced by disturbed flow. The 85th Congress of the European Atherosclerosis Society.
9. Pei-Ling Hsu, Jheng-Sin Chen, Fan-E Mo*. (2016, Oct). The matricellular protein CCN1 promotes neointima formation through integrin α6β1. The 7th Scientific Meeting of Asian Society for Vascular Biology.
10. Pei-Ling Hsu, Fan-E Mo*. (2016, Mar). Matricellular protein CCN1 mediates doxorubicin-induced cardiomyopathy in mice. The 31th Joint Annual Conference of Biomedical Science.