What if there were a way to know if a depressed patient would respond to an antidepressant before it was prescribed? Or provide patients with better pain control and increased quality of life while taking opioids.
How? CYP2D6 & CYP2C19 two very important enzymes part of the mixed function oxidases known by Cytochrome p450 - CYP450, known to metabolize most of opioid and mental health drugs in clinical use. The current available evidence predict enzyme activity level based on specific genotypes.
Why? Antidepressants are some of the most popular drugs in the United States, and their usage shows no signs of waning. According to the National Center for Health statistics 13% of people 12 years and older took antidepressants. Nearly 92 million U.S. adults, or about 38 percent of the population, took a legitimately prescribed opioids.
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