Publications

Yoo Jin Jang, Dong-Gyu Heo, Eunjin Hong.

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology & Therapeutics 

https://doi.org/10.1002/cpt.70345  (Corresponding author)   

Madeline Sanders, Eunjin Hong‡, Manya Jain, Paul Beringer‡.

Effect of concomitant rifampin and clarithromycin on elexacaftor-tezacaftor-ivacaftor using a PBPK modeling approach

Expert Opinion on Drug Metabolism & Toxicology

https://doi.org/10.1080/17425255.2026.2689048   (‡: Co-corresponding author) 

Minji Kim, Eunjin Hong.

Analysis of Real‐World Data Utilization in the Orphan Drug Approval Process: Focusing on New Drug Marketing Applications Submitted to the FDA

Clinical Pharmacology & Therapeutics 

https://doi.org/10.1002/cpt.70228  (Corresponding author)   

Seonyoung Byoun, Dong-Gyu Heo, Minsoo Lee, Ryunghwa Lee, Yuanyuan Li, Ju-Yeun Lee, Eunjin Hong‡, Wooin Lee‡.

Enhanced CYP2C19-mediated drug-drug interaction risk with escitalopram in geriatric populations

Frontiers in Pharmacology 

https://doi.org/10.3389/fphar.2025.1711196  (‡: Co-corresponding author) 

Madeline  Sanders†,  Eunjin  Hong†,  Peter  Chung  et  al.  

Evaluation  of  the  drug  interaction  between  rifabutin  and elexacaftor/tezacaftor/ivacaftor (ETI)

Journal of Cystic Fibrosis  

https://doi.org/10.1016/j.jcf.2025.09.002  (†: Co-first author)

Yoo Jin Jang, Doh Kwan Kim, Shin-Won Lim, Eunjin Hong. 

Impact of CYP2C19 Phenotype on Escitalopram Response in Geriatrics:  Based  on  Physiologically-Based  Pharmacokinetic  Modeling  and  Clinical  Observation

Clinical  Pharmacology  & Therapeutics 

https://doi.org/10.1002/cpt.3537  (Corresponding author)   

Dong-Gyu Heo, Madeline Sanders, Vinicius Calado Nogueira de Moura, Charles L Daley, Paul M Beringer‡, Eunjin Hong‡.

Dose optimization of omadacycline for the treatment of nontuberculous mycobacterial pulmonary disease (NTM-PD) using a physiologically based pharmacokinetic modeling approach

Journal of Pharmaceutical Investigation 

https://doi.org/10.1007/s40005-025-00776-0  (‡: Co-corresponding author) 

Yunjoung Kim, Eunjin Hong‡, Hyekyung Park‡

Community pharmacists’ perceptions of dispensing long-term prescriptions exceeding 90 days–A survey of pharmacists from a single pharmacy chain

Korean Journal of Clinical Pharmacy (2025)  (‡: Co-corresponding author) 

Eunjin Hong, Mary F Hebert, Emily Fay et al. 

Predicting Maternal and Fetal Exposures of Elexacaftor–Tezacaftor–Ivacaftor during Pregnancy through Physiologically Based Pharmacokinetic Models

Clinical Pharmacology & Therapeutics 

https://doi.org/10.1002/cpt.3705 (First author)

Eunjin Hong, Sarah Parsons, Laura Sass et al. 

Preliminary evidence for sustained efficacy of CFTR modulator therapy with concomitant rifabutin administration

Journal of Cystic Fibrosis  

https://doi.org/10.1016/j.jcf.2023.11.015 (First author)

Eunjin Hong, Regina Li, Alan Shi et al. 

Safety of elexacaftor/tezacaftor/ivacaftor dose reductions: mechanistic exploration through physiologically based pharmacokinetic modeling and a clinical case series

Pharmacotherapy 

https://doi.org/10.1002/phar.2786 (First author)

Tian Xia, Xin Wu, Eunjin Hong et al. 

Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion

PLoS Pathogen 

https://doi.org/10.1371/journal.ppat.1011232

Eunjin Hong, Eugeniu Carmanov, Alan Shi et al.

Application of physiologically-based pharmacokinetic modeling to predict drug- drug interactions between ivacaftor and tacrolimus in lung transplant patients 

Pharmaceutics 

https://doi.org/10.3390/pharmaceutics15051438 (First author)

Eunjin Hong, Alan Shi, Paul Beringer. 

Drug-drug interactions involving CFTR modulators: a review of the evidence and clinical implications

Expert Opinion on Drug Metabolism & Toxicology (2023) 

https://doi.org/10.1080/17425255.2023.2220960 (First author)

Eunjin Hong, Lisa Almond, Peter Chung et al. 

Physiologically‐Based Pharmacokinetic‐Led Guidance for Patients with Cystic Fibrosis Taking Elexacaftor‐Tezacaftor‐Ivacaftor With Nirmatrelvir‐Ritonavir for the Treatment of COVID‐19

Clinical Pharmacology & Therapeutics 

https://doi.org/10.1002/cpt.2585 (First author)

Eunjin Hong, Lisa Almond, Peter Chung et al.

Physiologically-Based Pharmacokinetic (PBPK) modeling to guide management of drug interactions between elexacaftor-tezacaftor-ivacaftor and antibiotics for the treatment of non-tuberculosis mycobacteria (NTM)

Antimicrobial Agents and Chemotherapy 

https://doi.org/10.1128/aac.01104-2212 (First author)

Weiqiang Chen, Suan-Sin Foo, Eunjin Hong et al. 

Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses

Nature Microbiology 

https://doi.org/10.1038/s41564-020-00850-3