Welcome!

The PhABLE group for Physics of Adaptation, Learning, and Evolution in Biology [acronym sbj. to permutation invariance] is part of the Yale Center for Systems and Engineering Immunology (CSEI), the Yale QBio institute, and the departments of Immunobiology, Biomedical engineering, and Physics at Yale. 

We study how biological systems learn and adapt to their environments, and over longer time scales, how they evolve functional molecular programs and machinery. Our research bridges physics, mathematics, and computer science to uncover the principles underlying biological function, with a special focus on the immune system. By moving beyond description toward predictive understanding, we aim to develop frameworks that guide the rational design of control strategies for next-generation immune engineering.