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Selected Publications:
Selected Publications:
Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment. Padi SKR, Godek RJ, Peti W, Page R. Nat Struct Mol Biol. 2025 Apr 17. doi: 10.1038/s41594-025-01535-3.
A protein phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome. Choy MS, Nguyen HT, Kumar GS, Peti W, Kettenbach AN, Page R. Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2415383121
Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19; Padi, S.K.R., Vos. M.R., Godek, R.J., Fuller, J.R., Kruse, T., Hein, J.B., Nilsson, J., Kelker, M.S., Page, R. & Peti, W. (2024), Nature, 635(7993), 195-203
Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction; Srivastava G, Choy MS, Bolik-Coulon N, Page R, Peti W. Nature Communication. 2023 Mar 31; 14(1):1798
Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5; Hunashal Y, Kumar GS, Choy MS, D'Andrea ED, Da Silva Santiago A, Schoenle MV, Desbonnet C, Arthur M, Rice LB, Page R, Peti W. Nature Communication. 2023 Jul 17; 14(1):4268
Conserved conformational dynamics determine enzyme activity; Torgeson. K.R., Clarkson, M.W., Granata, D., Lindorff-Larsen, K., Page, R. & Peti, W. (2022), Science Advances, 8, eabo5546.
The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1; Singh, J.P, Li, Y., Chen, Y.-Y., Hsu, S.T.D., Page, R., Peti W. & Meng, T.C. (2022), Nature Communication, 13:94.
Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin; Hendus-Altenburger R, Wang X, Sjøgaard-Frich LM, Pedraz-Cuesta E, Sheftic SR, Bendsøe AH, Page R, Kragelund BB, Pedersen SF, Peti W. Nature Communication. 2019 August 2; 10(1): 3498
SDS22 selectively recognizes and traps metal-deficient inactive PP1; Choy MS, Moon TM, Ravindran R, Bray JA, Robinson LC, Archuleta TL, Shi W, Peti W, Page R. Proc Natl Acad Sci USA. 2019 October 8; 116 (41) 20472-20481
Identification of the Substrate Recruitment Mechanism of the Muscle Glycogen Protein Phosphatase 1 Holoenzyme; Kumar GS, Choy MS, Koveal DM, Lorinsky MK, Lyon SP, Kettenbach AN, Page R, Peti W. Science Advances. 2018 Nov 14; 4(11), eaau6044
Dynamic Activation and Regulation of the Mitogen-Activated Protein Kinase p38; Kumar GS, Clarkson MW, Kunze MBA, Granata D, Wand AJ, Lindorff-Larsen K, Page R, Peti W. Proc Natl Acad Sci USA. 2018 May 1; 115 (18), 4655-4660
PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors; Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W. J Am Chem Soc. 2017 Dec 13; 139(49):17703-17706
Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Choy MS, Li Y, Machado LESF, Kunze MBA, Connors CR, Wei X, Lindorff-Larsen K, Page R, Peti W. Mol Cell. 2017 Feb 16; 65(4):644-658
The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. Kumar GS, Gokhan E, De Munter S, Bollen M, Vagnarelli P, Peti W, Page R. Elife. 2016 Aug 30; 5. pii: e16539
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