PE Lab - Publications

PE Lab

41. P. Lahiri, S. Priyadarshini, M. Saini, M. Agrawal, S. A. Mohid, R. S. Rajmani, V. S. M. Ammineni, P. Biswas, A. Asok, A. K. Baidya, A. Bhunia, G. Reddy, R. Pathania, J. Chatterjee. Turn-engineering tunes the conformational rigidity of β-hairpin AMPs in achieving membrane selectivity and killing drug-resistant ESKAPE pathogens. Chem. Sci. 2025, 16, (ASAP).

40. P. Ghosh, N. Raj, H. Verma, M. Patel, S. Chakraborti, B. Khatri, C. M. Doreswamy, S. R. Anandakumar, S. Seekallu, M. B. Dinesh, G. Jadhav, P. N. Yadav, J. Chatterjee. An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides. Nat. Commun. 2023, 14, 6050.

39. J. Bhowmick, M. Nag, P. Ghosh P, R. S. Rajmani, R. Chatterjee, K. Karmakar, K. Chandra, J. Chatterjee, D. Chakravortty, R. Varadarajan. A CcdB toxin-derived peptide acts as a broad-spectrum antibacterial therapeutic in infected mice. EMBO Rep. 2023, 24, e55338.

38. B. Khatri, I. Pramanick, S. K. Malladi, R. S. Rajmani, S. Kumar, P. Ghosh, N. Sengupta, R. Rahisuddin, N. Kumar, S. Kumaran, R. P. Ringe, R. Varadarajan, S. Dutta, J. Chatterjee, A proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein. Nat. Chem. Biol. 2022, 18, 1046-1055.

37. K. E. Fiore, M. J. Patist, S. Giannakoulias, C-H. Huang, H. Verma, B. Khatri, R. P. Cheng, J. Chatterjee, E. J. Petersson, Structural impact of thioamide incorporation into a β-hairpin. RSC Chem. Biol. 2022, 3, 582-591.

36. B. Khatri, S. Raghunathan, S. Chakraborti, R. Rahisuddin, S. Kumaran, R. Tadala, P. Wagh, U. Deva Priyakumar, J. Chatterjee, Desolvation of peptide bond by O to S substitution impacts protein stability. Angew. Chem. Int. Ed. 2021, 60, 24870-24874.

35. B. Khatri, N. Raj, J. Chatterjee, Opportunities and challenges in the synthesis of thioamidated peptides. Methods Enzymol. 2021, 656, 27-57.

34. P. Ghosh and J. Chatterjee, CH-π Interaction between cross strand amino acid pair stabilizes β-hairpins. Chem. Commun. 2020, 56, 14447-14450.

33. B. Khatri, P. Majumder, J. Nagesh, A. Penmatsa, J. Chatterjee, Increasing protein stability by engineering n → π* interaction at the β-turn. Chem. Sci. 2020, 11, 9480-9487.

32. B. Khatri, P. Bhat, J. Chatterjee, Convenient synthesis of thioamidated peptides and proteins. J. Pept. Sci. 2020, 26, 3248-3256.

31. B. Khatri, V. R. Nuthakki, J. Chatterjee, Strategies to enhance metabolic stabilities. Methods Mol. Biol. 2019, 2001, 17-40.

30. P. Lahiri, H. Verma, A. Ravikumar, J. Chatterjee, Protein stabilization by tuning the steric restraint at the reverse turn. Chem. Sci. 2018, 9, 4600-4609.

29. H. Verma, B. Khatri, S. Chakraborti, J Chatterjee, Increasing the bioactive space of peptide macrocycles by thioamide substitution. Chem. Sci. 2018, 9, 2443-2451.

28. K. Chandra, P. Garai, J. Chatterjee, D. Chakravortty, Peptide transporter YjiY influences the expression of the virulence gene mgtC to regulate biofilm formation in Salmonella. FEMS Microbiol. Lett. 2017, 364, fnx236.

27. S. Vishwanath, S. Banerjee, A. K. Jamithireddy, N. Srinivasan, B. Gopal, J. Chatterjee, Design, synthesis, and experimental validation of peptide ligands targeting Mycobacterium tuberculosis σ factors. Biochemistry 2017, 56, 2209-2218.

26. S. Mukherjee and J. Chatterjee, Suppressing the epimerization of endothioamide peptides during Fmoc/t‐Bu‐based solid phase peptide synthesis. J. Pept. Sci. 2016, 22, 664-672.

25. D. Ghosh, P. Lahiri, H. Verma, S. Mukherjee, J. Chatterjee, Engineering β-sheets employing N-methylated heterochiral amino acids. Chem. Sci. 2016, 7, 5212-5218.

24. P. Garai, A. Lahiri, D. Ghosh, J. Chatterjee, D. Chakravortty, Peptide-utilizing carbon starvation gene yjiY is required for flagella-mediated infection caused by Salmonella. Microbiology 2016, 162, 100-116.

23. S. Mukherjee, H. Verma, J. Chatterjee, Efficient site-specific incorporation of thioamides into peptides on a solid support. Org. Lett. 2015, 17, 3150-3153.

Publications from post-doctoral and doctoral research

22. N. Madroñal, J. M. Delgado-Garcia, A. Fernández-Guizán, J. Chatterjee, M. Köhn, C. Mattucci, A. Jain, T. Tsetsenis, A. Illarionova, V. Grinevich, C. T. Gross, A. Gruart, Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells. Nat. Commun. 2016, 7, 10923.

21. U. K. Marelli, O. Ovadia, A. O. Frank, J. Chatterjee, C. Gilon, A. Hoffman, H. Kessler, Cis-peptide bonds: A key to intestinal permeability of peptides? Chem. Eur. J. 2015, 21, 15148-15152.

20. C. Meyer, B. Hoeger, J. Chatterjee, M. Köhn, Azide-alkyne cycloaddition mediated cyclization of phosphonopeptides and their evaluation as PTP1B binders and enrichment tools. Bioorg. Med. Chem. 2015, 23, 2848-2853.

19. G. Reither, J. Chatterjee, M. Beullens, C. Schultz, M. Köhn, M. Bollen, Chemical activators of protein phosphatase-1 induce calcium release inside intact cells. Chem. Biol. 2013, 20, 1179-1186.

18. J. Chatterjee and M. Köhn, Targeting the untargetable: Recent advances in the selective chemical modulation of protein phosphatase-1 activity. Curr. Opin. Chem. Biol. 2013, 17, 361-368.

17. J. Chatterjee, F. Rechenmacher, H. Kessler, N-Methylation of peptides and proteins: an important element for modulating biological functions. Angew. Chem. Int. Ed. 2013, 52, 254-269.

16. J. Chatterjee, M. Beullens, R. Sukackaite, J. Qian, B. Lesage, D. J. Hart, M. Bollen, M. Köhn, Development of a peptide that selectively activates protein phosphatase-1 in living cells. Angew. Chem. Int. Ed. 2012, 51, 10054-10059.

15. J. G. Beck, J. Chatterjee, B. Laufer, U. K. Marelli, A. O. Frank, S. Neubauer, O. Ovadia, S. Greenberg, C. Gilon, A. Hoffman, H. Kessler, Intestinal permeability of cyclic peptides: Common key backbone motif identified. J. Am. Chem. Soc. 2012, 134, 12125-12133.

14. J. Chatterjee, B. Laufer, H. Kessler, Synthesis of N-methylated cyclic peptides. Nat. Protocols 2012, 7, 432-444.

13. J. Chatterjee, B. Laufer, J. C. Reubi, G. Keri, H. Kessler, Multiple N-methylated cyclic hexapeptides for treatment of neurogenic inflammation. ACS Med. Chem. Lett. 2011, 2, 509-514.

12. O. Ovadia, S. Greenberg, J. Chatterjee, B. Laufer, F. Operrer, C. Gilon, H. Kessler, A. Hoffman, The effect of multiple N-methylation on intestinal permeability of peptides. Mol. Pharm. 2011, 8, 479-487.

11. B. Laufer, A. O. Frank, J. Chatterjee, T. Neubauer, C. Mas-Moruno, G. Kummerlöwe, H. Kessler, The impact of amino acid side chain mutations in conformational design of peptides and proteins. Chem. Eur. J. 2010, 16, 5385-5390.

10. H. Kessler, J. Chatterjee, L. Doedens, F. Operrer, E. Biron, D. Hoyer, H. Schmid, C. Gilon, V. J. Hruby, D. F. Mierke, New perspective in peptide chemistry by N-alkylation. Adv. Exp. Med. Biol. 2009, 611, 229- 231.

9. B. Laufer, J. Chatterjee, A. O. Frank, H. Kessler, Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides? J. Pept. Sci. 2009, 15, 141-146.

8. J. Chatterjee, H. Kessler, New perspectives in peptide chemistry by N-alkylation. Chim. Oggi-Chem. Today 2008, 26, 4-5.

7. J. Chatterjee, C. Gilon, A. Hoffman, H. Kessler, N-Methylation: A new perspective in peptide medicinal chemistry. Acc. Chem. Res. 2008, 41, 1331-1342.

6. E. Biron, J. Chatterjee, O. Ovadia, D. Langenegger, J. Brueggen, D. Hoyer, H. Schmid, R. Jalenik, C. Gilon, A. Hoffman, H. Kessler, Improving oral bioavailability of peptides via multiple N-methylation: Somatostatin analogs. Angew. Chem. Int. Ed. 2008, 47, 2595-2599.

5. J. Chatterjee, D. F. Mierke, H. Kessler, Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides. Chem. Eur. J. 2008, 14, 1508-1517.

4. J. Chatterjee, O. Ovadia, G. Zahn, L. Marinelli, A. Hoffman, C. Gilon, H. Kessler, Multiple N-methylation by a designed approach enhances receptor selectivity. J. Med. Chem. 2007, 50, 5878-5881.

3. J. Chatterjee, D. F. Mierke, H. Kessler, N-Methylated cyclic pentaalanine peptides as template structures. J. Am. Chem. Soc. 2006, 128, 15164- 15172.

2. E. Biron, J. Chatterjee, H. Kessler, Solid-phase synthesis of 1,3-azole based peptides and peptidomimetics. Org. Lett. 2006, 8, 2417-2420.

1. E. Biron, J. Chatterjee, H. Kessler, Optimized selective N-methylation of peptides on solid support. J. Pept. Sci. 2006, 12, 213-219.

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