RESEARCH

ANTIBODY-BASED THERAPEUTICSS Antibody therapeutics is one of the most successful and important drugs for treating patients with cancer. As a collaboration with the Jeong lab at Hongik University, we are developing and validating the next-generation antibody therapeutics targeting cancer cells. To this end, we developed the SampleStream platform-top-down mass spectrometry (SampleStream-TDMS) as a streamlined and high-throughput workflow for intact protein profiling. 

NATURAL PRODUCT DISCOVERYSThe method of combining metabolomics and genomics to simultaneously illuminate novel chemical structures with their biosynthesis at large scale is known as metabologenomics. The metabologenomics platform provides a new screen for secondary metabolites whose data can be mined to identify new members of interesting structural classes, to determine the biosynthetic origin of a known natural product, or to identify entirely new structural classes and biosyntheses.