Approach based on the fact that form dictates function, which defines form... 

• define important parameters that can be controlled externally and identified as influential in defining a tissue shape (from biology and physics) 

• test them in a simple cell culture environment using differentiated cells or iPSCs 

• register cell response when these parameters are tuned (independently, decoupled and collaboratively or competitively)

• observe how cells remodel, assemble and organize their environment and adopt a certain shape

• verify if the specific cell markers are there

• verify cell and tissue function

• provide feedback on how to tune the parameters for cells to perform better (consider using different cells)

• then test co-culture