Research

Osmolyte-Water/Osmolyte-Protein Interaction

Usually, external solutes alter the local structural arrangement of the water hydrogen bond (H-bond) network. However, urea has a negligible effect on the local structure of water, irrespective of its concentration. The urea-water system was investigated  extensively. Despite widespread exploration, our understanding of the precise molecular mechanisms responsible for protein denaturation induced by urea still needs to be improved. Our primary goal is to include explicit polarizability  We aim to understand the  this problem in microscopic details, with the help of  theoretical spectroscopy .