Publications
Joseph V, Pagliardini S, Belaidi E. Editorial: Causes and Consequences of Sleep Apnea: Spotlights on the Roles of Sex and Sex Hormones. Front Physiol. 2022 Feb 23;13:857627. doi: 10.3389/fphys.2022.857627. eCollection 2022. PMID: 35283785
Hauer BE, Pagliardini S, Dickson CT. Prefrontal-Hippocampal Pathways Through the Nucleus Reuniens Are Functionally Biased by Brain State. Front Neuroanat. 2022 Jan 31;15:804872. doi: 10.3389/fnana.2021.804872. eCollection 2021. PMID: 35173588
Saini JK, Janes TA, MacLean JE, Pagliardini S. Expiratory activity during sleep in children. J Sleep Res. 2021 Dec 18:e13539. doi: 10.1111/jsr.13539. Online ahead of print.PMID: 34921704
Baddam P, Biancardi V, Roth DM, Eaton F, Thereza-Bussolaro C, Mandal R, Wishart DS, Barr A, MacLean J, Flores-Mir C, Pagliardini S, Graf. Neural crest-specific deletion of Bmp7 leads to midfacial hypoplasia, nasal airway obstruction, and disordered breathing modelling Obstructive Sleep Apnea. Dis Model Mech. 2021 Jan 11;14(2):dmm047738. doi: 10.1242/dmm.047738. Online ahead of print.
Biancardi V, Saini J, Pageni A, Prashaad M H, Funk GD, Pagliardini S. Mapping of the excitatory, inhibitory, and modulatory afferent projections to the anatomically defined active expiratory oscillator in adult male rats. J Comp Neurol. 2020 Jul 12. doi: 10.1002/cne.24984. Online ahead of print. PMID: 32656849
Pisanski A, Ding X, Koch NA, Pagliardini S. Chemogenetic modulation of the parafacial respiratory group influences the recruitment of abdominal activity during REM sleep. Sleep. 2020 May 12;43(5):zsz283. doi: 10.1093/sleep/zsz283. PMID: 31747042
Hauer BE, Pagliardini S, Dickson CT. The Reuniens Nucleus of the Thalamus Has an Essential Role in Coordinating Slow-Wave Activity between Neocortex and Hippocampus. eNeuro. 2019 Oct 17;6(5):ENEURO.0365-19.2019. doi: 10.1523/ENEURO.0365-19.2019. Print 2019 Sep/Oct. PMID: 31548369
Reklow RJ, Alvares TS, Zhang Y, Miranda Tapia AP, Biancardi V, Katzell AK, Frangos SM, Hansen MA, Toohey AW, Cass CE, Young JD, Pagliardini S, Boison D, Funk GD. The Purinome and the preBötzinger Complex - A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response. Front Cell Neurosci. 2019 Aug 21;13:365. doi:10.3389/fncel.2019.00365. eCollection 2019. PMID: 31496935
Agarwal J, Saad E, Fontaine G, Pagliardini S, Dafoe W, Killian K, Gibney RTN, Huston J, Vethanayagam D. Routine use of post-bronchodilator testing in pulmonary function testing labs. Clin Invest Med. 2019 Jan 30;41(4):E204-E210. doi: 10.25011/cim.v41i4.32224. PMID: 30737980
Gazzaz M, Saini J, Pagliardini S, Tsui B, Jeffery C, El-Hakim H. Comparison of inhaled versus intravenous anesthesia for laryngoscopy and laryngeal electromyography in a rat model. J Otolaryngol Head Neck Surg. 2018 Oct 20;47(1):64. doi: 10.1186/s40463-018-0312-9. PubMed PMID: 30342558; PubMed Central PMCID: PMC6196000.
Hauer BE, Negash B, Chan K, Vuong W, Colbourne F, Pagliardini S, Dickson CT. Hyperoxia enhances slow-wave forebrain states in urethane-anesthetized and naturally sleeping rats. J Neurophysiol. 2018 Oct 1;120(4):1505-1515. doi: 10.1152/jn.00373.2018. Epub 2018 Jun 27. PubMed PMID: 29947598; PubMed Central PMCID: PMC6230787.
Rajani V, Zhang Y, Jalubula V, Rancic V, SheikhBahaei S, Zwicker JD, Pagliardini S, Dickson CT, Ballanyi K, Kasparov S, Gourine AV, Funk GD. Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca2+ -dependent P2Y1 receptor mechanism. J Physiol. 2018 Aug;596(15):3245-3269. doi: 10.1113/JP274727. Epub 2017 Jul 27. PubMed PMID: 28678385; PubMed Central PMCID: PMC6068109.
Pisanski A, Pagliardini S. The parafacial respiratory group and the control of active expiration. Respir Physiol Neurobiol. 2018 Jun 19. pii: S1569-9048(18)30100-9. doi: 10.1016/j.resp.2018.06.010. [Epub ahead of print] Review. PubMed PMID: 29933053.
Saini JK, Pagliardini S. Breathing During Sleep in the Postnatal Period of Rats: The Contribution of Active Expiration. Sleep. 2017 Dec 1;40(12). doi: 10.1093/sleep/zsx172. PubMed PMID: 29294135.
da Silva GSF, Sabino JPJ, Rajani V, Alvares TS, Pagliardini S, Branco LGS, Funk GD. Excitatory Modulation of the preBötzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide. Front Physiol. 2017 Jun 30;8:452. doi: 10.3389/fphys.2017.00452. eCollection 2017. PubMed PMID: 28713283; PubMed Central PMCID: PMC5492353.
Boutin RC, Alsahafi Z, Pagliardini S. Cholinergic modulation of the parafacial respiratory group. J Physiol. 2017 Feb 15;595(4):1377-1392. doi: 10.1113/JP273012. Epub 2016 Dec 11. PubMed PMID: 27808424; PubMed Central PMCID: PMC5309363.
Li P, Janczewski WA, Yackle K, Kam K, Pagliardini S, Krasnow MA, Feldman JL. The peptidergic control circuit for sighing. Nature. 2016 Feb 18;530(7590):293-297. doi: 10.1038/nature16964. Epub 2016 Feb 8. PubMed PMID: 26855425; PubMed Central PMCID: PMC4852886.
Andrews CG, Pagliardini S. Expiratory activation of abdominal muscle is associated with improved respiratory stability and an increase in minute ventilation in REM epochs of adult rats. J Appl Physiol (1985). 2015 Nov 1;119(9):968-74. doi: 10.1152/japplphysiol.00420.2015. Epub 2015 Sep 3. PubMed PMID: 26338455; PubMed Central PMCID: PMC4628995.
ElMallah MK, Pagliardini S, Turner SM, Cerreta AJ, Falk DJ, Byrne BJ, Greer JJ, Fuller DD. Stimulation of Respiratory Motor Output and Ventilation in a Murine Model of Pompe Disease by Ampakines. Am J Respir Cell Mol Biol. 2015 Sep;53(3):326-35. doi: 10.1165/rcmb.2014-0374OC. PubMed PMID: 25569118; PubMed Central PMCID: PMC4566070.
Alsahafi Z, Dickson CT, Pagliardini S. Optogenetic excitation of preBötzinger complex neurons potently drives inspiratory activity in vivo. J Physiol. 2015 Aug 15;593(16):3673-92. doi: 10.1113/JP270471. Epub 2015 Jul 14. PubMed PMID: 26010654; PubMed Central PMCID: PMC4560590.
Viczko J, Sharma AV, Pagliardini S, Wolansky T, Dickson CT. Lack of respiratory coupling with neocortical and hippocampal slow oscillations. J Neurosci. 2014 Mar 12;34(11):3937-46. doi: 10.1523/JNEUROSCI.3581-13.2014. PubMed PMID: 24623771.
Pagliardini S, Funk GD, Dickson CT. Breathing and brain state: urethane anesthesia as a model for natural sleep. Respir Physiol Neurobiol. 2013 Sep 15;188(3):324-32. doi: 10.1016/j.resp.2013.05.035. Epub 2013 Jun 7. Review. PubMed PMID: 23751523.
Pagliardini S, Gosgnach S, Dickson CT. Spontaneous sleep-like brain state alternations and breathing characteristics in urethane anesthetized mice. PLoS One. 2013 Jul 30;8(7):e70411. doi: 10.1371/journal.pone.0070411. Print 2013. PubMed PMID: 23936201; PubMed Central PMCID: PMC3728022.
Pagliardini S, Greer JJ, Funk GD, Dickson CT. State-dependent modulation of breathing in urethane-anesthetized rats. J Neurosci. 2012 Aug 15;32(33):11259-70. doi: 10.1523/JNEUROSCI.0948-12.2012. PubMed PMID: 22895710.
Pagliardini S, Janczewski WA, Tan W, Dickson CT, Deisseroth K, Feldman JL. Active expiration induced by excitation of ventral medulla in adult anesthetized rats. J Neurosci. 2011 Feb 23;31(8):2895-905. doi: 10.1523/JNEUROSCI.5338-10.2011. PubMed PMID: 21414911; PubMed Central PMCID: PMC3142740.
Tan W, Pagliardini S, Yang P, Janczewski WA, Feldman JL. Projections of preBötzinger complex neurons in adult rats. J Comp Neurol. 2010 May 15;518(10):1862-78. doi: 10.1002/cne.22308. PubMed PMID: 20235095; PubMed Central PMCID: PMC3494295.
Huxtable AG, Zwicker JD, Poon BY, Pagliardini S, Vrouwe SQ, Greer JJ, Funk GD. Tripartite purinergic modulation of central respiratory networks during perinatal development: the influence of ATP, ectonucleotidases, and ATP metabolites. J Neurosci. 2009 Nov 25;29(47):14713-25. doi: 10.1523/JNEUROSCI.2660-09.2009. PubMed PMID: 19940166.
Pagliardini S, Ren J, Gray PA, Vandunk C, Gross M, Goulding M, Greer JJ. Central respiratory rhythmogenesis is abnormal in lbx1- deficient mice. J Neurosci. 2008 Oct 22;28(43):11030-41. doi: 10.1523/JNEUROSCI.1648-08.2008. PubMed PMID: 18945911.
Buccafusca R, Venditti CP, Kenyon LC, Johanson RA, Van Bockstaele E, Ren J, Pagliardini S, Minarcik J, Golden JA, Coady MJ, Greer JJ, Berry GT. Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain. Mol Genet Metab. 2008 Sep-Oct;95(1-2):81-95. doi: 10.1016/j.ymgme.2008.05.008. PubMed PMID: 18675571.
Hurd PL, Bailey AA, Gongal PA, Yan RH, Greer JJ, Pagliardini S. Intrauterine position effects on anogenital distance and digit ratio in male and female mice. Arch Sex Behav. 2008 Feb;37(1):9-18. PubMed PMID: 18080736.
Pagliardini S, Rent J, Wevrick R, Greer JJ. Neurodevelopmental abnormalities in the brainstem of prenatal mice lacking the Prader-Willi syndrome gene Necdin. Adv Exp Med Biol. 2008;605:139-43. PubMed PMID: 18085261.
Wolansky T, Pagliardini S, Greer JJ, Dickson CT. Immunohistochemical characterization of substance P receptor (NK(1)R)-expressing interneurons in the entorhinal cortex. J Comp Neurol. 2007 May 20;502(3):427-41. PubMed PMID: 17366610.
Pagliardini S, Ren J, Wevrick R, Greer JJ. Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin. Am J Pathol. 2005 Jul;167(1):175-91. PubMed PMID: 15972963; PubMed Central PMCID: PMC1603432.
Pagliardini S, Adachi T, Ren J, Funk GD, Greer JJ. Fluorescent tagging of rhythmically active respiratory neurons within the pre-Bötzinger complex of rat medullary slice preparations. J Neurosci. 2005 Mar 9;25(10):2591-6. PubMed PMID: 15758169.
Pagliardini S, Ren J, Greer JJ. Ontogeny of the pre-Bötzinger complex in perinatal rats. J Neurosci. 2003 Oct 22;23(29):9575-84. PubMed PMID: 14573537.
Battaglia G, Bassanini S, Granata T, Setola V, Giavazzi A, Pagliardini S. The genesis of epileptogenic cerebral heterotopia: clues from experimental models. Epileptic Disord. 2003 Sep;5 Suppl 2:S51-8. PubMed PMID: 14617421.
Battaglia G, Pagliardini S, Saglietti L, Cattabeni F, Di Luca M, Bassanini S, Setola V. Neurogenesis in cerebral heterotopia induced in rats by prenatal methylazoxymethanol treatment. Cereb Cortex. 2003 Jul;13(7):736-48. PubMed PMID: 12816889.
Gardoni F, Pagliardini S, Setola V, Bassanini S, Cattabeni F, Battaglia G, Di Luca M. The NMDA receptor complex is altered in an animal model of human cerebral heterotopia. J Neuropathol Exp Neurol. 2003 Jun;62(6):662-75. PubMed PMID: 12834111.
Ren J, Lee S, Pagliardini S, Gérard M, Stewart CL, Greer JJ, Wevrick R. Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice. J Neurosci. 2003 Mar 1;23(5):1569-73. PubMed PMID: 12629158.
Battaglia G, Pagliardini S, Ferrario A, Gardoni F, Tassi L, Setola V, Garbelli R, LoRusso G, Spreafico R, Di Luca M, Avanzini G. AlphaCaMKII and NMDA-receptor subunit expression in epileptogenic cortex from human periventricular nodular heterotopia.Epilepsia. 2002;43 Suppl 5:209-16. PubMed PMID: 12121323.
Hwang SJ, Pagliardini S, Rustioni A, Valtschanoff JG. Presynaptic kainate receptors in primary afferents to the superficial laminae of the rat spinal cord. J Comp Neurol. 2001 Jul 30;436(3):275-89. PubMed PMID: 11438930.
Hwang SJ, Pagliardini S, Boukhelifa M, Parast MM, Otey CA, Rustioni A, Valtschanoff JG. Palladin is expressed preferentially in excitatory terminals in the rat central nervous system. J Comp Neurol. 2001 Jul 23;436(2):211-24. PubMed PMID: 11438925.
Di Luca M, Gardoni F, Finardi A, Pagliardini S, Cattabeni F, Battaglia G, Missale C. NMDA receptor subunits are phosphorylated by activation of neurotrophin receptors in PSD of rat spinal cord. Neuroreport. 2001 May 8;12(6):1301-5. PubMed PMID: 11338211.
Pagliardini S, Giavazzi A, Setola V, Lizier C, Di Luca M, DeBiasi S, Battaglia G. Subcellular localization and axonal transport of the survival motor neuron (SMN) protein in the developing rat spinal cord. Hum Mol Genet. 2000 Jan 1;9(1):47-56. PubMed PMID: 10587577.
Capra V, Ravasi S, Bolla M, Viappiani S, Pagliardini S, Belloni PA, Mezzetti M, Folco GC, Nicosia S, Rovati GE. Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. Adv Exp Med Biol. 1999;469:313-8. PubMed PMID: 10667347.