Embedded Files
Google Scholar: Rebecca Page
2024, selected
Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Padi, S.K.R., Vos, M.R., Godek, R.J., Fuller, J.R., Kruse, R., Hein, J.B., Kelker, M.S., Page, R., Peti, W. Nature. (2024). 625: .
The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to primer metal exchange. Choy, M.S., Srivistava, G., Robinson, L.C.,, Tatchel, K., Page, R., Peti, W. Journal of Biological Chemistry. (2024). 300: 105515.
2023, selected
Molecular basis of beta-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5. Hunashal, Y., Kumar, SG.S., Choy, M.S., D D'Andrea, E.D., Da Silva Santiago, A.D.S, Schoenle, M.V., Desbonnet, C., Arthur, M. . Nature Comm (2023). 13:94.
Inhibitor-3 inhibits protein phosphatase 1 via a metal biniding dynamic protein-protein interaction. Srivastava, G., Choy, M.S., Bolik-Coulon, N.,, Page, R., Peti W. Nature Comm (2023). 14:1.
Structural mechanism for inhibition of PP2A-B56a and oncogenicity by CIP2A. Pavic, K, et al. Nature Communications.. (2023). 14:1143.
2022, selected
The ribosomal RNA processing 1B:protein phosphtase 1 holoenzyme reveals non-canonical PP1 interaction motifs. Srivastava, G., Baja, R., Kumar, G.S., Gaudreau-Lapierre, A., Nicolas, H., Chamousset, D., Kreitler, D. Peti, W. Trinkle-Mulcahy, L, Page, R. (2022). 14:1143.
Degradation of the E. coli antitoxin MqsA by the proteolytic complex ClpXP is regulated by zinc occupancy and oxidation. Vos, M.R., Piraino, B., LaBreck, C.J., Rahmani, N., Trebino, C.E., Schoenle, M., Peti W., Camberg, J.L., Page, R. Journal of Biological Chemistry. (2022). 298: 101557.
The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1. Singh, J.P., Li, Y., Hsu, S.D., Page, R., Peti W., Meng. T.C. Nature Comm (2022). 13:94.
Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex. Zhang, R. Kumar, G.S., Hansen, U., Zoccheddu, M., Sacchetti, C., Holmes, Z.J., Lee, M.C., Beckmann, D., Wen, Y., Mikulski, Z., Yang, S., Santelli, E., Page, R., Boin, F., Peti, W., Bottnin, N. JCI Insight.. (2022). 7:e155761.
2021, selected
NMR based SARS-CoV-2 Antibody Screening. Schoenla, M.V., Li, Y., Yuan, M., Clarkson, M.W., Peti, W.., Page, R.JACS (2021). 143: 7930-7934.
PP2A/B55a substrate recruitment as defined by the retinoblastoma-related protein p107. Fowle, H., Zhao, Z., Xu, Q., Wasserman, J.S., Wang, X., Adeyemi, M., Feiser, F., Kurimchak, A.N., Atar, Diba, McEwan, B.C., Kettenbach, A.N., Page, R., Peti W., Dunbrack, R.L., Grana, X.eLife (2021). 10:e63181.
1H, 15N, 13C sequence specific backbone assignment of the MAP kinase binding domain of the dual specificity phosphatse 1 and its interaction with the MAPK p38. Kumar, G.S., Page, R., Peti, W. Biomolecular NMR Assign.. (2021). 15:243-248.
The interaction of p38 with its upstream kinase MKK6. Kumar, G.S, Page R,, Peti, W. Protein Sci. (2021). 30: 908-913.
2020, selected
A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment. Wang, X., Garvanska, D.H., Nasa,I., Ueki, Y., Zhang, G., Kettenbach, A.N., Peti, W., Nilsson, J., Page, R.eLife (2020). 9: e55966
The structure of the RCAN1;CN complex explains the inhibition of and substrate recruitment by calcineurin. Li, Y., Sheftic, S.R., Grigoriu, S., Schwieters, C.D., Page, R., Peti W.Science Advances (2020). 6:eaba3681
Cooperative dynamics across distinct structural elements regulate PTP1B activity. Torgeson, K.R., Clarkson, M.W., Kumar, G.S., Page R, Peti W. Journal of Biological Chemistry. (2020). 295: 13829-13837
The mode of action of the protein tyrosine phosphatase 1B inhibitor Ertiprotafib. Kumar, G.S, Page R,, Peti, W. PLoSONE (2020). 15:e0240044
2019, selected
SDS22 selectively recognizes and traps metal-deficient inactive PP1 . Choy, M.S., Moon. T.M., Ravindran, R. Bray, J.A., Robinson, L.C., Archuleta, T.L., Shi, W., Peti, W. Tatchell, K. Page, R. PNAS. (2019). 116: 20472-20481
Molecular basis for the binding and selective dephosphorylation of Na/H exchanger 1 by calcineurin. Hendus-Altenburger, R., Wang, X., Sjogaard-Frich, L.M., Pedraz-Cuesta, E., Sheftic, S.R., Bendsoe, A.H., Page R, , Kragelund, B.B., Pedersen, S.F., Peti W. Nature Communications (2019). 10: 1.08
ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Bertran, M.T., Mouilleron, S., Zhou, Y., Bajaj, R., Uliana, F., Kumar, G.S., von Drogen, A., Lee, R., Banerjee, J.J., Hauri, S., O'Reilly, N., Gstaiger, M., Page R, Peti W. , Tapon, N. Nature Communications. (2019). 10. 1.02
Leveraging new definitions of the LxVP SLiM to discover novel Calcineurin regulators and substrates. Brauer, B.L., Moon, T.M., Sheftic, S.R., Nasa, I., Page R,, Peti, W., Kettenbach, A.N. ACS Chemical Biology (2019).
2018, selected
KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive. Bajaj R, Bollen M, Peti W, Page R. Structure. (2018): 26: 1327-1336 .
Dynamic activation and regulation of the mitogen-activated protein kinase p38. Kumar GS, Clarkson MW, Kunze MBA, Granata D, Wand AJ, Lindorff-Larsen K, Page R, Peti W.PNAS (2018).115:4655-60.
The structures of penicillin-binding protein 4 (PBP4) and PBP5 from provide structural insights into β-lactam resistance. Moon, TM, D'Andréa, ED, Lee, CW, Soares, Jakonic, J, Desbonnet, C,,Garcia-Solache, M, Rive, LB, Page, R., Peti, W. J Biol Chem (2018). 293: 18574-18584.
Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme .Kumar, G.S., Choy, M., Koveal, D.M., Lorinsky, M.K., Lyons, S.P., Kettenbach, A.N., Page, R., Peti W. Science Advances (2018). 4:11-11.
2017, selected
PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W.JACS. (2017)139:17703-6.
Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Choy MS, Li Y, Machado LESF, Kunze MBA, Connors CR, Wei X, Lindorff-Larsen K, Page R, Peti W.Molecular Cell (2017)65:644-58.
The KIM-family PTPs use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation.Machado LESF, Shen TL, Page R, Peti W.J Biol Chem (2017) 292:8786-96.
Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome.Machado LESF, Critton DA, Page R, Peti W.ACS Omega (2017) 2:8313-18
2016, selected
Expanding the PP2A Interactome by Defining a B56-Specific SLiM.Wang X, Bajaj R, Bollen M, Peti W, Page R.Structure (2016) 24:2174-81.
The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.Kumar GS, Gokhan E, De Munter S, Bollen M, Vagnarelli P, Peti W, Page R. eLife (2016) 5. pii: e16539
Toxin-antitoxin systems in bacterial growth arrest and persistence.Page R, Peti W.Nature Chemical Biology. (2016) 12:208-14.
Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM. Sheftic SR, Page R, Peti W. Sci Rep. (2016) 6:38920
2015, selected
Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase . Choy, MS, Yusoff, P, Lee, IC, Newton, JC, Goh, CW, Page, R, Shenolikar, S, Peti, W. Cell Reports (2015) 11: 1885-1891.
PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. Krishnan, N, Krishnan, K, Connors, CR, Choy, MS, Page, R, Peti, W, van Aelst, L, Shea, SD, Tonks, NK. J Clinical Investigations (2015) 125: 3163-3177.
Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable. Peti, W, Page, R. Bioinorganic and medicinal chemistry. (2015) 23: 2781-2785.
The MqsR/MqsA toxin/antitoxin system protects Escherichia coli during bile acid stress. Kwan, BW, Lord, DM, Peti, W, Page, R, Benedik, MJ, Wood, TK. Environ Microbiology. (2105) 17: 3168-3181.
2014, selected
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Krishnan, N, Koveal, D, Miller, DH, Xue, B, Akshinthala, SD, Kragelj, J, Jensen, MR, Gauss, CM, Page, R, Blacledge, M, Muthuswamy, SK, Peti, W, Tonks, NK. Nature Chemical Biology (2014). 10: 558-566.
Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code. Choy, MS, Hieke, M, Kumar, GS, Lewis, GR, Gonzales-DeWhitt, Kessler, RP, Stein, BJ, Hessenberger, M, Nairn, AC, Peti, W, Page, R. PNAS (2014). 111: 4097-4102.
McbR/YncC: implications for the mechanism of ligand and DNA binding by a bacterial GntR transcriptional regulator involved in biofilm formation. Lord, DM, Baran, AU, Soo, VWC, Wood, TK, Peti, W, Page, R. Biochemistry (2014). 53: 7223-7231.
BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH. Lord, DM, Baran AU, Wood, TK, Peti, W, Page, R. PLoS one (2014). 9: 9.09.
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