UK PACT – Prophylactic Antibiotics in Complex Trauma

What is the PACT Study?

Any UK hospital treating any complex tibia fractures.

This includes:

Link to AO classification here - AO tibia classification

We want as many hospitals as possible to take part.

Click HERE to see if you hospital is taking part
Visit PACT Information if you want to get involved or find want to find to find out more information

Nearly 1 in 10 people with a complex fracture will get a Fracture Related Infection (FRI)
Patients with a FRI have a poor quality of life
Finding the best way to reduce FRI in complex fractures is the number 1 JLA research priority
Researching local antibiotics is a recomended area for research by NICE

We will audit current practice against NICE guidelines - NICE recommend systemic prophylactic antibiotics for fracture fixation surgery
We will explore how complex fractures are currently being managed across the UK
We will describe the current variation in prophylactic antibiotic treatment strategies used in complex fractures across the UK
We will identify hospitals trating complex fractures that will be willing to take part in further research (using local antibiotic)

NICE currently reccoment priophylactic systemic antibiotics. They do not reccomend local antibiotics

NICE specify that the use of local antibiotics before wound closure is a reccomended area for research

Finding the best way to lower infection is the number 1 research priority from the JLA PSP

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