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My research aims to create translational, patient-specific organ-on-a-chip disease models that integrate tissue engineering, stem cell culture, microbiology, genetics, molecular biology, and microfluidics, using them to uncover biological insights in unresolved clinical questions where other models fail to address.
Cancer Progression Modeling in Organ Chips
Cancer Progression Modeling in Organ Chips
Patient-derived tumor models in personalized drug therapy (Mechanobiology in Medicine 2023)
Modulation of chemoresistance and vascular permeability during hepatocellular carcinoma progression (Small Structures 2023)
Hepatocellular carcinoma chemoresistance regulation by tumor microenvironment (Frontiers in Oncology 2021)
Microfluidic liver-on-a-chips to optimize transarterial hyperthermia and thermoembolization methods (Pharmaceutics 2020)
Impact of chronic liver diseases on vascular components of liver-on-a-chips (Micromachines 2020)
Drug associated liver toxicity and treatment efficacy (Biotech. & Bioeng. 2019)
Recapitulation of the complex vascular architecture of tumor microenvironments (Biotech. & Bioeng. 2018)
Modeling Intestinal Disorders in Organ Chips
Modeling Intestinal Disorders in Organ Chips
IBD Drivers in Human Organ Chips (medRxiv 2024)
Intestinal Organ Chip disease models (Nature Rev. Gastroenterol. & Hepatol. 2024)
Modeling mucus physiology and pathophysiology in human organs-on-chips (ADDR 2022)
Tissue Biomechanics of Cancer Progression
Tissue Biomechanics of Cancer Progression
Multi-omics integrated micromechanical changes in epithelial and stroma in esophageal cancer progression (BioRxiv 2023)
Modeling of Tumor Growth and Solute Transport in Biological Tissues
Modeling of Tumor Growth and Solute Transport in Biological Tissues
Tumor microenvironment stress on cancer growth and survival (Math. Biosc. Eng. 2022)
Drug binding to polymeric materials in organ-on-a-chips (Lab on a Chip 2021)
Solute size on drug transport and clearance from tumor microenvironment (Journal of Biol. Eng. 2019)
Temporal calibration of in vitro hepatocellular carcinoma growth (Scientific Rep. 2018)
Nanoparticle Synthesis in Dropled-Based Microfluidic Reactors
Nanoparticle Synthesis in Dropled-Based Microfluidic Reactors
Mixing efficacy of solutes in droplet-based microfluidic reactors (Microfluidics & Nanofluidics 2015)
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