Our first project delves into the intricate relationship between the mycomembrane and plasma membrane domains in mycobacteria. We explore how the synthesis of the mycomembrane relies on these domains, revealing a fascinating feedback mechanism that coordinates cell envelope integrity and function.

In our second project, we investigate the potential of membrane fluidizers as new antibacterial agents. These fluidizers exhibit bacteriostatic effects and enhance membrane permeability, opening avenues for synergistic treatments with existing antibiotics. This research aims to identify combinations that can overcome bacterial resistance and improve therapeutic outcomes. 

Our third project focuses on understanding the pathoadaptation mechanisms of mycobacterial cell envelopes. By comparing the cell envelope structures of environmental (non-pathogenic) and clinical (pathogenic) mycobacteria, we aim to uncover the adaptations that enable pathogenicity. This knowledge will provide insights into how mycobacteria evolve to thrive in host environments, potentially leading to new targets for therapeutic intervention.