Ori Braitbard, Ph.D.

Cell phone: (972)-52-3809071

Email: orib@g.jct.ac.il

Research areas

· Cancer research - Viral involvement in cancerous tumors and cancer treatment through the activation of the immune system and the development of innovative chemotherapies.

· Bioinformatic analysis - Genomic and proteomic analysis of MMTV related cancer cells.

· Development of chemotherapy drugs - in vivo and in vitro tests of titanium-based complexes to test toxicity, efficacy, and mechanisms of action against cancer cells and tumors.

1. Immunotherapy against MMTV-associated breast cancer

Mouse Mammary Tumour Virus (MMTV) is a type B retrovirus associated with mammary carcinoma and lymphoma in laboratory mice. An increasing body of evidence in recent years supports the involvement of MMTV in approximately 37% of human breast cancers. These findings suggest the use of p14 (the surface protein of MMTV) for immunotherapy - vaccination and passive immunization against malignant cancers that harbor MMTV.

2. Biological Applications of Ti(IV) Complexes

Ti(IV) complexes are promising anti-cancer agents, exhibiting high cytotoxic activity toward numerous cancer cell lines, and demonstrating high stability in an aqueous environment. We examined the correlation between the complex properties - structure, hydrolytic stability, and cytotoxicity in vitro and in vivo, revealing insights into the biological mechanism of their cytotoxicity and suggesting an apoptotic cell death pathway.

3. Bioinformatics analysis of data from various sources

Utilizing a variety of biological data sources, such as proteomics, DNA arrays, and literature citations, we aimed to understand connections between biological phenomena (e.g., metastasis) and gene expression in different cells, as well as connections between different diseases and gene expression patterns in different diseases, to unveil potential associations among them.

Academic Education

2006- 2010 Post-Doctoral fellow, Dept. of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Israel.

Supervisor: Prof. Jacob Hochman

Research interests: 1. Developing novel approaches toward reversal of multi-drug resistance in cancer. 2. Vaccination against breast cancer.

2001- 2005 Ph.D., Dept. of Biological Chemistry, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Israel.

Supervisors: Prof. Wilfred D. Stein and Prof. Deborah Rund.

Research Title:

Characterization of proteins that are involved in resistance to chemotherapy in different kinds of leukemia

1999-2000 M.Sc., Dept. of Biological Chemistry, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Israel.

Supervisor: Prof. Wilfred D. Stein

Thesis Title: Methods to estimate the amount and cost of production of P- glycoprotein from different sources of membranes.

1996-99 B.Sc. Degree in Biology, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel.

1992-95 Senior Teacher Degree in Bible and Gmara, The E.M. Liphshitz Religious Teachers College, Kiryat Shmona (the northern branch), Israel.

Academic Appointments

2000- 2006 Teacher, Department of Applied Physics, Biomedical engineering program, Jerusalem College of Technology.

2007- 2010 Senior Teacher, Department of Computer Science, Biomedical engineering program and Bioinformation/ Chemo-information, Jerusalem College of Technology.

2011- 2016 lecturer, Department of Computer Science, Bioinformation program, Jerusalem College of Technology.

2016- present Senior lecturer, The Faculty of Life and Health Sciences, Department of Bioinformatics, Jerusalem College of Technology ( since 2018 in the regular appointment)

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