The rail link will reduce the travel time between Dhaka and Jessore from ten hours to only two hours once operational. The alternate route provided by the project will be 212km shorter than the existing Dhaka-Jessore-Khulna railway line.
Some elements, such as actinium, require very high temperatures to be efficiently driven out of the production target. Therefore, the development of a target material that is stable up to a temperature of at least 2000 C is an essential condition for this approach. The only compound with the right properties is thorium carbide (ThC) which is also pyrophoric and a safety hazard. It has been demonstrated on UC, which is somewhat less pyrophoric than ThC, that it is possible to render the material sufficiently inert by adjusting its carbon content, particle size and sintering. Whether it will be possible to develop a ThC material that is sufficiently inert to obtain safety approval for the operation of isotope production targets is a major risk for the complete success of the project. Regardless, the separation techniques proposed above could be adapted for other targets.
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Background: OA symptoms and progression are mechanically-driven, but synovial inflammation (synovitis) is prevalent in >70% of knees with OA. Knee inflammation is associated with worse symptoms and much higher risk of future joint damage (progression). This strong epidemiologic data suggests that mechanically-driven inflammation is a key driver of worse outcomes for patients with knee OA. To leverage this into a treatment opportunity, we must explore and discover the mechanisms linking abnormal joint loading mechanics to knee inflammation. Further, since joint repair mechanisms are also active in knee OA, segregating which mechanisms are helpful (friend) or harmful (foe) is critical to identifying effective anti-mechanical medicines. None of this has been possible until now.
This project aims to clearly articulate the conditions necessary and sufficient for inducing earthquakes. To do this, we will focus on a case study area in northeast British Columbia where felt earthquakes linked to fluid injection have occurred, but the conditions required to cause them are unknown. As a first step toward a large-scale observatory at an injection site to study the earthquake source in detail, this project will measure the critical physical characteristics of a site that may impact the occurrence of induced events. We will use drill core samples already collected from the subsurface to measure and infer structural, frictional and hydrogeological properties of the faults at depth and how they change under stress perturbation from injection. These parameters will be used to build numerical models to create earthquake rupture scenarios with input from new and existing earthquake and groundwater contamination monitoring efforts and fluid injection parameters. Integrating these datasets will allow us to predict injection rates and volumes that may trigger seismicity in faults and elucidate which fault conditions are most valuable to know before beginning a new operation. In tandem, we will investigate how the perceived environmental, human and social consequences of induced earthquakes can be integrated into a regulatory framework built on quantitative assessment of the seismic susceptibility of a specific fluid-injection operation. The results will inform the mechanics of inducing earthquakes generally, and therefore be applicable worldwide. ff782bc1db
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