Funding

Dean's Office Innovation Fund (AW McHill)         10/31/2022-10/31/2025

Funder: OHSU School of Nursing 

Title: Circadian Based Time-Restricted Eating Paradigm to Improve Cardiometabolic Health and Prevent Disease

Major goals: 1) Investigate if a personalized, circadian-based time restricted feeding intervention will acutely improve cardiometabolic health independent of weight loss in overweight adult; and 2) To determine if this personalized intervention will chronically (16 weeks) decrease weight and improve cardiometabolic health in overweight adults.

Dr. McHill's Role: Principal Investigator

R01HL156948 (AW McHill)                                                                    09/1/2022 - 08/31/2026

Funder: NIH/NHLBI                                                     

Title: Uncovering the Impact of Diet on the Human Circadian Timing System

Major Goals: Identify the impact of a high-fat diet on human circadian entrainment and responses to light. We will also examine markers of cardiometabolic health, cognition, learning, and well-being during circadian misalignment and re-entrainment.

Dr. McHill's Role: Principal Investigator

K01 HL146992-01 (AW McHill)                                                                 04/01/2019-03/31/2023 

Funder: NIH/NHLBI                              

Title: Uncovering Circadian Mechanisms of Poor Cardiometabolic Health

Major Goals: Determine the impact of the transition to a bus-driving schedule on weight management behaviors and design intervention to reduce weight and improve health.

Dr. McHill's Role: Principal Investigator

R01 HL163232 (SS Thosar)                                                                             04/01/2022- 03/31/2027

Funder: NIH/NHLBI

Title: Sleep and circadian mechanisms in hypertension

Major Goals: The major goal of this project is to understand how sleep and the endogenous circadian system affects cardiovascular physiology in people with hypertension.

Dr. McHill's Role: Co-Investigator

R35 HL155681 (SA Shea)                                                                                 01/01/2021 - 12/31/2027

Funder: NIH/NHLBI

Title: Endogenous circadian mechanisms underlying cardiovascular risk.

Overall goal: There are clear day/night patterns in the timing of adverse cardiovascular events, including myocardial infarction, stroke and sudden cardiac death which all strike most frequently in the morning. This research program will examine how circadian rhythms in the cardiovascular system, behavior-related alterations in the cardiovascular system, and an individual’s own vulnerability may interact to affect risk for adverse cardiovascular events. This research will lay the groundwork for optimizing timed therapies for cardiovascular disease.

Dr. McHill's Role: Co-Investigator

U19 OH010154 (Hammer L)                                                                       09/01/2021 - 08/31/2026 

Funder: CDCP/NIOSH

Title: Oregon Healthy Workforce Center  

Major Goals: This project will systematically examine the association between work schedule and psychosocial determinants of sleep (e.g, work-life conflict, substance use), sleep duration or quality, safety and cardiovascular risk.

Dr. McHill's Role: Co-Investigator

R56HL156948 (AW McHill)                                                          09/15/2021 - 08/31/2022

Funder: NIH/NHLBI                                                     

Title: Uncovering the Impact of Diet on the Human Circadian Timing System

Major Goals: Identify the impact of a high-fat diet on human circadian entrainment and responses to light. We will also examine markers of cardiometabolic health, cognition, learning, and well-being during circadian misalignment and re-entrainment.

Dr. McHill's Role: Principal Investigator

Oregon Institute of Occupational Health Sciences Innovation Funds (AW McHill / R Olson)   

5/01/2018-4/30/2022

Title: Impact of the Transition into Mass Transit Bus Driving on Workers’ Dietary Behaviors Relative to and Circadian Timing and Overall Energy Balance

Overall Goal: Obtain preliminary data to determine the impact of the transition to a bus driving schedule on weight management behaviors.

 Dr. McHill's Role: Co-PI/Project Leader

OHSU School of Nursing (M Song)                                                                 07/01/20 – 06/31/22

Title: Human Subject Research in the COVID-19 Era and Beyond: Virtual Tools and Social Distancing

Overall Goal: The goal of this research group is to adapt in the short term to the immediate circumstances of research during the COVID-19 era by exploring opportunities to apply new methods to future research with rural populations.

Dr. McHill's Role: Co-Investigator 

NIH R01 HL140577 (SA Shea)                                                                     09/15/2017-05/31/2021

Title: Circadian Mechanisms of Cardiovascular Risk in Obesity

Overall Goal: The goal is to determine if obese individuals have normal or abnormal circadian rhythms in CV reactivity to stresses as compared to lean individuals.

 Dr. McHill's Role: Co-Project Leader

Participant & Clinical Interactions Management Award (AW McHill)                 07/01/2020-06/31/2021

Oregon Clinical & Translational Research Institute    

Title: Uncovering Mechanisms of Poor Cardiometabolic Health during the Transition to Night Shift Work

Overall Goal: Major goals of this project are to determine the impact of the transition to a night shift schedule on cardiometabolic and safety outcomes.

Dr. McHill's Role: Principal Investigator

Participant & Clinical Interactions Management Award (AW McHill)                 08/01/2019-07/31/2020

Oregon Clinical & Translational Research Institute    

Title: Uncovering Biomarkers of Poor Cardiometabolic Health Altered by Circadian Timing

Overall Goal: The goal of this project is to phenotype potential cardiometabolic biomarkers altered by shiftwork and shifts in meal timing via research participant blood sampling.

Dr. McHill's Role: Principal Investigator

NIH R01 HL125893 (SA Shea)                                                                  07/15/2015-03/31/2019

Title: Circadian Rhythms and Cardiovascular Risk

Overall Goal: The goal is to determine if the internal body clock affects cardiovascular function differently in people with treated and untreated sleep apnea compared to healthy people, perhaps explaining the different timing of adverse events in this population.

Dr. McHill's Role: Co-Project Leader

NIH 1KL2TR002370-01 (D Jacoby /AW McHill)                                  08/01/2017-07/31/2019

Title: Influence of Circadian Misalignment and Obstructive Sleep Apnea on Energy Balance and Glucose Metabolism

Overall Goal: Determine the impact of circadian misalignment and obstructive sleep apnea on energy and glucose metabolism and obtain the training necessary to become an independent investigator.

Dr. McHill's Role: Principal Investigator/Project Leader

NIH 1F32DK107146-01A1 (AW McHill)                                                                   06/30/16-06/29/17

Title: Influence of Meal Timing and Sleep Variability on Macronutrient Intake and Body Composition in College Undergraduates

Overall Goal: Determine the relationship between the timing of food consumption and sleep and circadian measures in college undergraduates

Dr. McHill's Role: Principal Investigator/Project Leader

NIH 1RO1GM105018-01 (EB Klerman and CA Czeisler)                                  07/18/13-03/31/18

Title: Multi-Scale Modeling of Sleep Behaviors in Social Networks

Overall Goal: Quantify the effects of social networks on sleep in college students and develop mathematical models that encompasses an individual’s social network. 

Dr. McHill's Role: Project Leader

NIH 5R01HL114088-04 (EB Klerman)                                                                     05/01/12-04/30/16

Title: Sleep Duration Required to Restore Performance During Chronic Sleep Restriction

Overall Goal: Determine the dynamics of the short- and long-term consequences of chronic sleep restriction and how they combine with circadian timing to determine performance at any given time. 

Dr. McHill's Role: Project Leader

NIH 5T32HL007901-17 (CA Czeisler/ AW McHill)                                               08/01/98-06/30/18

Title: Training in Sleep, Circadian, and Respiratory Neurobiology

Overall Goal: Develop and train young sleep and circadian research scientists

Dr. McHill's Role: Post-doctoral Trainee/Project Leader

NIH 5R21DK092624-02 (KP Wright Jr.)                                                        05/01/12-04/30/14

Title: Circadian Misalignment and Energy Metabolism

Overall Goal: Determine whether eating at night alters physiological mechanisms that promote weight gain and obesity.

Dr. McHill's Role: Project Leader

Dean’s Graduate Student Research Grant  (AW McHill )                              11/01/13-07/01/14

Title: Early Morning Food Intake as a Novel Risk Factor for Metabolic Dysregulation

Overall Goal: Determine whether eating at in the early morning, as common in shiftwork, alters  

physiological mechanisms that promote metabolic dysregulation.

Dr. McHill's Role: Principal Investigator / Project Leader