Peer-reviewed paper
*first author; $ corresponding author
Hui-Yen Chuang$,*, Wei-Chan Lin*, Yu-Chieh Jill Kao, Chen-Hsuan Chiang, Carmel T. Chan, Aloma L. D’Souza, Sanjiv S. Gambhir, Sharon S. Hori$. Dual-biomarkers encoding tumor-activatable minicircles with scaffold/matrix attachment region motif for sensitive and sustained blood and urine-based cancer detection. (In submission)
Hui-Wen Chan*, Deng-Yu Kuo*, Yu-Chieh Jill Kao, Yun-Xuan Tang, Hui-Yen Chuang$. β-Caryophyllene induces PPARγ-mediated apoptosis and enhances the radiosensitivity in colorectal cancer cells. (In submission)
Han-Hsi Kuo*, Hui-Wen Chan, Ming-Huang Chen, Yi-Jang Lee, Hui-Yen Chuang$, Yu-Chan Chang$. High-dose irradiation promotes macrophage-mediated engulfment of triple-negative breast cancer through M1 polarization via the IKZF1-CCL5 axis. (In revision)
Hui-Wen Chan, Pei-Wei Sheung, Stella Tzu-Ming Tsao, Chun-Yi Wu, Hui-Yen Chuang$ (2025, Aug). Gold nanoparticle-loaded macrophages enhance radiotherapy via immune remodeling in oral cancer. Materials Today Bio, 2025;33:102029. doi:10.1016/j.mtbio.2025.102029. (SCI, 9/124, ENGINEERING, BIOMEDICAL).
Hui-Wen Chan, Wei-Chan Lin, Deng-Yu Kuo, Hui-Yen Chuang$ (2025, Feb). Beta-Caryophyllene Augments Radiotherapy Efficacy in GBM by Modulating Cell Apoptosis and DNA Damage Repair via PPARγ and NF-κB Pathways. Phytotherapy Research, 2025;39(2):776-788. doi: 10.1002/ptr.8413. (SCI, 30/352, PHARMACOLOGY & PHARMACY).
Hui-Yen Chuang, Hui-Wen Chan, Kuang-Chung Shih* (2025 Jan-Feb). Suppression of colorectal cancer growth: Interplay between curcumin and metformin through DMT1 downregulation and ROS-mediated pathways. Biofactors. 2025;51(1): e2137. doi: 10.1002/biof.2137. (SCI, 38/191, ENDOCRINOLOGY & METABOLISM).
Ching-I Chen, Deng-Yu Kuo, Hui-Yen Chuang$ (2025, Jan). FASN inhibition shows the potential for enhancing radiotherapy outcomes by targeting glycolysis, AKT, and ERK pathways in breast cancer. International Journal of Radiation Biology, 2025;101(3):292-303. doi: 10.1080/09553002.2024.2446585. (SCI, 8/41, NUCLEAR SCIENCE & TECHNOLOGY).
Ching-I Chen, Hui-Wen Chan, Ching-Yi Shen, Hui-Yen Chuang$ (2024, Dec). Targeting Fatty Acid Synthase to Halt Tumor Progression and Enhance Radiosensitivity in Breast Cancer Cells. Journal of Medical and Biological Engineering, 2024;44:903-913. doi:10.1007/s40846-024-00920-5. (SCI, 95/124, ENGINEERING, BIOMEDICAL).
Hui-Wen Chan, Deng-Yu Kuo, Pei-Wei Shueng, and Hui-Yen Chuang$ (2024, Dec). Visualizing the Tumor Microenvironment: Molecular Imaging Probes Target Extracellular Matrix, Vascular Networks, and Immunosuppressive Cells. Pharmaceuticals, 17(12).1663. (SCI, 46/354, PHARMACOLOGY & PHARMACY).
Kuang-Chung Shih, Hui-Wen Chan, Chun-Yi Wu, Hui-Yen Chuang$ (2023, May). Curcumin Enhances the Abscopal Effect in Mice with colorectal Cancer by Acting as an Immunomodulator. Pharmaceutics, 15, 1519. (SCI, 34/352, PHARMACOLOGY & PHARMACY).
Chao-Cheng Chen, Yang-Hsiang Chan, Syue-Liang Lin, Huihua Kenny Chiang, Yi-Jang Lee$ & Hui-Yen Chuang$ (2022, Oct). Theranostic Radiolabeled Nanomaterials for Molecular Imaging and potential Immunomodulation Effects. Journal of Medical and Biological Engineering, https://doi.org/10.1007/s40846-022-00715-6. (SCI, 95/124, ENGINEERING, BIOMEDICAL).
Chao-Yu Shen, Chia-Fen Lee, Wei-Taur Chou, Jeng-Jong Hwang, Yeu-Sheng Tyan$, Hui-Yen Chuang$ (2022, Jun). Liposomal β-sitosterol suppresses metastasis of CT26/luc colon carcinoma via inhibition of MMP-9 and evoke of immune system. Pharmaceutics, 14:1214. (SCI, 34/352, PHARMACOLOGY & PHARMACY).
Pei-Wei Shueng, Hui-Wen Chan, Wei-Chan Lin, Deng-Yu Kuo*, Hui-Yen Chuang$ (2022, Jun). Orlistat resensitizes sorafenib-resistance in hepatocellular carcinoma cells through modulating metabolism. International Journal of Molecular Sciences, 23:6501. (SCI, 72/319, BIOCHEMISTRY & MOLECULAR BIOLOGY).
Pei-Wei Shueng, Kuang-Chung Shih, Sanjiv Sam Gambhir, Deng-Yu Kuo$, Hui-Yen Chuang$ (2022, Mar). Cancer detection using an artificial secretable microRNA found in blood and urine. Biomedicines, 10:621. (SCI, 88/352, PHARMACOLOGY & PHARMACY).
Elise R. Robinson, Gayatri Gowrishankar, Aloma L. D'Souza, Azadeh Kheirolomoom, Tom Haywood, Sharon S. Hori, Hui-Yen Chuang, Yitian Zeng, Spencer K. Tumbale, Amin Aalipour, Corinne Beinat, Israt S. Alam, Ataya Sathirachinda, Masamitsu Kanada, Ramasamy Paulmurugan, Katherine W. Ferrara*, Sanjiv S. Gambhir (2021, Jul). Minicircles for a two-step blood biomarker and PET imaging early cancer detection strategy. Journal of Controlled Release, 2021;335:281-289. (SCI, 12/352, PHARMACOLOGY & PHARMACY).
Hui-Yen Chuang*, Yeu-Sheng Tyan, Jeng-Jong Hwang, Wei-Chan Lin (2021, Apr). A combination of sorafenib and radiotherapy reduces NF-κB activity and growth of hepatocellular carcinoma in an orthotopic mouse model. Oncology Letters, 337. (SCI, 216/326, ONCOLOGY).
Fu CK*, Chien YC*, Chuang HY*, Wang YC, Hwang JJ, Yang MD, Yu CC, Chen JC, Chang WS$, Bau DT$, Tsai CW$ (2020, Feb). The Association of MMP7 Promoter Polymorphisms With Gastric Cancer. Anticancer Research, 40:659-702. (SCI)
Chuang HY*, Lee YP, Lin WC, Hwang JJ (2019). Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway. Scientific Reports, 9:13284. (SCI)
Aalipour A*, Chuang HY, Murty S, D'Souza AL, Park SM, Gulati GS, Patel CB, Beinat C, Simonetta F, Martinić I, Gowrishankar G, Robinson ER, Aalipour E, Zhian Z, Gambhir SS$ (2019). Engineered immune cells as highly sensitive cancer diagnostics. Nature Biotechnology, 37(5):531-539. (SCI, Biotechnology& Applied microbiology). (SCI)(Featured on the cover)
Chen JC*, Chuang HY*, Liao YJ, Hsu FT, Chen YC, Wang WH, Hwang JJ$ (2019). Enhanced cytotoxicity of human hepatocellular carcinoma cells following pretreatment with sorafenib combined with trichostatin A. Oncology letter, 17: 638-645, 2019. (SCI)
Lee JR, Chan CT, Ruderman D, Chuang HY, Gaster RS, Atallah M, Mallick P, Lowe SW, Gambhir SS$, Wang SX$ (2017). Longitudinal monitoring of antibody responses against tumor cells using magneto-nanosensors with a nanoliter of blood. Nano letters, 17:6644-6652. (SCI).
Ronald JA*, Kim BS*, Gowrishankar G, Namavari M, Alam IS, D'Souza A, Nishikii H, Chuang HY, Ilovich O, Lin CF, Reeves R, Shuhendler A, Hoehne A, Chan CT, Baker J, Yaghoubi SS, VanBrocklin HF, Hawkins R, Franc BL, Jivan S, Slater JB, Verdin EF, Gao KT, Benjamin J, Negrin R, Gambhir SS$ (2017). A PET imaging strategy to visualize activated T cells in acute graft-versus-host disease elicited by allogenic hematopoietic cell transplant. Cancer Research, 77(11):2893-2902. (SCI).
Chen JC*, Chuang HY, Hsu FT, Chen YC, Chien YC, Hwang JJ$. (2016) Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model. Oncotarget;7(51):85450-85463
Ronald JA*, D'Souza AL*, Chuang HY, Gambhir SS$. (2016) Artificial microRNAs as novel secreted reporters for cell monitoring in living subjects. PLoS One;11(7):e0159369 (SCI).
Shen YA*, Wang CY, Chuang HY, Hwang JJ, Chi WH, Shu CH, Ho CY, Li WY, Chen YJ$. (2016) CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation. Oncotarget;7(36):58351-58366
Wang WH, Chuang HY, Chen CH, Chen WK, Hwang JJ$. (2016) Lupeol acetate ameliorates collagen-induced arthritis and osteoclastogenesis of mice through improvement of microenvironment. Biomed. Pharmacother;79:231-240. (SCI)
Hsu FT, Chen TC, Chuang HY, Chang YF, Hwang JJ$. (2015) Enhancement of adoptive T Cell transfer with single low dose pretreatment of doxorubicin or paclitaxel in mice. Oncotarget;6: 44134–44150.
Fang CK*, Chuang HY*, Wang WH, Liu RS, Wang SJ, Hwang JJ$. (2015) Chronic Effects of Cocaine on Dopaminergic and Serotonergic Systems of Rats. Current Molecular Imaging;4: 43-52
Ronald JA*, Chuang HY, Dragulescu-Andrasi A, Hori SS, Gambhir SS. (2015) Detecting cancers through tumor-activatable minicircles that lead to a detectable blood biomarker. PNAS;112:3068-3073. (SCI).
Chuang HY*, Chang YF*, Liu RS, Hwang JJ$. (2014) Serial low doses of sorafenib enhance therapeutic efficacy of adoptive T cell therapy in a murine model by improving tumor microenvironment. PLoS ONE;9: e109992. (SCI).
Fang CK*, Chang YF, Chuang HY, Chen HW, Hwang JJ$. (2014) Molecular imaging of neuropsychiatry and boron neutron capture therapy in neuro-oncology. Current Molecular Imaging;3:15-26
Ronald JA*, Cusso L, Chuang HY, Yan X, Dragulescu-Andrasi A, Gambhir SS$. (2013) Development and validation of non-integrative, self-limited, and replicating minicircles for safe reporter gene imaging of cell-based therapies. PLoS ONE;8: e73138. (SCI).
Chen HW*, Chang YF, Chuang HY, Tai WT, Hwang JJ$. (2012) Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc bearing animal model. Pros Cancer Pros Disease;15:260-264. (SCI).
Chang YF*, Chuang HY*, Hsu CH, Liu RS, Gambhir SS, Hwang JJ$. (2012) Immunomodulation of curcumin on adoptive therapy with T cell functional imaging in mice. Cancer Prev Res;5:444-452. (SCI).
Chuang HY*, Chang YF*, Hwang JJ$. (2011) Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal. Biomed. Pharmacother;65:286-292. (SCI)
Liu JH, Wann H, Chen MM, Pan WH, Chen YC, Liu CM, Yeh MY, Tsai SK, Young MS, Chuang HY, Chao FP, Chao HM$. (2010) Baicalein significantly protects human retinal pigment epithelium cells against H₂O₂-induced oxidative stress by scavenging reactive oxygen species and downregulating the expression of matrix metalloproteinase-9 and vascular endothelial growth factor. J Ocul Pharmacol Ther;26:421-429
Liu JH, Chen MM, Huang JW, Wann H, Ho LK, Pan WH, Chen YC, Liu CM, Yeh MY, Tsai SK, Young MS, Ho LT, Kuo CD, Chuang HY, Chao FP, Chao HM$. (2010) Therapeutic effects and mechanisms of action of mannitol during H2O2-induced oxidative stress in human retinal pigment epithelium cells. J Ocul Pharmacol Ther;26(3):249-257