Publications

📑Peer-Reviewed Articles

1. Hui-Wen Chan, Pei-Wei Sheung, Stella Tzu-Ming Tsao, Chun-Yi Wu, Hui-Yen Chuang. Gold Nanoparticle-Loaded Macrophages Enhance Radiotherapy via Immune Remodeling in Oral Cancer. Mater Today Bio. 2025; Jun 27:33:102029

2. Hsin-Hua Hsieh, Shih-Po Su, Yang-Hsiang Chan, Huihua Kenny Chiang, Yi-Jang Lee, *Chun-Yi Wu. Development of Theranostic 177Lu-Labeled Polymeric Nanoparticles (177Lu-PNPs) for the Treatment of Head and Neck Cancer. ACS Applied Bio Materials 2025;8(6):5266-5275

3. Cong-Yong Gao, Yi-Ju Pan, Wei-Shen Su, Chun-Yi Wu, Ting-Yu Chang, Feng-Yi Yang. Abdominal ultrasound stimulation alleviates DSS-induced colitis and behavioral disorders in mice by mediating the microbiota–gut–brain axis balance. Neurotherapeutics 2025;22(2):e00494.

4. Jing-Ren Tseng, Cheng-Lung Hsu, Hsin-Hua Hsieh, Hung-Chu Ho, *Yi-Hsiu Chung, *Chun-Yi Wu. The synergy of 177Lu-FAPI-46 with tyrosine kinase inhibitor in a sarcoma patient-derived xenograft mouse model. Biomed J 2024;47(3):100744. 

5. Hsin-Hua Hsieh, Pei-An Chu, Yu-Hsin Lin, Yu-Chieh Jill Kao, Yi-Hsiu Chung, Shih-Ting Hsu, Jia-Min Mo, *Chun-Yi Wu, *Shin-Lei Peng. Imaging diabetic cardiomyopathy in a type 1 diabetic rat model using 18F-FEPPA PET. Nucl Med Biol 2024; 128-129:108878.

6. Hsin-Hua Hsieh, Chuan-Lin Chen, Hui-Wen Chan, Kwan-Hwa Chi, *Chun-Yi Wu. Enhanced antitumour response of gold nanostar-mediated photothermal therapy in combination with immunotherapy in a mouse model of colon carcinoma. Br J Cancer 2024;130(3):406-416. 

7. Chun-Yi Wu, Yu-Hsin Lin, Hsin-Hua Hsieh, Yi-Hsiu Chung, Shin-Ting Hsu, *Shin-Lei Peng. The effect of estrogen therapy on cerebral metabolism in diabetic female rats. Comput Struct Biotechnol J 2023; 21:4769-4776. 

8. Yao-Wen Chang, Huey-Wen Hsiao, Ju-Pei Chen, Sheue-Fen Tzeng, Chin-Hsien Tsai, Chun-Yi Wu,  Hsin-Hua Hsieh, Santiago J Carmona, Massimo Andreatta, Giusy Di Conza, Mei-Tzu Su, Pandelakis A Koni, Ping-Chih Ho, Hung-Kai Chen, *Muh-Hwa Yang. CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells. Cell Rep Med 2023; 4(8):101154. 

9. Chun-Yi Wu, Sheng-Min Huang, Yu-Hsin Lin, Hsin-Hua Hsieh, Lok Wang Lauren Chu, Hui-Chieh Yang, Shao-Chieh Chiu, *Shin-Lei Peng. Reproducibility of diffusion tensor imaging-derived parameters: implications for the streptozotocin-induced type 1 diabetic rats. MAGMA 2023; 36(4):631-639.

10. Li-An Chen, Yueh-Hsiang Yu, Wei-Ting Tian, Wei-Chen Lin, Cedric Grauffel, Chun-Yi Wu, Chuan-Lin Chen, Carmay Lim, Hsing-Mao Chu, Tse-Wen Chang, *Chi-Jiun Peng. Site-specific Conjugation of 6 DOTA Chelators to a CA19-9-targeting scFv-Fc Antibody for Imaging and Therapy. J Med Chem 2023; 66(15):10604-10616.

11. Ting-Yu Chang, Wen-Yi Chang, Yi-Wei Chen, Ming-Che Ho, Chi-Wei Chang, Sie-Ong Lau, Nan-Jing Peng, *Chun-Yi Wu. Comparison of the synthesis and biological properties of no-carrier-added and carrier-added 4-borono-2-[18F]fluorophenylalanine ([18F]FBPA). Nucl Med Biol 2023;116-117:108313

12. Hui-Wen Chan, Yi-Hsuan Lo, Deng-Yuan Chang, Jia-Je Li, Wen-Yi Chang, Chih-Hao Chen, Chih-Hsien Chang, Chuan-Lin Chen, Hsin-Ell Wang, Ren-Shyan Liu, and *Chun-Yi Wu. Radiometal-labeled chitosan microspheres as transarterial radioembolization agents against hepatocellular carcinoma. Gels 2022;8:180

13. Sheng‑Min Huang, Chun‑Yi Wu, Yu‑Hsin Lin Hsin‑Hua Hsieh, Hui‑Chieh Yang, Shao‑Chieh Chiu and Shin‑Lei Peng. Differences in brain activity between normal and diabetic rats under isoflurane anesthesia: a resting‑state functional MRI study. BMC Medical Imaging 2022;22:136

14. Hsin-Hua Hsieh, Wei-Ying Kuo, Jia-Jia Lin, Hong-Sen Chen, Hung-Ju Hsu, *Chun-Yi Wu. Tumor-targeting ability of novel anti-prostate-specific membrane antigen antibodies. ACS Omega 2022;7: 31529-31537

15. Chun-Yi Wu, Hsin-Hua Hsieh, Pei-An Chu, Wen-Hsiang Hong, Ting-Yu Chang, Chia-Fang Hsu, Siao-Ting Lin, Po-Hsun Su, Shin-Lei Peng. Comparison of 18F-FDG, 18F-Fluoroacetate, and 18F-FEPPA for imaging liver fibrosis in a bile duct-ligated rat model. Molecular Imaging 2021:7545284

16. Chun-Yi Wu, Yu-Hsin Lin, Hsin-Hua Hsieh, *Shin-Lei Peng. Sex differences in the effect of diabetes on cerebral glucose metabolism. Biomedicines 2021;9:1661.

17. Min-Ying Lin, Hsin-Hua Hsieh, Jyh-Cheng Chen, Chuan-Lin Chen, Nin-Chu Sheu, Wen-Sheng Huang, Shinn-Ying Ho, Ting-Wen Chen, *Yi-Jang Lee, *Chun-Yi Wu. Brachytherapy approach using Lu-177 conjugated gold nanostars and evaluation of biodistribution, tumor retention, dosimetry and therapeutic efficacy in head and neck tumor model. Pharmaceutics 2021;13:1903

18. Chun-Yi Wu, Hsin-Hia Hsieh, Ting-Yu Chang, Jia-Jia Lin, Chin-Ching Wu, Ming-Hua Hsu, Ming-Chia Lin, Shin-Lei Peng. Development of MRI-detectable boron-containing gold nanoparticle-encapsulated biodegradable polymeric matrix for boron neutron capture therapy (BNCT). Int. J Mol. Sci. 2021;22:8050

19. Yi-Hsuan Lo, Ting-Yu Chang, Chuan-Lin Chen, Ming-Hsien Lin, Hsin-Ell Wang, Chi-Wei Chang, Ren-Shyan Liu and *Chun-Yi Wu. Development of radiofluorinated nicotinamide/picolinamide derivatives as diagnostic probes for the detection of melanoma. Int. J Mol. Sci. 2021;22:6432

20. Fang-Ju Cheng,  Chia-Hung Chen,  Wen-Chen Tsai,  Bo-Wei Wang, Meng-Chieh Yu,  Te-Chun Hsia, Ya-Ling Wei,  Yu-Chun Hsiao,  Dai-Wei Hu, Chien-Yi Ho,  Tzong-Shiun Li, Chun-Yi Wu,  Wen-Yu Chou, Yung-Luen Yu,  Chih-Hsin Tang, Chih-Yi Chen,  Chuan-Mu Chen, Jennifer L. Hsu,  Hsiao-Fan Chen, Yeh Chen,  Chih-Yen Tu, Mien-Chie Hung,  Wei-Chien Huang. Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC. Oncogene 2021;40(6):1162-1175

21. Chao-Cheng Chen, Yang-Yi Chen, Yi-Hsuan Lo, Ming-Hsien Lin, Chih-Hsien Chang, Chuan-Lin Chen, Hsin-Ell Wang and *Chun-Yi Wu. Evaluation of Radioiodinated Fluoronicotinamide/Fluoropicolinamide-Benzamide Derivatives as Theranostic Agents for Melanoma.  Int. J Mol. Sci. 2020;21:6597

22. Chun-Yi Wu, Jia-Jia Lin, Wen-Yi Chang, Cheng-Ying Hsieh, Chin-Ching Wu, Hong-Sen Chen, Hung-Ju Hsu, An-Suei Yang, Ming-Hua Hsu, Wei-Ying Kuo. Development of theranostic active-targeting boron-containing gold nanoparticles for boron neutron capture therapy (BNCT). Colloids and Surfaces B: Biointerfaces 2019;183:1103

23. Chun-Yi Wu, Yang-Yi Chen, Jia-Jia Lin, Jui-Ping Li, Jen-Kun Chen, *Te-Chun Hsieh, *Chia-Hung Kao. Development of a novel radioligand for imaging 18-kD translocator protein (TSPO) in a rat of Parkinson’s disease. BMC Medical Imaging 2019;19:78

24. Shin-Lei Peng, Han Chiu, Chun-Yi Wu, Chiun-Wei Huang, Yi-Hsiu Chung, Cheng-Ting Shih, Wu-Chung Shen. The effect of caffeine on cerebral metabolism during alpha-chloralose anesthesia differs from isoflurane anesthesia in the rat brain. Psychopharmacology 2019;236(6):1749-1757

25. Chin-Ho Tsao, Chun-Yi Wu, Chi-Wei Chang, Hsin-Ell Wang, Bing-Fu Shih, Ren-Shyan Liu. Micro-PET imaging of [18F]fluoroacetate combined with [18F]FDG to differentiate chronic Mycobacterium tuberculosis infection from an acute bacterial infection in a mouse model: a preliminary study. Nucl Med Commun. 2019;40(6)639-644

26. Wei-Ying Kuo, Hung-Ju Hsu, Chun-Yi Wu, Hong-Sen Chen, Yu-Chi Chou, Yueh-Liang Tsou, Hung-Pin Peng, Jhih-Wei Jian, Chung-Ming Yu, Yi-Kai Chiu, Ing-Chien Chen, Chao-Ping Tung, Michael Hsiao, Chia-Lung Lin, Yong Alison Wang Andrew H-J. Wang, An-Suei Yang. Antibody-drug conjugates with HER2-targeting antibodies derived from synthetic antibody libraries are highly potent against HER2 positive human gastric tumor in xenograft models. MAbs. 2019;11(1):153-165

27. Wei-Ying Kuo, Jia-Jia Lin, Hung-Ju Hsu, Hong-Sen Chen, An-Suei Yang, *Chun-Yi Wu. Noninvasive assessment of characteristics of novel anti-HER2 antibodies by molecular imaging in a human gastric cancer xenograft-bearing mouse model. Sci Rep. 2018;8(1):13735-13744.

28. Chun-Yi Wu, Jo-Hsin Tang, Pei-Chia Chan, Jia-Je Li, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang. Monitoring tumor response after liposomal Doxorobicin in combination with liposomal vinorelbine treatment using 3’-deoxy-3’[18F]fluorothymidine PET. Mol Imag Biol 2017 Jun;19(3):408-420.

29. Wei-Ying Kuo, Luen Hwu, Chun-Yi Wu, Jhih-Shian Lee, Chi-Wei Chang, Ren-Shyan Liu. STAT3/NF-κB-regulated lentiviral TK/GCV suicide gene therapy for cisplatin-resistant triple-negative breast cancer. Theranositics 2017;7(3):647-663.

30. Yo-Liang Lai, Chun-Yi Wu, K. S. Clifford Chao. Biological Imaging in clinical oncology: radiation therapy on functional imaging. Int J Clin Oncol. 2016;21(4):626-632. 

31. *Wei-Ying Kuo, *Chun-Yi Wu (co-first author), Luen Hwu, Jhih-Shian Lee, Cheng-Han Tsai, Kang-Ping Lin, Hsin-Ell Wang, The-Ying Chou, Chun-Ming Tsai, Juri Gelovani, Ren-Shyan Liu. Enhancement of tumor initiation and expression of KCNMA1, MORF4L2, and ASPM genes in the adenocarcinoma of lung xenograft after vorinostat treatment. Oncotarget 2015;6(11):8663-8675. 

32. *Pei-Chia Chan, *Chun-Yi Wu (co-first author), Lin-Shan Chou, Chung-Hsien Ho, Chi-Wei Chang, Shih-Hwa Chiou, Wuu-Jyh Lin, Fu-Du Chen, C. Allen Chang, Jeng-Jong Hwang, Ren-Shyan Liu, Hsin-Ell Wang. Monitoring tumor response after histone deacetylase inhibitor treatment using 3’-deoxy-3’[18F]-fluorothymidine PET. Mol Imag Biol 2015;17:394-402.

33. *Chun-Yi Wu, *Pei-Chia Chan, Lin-Shan Chou, Chi-Wei Chang, Feng-Yi Yang, Ren-Shyan Liu, Shih-Hwa Chiou, Sang-Hue Yen, Yi-Wei Chen, Hsin-Ell Wang. Pulsed focused ultrasound enhances boron drug accumulation in a human head and neck cancer xenograft-bearing mouse model. Mol Imag Biol 2014;16:95-101 

34. *Pei-Chia Chan, *Chun-Yi Wu (co-first author), Wei-Ting Chang, Chih-Yuan Lin, Ren-Shyan Liu, Mian M Alauddin, Wuu-Jyh Lin, Hsin-Ell Wang. Monitoring tumor response with 18F-FMAU in a sarcoma-bearing mouse model after liposomal vinorelbine treatment. Nucl Med & Biol. 2013;40:1035-1042. 

35. Wen-Yi Chang, Wei-Ti Kuo, Chun-Yi Wu, Chih-Yuan Lin, Pei-Chia Chan, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang, Chuan-Lin Chen. Evaluation of 131/125I-5-2’-deoxycytidine as a novel proliferation probe in a tumor mouse model. Appl Radiat Isot. 2013;77:166-173.  

36. Chun-Yi Wu, Lin-Shan Chou, Pei-Chia Chan, Chung-Hsien Ho, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Wuu-Jyh Lin, Hsin-Ell Wang. Monitoring tumor response with radiolabeled nucleoside analogues in a hepatoma-bearing mouse model early after Doxisome® treatment. Mol Imag Biol 2013;15:326-335

37. Chun-Yi Wu, Hsin-Ell Wang, Ming-Hsien Lin, Li-Shing Chu, Ren-Shyan Liu. Radiolabeled nucleosides for predicting and monitoring the cancer therapeutic efficacy of chemdrugs. Curr Med Chem 2012; 19:3315-3324. 

38. Pei-Chia Chan, Chun-Yi Wu, Wen-Yi Chang, Mian M. Alauddin, Ren-Shyan Liu, Wuu-Jyh Lin, Fu-Du Chen, Chuan-Lin Chen, Hsin-Ell Wang. Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging. Nucl Med & Biol. 2011;38:987-995.  

39. Ren-Shyan Liu, Ta-Kai Chou, Chih-Hsien Chang, Chun-Yi Wu, Chi-Wei Chang, Tsui-Jung Chang, Shih-Jen Wang, Wuu-Jyh Lin and Hsin-Ell Wang. Biodistribution, pharmacokinetics and PET imaging of 18F-FMISO, 18F-FDG, and 18F-FAc in a sarcoma- and inflammation-bearing mouse model. Nucl Med & Biol. 2009;36:305-12. 

40. Chun-Yi Wu, Pei-Chia Chan, Wei-Ting Chang, Ren-Shyan Liu, Mian M. Alauddin and Hsin-Ell Wang. Radiosynthesis of F-18 labeled cytidine analogue 2’-fluoro-5-iodo-1-b-D-arabinofuranosylcytosine (18F-FIAC). Appl Radiat Isot. 2009;67:1362-1365.