Nucleus2 connects to your computer via high speed Ethernet for DAW control and Dante Audio. It also features a USB connection and appears to your host computer as a standard keyboard enabling key command emulation. There are three USB ports on the back which operate as a USB hub. A standard jack footswitch connection is also included and there is also an SD card slot for Profile storage. Configuration and mapping of Key commands and DAW Commands is via a remote "SSL Logicitivity" browser, which allows differing control profile sets to be stored and recalled.

Hi, I currently use a Roon Nucleus to stream Tidal to a Sonore Microrendu, which is connected via a USB cable to a Chord Dave DAC. I control the Nucleus using the Roon App on my iPhone and I control the Chord Dave using the Chord handheld remote control. However, is there a universal remote control which can control both the Nucleus and Chord Dave at the same time? Or even just a simple handheld remote to control the Nucleus for skipping tracks? I prefer not to have to unlock my iPhone every time I want to skip tracks, and a conventional handheld remote control for the Nucleus would be more convenient. Thank you.


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I think it would be great if Roon were to come out with a small handheld remote for their Nucleus users with only two functions: Pause and Advance (to the Next Track). It would be so convenient not to have to mess with the iPad when the phone rings or other interruptions occur.

A raspberry pi with flirc.tv or OSMC remote and ropieee.org could do this. I use something like this with the OSMC remote for my wife to reduce volume or pause sound when she needs to take a call while I play through my lumin d1.

Objectives:  The aim of this study was to determine the suitability of commercially available video conferencing technology and remote control software for remote programming of sound processors in Nucleus cochlear implant recipients by assessing the feasibility, efficiency, risks, and benefits of remote programming compared to face-to-face programming.

Methods:  This was a randomized, prospective study. Seventy Nucleus implant recipients were recruited for a random sequence comparison of one remote and one local programming session each. The time required for local or remote programming was measured and resulting MAP T and C levels were compared. The recipient provided feedback on the local and remote programming session. The audiologist and monitoring clinician were asked for their feedback on remote programming.

Results:  Remote programming sessions were successfully finished for 69 recipients. No significant differences between T and C levels obtained by local and remote programming were found. The audiologists and monitoring clinicians agreed that the remote programming system provided an acceptable level of performance after most sessions. More than 50 participating recipients considered remote programming an efficient alternative to face-to-face-programming.

Acanthamoeba are infected by a remarkable diversity of large dsDNA viruses, the infectious cycles of which have been characterized using genomics, transcriptomics and electron microscopy. Given their gene content and the persistence of the host nucleus throughout their infectious cycle, the Marseilleviridae were initially assumed to fully replicate in the cytoplasm. Unexpectedly, we find that their virions do not incorporate the virus-encoded transcription machinery, making their replication nucleus-dependent. However, instead of delivering their DNA to the nucleus, the Marseilleviridae initiate their replication by transiently recruiting the nuclear transcription machinery to their cytoplasmic viral factory. The nucleus recovers its integrity after becoming leaky at an early stage. This work highlights the importance of virion proteomic analyses to complement genome sequencing in the elucidation of the replication scheme and evolution of large dsDNA viruses.

Following the characterization of a new member of the Marseilleviridae family isolated from an environmental sample collected near Noumea in New Caledonia, we here compared the genomes and the virion proteomes of Noumeavirus with that of Melbournevirus, its most distant relative within the family. Unexpectedly, the virus-encoded transcription machinery is absent from their virions, implying that they must initiate their replication using the cellular transcription machinery, normally confined in the nucleus. Detailed TEM and fluorescence microscopy studies were focused on the host nucleus in search for evidences of viral DNA transfer during the early stage of Noumeavirus infectious cycle. Our results revealed a transient recruitment of nuclear proteins that could not have been suspected without the proteomic analysis of the virions.

Twenty one host proteins are uniquely shared by the Noumeavirus and Melbournevirus virions (Supplementary Table 2). Two correspond to abundant proteins ranked 4th (Glyceraldehyde-3-phosphate dehydrogenase) and 18th (hypothetical, protein-binding domain) in proteomes from uninfected cells (Supplementary Table 2). Their unique presence might thus be specific to the Marseilleviridae infection process. We noticed a strong bias for small GTPase (six RAS-like homologues) that could be involved in the rapid trafficking of viral and cellular components to and from the host nucleus, together with cytoskeleton proteins (alpha and beta tubulin, calponin) and one kinase (Supplementary Table 2). Among the host proteins only identified in Melbournevirus and Noumeavirus virions, one is made of tandem histone domains and was found in low abundance in the proteome of uninfected A. castellanii cells (ranked 1,621st). Interestingly, a homologue of this protein is encoded by the Iridoviridae and essential for viral replication42. As such protein is normally confined to the nucleus, its detection in Marseilleviridae particles suggests that nuclear components may infiltrate the cytoplasmic viral factory where virions are assembled.

Two Mollivirus methyltransferases containing either a nucleolar or a nuclear localization signal (NoLS, ML216 or NLS, ML135) were cloned into the pGAPDH-GFP amoebal expression plasmid79 to yield a C-terminally GFP-tagged protein targeted to the nucleolus or the nucleus. The A. castellanii SUMO protein (g993-141726-142284, -mrs.fr/cgi-bin/gb2/gbrowse/Acas_2/) fused with a C-terminal GFP tag was used to monitor the passive diffusion of small proteins out of the nucleus.

How to cite this article: Fabre, E. et al. Noumeavirus replication relies on a transient remote control of the host nucleus. Nat. Commun. 8, 15087 doi: 10.1038/ncomms15087 (2017).

IN TMFX to get 16 faders to address it you need to assign the left and right side of the Nucleus to 2 different Midi remote pages and enable Mackie Control Protocol for both those pages in TMFX. The ports you assign must be ODD/ Even numbered ports. On Nucleus DAW 1 corresponds to ports 1&2 DAW 2 to ports 3&4 and DAW 3 to ports 5&6.

Cool Paul - Thanks a lot !!! Worked perfect with the provided Dropbox links! I appreciate your help so much. I am now away from the nucleus, but will try later!! I already have an Idea - I think I missed the "Submix linked to MIDI controller" bit. Anyway - I'll give feedback! thanks once again to everybody - been great help and supportive so far!

The 8 snapshots are more than enough for me. I never change workspaces and unless you have a good reason I suggest you do the same. It is possible that when you save the workspace it saves the MIDI remote setting along with it which would be consistent with the behaviour you describe above.

Thanks Paul for that message! Yes, please put me on that list. Yeah, face to face is for sure better, on the other hand remote will allow also people from abroad to attend, that cannot make it to AUS. Maybe Hybrid? My wife is doing it with her QiGong and Meditation classes now, and it's quite successful. Do I owe you something for solving my problem?

Yes remote. It's hard to get the sound quality where it needs to be when teaching music production where sound and fine distinctions with that are so important. That's the big reason but you never know I might change my view as new technologies come around.

Dear Paul - OK so thank you very much for your time!!! Yes, of course the sound quality might be a problem. I have attended a engineering class remote here at Hofa in Germany. Besides "Theoretical" teaching (reading) they send us files, which we than have to do certain manipulations to (i. e. compression, EQ, Effects etc.) and send the result back to them for evaluation. But of course your Masterclass would follow a different concept. Anyway, please keep me in the loop - never been to Australia anyway and it's definately a place on my bucket list.

Hello,

I got myself a beautiful Digiface USB for my control room system and everything is working well, except for the Mackie Control Extender layout of TotalMix in my SSL Nucleus.

Midi connections in Nucleus are made via IP Midi. Nucleus creates 3 assignable layers of Mackie Control + Extender divided in 6 virtual MIDI ports . In the SSL remote software and hardware this corresponds to DAW 1, 2, 3. 

Quoting some previous post here by paulnajar: "IN TMFX to get 16 faders to address it you need to assign the left and right side of the Nucleus to 2 different Midi remote pages and enable Mackie Control Protocol for both those pages in TMFX. The ports you assign must be ODD/ Even numbered ports. On Nucleus DAW 1 corresponds to ports 1&2 DAW 2 to ports 3&4 and DAW 3 to ports 5&6.

The Nucleus presents as a Mackie Control Universal for it's left bank of 8 channels via one virtual midi port and a second Mackie Control Extender for is right bank of 8 channels via a second virtual midi port so in TMFX I am using the"Extender To" setting so TMFX sees the controller as one 16 channel device "

 

So I expect to have 16 brown channels in TotalMix reflected to 16 Channels in Nucleus.

I followed all the instructions but no matter what I do, the first 8 channels work as expected, while the next 9-16 (that should be the extender part) won't work, and will duplicate the first 8, shifted by one channel (from 2 to 9). 

In the Mixer of TotalMix the first 8 channels get the brown color, while only the first channel of the extender becomes brown. e24fc04721

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