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主持人 Session Chair
侯明宏 博士
Dr. Ming-Hon Hou
侯明宏 博士
Dr. Ming-Hon Hou
中興大學 生命科學院副院長
中興大學 基資所 特聘教授
劉沛棻 博士
Dr. Pei-Fen Liu
劉沛棻 博士
Dr. Pei-Fen Liu
國立中興大學食品暨應用生物科技學系 副教授
朱雪萍 博士
Dr. Hsueh-Ping Chu
朱雪萍 博士
Dr. Hsueh-Ping Chu
國立台灣大學分子與細胞生物學研究所 助理教授
王淑鶯 博士
Dr. Shu-Ying Wang
王淑鶯 博士
Dr. Shu-Ying Wang
國立成功大學微生物及免疫學研究所 副教授
國立成功大學微生物及免疫學研究所 副教授
蕭貴陽 博士
Dr. Kuei-Yang Hsiao
蕭貴陽 博士
Dr. Kuei-Yang Hsiao
國立中興大學 生物化學研究所 助理教授
羅玉枝博士
Dr. Yu-Chin Lo
羅玉枝博士
Dr. Yu-Chin Lo
國立成功大學生物科技與產業科學系 副教授
Keynote speaker
Naoki Sugimoto
Naoki Sugimoto
RESEARCH INTERESTS
Biophysical Chemistry of Nucleic Acids and their related molecules
WORK EXPERIENCE
2012- Member of Board of Trustees, Konan Gakuen (The Konan School Corporation)
2009-2010 Dean of Graduate school of Frontiers of Innovative Research in Science and Technology (FIRST),
Konan University
2003- Director of Frontier Institute for Bimolecular Engineering Research（FIBER), Konan University
2001-2003 Director of High technology Research Center (HRC), Konan University
1994- Professor, Konan University
1991-1994 Associate Professor, Konan University
1988-1991 Assistant Professor, Konan University
1985-1988 Postdoc and Research Associate, University of Rochester, NY, USA
ACTIVITIES
2023- Member of Board of Trustees, The Chemical Society of Japan (CSJ)
2020- Fellow of Japan Society of Nucleic Acids Chemistry (JSNAC)
2017-2020 President of Japan Society of Nucleic Acids Chemistry (JSNAC)
2015- 2017 Member of Board of Trustees, The Chemical Society of Japan (CSJ)
2015- Member of Editorial Board of the Scientific Reports
2013-2017 Auditor of Division of Biofunctional Chemistry, The Chemical Society of Japan (CSJ)
2012- Member of the Editorial Board of the RNA Nanotechnology
2011-2013 Chair of Division of Biofunctional Chemistry, The Chemical Society of Japan (CSJ)
2010-2013 Program officer of Working Group of Japan Society for the Promotion of Science (JSPS)
2008-2012 Member of the Review committee of Human Frontier Science Program(HFSPO), France
2007- Member of the Editorial Board of the Nucleic Acids Research
AWARDS
2020 The Chemical Society of Japan Award
2018 The Imbach-Townsend Award, IS3NA (International Society for Nucleosides, Nucleotides, and
Nucleic Acids)
2014 JSCC Contribution Award, Japan Society of Coordination Chemistry
2013 JSPS HIRAMEKI☆TOKIMEKI SCIENCE Promotion Award
2008 The Chemical Society of Japan, Academic Award
2006 Hyogo Science Award, Japan
2005 Distinguished Scientist Award, International Copper Association (ICA) USA
2004 The Dr. Masao Horiba’s Award, Japan
1991 The Chemical Society of Japan Award for the special speaker of young generation
1990 The Chemical Society of Japan Award for the Frontier of Chemistry
PUBLICATIONS
More than 500 publications (included Journals, Reviews, and Books)
Speakers
Lee Wei Yang(楊立威)
Positions and Employment
2006-2009 JSPS fellow, Inst. of Molecular and Cellular Bioscience, University of Tokyo, Japan
2010-2011 Postdoc, Dept. of Chemistry and Chemical Biology, Harvard University, USA
2011-2018 Assistant Professor, Associate Professor (2015-2018) and Professor, NTHU, Taiwan
2020- Director of Institute of Bioinformatics and Structural Biology, NTHU, Taiwan
2021- Director of Biomedical Artificial Intelligence, NTHU, Taiwan
Professional Specialty
Protein Dynamics
Structural Biology and Bioinformatics
Drug Design and Protein Design
Selected publications
Tsai et al.(2022) Helical Structure Motifs Made Searchable to Facilitate the Functional Peptide Design. Nature Communications 13, Article number: 102.
Chang et al. (2019) Resolution-exchanged structural modeling and simulations jointly unravel that subunit rolling underlies the mechanism of programmed ribosomal frameshifting. Bioinformatics, 35, p945–952.
Liu et al. (2018) Drug Repurposing Screening Identifies tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy. Theranostics. 8, 830-845.
Chao-Han Cheng (鄭照翰)
Chao-Han Cheng (鄭照翰)
Positions and Employment
Assistant Professor, Department of Applied Chemistry, National Pingtung University (2018-)
Engineer, Laser and Additive Manufacturing Technology Center, Industrial Technology Research Institute (2016-2018)
PostDoc, Molecular Spectroscopy Laboratory, RIKEN (Japan) (2012-2015)
PostDoc, Institute of Atomic and Molecular Sciences, Academia Sinica (2008-2011)
Professional Specialty
Physical chemistry
Biophysical chemistry
Photophysical chemistry
Femtochemistry
Selected publications
1. Chao-Han Cheng, Kunihiko Ishii*, and Tahei Tahara*, “Microsecond Equilibrium Dynamics of Hairpin-Forming Oligonucleotides Quantified by Two-Color Two-Dimensional Fluorescence Lifetime Correlation Spectroscopy”, J. Phys. Chem. B, 2020, 19, 10673.
2. Chao-Han Cheng, Wen-Zhen Wang, Shie-Ming Peng, and I-Chia Chen*, “Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy”, PCCP, 2017, 19, 25471.
Yei-Chen Lai (賴奕丞)
Positions and Employment
02/2022-present Assistant professor
Department of Chemistry, National Chung Hsing University, Taiwan
03/2020-01/2022 Postdoctoral researcher
Department of Chemical & Biomolecular Engineering, University of California Los Angeles, CA, USA
Advisor: Irene A. Chen
07/2018-03/2020 Postdoctoral researcher
Department of Chemistry & Biochemistry, University of California Santa Barbara, CA, USA
Advisor: Irene A. Chen
12/2017-06/2018 Postdoctoral researcher
Department of Chemistry, National Tsing Hua University, Taiwan
Advisor: Yun-Wei Chiang
Professional Specialty
Ribozyme Biophysics; Biomolecular design; Physical chemistry of protocell system; Molecular evolution in vitro
Honors and awards
2018-2019 Postdoctoral research abroad program fellow (funded by MOST, Taiwan)
2015-2016 Scholarship of Chung Hua rotary educational foundation
2016 HOPE meeting fellow (8th HOPE Meeting)
Selected publications
1. Y.-C. Lai, Z. Liu, I.A. Chen* “Encapsulation of ribozymes inside model protocells leads to faster evolutionary adaptation” Proc. Natl. Acad. Sci. USA, 2021, 118(21), e2025054118.
2. Y.-C. Lai†, Y.-H. Kuo†, and Y.-W. Chiang* “Identifying Protein Conformational Dynamics Using Spin-label ESR” Chem. Asian J., 2019, 14, 3981. (†Equal contribution)
3. Y.-C. Lai, T.-C. Sung, C.-C. Li, C.-W. Chang, and Y.-W. Chiang* “The Role of Cardiolipin in Promoting the Membrane Pore-forming Activity of BAX Oligomers“ Biochim. Biophys. Acta, 2019, 1861, 268.
Chun-Jung Chen (陳俊榮)
Positions and Employment
Scientist, Life Science Group, Scientific Research Division, National Synchrotron Radiation Research Center (NSRRC) (2011~); Deputy Director, NSRRC (2018-2022)
Joint Professor, Dept. of Physics, National Tsing Hua University (2011~)
Joint Professor, Dept. of Biotechnology and Industrial Sciences, National Cheng Kung University (2011~)
Joint Professor, Dept. of Biological Science & Technology. National Yang Ming Chao Tung University (2018~)
Professional Specialty
Structural biology, protein crystallography, biochemistry, biophysics, virology, Synchrotron application
Honors and awards
Chair, Taiwan Crystallographic Society (2020~)
Award of Future Tech of MOST (NSTC) (2017, 2019)
Lam Research Award (2016)
Selected publications
1. Chen, N.-C., Wang, C.-H., Yoshimura, M., Yeh, Y.-Q., Guan, H.-H., Chuankhayan, P., Lin, C.-C., Lin, P.-J., Huang, Y.-C., Wakatsuki, S., Ho, M.-C.*, Chen, C.-J.* “Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions” Nature Commun. (2023) 14: 545.
2. Chan, S. I.*, Chuankhayan, P., Nareddy, Pavan K., Tsai, I-K., Tsai, Y.-F., Chen, K. H.-C., Yu, S. S.-F.*, Chen, C-J.* “The mechanism of PQQ-dependent hydride transfer chemistry from spectroscopic and high-resolution X-ray structural studies of the methanol dehydrogenase from Methylococcus capsulatus (Bath)”. J. Am. Chem. Soc. (2021) 143, 9, 3359-3372.
3. Chen, N.-C., Yoshimura, M, Miyazaki, N., Guan, H.-H., Chuankhayan, P., Lin, C.-C., Chen, S.-K., Lin, P.-J., Huang, Y.-C., Iwasaki, K., Nakagawa, A., Chan, S. I., Chen, C.-J.* “The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism” Commun. Biol. (2019) 2:72.
Chyuan-Chuan Wu (吳權娟)
Positions and Employment
2020~present
Assistant Professor, Department of Biochemistry and Molecular Biology,
College of Medicine, National Cheng Kung University, Tainan, Taiwan
2016~2020
Postdoctoral Research, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
2014~2016
Postdoctoral Research, The Jack H. Skirball Center for Chemical Biology and
Proteomics, Salk Institute for Biological Studies, La Jolla, California, USA
Professional Specialty
Structural biology, Biochemistry, Molecular biology
Selected publications
1.
Wu, C.C., Lin, J.L.J., Yang-Yen, H.F., and Yuan, H.S.* (2019) A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication. Nucleic Acids Res. 47:5405-5419.
2.
Wu, C.C.1, Baiga, T.J.1, Downes, M.1, La Clair, J.J., Atkins, A.R., Richard, S.B., Fan, W., Stockley-Noel, T.A., Bowman, M.E., Noel, J.P.*, and Evans, R.M.* (2017) Structural basis for specific ligation of the peroxisome proliferator-activated receptor delta. Proc Natl Acad Sci U S A. 114:E2563-E2570. (1These authors contribute equally to this work)
3.
Wu, C.C., Li, T.K., Farh, L., Lin, L.Y., Lin, T.S., Yu, Y.J., Yen, T.J., Chiang, C.W., Chan, N.L.* (2011) Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. Science 333:459-462.
Nien-Jen Hu(胡念仁)
Positions and Employment
2021- present
Associate professor, Institute of Biochemistry, National Chung-Hsing University, Taiwan
2013-2021
Assistant professor, Institute of Biochemistry, National Chung-Hsing University, Taiwan
2010-2013
Postdoctoral research associate, Research Complex at Harwell (Diamond Light Source synchrotron), UK
2007-2010
Postdoctoral research associate, Division of Molecular Biosciences, Imperial College London, UK
Professional Specialty
Membrane proteins account for 30% of sequenced genome and 50% of manufactured drugs are designed based on those proteins. In spite of the crucial roles of cell physiology and signal transduction many transporting mechanisms and conformational details remain uncertain. My research interests focus on structural biology and function characterisation of the integral membrane proteins. We are currently working on the structures of novel ion channels and transporters in bacteria using cryo-EM and X-ray crystallography. Biophysical techniques will be also employed to characterize the function and dynamics of the integral membrane proteins.
Selected publications
1. Lu, P. H., Li, C. C., Chiang, Y. W., Liu, J. H., Chiang, W. T., Chao, Y. H., Li, G. S., Weng, S. E., Lin, S. Y., and Hu, N. J. (2021) Dissecting the Conformational Dynamics of the Bile Acid Transporter Homologue ASBTNM. J Mol Biol 433, 166764
2. Lin, Y. H., Lin, S. Y., Li, G. S., Weng, S. E., Tzeng, S. L., Hsiao, Y. H., and Hu, N. J. (2019) Site-Directed Alkylation Detected by In-Gel Fluorescence (SDAF) to Determine the Topology Map and Probe the Solvent Accessibility of Membrane Proteins. Sci Rep 9, 13171
3. Hu, N. J., Iwata, S., Cameron, A. D., and Drew, D. (2011) Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. Nature 478, 408-411
Chia-Liang Lin (林佳良)
Positions and Employment
2021 - current Assistant Professor, Institute of Biochemistry, National Chung Hsing University, Taiwan
2020 - 2021 Assistant Research Scientist, National Synchrotron Radiation Research Center, Taiwan
2017 - 2019 Research Association, Department of Molecular and Cell Biology, University of Leicester, UK
2015 - 2017 Postdoctoral Training Fellow, Section of Structural Biology, Department of Medicine, Imperial College London, UK
Professional Specialty
Chromatin Biology, DNA/RNA Binding Protein, Structural Biology, X-ray Crystallography, Cryo-EM
Selected publications
Wang Z. A.*, Millard C. J.*, Lin C. L.*, Gurnett J. E., Wu M., Lee K., Fairall L., Schwabe J. W. R., Cole P. A. (2020) Diverse nucleosome site-selectivity among histone deacetylase complexes. eLife 9, e57663
Willhoft O.*, Ghoneim M.*, Lin C. L.*, Chua E. Y. D., Wilkinson M., Chaban Y., Ayala R., McCormack E. A., Ocloo L., Rueda D. S., Wigley D. B. (2018) Structure and dynamics of the yeast SWR1-nucleosome complex. Science 362, eaat7116
Lin C. L., Chaban Y., Rees D. M., McCormack E. A., Ocloo L., Wigley D. B. (2017) Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex. Nucleic Acids Res. 45, 7249-7260
Jhih-Wei Chu (朱智瑋)
Positions and Employment
Professor, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC, 2013-present
Professional Specialty
Biosystems simulation; theory and methodology of multiscale modeling; protein conformational dynamics and allostery; drug discovery and development.
Honors and awards
International Outstanding Junior Scholar Award, Foundation for the Advancement of Outstanding Scholarship, Taiwan, 2013.
Award for Recruiting Outstanding International Scholars, National Science Council, Taiwan, 2013.
Chancellor’s Faculty Partnership Award, UC Berkeley, 2009
Selected publications
Yu, C. C.; Raj, N.; Chu, J.-W., Edge weights in a protein elastic network reorganize collective motions and render long-range sensitivity responses, J. Chem. Phys. (2022) 156, 245105.
Raj, N.; Click, T.; Yang H.; Chu, J.-W., Structure-Mechanics Statistical Learning Uncovers Mechanical Relay in Proteins, Chem. Sci. (2022) 13, 3688-3696.
Huang, K.-W.; Chen, J.-W.; Hua, T.-Y.; Chu, Y.-Y.; Chiu, T.-Y.; Liu, J.- Y.; Tu, C.I.; Hsu, K.C.; Kao, Y.-T.; Chu. J.-W.; Hsiao, Y.-Y., Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites, JACS Au, (2021)1, 2315-2327.
I-Ren Lee(李以仁)
Positions and Employment
2020-present Associate Professor of Chemistry, National Taiwan University.
2020-present Associate Professor of Chemistry, National Taiwan University.
2014-2020 Assistant Professor of Chemistry, National Taiwan University.
2014-2020 Assistant Professor of Chemistry, National Taiwan University.
2012-2014 Postdoctoral Research Associate, Department of Physics,
2012-2014 Postdoctoral Research Associate, Department of Physics,
University of Illinois at Urbana Champaign, USA (Advisor: Taekjip Ha)
University of Illinois at Urbana Champaign, USA (Advisor: Taekjip Ha)
2010-2012 Postdoctoral Research Associate, Division of Chemistry and Chemical Engineering,
2010-2012 Postdoctoral Research Associate, Division of Chemistry and Chemical Engineering,
California Institute of Technology, USA. (Advisor: Ahmed H. Zewail)
California Institute of Technology, USA. (Advisor: Ahmed H. Zewail)
Professional Specialty
Single-molecule Spectroscopy, Nucleic Acid and Protein Structural Dynamics.
Single-molecule Spectroscopy, Nucleic Acid and Protein Structural Dynamics.
Honors and awards
2021-2024 Excellent Young Scholar, Ministry of Science and Technology (National Science Council)
2021-2024 Excellent Young Scholar, Ministry of Science and Technology (National Science Council)
Selected publications
1. Long-Range Hairpin Slippage Reconfiguration Dynamics in Trinucleotide Repeat Sequences. J. Phys. Chem. Lett. 2019, 10 (14), 3985-3990.
2. Huang, T. Y.; Chang, C. K.; Kao, Y. F.; Chin, C. H.; Ni, C. W.; Hsu, H. Y.; Hu, N. J.; Hsieh, L. C.; Chou, S. H.; Lee, I. R.; Hou, M. H. Parity-dependent hairpin configurations of repetitive DNA sequence promote slippage associated with DNA expansion. Proc. Natl. Acad. Sci. U. S. A. 2017, 114 (36), 9535-9540.
Ambadas B. Rode
Positions and Employment
Assistant Professor (09 August 2018 – till date) Regional Centre for Biotechnology, Faridabad
Ramalingaswami Re-entry Fellow (16 April 2018 – 15 April 2023)
Regional Centre for Biotechlogy, Faridabad
Research Assistant Professor Fellow (1 Oct 2017 – 30 April 2018)
(PI) Frontier Institute for Bimolecular Engineering Research,
Konan University, Kobe, Japan.
JSPS Postdoctoral Fellow (1 Oct 2015 - 30 Sep 2017; 2 years)
(Co-PI) Frontier Institute for Bimolecular Engineering Research,
Konan University, Kobe, Japan.
Postdoctoral Researcher (1 April 2012 - 30 Sep 2015; 3 years and 6 months) Frontier Institute for Bimolecular Engineering Research,
Konan University, Kobe, Japan.
R & D Research Chemist (26 Dec 2006 - 06 Feb 2008; 1 year and 1 month) Sai Life Sciences (MNC) (formerly known as SAI Advantium Pharma), Pune, India.
Professional Specialty
Targeting and tuning nucleic acid structures for therapeutic and biotechnology applications
Honors and awards
India EMBO Lecture Course Grant (2022) as an Organizer from European Molecular Biology Organization.
Ramalingaswami Re-entry Fellowship (2017).
Ramanujan Fellowship (2017).
JSPS Postdoctoral Fellowship (2015).
The Chemical Society of Japan (CSJ) Oral Presentation Award for the presentation at 97th Annual meeting of the chemical Society of Japan (2017).
Selected publications
Ojha, D., Rode A. B.* Recent Advances in Aptamer Generation for Synthetic Biology Applications, Journal of the Japan Society of Nucleic Acids Chemistry 3, 7-11(2019).
Kauthale, S., Tekale, S., Rode, A. B. Patil, R. Sangshetti,J. Kótai, L. Pawar R. Eaton’s Reagent Catalyzed Synthesis, In vitro, α-amylase inhibitory activity and molecular docking study of some Schiff’s bases as diabetic-II inhibitors. European Chemical Bulletin 8 (11), 356-362 (2019).
Rode, A. B.; Endoh, T.; Sugimoto, N. Crowding Shifts the Riboswitch Aptamer-FMN Recognition Mecha-nism from Conformational Selection to Induced Fit.
Tai-Lin Chen(陳泰霖)
Tai-Lin Chen(陳泰霖)
Positions and Employment
2022.08-
Assistant Professor Post-baccalaureate Medicine, National Chung-Hsing University Pharmacology
2019.08-2022.07
Assistant Professor School of Pharmacy, China Medical University, Taiwan Dispensing Pharmacy, Drug Discovery and Development, Material Medica
2018.07-2019.07
Postdoctoral Scholar Academia Sinica
Discovery of 1,2-bis(hydroxymethyl)pyrrolo[2,1-a]phthalazines and 1,2-bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazines in small cell lung cancer
2018.02-2018.06
Postdoctoral Fellow Taiwan Biobank
Maintenance of Taiwan Biosignatures Projects
Professional Specialty
Medicinal chemistry in drug design (liquid phase, solid phase synthesis, and molecular modeling)
Pharmacology In Vitro and In Vivo study (xenograft model and lung orthotropic model)
Toxicity study of small molecule
Molecular biology in DNA damage, chemical sequencing, protein purification, molecular cloning
Selected publications
Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids that Inhibit Angiogenesis and Induce DNA Crosslinks., Chen TL, Patel AS, Jain V, Kuppusamy R, Lin YW, Hou MH, Su TL*, Lee TC, J Med Chem, 2021, 64, 12469-12486
Antitumor Effects of the Novel Quinazolinone Holu-12: Induction of Mitotic Arrest and Apoptosis in Human Oral Squamous Cell Carcinoma CAL27 Cells., Lai KC, Chia YT, Yih LH, Lu YL, Chang ST, Hong ZX, Chen TL# and Hour MJ#, * co-corresponding author, Anticancer Research 2021, 41: 259-268
Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1-a]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Crosslinks. Chang SM*, Jain Vicky*, Chen TL*, Patel Anilkumar, Pidugu HB, Lin YW, Wu MH, Huang JR, Wu HC, Shah Anamik, Su TL, Lee TC. J Med Chem, * co-first author, 2019 Mar，62(5):2404-2418.
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