演講者 Speakers

RESEARCH INTERESTS

Biophysical Chemistry of Nucleic Acids and their related molecules

WORK EXPERIENCE

2012-   Member of Board of Trustees, Konan Gakuen (The Konan School Corporation)

2009-2010  Dean of Graduate school of Frontiers of Innovative Research in Science and Technology (FIRST),  

                   Konan University

2003-          Director of Frontier Institute for Bimolecular Engineering Research（FIBER), Konan University

2001-2003  Director of High technology Research Center (HRC), Konan University

1994-    Professor, Konan University

1991-1994  Associate Professor, Konan University

1988-1991  Assistant Professor, Konan University

1985-1988  Postdoc and Research Associate, University of Rochester, NY, USA

ACTIVITIES

2023-    Member of Board of Trustees, The Chemical Society of Japan (CSJ)

2020-    Fellow of Japan Society of Nucleic Acids Chemistry (JSNAC)

2017-2020  President of Japan Society of Nucleic Acids Chemistry (JSNAC)

2015- 2017 Member of Board of Trustees, The Chemical Society of Japan (CSJ)

2015-    Member of Editorial Board of the Scientific Reports

2013-2017  Auditor of Division of Biofunctional Chemistry, The Chemical Society of Japan (CSJ)

2012-        Member of the Editorial Board of the RNA Nanotechnology

2011-2013  Chair of Division of Biofunctional Chemistry, The Chemical Society of Japan (CSJ)

2010-2013  Program officer of Working Group of Japan Society for the Promotion of Science (JSPS)

2008-2012  Member of the Review committee of Human Frontier Science Program(HFSPO), France

2007-      Member of the Editorial Board of the Nucleic Acids Research 

AWARDS

2020   The Chemical Society of Japan Award

2018   The Imbach-Townsend Award, IS3NA (International Society for Nucleosides, Nucleotides, and 

                Nucleic Acids)

2014 　　JSCC Contribution Award, Japan Society of Coordination Chemistry

2013   JSPS HIRAMEKI☆TOKIMEKI SCIENCE Promotion Award

2008   The Chemical Society of Japan, Academic Award

2006  Hyogo Science Award, Japan

2005   Distinguished Scientist Award, International Copper Association (ICA) USA

2004  The Dr. Masao Horiba’s Award, Japan

1991     The Chemical Society of Japan Award for the special speaker of young generation

1990   The Chemical Society of Japan Award for the Frontier of Chemistry

PUBLICATIONS

More than 500 publications (included Journals, Reviews, and Books)

Positions and Employment

Assistant Professor, Department of Applied Chemistry, National Pingtung University (2018-)

Engineer, Laser and Additive Manufacturing Technology Center, Industrial Technology Research Institute (2016-2018)

PostDoc, Molecular Spectroscopy Laboratory, RIKEN (Japan) (2012-2015)

PostDoc, Institute of Atomic and Molecular Sciences, Academia Sinica (2008-2011)

Professional Specialty

Physical chemistry

Biophysical chemistry

Photophysical chemistry

Femtochemistry

Selected publications

1.  Chao-Han Cheng, Kunihiko Ishii*, and Tahei Tahara*, “Microsecond Equilibrium Dynamics of Hairpin-Forming Oligonucleotides Quantified by Two-Color Two-Dimensional Fluorescence Lifetime Correlation Spectroscopy”, J. Phys. Chem. B, 2020, 19, 10673.

2.   Chao-Han Cheng, Wen-Zhen Wang, Shie-Ming Peng, and I-Chia Chen*, “Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy”, PCCP, 2017, 19, 25471.

Positions and Employment 

Scientist, Life Science Group, Scientific Research Division, National Synchrotron Radiation Research Center (NSRRC) (2011~); Deputy Director, NSRRC (2018-2022)

Joint Professor, Dept. of Physics, National Tsing Hua University (2011~)

Joint Professor, Dept. of Biotechnology and Industrial Sciences, National Cheng Kung University (2011~)

Joint Professor, Dept. of Biological Science & Technology. National Yang Ming Chao Tung University (2018~)

Professional Specialty

Structural biology, protein crystallography, biochemistry, biophysics, virology, Synchrotron application

Honors and awards 

Chair, Taiwan Crystallographic Society (2020~)

Award of Future Tech of MOST (NSTC) (2017, 2019)

Lam Research Award (2016)

Selected publications

1.    Chen, N.-C., Wang, C.-H., Yoshimura, M., Yeh, Y.-Q., Guan, H.-H., Chuankhayan, P., Lin, C.-C., Lin, P.-J., Huang, Y.-C., Wakatsuki, S., Ho, M.-C.*, Chen, C.-J.* “Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid assembly with dynamic motions” Nature Commun. (2023) 14: 545.

2.     Chan, S. I.*, Chuankhayan, P., Nareddy, Pavan K., Tsai, I-K., Tsai, Y.-F., Chen, K. H.-C., Yu, S. S.-F.*, Chen, C-J.* “The mechanism of PQQ-dependent hydride transfer chemistry from spectroscopic and high-resolution X-ray structural studies of the methanol dehydrogenase from Methylococcus capsulatus (Bath)”. J. Am. Chem. Soc. (2021) 143, 9, 3359-3372.

3.    Chen, N.-C., Yoshimura, M, Miyazaki, N., Guan, H.-H., Chuankhayan, P., Lin, C.-C., Chen, S.-K., Lin, P.-J., Huang, Y.-C., Iwasaki, K., Nakagawa, A., Chan, S. I., Chen, C.-J.* “The atomic structures of shrimp nodaviruses reveal new dimeric spike structures and particle polymorphism” Commun. Biol. (2019) 2:72.

Positions and Employment

2021- present

Associate professor, Institute of Biochemistry, National Chung-Hsing University, Taiwan

2013-2021

Assistant professor, Institute of Biochemistry, National Chung-Hsing University, Taiwan

2010-2013

Postdoctoral research associate, Research Complex at Harwell (Diamond Light Source synchrotron), UK

2007-2010

Postdoctoral research associate, Division of Molecular Biosciences, Imperial College London, UK

Professional Specialty

Membrane proteins account for 30% of sequenced genome and 50% of manufactured drugs are designed based on those proteins. In spite of the crucial roles of cell physiology and signal transduction many transporting mechanisms and conformational details remain uncertain. My research interests focus on structural biology and function characterisation of the integral membrane proteins. We are currently working on the structures of novel ion channels and transporters in bacteria using cryo-EM and X-ray crystallography. Biophysical techniques will be also employed to characterize the function and dynamics of the integral membrane proteins.

Selected publications

1.     Lu, P. H., Li, C. C., Chiang, Y. W., Liu, J. H., Chiang, W. T., Chao, Y. H., Li, G. S., Weng, S. E., Lin, S. Y., and Hu, N. J. (2021) Dissecting the Conformational Dynamics of the Bile Acid Transporter Homologue ASBTNM. J Mol Biol 433, 166764

2.     Lin, Y. H., Lin, S. Y., Li, G. S., Weng, S. E., Tzeng, S. L., Hsiao, Y. H., and Hu, N. J. (2019) Site-Directed Alkylation Detected by In-Gel Fluorescence (SDAF) to Determine the Topology Map and Probe the Solvent Accessibility of Membrane Proteins. Sci Rep 9, 13171

3.     Hu, N. J., Iwata, S., Cameron, A. D., and Drew, D. (2011) Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. Nature 478, 408-411

Positions and Employment

Professor, Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC, 2013-present

Professional Specialty

Biosystems simulation; theory and methodology of multiscale modeling; protein conformational dynamics and allostery; drug discovery and development.

Honors and awards

International Outstanding Junior Scholar Award, Foundation for the Advancement of Outstanding Scholarship, Taiwan, 2013.

Award for Recruiting Outstanding International Scholars, National Science Council, Taiwan, 2013.

Chancellor’s Faculty Partnership Award, UC Berkeley, 2009

Selected publications

1. Yu, C. C.; Raj, N.; Chu, J.-W., Edge weights in a protein elastic network reorganize collective motions and render long-range sensitivity responses, J. Chem. Phys. (2022) 156, 245105.

2. Raj, N.; Click, T.; Yang H.; Chu, J.-W., Structure-Mechanics Statistical Learning Uncovers Mechanical Relay in Proteins, Chem. Sci. (2022) 13, 3688-3696.

3.  Huang, K.-W.; Chen, J.-W.; Hua, T.-Y.; Chu, Y.-Y.; Chiu, T.-Y.; Liu, J.-     Y.; Tu, C.I.; Hsu, K.C.; Kao, Y.-T.; Chu. J.-W.; Hsiao, Y.-Y., Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites, JACS Au,  (2021)1, 2315-2327.

Positions and Employment

Assistant Professor (09 August 2018 – till date) Regional Centre for Biotechnology, Faridabad

Ramalingaswami Re-entry Fellow (16 April 2018 – 15 April 2023)

Regional Centre for Biotechlogy, Faridabad

Research Assistant Professor Fellow (1 Oct 2017 – 30 April 2018)

(PI) Frontier Institute for Bimolecular Engineering Research,

Konan University, Kobe, Japan.

JSPS Postdoctoral Fellow (1 Oct 2015 - 30 Sep 2017; 2 years)

(Co-PI) Frontier Institute for Bimolecular Engineering Research,

Konan University, Kobe, Japan.

Postdoctoral Researcher (1 April 2012 - 30 Sep 2015; 3 years and 6 months) Frontier Institute for Bimolecular Engineering Research,

Konan University, Kobe, Japan.

R & D Research Chemist (26 Dec 2006 - 06 Feb 2008; 1 year and 1 month) Sai Life Sciences (MNC) (formerly known as SAI Advantium Pharma), Pune, India.

Professional Specialty

Targeting and tuning nucleic acid structures for therapeutic and biotechnology applications

Honors and awards

India EMBO Lecture Course Grant (2022) as an Organizer from European Molecular Biology Organization.

Ramalingaswami Re-entry Fellowship (2017).

Ramanujan Fellowship (2017).

JSPS Postdoctoral Fellowship (2015).

The Chemical Society of Japan (CSJ) Oral Presentation Award for the presentation at 97th Annual meeting of the chemical Society of Japan (2017).

Selected publications

1. Ojha, D., Rode A. B.* Recent Advances in Aptamer Generation for Synthetic Biology Applications, Journal of the Japan Society of Nucleic Acids Chemistry 3, 7-11(2019).

2. Kauthale, S., Tekale, S., Rode, A. B. Patil, R. Sangshetti,J. Kótai, L. Pawar R. Eaton’s Reagent Catalyzed Synthesis, In vitro, α-amylase inhibitory activity and molecular docking study of some Schiff’s bases as diabetic-II inhibitors. European Chemical Bulletin 8 (11), 356-362 (2019).

3. Rode, A. B.; Endoh, T.; Sugimoto, N. Crowding Shifts the Riboswitch Aptamer-FMN Recognition Mecha-nism from Conformational Selection to Induced Fit.