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穿戴裝置研究突破
近年穿戴式裝置被廣泛使用許多大廠相繼推出不同種類的產品，然而其功能與市場仍有一定的精進空間，而BEAR LAB試圖由血管健康的角度以提供更多樣的訊息，如：老年照護、青壯年警示、居家保健等主題，使穿戴式裝置功能更加完善。
為了這項目標，BEAR LAB穿戴裝置研究致力於提升醫療預測的準確度，且密切與各大醫院進行合作，如：雙和醫院、台北聯醫仁愛院區、慈濟醫院及三軍總醫院等，應用範圍涵蓋心血管、心智健康、代謝疾病、腎臟疾病等多個領域，希望提供更精準的健康監測。目前重大突破成果包括三項核心技術（血管健康度、心智健康度[包括MCI輕度障礙]及現有穿戴技術突破[自動波形品質判別、脈波速度PTT、血氧飽和濃度]），與三大應用方向（老人照護、青壯年預警及居家保健）：
核心技術：
血管健康度、心智健康度（MCI輕度認知障礙偵測）、現有穿戴技術之突破、血氧飽和濃度量測突破、波形品質自動判別
應用方向：
2024最新健康度指標開發、老年照護、青壯年警示、居家保健
未來BEAR LAB將持續發展技術，以提供更精準且普及的健康監測研究！
核心技術1：血管健康度
核心技術1：血管健康度
核心技術2：心智健康度
核心技術2：心智健康度
心智健康度應用：MCI（輕度認知障礙偵測）
心智健康度應用：MCI（輕度認知障礙偵測）
核心技術3：現有穿戴技術之突破
核心技術3：現有穿戴技術之突破
血氧飽和濃度量測突破
血氧飽和濃度量測突破
波形品質自動判別
波形品質自動判別
應用方向1：老年照護
應用方向1：老年照護
肌少症
肌少症
城鄉差距
城鄉差距
應用方向3：居家保健
應用方向3：居家保健
運動效益偵測
運動效益偵測
血管營養評估
血管營養評估
新冠肺炎相關主題
新冠肺炎相關主題
長新冠症狀偵測與評估
長新冠症狀偵測與評估
BNT疫苗副作用成果
BNT疫苗副作用成果
長新冠症狀偵測與評估
長新冠症狀偵測與評估
貧血健康度
貧血健康度
應用方向2：青壯年預警
應用方向2：青壯年預警
代謝相關疾病（糖尿病前期、代謝症候群 ）
代謝相關疾病（糖尿病前期、代謝症候群 ）
腎臟相關疾病
腎臟相關疾病
癌症相關：乳癌偵測
癌症相關：乳癌偵測
乳癌預後自動評估
乳癌預後自動評估
榮譽榜
BEAR-Lab AI-Wearables
Using vascular properties to assess human physiologic or disease status
許昕教授
(Hsin Hsiu, PhD)
學歷：
(1) Ph.D, Institute of Electrical Engineering, National Taiwan University
(2) Master, Institute of Electrical Engineering, National Taiwan University
(3) Bachelor, Department of Electrical Engineering, National Taiwan University
經歷：
(1) Professor, Institute of Biomedical Engineering, National Taiwan University of Science and Technology, 2017/02 till now
(2) Director, Institute of Biomedical Engineering, National Taiwan University of Science and Technology, 2018/08-2021/07
專長：
(1) 穿戴式生醫電子；(2) 血流訊號人工智慧分析
聯絡方式：
hhsiu@mail.ntust.edu.tw
焦點消息
一、長期創新發展方向：五合一心血管健康評估
「五合一心血管健康評估」簡介：
先進行血管健康度分析，再進行肌少症風險度、心智風險度、代謝症候群風險度、糖尿病風險度、運動健康度等，尚可進行新冠疫苗風險度測試。
先對整體血管健康進行評估，再經由分析提供可進行醫療諮詢的建議方向。
僅需進行一次脈波量測 (<1分鐘)，藉由醫療院所累積收案為基礎，建構出AI演算模型，即可針對各種不同疾病，提供健康或風險狀態之評估輔助資訊。
省時省力，即時安全，全方位醫療資訊，引導至適當科別進一步處理。
各項應用皆累積正式臨床研究與論文發表，長期醫療合作團隊為諮詢後盾。
二、2023/2/2 重要發展方向：中年族群工作負荷對身心健康狀態之評估
基於先前執行的累積經驗，在接下來的規劃中，除了延續過去老年族群活動舉辦之外，將心智與血管健康關注之年齡層，進一步拓展至社會中堅之中年，在此架構下，將提供適合於不同族群不同面向之身心健康之策略調整，以進一步增廣智慧裝置於居家應用的實用價值與內涵。
中年族群為家庭的經濟來源主力與重心，因此是社會運作的中堅組成。在現代化社會中，中年族群承擔撫養長輩、教養兒女，同時還需從事各式經濟活動，沈重負擔若對人體造成傷害，對家庭進而社會都會帶來重大衝擊，尤其是突發性的急性心血管疾病、或心智功能損害等，常讓人措手不及，影響更是巨大。另一方面，中年族群的消費力較強，在前述需求下，對自身健康狀態瞭解也具有較強動機。因此在穿戴式生醫電子領域中，對於中年族群工作負荷狀態帶來身心健康影響程度，其即時有效的監控一直是全球的開發終極目標。
在初步研究的規劃中，配合大學社會責任計畫(USR)的執行，我們選定位於本校附近的民族實中作為執行場域，並以教職員為對象。民族實中緊鄰師大分部、台灣科技大學、台灣大學等文教區，校風淳樸、師資優秀、社會資源豐富，此活動並可進一步促進本研究執行之在地聯結。工作負荷之評估，考量執行的可行性，我們採用NASA task load index (NASA TLX)以問卷方式進行，與脈波AI分析之健康度作比較。
初步研究的結果如下二圖所示。橫軸愈往右代表工作負荷愈大，縱軸愈往上則代表血管或心智的疾病風險增高。由結果圖可看出，當工作負荷愈大時，不僅血管疾病風險提高，心智健康相關風險也提高，也就是過重的工作負荷將帶來身心兩方面的傷害。由於本量測僅需一分鐘的擷取時間，且多種健康度分析也僅需一次量測的數據，即可提供全面的資訊，日後持續擴大研究規模，此一量測分析系統可望對於中年族群的保健與疾病風險警示，以便利可靠的方式提供輔助的參考資訊。
三、USR大學社會責任計劃 : 智慧生醫電子開發成果與社區場域應用
1. USR計劃2020-2022簡要計畫成果
2. USR和平長老教會活動影片
研究內容
左圖為digital health領域中，2021 獲得最多投資的項目與金額。值得注意的是，前兩名分別為心智健康(mental health)以及心血管疾病(cardiovascular disease)。
脈波穿戴式裝置結合AI，基於過去累積臨床研究經驗，因應現今digital health發展趨勢，目前本實驗室開發兩大重點方向，在於建置：1.血管健康度；2.心智健康度。 發展此二項的思考在於：
(1) 由實用方面：此二項應用與老年化社會需求息息相關，血管健康度可協助評估血液供應進而重要器官生理運作狀態，心智健康則是攸關長者照護的重要指標。
(2) 由學理方面：血管健康度與動脈傳遞之脈波波形自然是息息相關。心智相關疾病如失智症，也由前人文獻中發現，常伴隨高血壓或血管硬化等血管特性改變，因此會影響脈波傳遞與波形。
目前所建構的量測系統，結合ECG (採用生物電極量測)、BPW(採用壓力感測器量測體表橈動脈血壓波形)、PPG(光血液動脈容積訊號)、LDF(雷射都卜勒微循環血流量測) — 四種循環生理訊號之量測與分析，分別對應至循環供血系統之上游(心臟跳動狀態)、中游(動脈脈波傳遞)、下游(微循環組織供血)各部分，以做出全面性的評估。
目前心血管、癌症、長照、復健等4大領域為主。癌症部分，現在已可偵測乳癌0～2期的期別，其精準度達到99％，另外長照領域的失智偵測也可達99％。除了高精準度外，脈波檢測儀的另一個優勢是功能先進且快速易用。功能部分，他以失智為例指出，目前醫界的失智程度診斷做法是讓患者填寫檢測量表，再從結果判斷症狀輕重，脈波檢測儀則是直接以血流波形的生理數據做為判斷，其結果會更客觀，而且也可讓病症有更仔細的分級，至於快速易用方面，現在醫療等級的穿戴式裝置，往往必須長時間配戴才能偵測出確實結果，脈波檢測儀則可將時間縮短至2分鐘左右，大幅縮短診療時間。
各項量測方式，對於前述現今全球面對雲端生醫電子應用之困境，我們皆累積相當成果，希望能有效解決此些問題：
● 非侵入式量測：量測技術橫跨電學、力學與光學量測，皆為非侵入式量測技術
● 使用方便、穩定可靠：目前量測硬體中，LDF為外購儀器，其餘包括ECG、BPW、PPG三項量測，以及相關擷取電路、連接電路等，皆已完成自製化，且多年硬體實作經 驗中，累積著重兼顧使用方便與穩定可靠之know how，部分關鍵技術目前已獲得或申請國內外專利。
需具生理狀態良好解析力：臨床實際測試我們建立之軟硬體系統效能，是目前研究工作的一大重點。研究成果中所列出之多篇論文，即為本研究室於多項慢性疾病(包括中風、糖尿病、多囊性卵巢症、代謝症候群、乳癌、冠心病、本態性高血壓、五十肩等)累積之研究成果，初步已可針對正常人與慢性病患者，所引發不同血流分佈與調控活動狀態，做出良好的解析，並依此開發療效與副作用之即時客觀評估指標。
獲取專利
著作目錄
1. Te OuYoung, Wan-Ling Weng, Ting-Yu Hu, Chia-Chien Lee, Li-Wei Wu, Hsin Hsiu*. Machine-learning analysis for discriminating radial pulse-waveform quality by applying different contact pressures. Sensors, in press. (SCI)
2. Chen CC, Chang CK, Chiu CC, Yang TY, Hao WR, Lin CH, Fang YA, Jian W, Hsu MH, Yang TL, Liu JC*, Hsiu H*. Machine Learning Analyses Revealed Distinct Arterial Pulse Variability According to Side Effects of Pfizer-BioNTech COVID-19 Vaccine (BNT162b2). J Clin Med. 2022 Oct 17; 11(20): 6119. doi: 10.3390/jcm11206119. PMID: 36294440; PMCID: PMC9605457. (SCI)
3. Ou Young T, Wu LW*, Hsiu H*, Peng TC, Chen WL. Characteristics of sarcopenia subjects in arterial pulse spectrum analysis. Front Public Health. 2022 6; 10: 969424. doi: 10.3389/fpubh.2022.969424. (SCI)
4. Chen Y-T, Hsiu H, Chen R-J, Chen P-N*. Stability of virtual reality haptic feedback incorporating fuzzy-passivity control. Measurement and Control. 2022; 0(0). doi:10.1177/00202940221105090 (SCI)
5. Hsin Hsiu*, Shun-Ku Lin, Wan-Ling Weng, Chaw-Mew Hung, Che-Kai Chang, Chia-Chien Lee, Chao-Tsung Chen. Discrimination of the cognitive function of community subjects using the arterial pulse spectrum and machine-learning analysis. Sensors, 2022; 22(3), 806. (SCI)
6. Hsiu H*, Liu JC, Yang CJ, Chen HS, Wu MS, Hao WR, Lee KY, Hu CJ, Wang YH, Fang YA. Discrimination of vascular aging using the arterial pulse spectrum and machine-learning analysis. Microvasc Res. 2021; 139: 104240 (SCI).
7. Shun-Ku Lin, Hsin Hsiu*, Hsi-Sheng Chen, Chang-Jen Yang. Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis. Sci Rep, 11, Article number: 8882 (2021). www.nature.com/articles/s41598-021-87903-7 . (SCI)
8. Ju-Chi Liu, Yi-Ping Hsu, Jia-Cheng Zhu, Wen-Rui Hao, Tsung-Yeh Yang, Li-Chun Sung, Pai-Feng Kao, Jaulang Hwang, Hsin Hsiu*. Beat-to-beat and spectral analyses of the noninvasive radial pulse and laser-Doppler signals in patients with hypertension. Clin Hemorheol Microcirc. 2021; 79(3): 365-379. (SCI).
9. Ping-Nan Chen*, Yung-Te Chen, Hsin Hsiu, and Ruei-Jia Chen. Impedance-Passivity based Haptic Control for Visual Surgery Training. Appl. Sci. 2021, 11, 1618. https://doi.org/10.3390/app11041618. (SCI)
10. Chao-Tsung Chen, Chin-Tsing Ting, Chun-Yeh Chen, Zong-Jhe Lyu, Chien-Cheng Chen, Yi-Sheng Chou, Chi-Feng Cheng, Chung-Hua Hsu, Hsin Hsiu*. Pulse-waveform and laser-Doppler indices for identifying colorectal-cancer patients. Biom Eng Appl Basis Comm 2020, 33(1), Article No: 2150005.
11. Feng-Cheng Lin, Hsin Hsiu*, Han-Si Chiu, Chao-Tsung Chen, Chung-Hua Hsu. Characteristics of pulse-waveform and laser-Doppler indices in frozen-shoulder patients. Biomedical Signal Processing and Control, 56 (2020) 101718. (SCI)
12. Chung-Hua Hsu, Chao-Tsung Chen, Jyh-Rou Liu, Hung-Bo Wu, Yi-Sheng Chou, Hsin Hsiu*. Comparison of complexity and spectral indices of skin-surface laser-Doppler signals in patients with breast cancer receiving chemotherapy and Kuan-Sin-Yin. Clin Hemorheol Microcirc. 2019; 73(4):553-563. doi: 10.3233/CH-190569 (SCI)
13. Hsin Hsiu*, Hsiao-Feng Hu, Yaw-Wen Chang. Using complexity and spectral analyses of noninvasive laser-Doppler signals in patients with metabolic syndrome. Complexity, Vol 2018, Article ID 6898024, https://doi.org/10.1155/2018/6898024. (SCI)
14. Hsin Hsiu*, Chao-Tsung Chen, Shuo-Hui Hung, Guan-Zhang Chen, Yu-Ling Huang. Differences in time-domain and spectral indexes of skin-surface laser-Doppler signals between controls and breast-cancer patients. Clin Hemorheol Micro, 69 (2018) 371–381. (SCI)
15. Hsin Hsiu*, Hsiao-Feng Hu, Hung-Chi Tsai. Differences in laser-Doppler indexes between skin-surface measurement sites in subjects with diabetes. Microvasc Res. 2018; 115: 1-7. (SCI)
16. Chao-Tsung Chen, Hsin Hsiu*, Shuo-Hui Hung, Guan-Zhang Chen, Yu-Ling Huang. Characteristics of spectral indexes of the blood pressure waveform in patients with breast cancer. Blood Press Monit, 2017; 22(4): 217-220. (SCI)
17. Hsiao-Feng Hu, Hsin Hsiu*, Ciao-Jyuan Sung, Chien-Hsing Lee. Combining laser-Doppler flowmetry measurements with spectral analysis to study different microcirculatory effects in human prediabetic and diabetic subjects. Laser Med Sci, 2017; 32: 327-334. (SCI)
18. Taipau Chia, Jian-Guo Bau*, Yung-Hui Li, Shan-Hua Wei, Hsin Hsiu; Ling Pao. Microcirculatory characteristics in neck/shoulder of the adults with sedentary and regular exercise lifestyles. J Med Biol Eng, 2017 Jun, DOI 10.1007/s40846-017-0248-y. (SCI)
19. Ju-Chi Liu, Hsin Hsiu*, Yi-Ping Hsu, Hung-Chi Tsai, Chung-Hsien Kuo. Changes in the spectral index of skin-surface laser Doppler signals of nude mice following the injection of CT26 tumor cells. Am J Can Res, 2016; 6(8): 1812-9. (SCI)
20. Yaw-Wen Chang, Hsin Hsiu*, Shu-Han Yang, Wen-Hwei Fang, Hung-Chi Tsai. Characteristics of beat-to-beat photoplethysmography waveform indexes in subjects with metabolic syndrome. Microvasc Res, 2016; 106: 80-87. (SCI)
21. Chao-Tsung Chen, Hsin Hsiu*, Jin-Shiang Fan, Fong-Cheng Lin, Yen-Ting Liu. Complexity analysis of beat-to-beat skin-surface laser-Doppler flowmetry signals in stroke patients. Microcirculation, 2015; 22(5): 370-7. (SCI)
22. Feng-Cheng Lin, Hsin Hsiu*, Yao-Chun Lin, Hsin-Yi Chung, Wei-Chen Hsu, Chao-Tsung Chen, Fu-Chi Chen. Effects of electroacupuncture stimulation at frequencies near the heart rate on the microcirculatory blood flow. Universal Journal of Biomedical Engineering, 3(4): 23-29, 2015.
23. Hsin Hsiu*, Wei-Chen Hsu, Yi-Fan Wu, Chia-Liang Hsu, Chih-Yu Chen. Differences in the skin-surface laser-Doppler signals between polycystic-ovary-syndrome and normal subjects. Microcirculation, 2014; 21(2):124-30. (SCI)
24. Hsin Hsiu*, Hsiao-Feng Hu, Chia Liang Hsu, Fone-Ching Hsiao, Shu-Han Yang. Complexity analysis of beat-to-beat skin-surface laser-Doppler signals in diabetic subjects. Microvasc Res, 2014; 93: 9-13. (SCI)
25. Chia-Liang Hsu, Hsin Hsiu*, Wei-Chen Hsu, Chih-Yu Chen. Characteristics of harmonic indexes of the arterial blood pressure waveform in polycystic ovary syndrome. Blood Press Monit, 2014; 19(4): 226-32. (SCI)
26. Hsin Hsiu*, Hsiao-Feng Hu, Kuan-Hsien Wu, Fone-Ching Hsiao. Characteristics in the beat-to-beat laser-Doppler waveform indices in diabetic subjects, Clin Hemorheol Micro, 2014; 57(4): 375-84. (SCI)
27. Hsin Hsiu*, Shih-Min Huang, Chao-Tsung Chen, Wei-Chen Hsu, Fong-Cheng Lin. Differences in the beat-to-beat parameters of skin-surface pulsatile laser-Doppler waveforms between stroke and normal subjects. Clin Hemorheol Microcirc, 2014; 58(2):353-62. (SCI)
28. Hsin Hsiu*, Wei-Chen Hsu, Chia-Liang Hsu, Jian-Guo Bau. Microcirculatory complexity responses to the application of skin-surface-contacting pressure stimulation around normal blood pressure. J Med Biol Eng, 2014; 34(2): 164-171. (SCI)
29. Hsin Hsiu*, Wei-Chen Hsu, Chia-Liang Hsu, Jian-Guo Bau, Chao-Tsung Chen, Yi-Syuan Liu. Complexity analysis on the microcirculatory-blood-flow response following acupuncture stimulation. Microvasc Res, 2013; 89: 34-9. (SCI)
30. Hsin Hsiu*, Chia-Liang Hsu, Chao-Tsung Chen, Wei-Chen Hsu, Fong-Cheng Lin. Effects of acupuncture on the harmonic components of the radial arterial blood-pressure waveform in stroke patients. Biorheology, 2013; 50(1): 69-81. (SCI)
31. Hsin Hsiu*, Chia-Liang Hsu, Chao-Tsung Chen, W. C. Hsu, Hsiao-Feng Hu, Fu-Chi Chen. Correlation of harmonic components between the blood pressure and photoplethysmography waveforms following local-heating stimulation. IJBBB, 2012; 2(4): 248-253. (invited paper).
32. Hsin Hsiu*, Wei-Chen Hsu, Chia-Liang Hsu, Wei-Chung Lin, Ming-Hung Ho, Chao-Tsung Chen, Hsiao-Feng Hu. Acute microcirculatory responses induced by skin-surface vibration stimulation at a frequency near the heart rate. Biorheology, 2012; 49(1): 15-25. (SCI)
33. Hsin Hsiu*, Shih-Ming Huang, Chia-Liang Hsu, Shih-Fan Hu, Hung-Wen Lin. Effects of cold stimulation on the harmonic structure of the blood pressure and photoplethysmography waveforms. Photomed Laser Surg, 2012; 30(2): 77-84. (SCI)
34. Hsin Hsiu*, Shih-Min Huang, Chao-Tsung Chen, Chia-Liang Hsu, Wei-Chen Hsu. Acupuncture stimulation causes bilaterally different microcirculatory effects in stroke patients. Microvascular Research 81(3): 289-94, 2011. (SCI)
35. Hsin Hsiu*, Wei-Chen Hsu, Chia-Liang Hsu, Shih-Ming Huang. Assessing the effects of acupuncture by comparing needling the hegu acupoint and needling nearby nonacupoints by spectral analysis of microcirculatory laser Doppler signals. Evid Based Complement Alternat Med. 2011. Article ID 435928, doi:10.1093/ecam/neq073. (SCI).
36. Hsin Hsiu*, Chia-Liang Hsu, Tsung-Lin Wu. Effects of different contacting pressure on the transfer function between finger photoplethysmographic and radial blood pressure waveforms. P I Mech Eng H, 225(H6), 575-584, 2011. (SCI)
37. Chao-Tsung Chen, Shih-Min Huang, Hsin Hsiu*, Wei-Chen Hsu, Feng-Cheng Lin, Hung-Wen Lin. Using a blood pressure harmonic variability index to monitor the cerebral blood flow condition in stroke patients. Biorehology, 48(3): 219-228, 2011. (SCI)
38. Hsin Hsiu*, Wei-Chen Hsu, Shih-Ming Huang, Chia-Ching Lin, Hung-Wen Lin. Assessing the microcirculatory response following oral administration of Liuwei-Dihuang by spectral analysis of skin-surface laser Doppler signals. J Chin Int Med, 9(10): 1101-9, 2011. (SCI).
39. Hsin Hsiu*, Shih-Min Huang, Tse-Lin Hsu. Evaluation of the function of arteriolar opening by variability in microcirculatory blood flow following angiotensin II administration in rats. Biorehology, 2010; 47(3): 239-253 (SCI)
40. Hsin Hsiu*, Chia-Liang Hsu, Ming-Yie Jan. Relations between beat-to-beat microcirculatory blood flow and variations therein. Photomed Laser Surg, 28(6): 785-792, 2010. (SCI).
41. Hsin Hsiu*, Wei-Chen Hsu, Bo-Hung Chen, Chia-Liang Hsu. Differences in the microcirculatory effects of local skin surface contact pressure stimulation between acupoints and nonacupoints: possible relevance to acupressure. Physiol. Meas. 31 (2010) 829-841 (SCI)
42. Hsin Hsiu, Wei-Chen Hsu*, Chia-Liang Hsu, Ming-Yie Jan, Yuh-Ying Lin Wang. Effects of acupuncture at the Hoku acupoint on the pulsatile laser Doppler signal at the heartbeat frequency. Laser Med Sci, 24(4): 553-560, 2009. (SCI)
43. Hsiu H*, Hsu WC, Huang SM, Hsu CL, Wang Lin YY. Spectral analysis of the microcirculatory laser Doppler signal at the Hoku acupuncture point. Laser Med Sci 24(3): 353-358, 2009. (SCI)
44. Hsin Hsiu*, Wei-Chen Hsu, Chia-Liang Hsu, Shih-Ming Huang, Yuh-Ying Lin Wang. Microcirculatory changes by laser Doppler after infra-red heating over acupuncture points – relevance to moxibustion. Photomed Laser Surg 27(6): 855-61, 2009. (SCI)
45. Hsin Hsiu*, Wei-Chen Hsu, Shu-Ling Chang, Chia-Liang Hsu, Shih-Ming Huang, Yuh-Ying Lin Wang. Microcirculatory effect of different skin contacting pressures around the blood pressure. Physiol. Meas. 29: 1421-1434, 2008. (SCI)
46. Hsiu H*, Hsu CL, Chiang WR, Chao PT, Hsu TL, Jan MY, Wang WK, Wang Lin YY. Connection between RR-interval length and the pulsatile microcirculatory flow. Physiol. Meas, 29: 245-254, 2008. (SCI)
47. Hsiu H, Chao PT., Hsu, WC, Jan MY, Wang Lin YY & Wang WK*. The possible role of arterial radial vibration in heart rate and blood pressure matching. P I Mech Eng H, Journal of Engineering in Medicine, 222(H5), 773-779, 2008. (SCI)
48. Hsiu, H., Huang SM, Chao PT, Jan MY, Hsu TL, Wang WK & Wang Lin YY*. Microcirculatory characteristics of acupuncture points obtained by laser Doppler flowmetry. Physiol. Meas., 28 (2007) N77-N86. (SCI)
49. Hsin H, PT Chao, WR Chiang, CL Hsu, MY Jan, WK Wang, YY Lin Wang*. Effect of pulse number on the pulse-based synchronized-averaging analysis in laser Doppler signal. Biom Eng Appl Basis Comm 19(3): 179-185, 2007. (SCI)
50. Hsiu, H., M.Y. Jan, W.K. Wang & Y.Y. Lin Wang*. Effects of double-HR-frequency mechanical stimulation on blood pressure waveform of rats. Physiol. Meas., 27 (2006) 131-144. (SCI)
51. Chao PT, Jan MY, Hsiu H, Hsu TL, Wang WK & Wang Lin YY*. Evaluating microcirculation by pulsatile laser Doppler signal. Phys. Med. Biol., 51: 845-854, 2006. (SCI)
52. Hsu TL, Chao PT, Hsiu H, Wang WK, Li SP & Wang Lin YY*. Organ-specific ligation-induced changes in harmonic components of the pulse spectrum and regional vasoconstrictor selectivity in Wistar rats. Exp. Physiol., 91.1: 163–170, 2006. (SCI)
53. Hsu TL, Hsiu H, Chao PT, Li SP, Wang WK & Wang Lin YY*. Three-block electrical model of renal impedance. Physiol. Meas. 26: 387-399. 2005. (SCI)
54. YC Kuo, SH Lo, PT Chao, H Hsiu, WK Wang, YY Lin Wang*. Raising harmonic variation of arterial pulse during the dying process in rats. Am. J. Chin. Med. 33(1): 73-85, 2005 (SCI).
55. H. Hsiu*, PT Chao, TL Hsu, WC Hsu, WK Wang. Effects of weak external mechanical force stimulation on the heart rate variability of rats. Biom Eng Appl Basis Comm, 16(6): 20-28, 2004 (SCI).
56. H. Hsiu, M.Y. Jan, Y.Y. Lin Wang, W.K. Wang*. Effects of aorta bending and renal ligation on the blood pressure: a simulation on arterial stiffening. Biom Eng Appl Basis Comm, 15(6): 32-37, 2003 (SCI)
57. Hsiu, H., Jan, M. Y., Wang Lin, Y. Y. & Wang, W. K*. Influencing the heart rate of rats with weak external mechanical stimulation. PACE 26: 36-43, 2003. (SCI)
58. Jan, M. Y., Hsiu, H., Hsu, T. L., Wang, W. K. & Wang Lin, Y. Y*. The physical conditions of different organs are reflected in the pressure pulse spectrum of the peripheral artery specifically. J. of Cardiovascular engineering 3(1):21-29, 2003. (EI)
59. Hsiu, H., Luo, K. J., Wang Lin, Y. Y. & Wang, W. K*. Semi-empirical resonance equations for the artery with organs. Biom Eng Appl Basis Comm 12(1): p1-9, 2000. (SCI)
60. Jan, M. Y., Hsiu, H., Hsu, T. L., Wang Lin, Y. Y. & Wang, W. K*. Measurement and analysis of the pulsatile renal cortical fluxes in rats with a fast laser Doppler flowmetry. Biom Eng Appl Basis Comm 12(2): p1-6, 2000. (SCI)
61. Jan, M. Y., Hsiu, H., Hsu, T. L., Wang Lin, Y. Y. & Wang, W. K*. The importance of the pulsatile microcirculation in relation to hypertension. IEEE Eng. Med. Biol., 19(3): p106-111, 2000. (SCI)
62. Wang Lin, Y. Y., Lia, W. C., Hsiu, H., Jan, M. Y. & Wang, W. K*. Effect of length on the fundamental resonance frequency of arterial models having radial dilatation. IEEE Trans. Bio-Med. Eng. 47: p313-318, 2000. (SCI)
63. Wang Lin, Y. Y., Chang, C. C, Chen, J. C., Hsiu, H. & Wang, W. K*. Pressure wave propagation in arteries. IEEE. Eng. Med. Biol., 16: p51-56, 1997. (SCI)
目前研究重要成果
2023/2/2 肌少症AI輔助偵測 :
Li-Wei Wu, Te OuYoung, Yu-Chih Chiu, Ho-Feng Hsieh, Hsin Hsiu*. Discrimination between possible sarcopenia and metabolic syndrome using the arterial pulse spectrum and machine-learning analysis. Nature Sci Rep, 12, 21452 (2022). (SCI).
Ou Young T, Wu LW*, Hsiu H*, Peng TC, Chen WL. Characteristics of sarcopenia subjects in arterial pulse spectrum analysis. Front Public Health. 2022 6; 10: 969424. doi: 10.3389/fpubh.2022.969424.
本實驗室與三軍總醫院家醫科暨健檢中心合作，結合脈波量測與AI分析，提供肌少症風險程度評估與早期警示。
肌少症是全身持續性骨骼肌重量和功能減少，不只影響行動能力、生活品質，還可能增加跌倒風險甚至危及生命。現有診斷肌少症的方式，經常伴隨著高成本、儀器低可及性以及可能有輻射曝露等問題，且通常需到醫院接受一系列檢查，因此能促進方便性、即時性且具有準確性的肌少症診斷工具便是迫切且尚未滿足的醫療需求。
現有研究已發現循環系統疾病與肌少症之間存在關聯性。動脈血管特性變化會影響肌少症疾病的發展。基於此一想法，我們結合脈波量測與AI分析，對於潛在肌少症，已可達到約83%的準確度，且已開發出簡單快速之運算演算法，適合於受試者裝置端運算應用。
目前的量測與分析檢測肌少症引起的動脈脈波傳輸條件變化，有助於提供一種非侵入式且易於使用的方法，來判別可能肌少症，未來可望結合雲端架構，來提供使用者更全面性的服務。
血管健康度：
Hsiu H*, Liu JC, Yang CJ, Chen HS, Wu MS, Hao WR, Lee KY, Hu CJ, Wang YH, Fang YA. Discrimination of vascular aging using the arterial pulse spectrum and machine-learning analysis. Microvasc Res. 2021; 139: 104240
美國於2021前半年，數位醫療領域中獲得最多投資第二名即為心血管疾病，心血管疾病長期佔據國人十大死因，因此與我國長照應用發展息息相關。
老化是心血管疾病的重要影響因子，會造成血管功能持續惡化，進而引發重大心血管疾病。動脈物理特性的改變，會影響到脈波傳遞與波形。血管老化的檢測，目前研發趨勢是期望由非侵入式方式進行。若能對血管老化狀態提供便利客觀的評估，將有助於心血管疾病的早期防治。
疾病所引發脈波變化常是複雜且微細的，由於心跳是準週期性，藉由頻域分析所得頻譜各諧波分量，有助於脈波波形之細部描述。另由於各諧波分量為互相獨立，適合作為AI分析之獨立輸入feature。基於我們過去與醫療院所於心血管疾病跨領域合作累積成果，證實脈波量測結合AI分析，可提供有關血管特性和血流變化的狀況，並有助於血管老化引發血管彈性特性改變之評估。
以此為基礎，我們執行目標在於：藉由非侵入式循環供血量測裝置與分析技術，結合醫院與社區收案，以及AI技術，以建制血管老化程度之輔助評估指標。具體產出目標為：非侵入生醫電子量測裝置與血管老化AI評估模型。重要拓展方向包括：(1)擴大收案；(2)完整臨床數據收集(如血液生化指標等)；(3)場域比較；(4)受試者分群比較。
目前已藉由USR大學社會責任計畫之執行，跨出醫院研究，而於社區場域廣泛提供長者之血管健康狀態評估。未來期望建構血管老化程度之輔助評估指標，以提供使用者或醫師參考。這將對國人健康福祉有所助益，在臨床應用層面拓展心血管功能評估檢測臨床應用，並增進我國生醫電子產業發展。
疫苗副作用警示：
Chen CC, Chang CK, Chiu CC, Yang TY, Hao WR, Lin CH, Fang YA, Jian W, Hsu MH, Yang TL, Liu JC*, Hsiu H*. Machine Learning Analyses Revealed Distinct Arterial Pulse Variability According to Side Effects of Pfizer-BioNTech COVID-19 Vaccine (BNT162b2). J Clin Med. 2022 Oct 17; 11(20): 6119. doi: 10.3390/jcm11206119.
本實驗室與雙和醫院心臟內科合作，結合脈波量測與AI分析，提供COVID-19疫苗副作用即時警示。
2019年開始，新冠肺炎所引發的全球大流行已經造成累積2.4億確診個案，也造成超過490萬的死亡病例。台灣面臨新冠肺炎的侵入，民生經濟也深受打擊，藉由新冠肺炎疫苗的研發，讓全世界得到一絲曙光。然而從國內外醫學研究指出，新冠肺炎疫苗帶來副作用，包括小至局部注射的疼痛，大至心肌炎、腦血管疾病、血栓、甚至死亡，皆讓民眾所感到不安畏懼，陷入確診得病以及疫苗副作用的兩難選擇。
新冠疫苗副作用中，有多項與心血管生理功能有關。在先前研究中，我們已建立一套結合機器學習分析，針對脈波波形之量測裝置與分析模式，有助於疾病引發血管彈性特性改變之評估，這形成我們於本研究計畫中，欲探討新冠疫苗引發心血管相關副作用評估預測之重要基礎。即使目前國人接種率逐漸提高，但仍可能爆發後續疫情，也仍有接種第二或第三劑之需求，這凸顯於此一課題厚植研發實力之重要性。
本研究藉由前瞻性的方式，將使用本研究團隊研發出可量測脈波供血參數的非侵入性測量系統，在疫苗接種前後(約七天)各進行一次一分鐘的量測，來了解血管特性的可能改變，並搭配雙和醫院團隊提供血液生化指數、心電圖、胸部X光片等臨床數據，藉由搭配事後分析民眾過去慢性病史和檢查結果的關聯性，以提供未來民眾施打疫苗的參考建議。
本研究目的在於：
一、透過客觀的生理訊號分析與症狀分析疫苗施打後人體的反應。二、建立各疫苗效應之脈波頻譜特徵。三、評估疫苗接種者在接種疫苗後，產生副作用之風險程度。由現有成果，已於注射疫苗前後，以及嚴重與輕微副作用受試者之間，觀察到明顯的脈波參數差異，並藉由AI分析協助，達到0.94的AUC辨識表現，代表已可提供極優良的副作用警示能力。未來將持續擴大收案數量，以建立穿戴裝置與結合機器學習分析結合應用的基礎。這不僅將對國人健康福祉有所助益，本計畫之執行成果，將有助於開展穿戴式裝置之應用新方向，而增進我國生醫電子產業發展。
失智症：
Shun-Ku Lin, Hsin Hsiu*, Hsi-Sheng Chen, Chang-Jen Yang. Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis. Sci Rep, 11, Article number: 8882 (2021). www.nature.com/articles/s41598-021-87903-7
Hsin Hsiu*, Shun-Ku Lin, Wan-Ling Weng, Chaw-Mew Hung, Che-Kai Chang, Chia-Chien Lee, Chao-Tsung Chen. Discrimination of the cognitive function of community subjects using the arterial pulse spectrum and machine-learning analysis. Sensors, 2022; 22(3), 806.
本實驗室與台北市立聯合醫院仁愛院區中醫科、以及和平183樂活關懷站、三峽榮家等社區場域合作，結合脈波量測與AI分析，提供心智狀態評估與失智症早期警示。
失智症被認為屬神經退化疾病，近年來發現也伴隨血管結構變化。腦功能運作有賴於血液運輸帶來養分與氧氣，腦部血管彈性特性改變將導致腦血流供應不足，進而引發神經功能損害。本計畫目標是藉由本研究團隊所獨特開發之非侵入式循環供血量測分析技術，結合於三大領域(醫院、健檢、社區)收案，配合AI分類判別技術，建立一套穿戴式早期偵測或療效評估之失智症評估系統，以提供客觀、即時、具生理意義之參考建議。
執行期望以醫院研究經驗為基礎，更邁入健檢或社區等民眾場域，以進行對使用者提供高親和與高臨床價值、以及對操作者更可靠的量測系統。期望逐步拓展場域接觸層面與參與人數，奠定AI分析基礎，並增進實戰場域擴大參與，以逐步往居家使用之目標邁進。
由現有成果，已於失智症患者與對照受試者，在特異度接近100%的狀況下，準確度可達接近90%(excellent discrimination)。此外在輕重症患者比較可發現準確率約為70%，這顯示在不同程度的失智症狀況下脈波表現會有所不同，BPW也具有一定的辨識能力(acceptable discrimination)。
不僅在醫院環境，在社區場域中的民眾受試者，也可發現心智風險度，與MMSE量表評估分數之間，具有顯著的相關變化性，代表脈波AI分析所得出的心智風險度，可有效協助心智健康狀態的非侵入式即時評估。
本研究期望提供穿戴式生醫電子的嶄新開發方向；在醫療上，期望能增進客觀評估；在AI分析層面，期望能開展出AI技術於醫療應用與醫療儀器開發的新方向。
復健與運動生理效應：
Feng-Cheng Lin, Hsin Hsiu*, Han-Si Chiu, Chao-Tsung Chen, Chung-Hua Hsu. Characteristics of pulse-waveform and laser-Doppler indices in frozen-shoulder patients. Biomedical Signal Processing and Control, 56 (2020) 101718.
李家謙，利用穿戴式脈波量測系統進行運動血管效應之評估，台灣科技大學醫工所碩士論文，2022
運動生理效應評估
長期進行跑步運動能有效降低各種原因引起的心血管疾病及其死亡風險。在運動訓練中，運動強度幾乎決定了本次訓練對身體的影響力，然而研究顯示，過高的強度對身體不僅沒有幫助，反而會增加血管硬化以及身體組織發炎的風險。目前的運動領域，最能方便取得的生理數據量測裝置是心律量測裝置，但是透過心律所能觀察的運動生理變化非常有限，其餘設備則受限於場地、專業操作人員、設備造價高昂等因素，不易被業餘運動人士或是自主訓練者取得並使用。
本實驗室期望能利用自行開發的血流脈波量測設備，針對運動所造成的血流供應與彈性特性的改變進行脈波量測與分析，透過靜態量測觀察長期效應評估運動所帶來的好處與心血管保護作用；透過動態量測觀察短期效應評估運動員耐受性與運動員的篩選。因此，如何更簡單方便的精準偵測心血管保護作用程度、鑑別運動員身體素質，以及觀察運動員耐受性為本研究主要探討之問題。
實驗結果顯示在靜態量測可由Ratio(頻譜振幅)與Angle(頻譜相位)觀察到運動族群與一般人之間存在顯著脈波差異，且上下游表現一致。透過Pulse effect index更可以看到PPG對於Normal與Athlete的分辨準確率高達89.66%，AUC為0.899；BPW的準確率為87.1%，AUC為0.878。可推測運動族群在血流傳遞方面具有更高的供血效率、更順暢的血液傳遞狀態。
2. 復健疾病應用：五十肩
五十肩正名為沾黏性關節囊炎，又名「肩周炎」、「冰凍肩」，人口盛行率約介於2~5%，通常好發於年齡40~65歲，且女性發生率高於男性。病狀的呈現是活動時逐漸有僵硬感，有輕微的疼痛與活動限制，然後症狀越來越明顯，出現肩關節活動度受限等情形，肩膀猶如被冰凍一般幾乎無法活動，進而影響日常生活造成生活上諸多不便。
五十肩疾病診斷及檢查的方式，除了靠醫師的問診及理學檢查外，醫師也會針對患者情況施予X光、核磁共振、超音波等檢查，另外患者在復健治療的過程中或治療後，在評估治療療效的方式除了以上所提之檢查外就是量表問卷的詢問填寫。然而以上由醫院儀器來做得這些檢查方式都較為複雜繁瑣也需耗時較久，進而會增加患者在回診的檢查時間，而在醫師問診及量表問卷的填寫上又多出自於患者本身主觀的自我感覺，無法有效客觀的比較整個治療過程中及前後症狀病況改善的情形及差異，因此在目前現有的療程中缺少了一項既具有客觀性且即時性的評估方式。
五十肩會引發或伴隨血管或血流特性的改變。如前人曾在患者觀察到肩部局部血流的下降，也有人觀察到在纖維化局部有微血管密度的增加。五十肩引發的疼痛被發現與局部血流變化有關，其背後機轉推論可能與局部組織血管神經變化有關。
此一成果代表的意義為：五十肩患者與對照組，其脈波與血流參數皆具有顯著的差異。LDF量測分析可應用於五十肩患者的局部血流供應與調控活動之評估；脈波時域與頻譜參數則有助於動脈血管彈性特性與其調控活動之評估。
由於本研究採用的量測技術，具有便利、親和度高、量測迅速等優點，未來可望開發成為一項輔助五十肩引發血流效應與病程評估的裝置。
穿戴裝置與AI分析技術結合開發：
Te OuYoung, Wan-Ling Weng, Ting-Yu Hu, Chia-Chien Lee, Li-Wei Wu, Hsin Hsiu*. Machine-learning analysis for discriminating radial pulse-waveform quality by applying different contact pressures. Sensors, minor revise. (SCI)
Chen Y-T, Hsiu H, Chen R-J, Chen P-N*. Stability of virtual reality haptic feedback incorporating fuzzy-passivity control. Measurement and Control. 2022; 0(0). doi:10.1177/00202940221105090 (SCI)
Ping-Nan Chen*, Yung-Te Chen, Hsin Hsiu, and Ruei-Jia Chen. Impedance-Passivity based Haptic Control for Visual Surgery Training. Appl. Sci. 2021, 11, 1618. https://doi.org/10.3390/app11041618. (SCI)
相關著作
相關著作
近年論文發表
Hsin Hsiu*, Hsiao-Feng Hu, Yaw-Wen Chang. Using complexity and spectral analyses of noninvasive laser-Doppler signals in patients with metabolic syndrome. Complexity, Vol 2018, Article ID 6898024, https://doi.org/10.1155/2018/6898024. (SCI; 2/100; MATHEMATICS, INTERDISCIPLINARY APPLICATIONS)
Hsin Hsiu*, Chao-Tsung Chen, Shuo-Hui Hung, Guan-Zhang Chen, Yu-Ling Huang. Differences in time-domain and spectral indexes of skin-surface laser-Doppler signals between controls and breast-cancer patients. Clin Hemorheol Micro, 69 (2018) 371–381. (SCI)
Hsin Hsiu*, Hsiao-Feng Hu, Hung-Chi Tsai. Differences in laser-Doppler indexes between skin-surface measurement sites in subjects with diabetes. Microvasc Res. 2018; 115: 1-7. (SCI)
Chao-Tsung Chen, Hsin Hsiu*, Shuo-Hui Hung, Guan-Zhang Chen, Yu-Ling Huang. Characteristics of spectral indexes of the blood pressure waveform in patients with breast cancer. Blood Press Monit, 2017; 22(4): 217-220. (SCI)
Hsiao-Feng Hu, Hsin Hsiu*, Ciao-Jyuan Sung, Chien-Hsing Lee. Combining laser-Doppler flowmetry measurements with spectral analysis to study different microcirculatory effects in human prediabetic and diabetic subjects. Laser Med Sci, 2017; 32: 327-334. (SCI)
Taipau Chia, Jian-Guo Bau*, Yung-Hui Li, Shan-Hua Wei, Hsin Hsiu; Ling Pao. Microcirculatory characteristics in neck/shoulder of the adults with sedentary and regular exercise lifestyles. J Med Biol Eng, 2017 Jun, DOI 10.1007/s40846-017-0248-y. (SCI)
Ju-Chi Liu, Hsin Hsiu*, Yi-Ping Hsu, Hung-Chi Tsai, Chung-Hsien Kuo. Changes in the spectral index of skin-surface laser Doppler signals of nude mice following the injection of CT26 tumor cells. Am J Can Res, 2016; 6(8): 1812-9. (SCI)
Yaw-Wen Chang, Hsin Hsiu*, Shu-Han Yang, Wen-Hwei Fang, Hung-Chi Tsai. Characteristics of beat-to-beat photoplethysmography waveform indexes in subjects with metabolic syndrome. Microvasc Res, 2016; 106: 80-87. (SCI)
Chao-Tsung Chen, Hsin Hsiu*, Jin-Shiang Fan, Fong-Cheng Lin, Yen-Ting Liu. Complexity analysis of beat-to-beat skin-surface laser-Doppler flowmetry signals in stroke patients. Microcirculation, 2015; 22(5): 370-7. (SCI)
Feng-Cheng Lin, Hsin Hsiu*, Yao-Chun Lin, Hsin-Yi Chung, Wei-Chen Hsu, Chao-Tsung Chen, Fu-Chi Chen. Effects of electroacupuncture stimulation at frequencies near the heart rate on the microcirculatory blood flow. Universal Journal of Biomedical Engineering, 3(4): 23-29, 2015.
Hsin Hsiu*, Wei-Chen Hsu, Yi-Fan Wu, Chia-Liang Hsu, Chih-Yu Chen. Differences in the skin-surface laser-Doppler signals between polycystic-ovary-syndrome and normal subjects. Microcirculation, 2014; 21(2):124-30. (SCI)
Hsin Hsi u*, Hsiao-Feng Hu, Chia Liang Hsu, Fone-Ching Hsiao, Shu-Han Yang. Complexity analysis of beat-to-beat skin-surface laser-Doppler signals in diabetic subjects. Microvasc Res, 2014; 93: 9-13. (SCI)
Chia-Liang Hsu, Hsin Hsiu*, Wei-Chen Hsu, Chih-Yu Chen. Characteristics of harmonic indexes of the arterial blood pressure waveform in polycystic ovary syndrome. Blood Press Monit, 2014; 19(4): 226-32. (SCI)
Hsin Hsiu*, Hsiao-Feng Hu, Kuan-Hsien Wu, Fone-Ching Hsiao. Characteristics in the beat-to-beat laser-Doppler waveform indices in diabetic subjects, Clin Hemorheol Micro, 2014; 57(4): 375-84. (SCI)
Hsin Hsiu*, Shih-Min Huang, Chao-Tsung Chen, Wei-Chen Hsu, Fong-Cheng Lin. Differences in the beat-to-beat parameters of skin-surface pulsatile laser-Doppler waveforms between stroke and normal subjects. Clin Hemorheol Microcirc, 2014; 58(2):353-62. (SCI)
Hsin Hsiu*, Wei-Chen Hsu, Chia-Liang Hsu, Jian-Guo Bau. Microcirculatory complexity responses to the application of skin-surface-contacting pressure stimulation around normal blood pressure. J Med Biol Eng, 2014; 34(2): 164-171. (SCI)
Hsin Hsiu*, Wei-Chen Hsu, Chia-Liang Hsu, Jian-Guo Bau, Chao-Tsung Chen, Yi-Syuan Liu. Complexity analysis on the microcirculatory-blood-flow response following acupuncture stimulation. Microvasc Res, 2013; 89: 34-9. (SCI)
Hsin Hsiu*, Chia-Liang Hsu, Chao-Tsung Chen, Wei-Chen Hsu, Fong-Cheng Lin. Effects of acupuncture on the harmonic components of the radial arterial blood-pressure waveform in stroke patients. Biorheology, 2013; 50(1): 69-81. (SCI)
Hsin Hsiu*, Chia-Liang Hsu, Chao-Tsung Chen, W. C. Hsu, Hsiao-Feng Hu, Fu-Chi Chen. Correlation of harmonic components between the blood pressure and photoplethysmography waveforms following local-heating stimulation. IJBBB, 2012; 2(4): 248-253. (invited paper).
Hsin Hsiu*, Wei-Chen Hsu, Chia-Liang Hsu, Wei-Chung Lin, Ming-Hung Ho, Chao-Tsung Chen, Hsiao-Feng Hu. Acute microcirculatory responses induced by skin-surface vibration stimulation at a frequency near the heart rate. Biorheology, 2012; 49(1): 15-25. (SCI)
Hsin Hsiu*, Shih-Ming Huang, Chia-Liang Hsu, Shih-Fan Hu, Hung-Wen Lin. Effects of cold stimulation on the harmonic structure of the blood pressure and photoplethysmography waveforms. Photomed Laser Surg, 2012; 30(2): 77-84. (SCI)
Te Ou Young; Tao-Chun Peng; Wei-Liang Chen; Hsin Hsiu*; Li-Wei Wu*. Classification of patients with sarcopenia using the arterial pulse spectrum analysis. Front. Public Health, in press. (SCI)
Chen, Yung-Te; Chen, Ping-Nan*; Hsiu, Hsin; Wei, Chih-Yuan. Stability of Virtual Reality Haptic Feedback Incorporating Fuzzy-Passivity Control. Measurement and Control, in press. (SCI)
Hsin Hsiu*, Shun-Ku Lin, Wan-Ling Weng, Chaw-Mew Hung, Che-Kai Chang, Chia-Chien Lee, Chao-Tsung Chen. Discrimination of the cognitive function of community subjects using the arterial pulse spectrum and machine-learning analysis. Sensors, 2022; 22(3), 806. (SCI)
Hsin Hsiu*, Liu JC, Yang CJ, Chen HS, Wu MS, Hao WR, Lee KY, Hu CJ, Wang YH, Fang YA. Discrimination of vascular aging using the arterial pulse spectrum and machine-learning analysis. Microvasc Res. 2021; 139: 104240 (SCI).
Shun-Ku Lin, Hsin Hsiu*, Hsi-Sheng Chen, Chang-Jen Yang. Classification of patients with Alzheimer’s disease using the arterial pulse spectrum and a multilayer-perceptron analysis. Sci Rep, 11, Article number: 8882 (2021). www.nature.com/articles/s41598-021-87903-7 . (SCI)
Ju-Chi Liu, Yi-Ping Hsu, Jia-Cheng Zhu, Wen-Rui Hao, Tsung-Yeh Yang, Li-Chun Sung, Pai-Feng Kao, Jaulang Hwang, Hsin Hsiu*. Beat-to-beat and spectral analyses of the noninvasive radial pulse and laser-Doppler signals in patients with hypertension. Clin Hemorheol Microcirc., in press. (SCI)
.
Ping-Nan Chen*, Yung-Te Chen, Hsin Hsiu, and Ruei-Jia Chen. Impedance-Passivity based Haptic Control for Visual Surgery Training. Appl. Sci. 2021, 11, 1618. (SCI)
Chao-Tsung Chen, Chin-Tsing Ting, Chun-Yeh Chen, Zong-Jhe Lyu, Chien-Cheng Chen, Yi-Sheng Chou, Chi-Feng Cheng, Chung-Hua Hsu, Hsin Hsiu*. Pulse-waveform and laser-Doppler indices for identifying colorectal-cancer patients. Biom Eng Appl Basis Comm 2020, 33(1), Article No: 2150005.
Feng-Cheng Lin, Hsin Hsiu*, Han-Si Chiu, Chao-Tsung Chen, Chung-Hua Hsu. Characteristics of pulse-waveform and laser-Doppler indices in frozen-shoulder patients. Biomedical Signal Processing and Control, 56 (2020) 101718. (SCI)
Chung-Hua Hsu, Chao-Tsung Chen, Jyh-Rou Liu, Hung-Bo Wu, Yi-Sheng Chou, Hsin Hsiu*. Comparison of complexity and spectral indices of skin-surface laser-Doppler signals in patients with breast cancer receiving chemotherapy and Kuan-Sin-Yin. Clin Hemorheol Microcirc. 2019; 73(4):553-563. doi: 10.3233/CH-190569 (SCI)
Hsin Hsiu*, Hsiao-Feng Hu, Yaw-Wen Chang. Using complexity and spectral analyses of noninvasive laser-Doppler signals in patients with metabolic syndrome. Complexity, Vol 2018, Article ID 6898024, https://doi.org/10.1155/2018/6898024. (SCI)
Hsin Hsiu*, Chao-Tsung Chen, Shuo-Hui Hung, Guan-Zhang Chen, Yu-Ling Huang. Differences in time-domain and spectral indexes of skin-surface laser-Doppler signals between controls and breast-cancer patients. Clin Hemorheol Micro, 69 (2018) 371–381. (SCI)
Hsin Hsiu*, Hsiao-Feng Hu, Hung-Chi Tsai. Differences in laser-Doppler indexes between skin-surface measurement sites in subjects with diabetes. Microvasc Res. 2018; 115: 1-7. (SCI)
Chao-Tsung Chen, Hsin Hsiu*, Shuo-Hui Hung, Guan-Zhang Chen, Yu-Ling Huang. Characteristics of spectral indexes of the blood pressure waveform in patients with breast cancer. Blood Press Monit, 2017; 22(4): 217-220. (SCI)
Hsiao-Feng Hu, Hsin Hsiu*, Ciao-Jyuan Sung, Chien-Hsing Lee. Combining laser-Doppler flowmetry measurements with spectral analysis to study different microcirculatory effects in human prediabetic and diabetic subjects. Laser Med Sci, 2017; 32: 327-334. (SCI)
Taipau Chia, Jian-Guo Bau*, Yung-Hui Li, Shan-Hua Wei, Hsin Hsiu; Ling Pao. Microcirculatory characteristics in neck/shoulder of the adults with sedentary and regular exercise lifestyles. J Med Biol Eng, 2017 Jun, DOI 10.1007/s40846-017-0248-y. (SCI)
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