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廖愛禾教授在微氣泡與超音波技術領域做出了重要貢獻，特別是在藥物傳遞系統與治療應用方面。最近，廖教授研究團隊開發了一種智慧無針超音波微泡給藥系統，致力於透過非侵入性方法提高治療效果。她的研究涵蓋多種創新方法，包括：
1. 內耳藥物傳遞
1. 內耳藥物傳遞
廖教授深入研究了超音波誘導微氣泡（USMB）空化效應，以提高藥物在內耳的傳遞效率。她的研究包括探討經耳道與經顱兩種方式，來幫助治療藥物通過圓窗膜，從而提高內耳疾病的治療效果。此外，Dr. Liao 共同開發了一種結合不同尺寸微氣泡與單換能器雙頻超音波的方法，能夠安全有效地將藥物遞送至內耳。這項技術在治療聽覺相關疾病方面具有潛力，能夠提高藥物在內耳結構中的精確性與療效。
🔗 相關研究 | 研究論文
2. 微氣泡特性優化
2. 微氣泡特性優化
廖教授研究了微氣泡的尺寸對超音波輔助藥物與基因傳遞的影響，她發現結合不同尺寸的微氣泡與單換能器雙頻超音波，可以安全有效地提升大分子藥物（如胰島素樣生長因子-1，IGF-1）的傳遞效率，特別是針對內耳相關疾病的治療。
🔗 相關研究
3. 促進毛髮生長
3. 促進毛髮生長
廖教授探索了一種層層組裝微氣泡藥物遞送系統，應用於生髮劑（如 Minoxidil）。透過結合超音波技術，她的研究顯示該系統可增強 Minoxidil 的經皮滲透能力，從而顯著改善毛髮生長效果。
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4. 經皮藥物傳遞
4. 經皮藥物傳遞
在一項針對經皮傳遞技術的研究中，廖教授採用低頻雙頻超音波來促進微氣泡空化效應，增強皮膚的通透性，進而提升藥物（如 Minoxidil）的吸收效率。此方法提供了一種無創的藥物輸送方式，提高藥物滲透能力與療效。
🔗 相關研究 | 研究論文
5. 抗菌應用
5. 抗菌應用
廖教授研究了溶菌酶包覆微氣泡結合超音波技術的抗菌效果。該方法能夠有效提高抗菌作用，為感染治療提供新的潛在應用方向。
🔗 相關研究
6. 癌症治療
6. 癌症治療
廖教授的研究也涉及腫瘤治療，她探討了超音波微氣泡技術如何提高化療藥物（如順鉑，Cisplatin）在腫瘤局部的濃度，從而增強腫瘤標靶治療效果，同時減少系統性副作用。此技術可望改善頭頸癌等癌症的治療結果。
🔗 相關研究
透過這些研究，Dr. Liao 推動了微氣泡與超音波技術在醫學領域的應用發展，為藥物傳遞、癌症治療、抗菌技術等提供了更有效且非侵入性的治療策略。她的研究不僅有助於基礎科學的發展，也為臨床醫學帶來創新突破。
另外廖愛禾教授在人工智慧（AI）醫學影像領域也做出了重要貢獻，特別是在深度學習技術的應用上，以提升診斷過程的準確性與效率。
深度學習在超音波影像中的應用
深度學習在超音波影像中的應用
在一項題為 「利用深度學習分析超音波影像來評估杜興氏肌肉失養症（Duchenne Muscular Dystrophy, DMD）患者的行動功能」 的研究中，Dr. Liao 與團隊開發了一種深度學習模型，用於分析 DMD 患者的肌肉功能。
此研究的目標是提供非侵入性且高效的方法，以評估 DMD 患者的行動功能。透過 AI 輔助超音波影像分析，此技術可望提升診斷準確度，並幫助醫生更有效地監測病情進展。
透過這些研究，Dr. Liao 推動了 AI 在醫學影像領域的應用發展，為精確診斷與疾病監測帶來了更高效的工具，促進未來智慧醫療的發展。
Prof. Ai-Ho Liao has made significant contributions to the field of microbubble and ultrasound technology, particularly in enhancing drug delivery systems and therapeutic applications. Recently, Dr. Liao developed an intelligent needle-free ultrasonic microbubble drug delivery system focusing on improving therapeutic effects through non-invasive methods. Her research encompasses various innovative approaches:
1. Inner Ear Drug Delivery: Dr. Liao has extensively studied the use of ultrasound-induced microbubble (USMB) cavitation to improve drug delivery to the inner ear. Her work includes exploring both transcanal and transcranial approaches to facilitate the passage of therapeutic agents through the round window membrane, thereby enhancing treatment efficacy for inner ear conditions. Moreover, Dr. Liao co-developed a method combining microbubbles of various sizes with single-transducer dual-frequency ultrasound to safely and efficiently deliver drugs to the inner ear. This technique holds promise for treating auditory-related conditions by improving the precision and effectiveness of drug delivery to the inner ear structures. https://insight.jci.org/articles/view/132880?utm_source=chatgpt.com
https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10450?utm_source=chatgpt.com
2. Optimization of Microbubble Characteristics: In her research, Dr. Liao has investigated the effects of microbubble size on ultrasound-mediated drug and gene delivery. She has demonstrated that combining microbubbles of various sizes with single-transducer dual-frequency ultrasound can safely and efficiently enhance the delivery of large molecular weight drugs, such as insulin-like growth factor 1 (IGF-1), to the inner ear.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10487305/?utm_source=chatgpt.com
3. Hair Growth Enhancement: Dr. Liao explored the use of a layer-by-layer microbubble-based delivery system to apply minoxidil, a common hair growth stimulant. By combining this system with ultrasound, his research achieved enhanced transdermal delivery of minoxidil, leading to improved hair growth outcomes.
https://www.thno.org/v06p0817?utm_source=chatgpt.com
4. Transdermal Drug Delivery: In a study focusing on transdermal delivery, Dr. Liao utilized low-frequency dual-frequency ultrasound-mediated microbubble cavitation to enhance the skin's permeability. This approach facilitated the delivery of therapeutic agents like minoxidil through the skin barrier, offering a non-invasive method to improve drug administration efficacy.
https://www.nature.com/articles/s41598-020-61328-0?utm_source=chatgpt.com
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0138500&utm_source=chatgpt.com
5. Antibacterial Applications: Investigating novel treatment models, Dr. Liao has assessed the antibacterial effects of lysozyme-shelled microbubbles combined with ultrasound. This approach has shown promise in enhancing antibacterial efficacy, potentially offering new avenues for treating infections.
https://www.nature.com/articles/srep41325?utm_source=chatgpt.com
6. Cancer Therapy: Dr. Liao's research also extends to oncology, where he has examined the use of ultrasound microbubbles to increase the local concentration of chemotherapeutic agents, such as cisplatin, within tumors. This strategy aims to enhance tumor targeting while reducing systemic toxicity, thereby improving treatment outcomes for head and neck cancers.
https://www.researchgate.net/lab/Ai-Ho-Liao-Lab?utm_source=chatgpt.com
Through these endeavors, Dr. Liao has advanced the application of microbubble and ultrasound technologies in medical treatments, contributing to the development of more effective and non-invasive therapeutic strategies.
Prof. Ai-Ho Liao also has made notable contributions to the integration of artificial intelligence (AI) in medical imaging, particularly in the application of deep learning techniques to enhance diagnostic processes.
Deep Learning in Ultrasound Imaging: In a study titled "Deep Learning of Ultrasound Imaging for Evaluating Ambulatory Function of Individuals with Duchenne Muscular Dystrophy," Dr. Liao and colleagues developed a deep learning model to assess muscle function in patients with Duchenne Muscular Dystrophy (DMD) using ultrasound images. This approach aimed to provide a non-invasive and efficient method for evaluating the ambulatory function in DMD patients, demonstrating the potential of AI to improve diagnostic accuracy and patient monitoring.
Through such research, Dr. Liao has advanced the application of AI in medical imaging, contributing to more precise and efficient diagnostic tools.
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