Publications

75. Jung, Bowon, Sunbeom Kwon, Eun Jin Heo, Yoon Seo Jang, Jae Sik Yu, Ki Hyun Kim, Ji Ah Kim, and Seulah Lee. "Phytochemical profiling of Sambucus racemosa ssp. pendula endemic to Ulleung Island, Korea." Biochemical Systematics and Ecology 127 (2026): 105256.

74. Huang, Tianqi, Jae Sik Yu, Gyo Chang Keum, and Hyun Ok Yang. "Dihydrotricetin from Euonymus hamiltonianus ameliorates neuroinflammation and exhibits neuroprotective effect in LPS-induced microglia." Biomedicine & Pharmacotherapy 193 (2025): 118810.

73. Hwang, Hyeon-Jeong, Hyeokjin Lim, Jae Sik Yu, Eun Seo Jang, Youngsang Nam, Yeo Jin Lee, Eun La Kim, Seonghwan Hwang, and Seoung Rak Lee. "Isolation and Characterization of Secondary Metabolites from Hydractinia-Associated Fungus, Penicillium brevicompactum MSW10-1, and Their Inhibitory Effects on Hepatic Lipogenesis." Marine Drugs 23, no. 7 (2025): 275.

72. Choi, Hyo-Sun, Joonki Kim, Sang-Bin Lee, Lijun Zhang, Dowan Kwon, Huynh Nguyen Khanh Tran, Siqi Zhang et al. "Euonymus hamiltonianus extract improves amnesia in APPswe/Tau transgenic and scopolamine-induced dementia models." Molecular Neurobiology 61, no. 12 (2024): 10845-10860.

71. Cho, C.H., Chae, S.H., Thi, N.H.L., Um, S.H., Lee, S., Yu, J.S., Kang, K.S. and Kim, K.H., 2025. Lambertianic Acid from Platycladus orientalis Inhibits Muscle Atrophy in Dexamethasone-Induced C2C12 Muscle Atrophy Cells. Plants, 14(9), p.1357.

70. Kim, Jae Hyeon, Heeju Kim, Minkuk Park, Byeongjun Park, Beomjune Park, Han Yong Park, Gakyung Lee, Yu, Jae Sik*. Comparative Metabolic Profiling of Different Raphanus sativus Cultivars and Their Antioxidant and Anti-Inflammatory Activities. Applied Sciences 2024, 15, 247.

69. Im, Joong-Ki, Dong-Ho Seo, Yu, Jae Sik, Sang-Ho Yoo. Efficient and novel biosynthesis of myricetin α-triglucoside with improved solubility using amylosucrase from Deinococcus deserti. International Journal of Biological Macromolecules 2024, 133205.

68. Lee, Seoung Rak, Marie Dayras, Janis Fricke, Huijuan Guo, Sven Balluff, Felix Schalk, Yu, Jae Sik, Se Yun Jeong, Bernd Morgenstern, Bernard Slippers, Christine Beemelmanns, Ki Hyun Kim. Molecular networking and computational NMR analyses uncover six polyketide-terpene hybrids from termite-associated Xylaria isolates. Communications Chemistry 2024, 7, 129.

67. Yu, Jae Sik*, Hee Ju Kim, Yeo Eun Kim, Hyun Ok Yang, Yu-Kyong Shin, Hyunjae Kim, Soyoon Park, and Gakyung Lee. Lipidomic Assessment of the Inhibitory Effect of Standardized Water Extract of Hydrangea serrata (Thunb.) Ser. Leaves during Adipogenesis. Nutrients 2024, 16, 1508.

66. Zhang, Siqi, Joonki Kim, Gakyung Lee, Hong Ryul Ahn, Yeo Eun Kim, Hee Ju Kim, Yu, Jae Sik, Miso Park, Keon Wook Kang, Ho Cheol Kim, Byung Hwa Jung, Sung Won Kwon, Dae Sik Jang, Hyun Ok Yang. Phytotherapeutic BS012 and Its Active Component Ameliorate Allergic Asthma via Inhibition of Th2-Mediated Immune Response and Apoptosis. Biomolecules & Therapeutics 2024, 32, 744.

65. Tran, Huynh Nguyen Khanh, Yu, Jae Sik*, Tianqi Huang, Gakyung Lee, Hyo Sun Choi, and Hyun Ok Yang. "Neuroprotective Effects of Chemical Constituents of Leaves of Euonymus hamiltonianus Wall." Plants 2024, 13, 1094. (*co-first author)

64. Rahmat, Endang, Jae Sik Yu*, Bum Soo Lee, Jiyoung Lee, Yeongjun Ban, Nam-Hui Yim, Jeong Hwan Park, Chang Ho Kang, Ki Hyun Kim, and Youngmin Kang. Secondary metabolites and transcriptomic analysis of novel pulcherrimin producer Metschnikowia persimmonesis KIOM G15050: A potent and safe food biocontrol agent. Heliyon 2024, 10 (*co-first author)

63. Ma, Chi Thanh, Tianqi Huang, Jae Sik Yu*, Tu Loan Ly, Kim Long Vu Huynh, Sung Won Kwon, Jeong Hill Park, and Hyun Ok Yang. Sesquiterpenoids and hexanorcucurbitacin from Aquilaria malaccensis agarwood with anti-inflammatory effects by inhibiting the STAT1/AKT/MAPK/NLRP3 pathway. RSC advances 2024, 14, 9391-9405. (*co-first author)

62. Ma, Chi Thanh, Sang Bin Lee, In Ho Cho, Jae Sik Yu, Tianqi Huang, Tae Min Lee, Tu Loan Ly, Sung Won Kwon, Jeong Hill Park, and Hyun Ok Yang. Agarperoxinols A and B: Two Unprecedented Tricyclic 6/6/7 Rearranged Humulene-Type Sesquiterpenoids That Attenuated the Neuroinflammation in LPS-Stimulated Microglial Models. ACS omega 2023, 8, 43873-43882.

61. Ham, Song Lim; Lee, Tae Hyun; Kim, Kyung Jun; Kim, Jung Ha; Hwang, Su Jung; Lee, Sun Ho; Yu, Jae Sik; Kim, Ki Hyun; Lee Hyo-Jung; Lee, Wonsik; Kim, Chung Sub. Discovery and Biosynthesis of Imidazolium Antibiotics from the Probiotic Bacillus licheniformis. Journal of Natural Products 2023, 86(4), 850-859.

60. Kim, Hye Ryeong; Kim, Jonghwan Kim; Yu, Jae Sik; Lee, Bum Soo; Kim, Ki Hyun; Kim, Chung Sub. Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis. Archives of Pharmacal Research 2023, 46(1), 35-43.

59. Lee, Dahae*; Yu, Jae Sik*; Ha, Ji Won; Lee, Seoung Rak; Lee, Bum Soo; Kim, Jin-Chul; Kim, Jung Kyu; Kang, Ki Sung; Kim, Ki Hyun Kim. Antitumor Potential of Withanolide Glycosides from Ashwagandha (Withania somnifera) on Apoptosis of Human Hepatocellular Carcinoma Cells and Tube Formation in Human Umbilical Vein Endothelial Cells. Antioxidants 2022, 11(9), 1761. (*co-first author)

58. Lee, Seoung Rak; Felix, Schalk; Schwitall, Jan W.; Guo, Huijuan; Yu, Jae Sik; Song, Moonyong; Jung, Won Hee; de Beer, Z. Wilhelm; Beemelmanns, Christine; Kim, Ki Hyun. GNPS-Guided Discovery of Madurastatin Siderophores from the Termite-Associated Actiniomadura sp. RB99. Chemistry-A European Journal, 2022, 28, e202200612

57. Yu, Jae Sik; Jeong, Se Yun; Li, Chunshun; Oh, Taehoon; Kwon, Mincheol; Ahn, Jong Seog; Ko, Sung-Kyun; Ko, Yoon-Joo; Cao, Shugeng; Kim, Ki Hyun. New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1). Archives of Pharmacal Research 2022, 45, 105-113.

56. Seulah Lee*; Yu, Jae Sik*; Lee, Seoung Rak*; Kim, Ki Hyun. Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis. Natural Product Reports 2022, 39, 512-559. (*co-first author)

55. Ha, Ji Won; Yu, Jae Sik; Lee, Bum Soo; Kang, Dong-Min; Ahn, Mi-Jeong; Kim, Jung Kyu; Kim, Ki Hyun. Structural Characterization of Withanolide Glycosides from the Roots of Withania somnifera and Their Potential Biological Activities. Plants 2022, 11, 767.

54. Han, Hee-Soo; Chung, Kyung-Sook; Shin, Yu-Kyong; Yu, Jae Sik; Kang, Seung-Hyun; Lee. Sun-Hee; Lee, Kyung-Tae. Effect of Standardized Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat Reduction in Overweight or Obese Humans: A Randomized Double-Blind Placebo-Controlled Study. Nutrients 2022, 14, 208.

53. Yu, Jae Sik*; Kim, Ji-Hoon*; Rashan, Luay; Kim, Inseo; Lee, Wonsik; Kim, Ki Hyun. Potential Antimicrobial Activity of Galloyl-Flavonoid Glycosides.. From Woodfordia uniflora Against Methicillin-Resistant Staphylococcus aureus. Frontiers in Microbiology 2022, 12, 784504. (*co-first author)

52. Lee, Seoung Rak; Lee, Bum Soo; Yu, Jae Sik; Kang, Heesun; Yoo,, Min Jeong; Yi, Sang Ah; Han, Jeung-Whan; Kim, Sil; Kim, Jung Kyu; Kim, Jin-Chul; Kim, Ki Hyun. Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera). Journal of Ginseng Research 2022, 46(3), 357-366

51. Lee, Seoung Rak; Guo, Huijuan; Yu, Jae Sik; Park, Minji; Dahse, Hans-Martin; Jung, Won Hee; Beemelmanns, Christine; Kim, Ki Hyun Revised structural assignment of azalomycins based on genomic and chemical analysis. Organic Chemistry Frontiers 2021, 8, 4791-4798.

50. Lee, Seulah; Kim, Chung Sub; Yu, Jae Sik; Kang, Heesun; Yoo, Min Jeong; Youn, Ui Joung; Ryoo, Rhim; Bae, Han Yong; Kim, Ki Hyun. Ergopyrone, a Styrylpyrone-Fused Steroid with a Hexacyclic 6/5/6/6/6/5 Skeleton from a Mushroom Gymnopilus orientispectabilis. Organic Letters 2021, 23, 3315-3319.

49. Kim, Eun-Nam; Kim, Ga-Ram; Yu, Jae Sik; Kim, Ki Hyun; Jeong, Gil-Saeng. Inhibitory Effect of (2R)-4-(4-hydroxyphenyl)-2-butanol 2-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside on RANKL-Induced Osteoclast Differentiation and ROS Generation in Macrophages. International Journal of Molecular Sciences 2021, 22, 222.

48. Lee, Kwang Ho; Kim, Jung Kyu; Yu, Jae Sik; Jeong, Se Yun; Choi, Jin Hee; Kim, Jin-Chul; Ko, Yoon-Joo; Kim, Seon-Hee; Kim, Ki Hyun. Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba. Archives of Pharmacal Research 2021, 1-11.

47. Alishir, Akida; Yu, Jae Sik; Park, Minji; Kim, Jin-Chul; Pang, Changhyun; Kim, Jung Kyu; Jang, Tae Su; Jung, Won Hee; Kim, Ki Hyun. Ulmusakidian, a new coumarin glycoside and antifungal phenolic compounds from the root bark of Ulmus davidiana var. japonica. Bioorganic & Medicinal Chemistry Letters 2021, 36, 127828.

46. Lee, Dahae; Yu, Jae Sik; Ryoo, Rhim; Kim, Jin-Chul; Jang, Tae Su; Kang, Ki Sung; Kim, Ki Hyun. Pulveraven A from the fruiting bodies of Pulveroboletus ravenelii induces apoptosis in breast cancer cell via extrinsic apoptotic signaling pathway. The Journal of Antibiotics 2021, 1-6.

45. Lee, Yong Hoon; Yoon, Sun-Young; Baek, Jiyun; Kim, Sung Jin; Yu, Jae Sik; Kang, Heesun; Kang, Ki Sung; Chung, Sang J.; Kim, Ki Hyun. Metabolite Profile of Cucurbitane-Type Triterpenoids of Bitter Melon (Fruit of Momordica charantia) and Their Inhibitory Activity against Protein Tyrosine Phosphatases Relevant to Insulin Resistance. Journal of Agricultural and Food Chemistry 2021, 69, 1816-1830.

44. Kim, Eui Jin*; Seo, Ji Bin*; Yu, Jae Sik*; Lee, Seoyoung, Lim, Jae Sung; Choi, Jeong Uk; Lee, Chang-Min; Rashan, Luay; Kim Ki Hyun; Cho, Young-Chang. Anti-Inflammatory Effects of a Polyphenol, Catechin-7,4′-O-Digallate, from Woodfordia uniflora by Regulating NF- B Signaling Pathway in Mouse Macrophages. Pharmaceutics 2021, 13, 408. (*co-first author)

43. Lim, Sung Ho*, Yu, Jae Sik*, Lee, Ho Seon; Choi, Chang-Ik; Kim, Ki Hyun. Antidiabetic Flavonoids from Fruits of Morus alba Promoting Insulin-Stimulated Glucose Uptake via Akt and AMP-Activated Protein Kinase Activation in 3T3-L1 Adipocytes. Pharmaceutics 2021, 13, 526. (*co-first author)

42. Yoon, Sun-Young*; Yu, Jae Sik*; Hwang, Ji Young; So, Hae Min; Seo, Seung Oh; Kim, Jung Kyu; Jang, Tae Su; Kim, Ki Hyun. Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance. Molecules 2021, 26, 1612. (*co-first author)

41. Yu, Jae Sik; Lim, Sung Ho; Lee, Seoung Rak; Choi, Chang-Ik; Kim, Ki Hyun. Antioxidant and anti-inflammatory effects of white mulberry (Morus alba L.) fruits on lipopolysaccharide-stimulated RAW 264.7 macrophages. Molecules 2021, 26, 920.

40. Baek, Su Cheol; Yi, Sang Ah; Lee, Bum Soo; Yu, Jae Sik; Kim, Jin-Chul; Pang, Changhyun; Jang, Tae Su; Lee, Jaecheol; Kim, Ki Hyun. Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Cathamus tinctorius). Biomedicines 2021, 9, 91.

39. Oh, Taehoon; Kwon, Mincheol; Yu, Jae Sik; Jang, Mina; Kim, Gun-Hee; Kim, Ki Hyun; Ko, Sung-Kyun; Ahn, Jong Seog. Ent-Peniciherqueinone Suppresses Acetaldehyde-Induced Cytotoxicity and Oxidative Stress by Inducing ALDH and Suppressing MAPK Signaling. Pharmaceutics 2020, 12, 1229.

38. Lee, Hyun Su; Yu, Jae Sik; Kim, Ki Hyun; Jeong, Gil-Saeng. Diketoacetonylphenalenone, Derived from Hawaiian Volcanic Soil-Associated Fungus Penicillium herquei FT729, Regulates T Cell Activation via Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathway. Molecules 2020, 25, 5374.

37. Lee, Kwang Ho; Yu, Jae Sik; Choi, Jin Hee; Kim, Seo-Hee; Ko, Yoon-Joo; Pang, Changhyun; Kim, Ki Hyun. Ginkgobilol, a new diarylpentanoid and an osteogenic diarylpentanoid analog from Ginkgo biloba leaves. Bioorg. Med. Chem. Lett. 2020, 30, 127641.

36. Yu, Jae Sik; Li, Chunshun; Kwon, Mincheol; Oh, Taehoon; Lee, Tae Hyun; Kim, Dong Hyun; Ahn, Jong Seog; Ko, Sung-Kyun; Kim, Chung Sub; Cao, Shugeng; Kim, Ki Hyun. Herqueilenone A, a unique rearranged benzoquinone-chromanone from the Hawaiian volcanic soil-associated fungal strain Penicillium herquei FT729. Bioorg. Chem. 2020, 105, 104397.

35. Lee, Dahae*; Yu, Jae Sik*; Huang, Peng; Qader, Mallique; Manavalan, Arulmani; Wu, Xiaohua; Kim, Jin-Chul; Pang, Changhyun; Cao, Shugeng; Kang, Ki Sung; Kim, Ki Hyun. Identification of Anti-Inflammatory Compouunds from Hawaiian Noni (Morinda citrifolia L.) Fruit Juice. Molecules 2020, 25, 4968. (*co-first author)

34. Lee, Sullim; Yu, Jae Sik; Phung, Hung Manh; Lee, Jeong Gun; Kim, Ki Hyun; Kang Ki Sung. Potential Anti-Skin Aging Effect of (-)-Catechin Isolated from the Root Bark of Ulmus davidiana var. japonica in Tumor Necrosis Factor-α-Stimulated Normal Human Dermal Fibroblasts. Antioxidants 2020, 9, 981.

33. Madadi, Elaheh; Sahand, Mazloum-Ravasan; Yu, Jae Sik; Ha, Ji Won; Hamed, Hamishehkar; Ki Hyun Kim. Therapeutic Application of Betalains: A Review. Plants 2020, 9, 1219.

32. Yu, Jae Sik; Sahar, Namood E; Bi, Yan-Ran; Jung, Kiwon; Pang, Changhyun; Huh, Joo Young; Kim, Ki Hyun. The Effects of Triterpenoid Saponins from the Seeds of Momordica cochinchinensis on Adipocyte Differentiation and Mature Adipocyte Inflammation. Plants 2020, 9, 984.

31. Baek, Su Cheol; Lee, Bum Soo; Yi, Sang Ah; Yu, Jae Sik; Lee, Jaecheol; Ko, Yoon-Joo; Pang, Changhyun; Kim, Ki Hyun. Discovery of Dihydrophaseic Acid Glucosides from the Florets of Carthamus tinctorius. Plants 2020, 9, 858.

30. Yu, Jae Sik; Park, Minji; Pang, Changhyun; Rashan, Luay; Jung, Won Hee; Kim, Ki Hyun. Antifungal Phenols from Woodfordia uniflora Collected in Oman. J. Nat. Prod. 2020, 83, 2261−2268.

29. Jo, Mun Seok; Lee, Seoyoung; Yu, Jae Sik; Baek, Su Cheol; Cho, Young-Chang; Kim, Ki Hyun. Megastigmane Derivatives from the Cladodes of Opuntia humifusa and Their Nitric Oxide Inhibitory Activities in Macrophages. J. Nat. Prod. 2020, 83, 684−692.

28. Park, Yong Joo; Kim, Dong Min; Jeong, Mi Ho; Yu, Jae Sik; So, Hae Min; Bang, In Jae; Kim, Ha Ryong; Kwon, Seung-Hwan; Kim, Ki Hyun; Chung, Kyu Hyuck. (-)-Catechin-7-O-β-D-Apiofuranoside Inhibits Hepatic Stellate Cells Activation by Suppressing STAT3 Signaling Pathway. Cells 2020, 9, 30.

27. Baek, Su Cheol; Lee, Seoyoung; Kim, Sil; Jo, Mun Seok; Yu, Jae Sik; Ko, Yoon-Joo; Cho, Young-Chang; Kim, Ki Hyun. Withaninsams A and B: Phenylpropanoid Esters from the Roots of Indian Ginseng (Withania somnifera). Plants 2019, 8, 527.

26. Jo, Mun Seok; Yu, Jae Sik; Lee, Joo Chan; Lee, Seoyoung; Cho, Young-Chang; Park, Hyun-Ju; Kim, Ki Hyun. Lobatamunsolides A-C, Norlignans from the Roots of Pueraria lobata and their Nitric Oxide Inhibitory Activities in Macrophages. Biomolecules 2019, 9, 755.

25. Song, Ji Hoon; Kim, Sil; Yu, Jae Sik; Park, Do Hwi; Kim, Song-Yi; Kang, Ki Sung; Lee, Sullim; Kim, Ki Hyun. Procyanidin B2 3′′-O-gallate Isolated from Reynoutria elliptica Prevents Glutamate-Induced HT22 Cell Death by Blocking the Accumulation of Intracellular Reactive Oxygen Species. Biomolecules 2019, 9, 412

24. So, Hae Min*; Yu, Jae Sik*; khan, Zarha; Subedi, Lalita; Ko, Yoon-Joo; Lee, Il Kyun; Park, Woo Sung; Chung, Sang J.; Ahn, Mi-Jeong; Kim, Sun Yeou; Kim, Ki Hyun. Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities. Bioorg. Chem. 2019, 91, 103145. (*co-first author)

23. Kim, Sil; Yu, Jae Sik; Lee, Ji Young; Choi, Sang Un; Lee, Jeongmi; Kim, Ki Hyun. Cytotoxic Withanolides from the Roots of Indian Ginseng (Withania somnifera). J. Nat. Prod. 2019, 82, 765−773.

22. Ahn, Soo-Yeon; Jo, Mun Seok; Lee, Dahae; Baek, Seon-Eun; Baek, Jiwon; Yu, Jae Sik; Jo, Jeyun; Yun, Hwayoung; Kang, Ki Sung; Yoo, Jeong-Eun; Kim, Ki Hyun. Dual effects of isoflavonoids from Pueraria lobata roots on estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells. Bioorg. Chem. 2019, 83, 135-144.

21. Lee, Seoung Rak; Lee, Dahae; Yu, Jae Sik; Benndorf, René; Lee, Sullim; Lee, Dong-Soo; Huh, Jungmoo; de Beer, Z. Wilhelm; Kim, Yong Ho; Beemelmanns, Christine; Kang, Ki Sung; Kim, Ki Hyun. Natalenamides A-C, Cyclic Tripeptides from the Termite-associated Actinomadura sp. RB99. Molecules 2018, 23, 3003

20. Lee, Seoung Rak; Choi, Eunyong; Jeon, Se Hun; Zhi, Xue Yan; Yu, Jae Sik; Kim, Seon-Hee; Lee, Jeongmi; Park, Ki-Moon; Kim, Ki Hyun. Tirucallane Triterpenoids from the Stems and Stem Bark of Cornus walteri that Control Adipocyte and Osteoblast Differentiations. Molecules 2018, 23, 2732.

19. Park, Yong Joo; Lee, Seoung Rak; Kim, Dong Min; Yu, Jae Sik; Beemelmanns, Christine; Chung, Kyu Hyuck; Kim, Ki Hyun. The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus Beauveria bassiana on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells. Molecules 2018, 23, 2568.

18. Lee, Tae Kyoung; Lee, Dahae; Yu, Jae Sik; Jo, Mun Seok; Baek, Su Cheol; Shin, Myoung-Sook; Ko, Yoon-Joo; Kang, Ki Sung; Kim, Ki Hyun. Biological Evaluation of a New Lignan from the Roots of Rice (Oryza sativa). Chem. Biodivers. 2018, 15, e1800333.

17. Lee, Dahae; Yu, Jae Sik; Lee, Seoung Rak; Hwang, Gwi Seo; Kang, Ki Sung; Park, Jae Gyu; Kim, Hyun Young; Kim, Ki Hyun, Yamabe, Noriko. Beneficial effects of bioactive compounds in mulberry fruits against anticancer drug-induced nephrotoxicity. Int. J. Mol. Sci. 2018, 19, 1117.

16. Yu, Jae Sik; Roh, Hyun-Soo; Baek, Kwan-Hyuck; Lee, Seul; Kim, Sil; So, Hae Min; Moon, Eunjung; Pang, Changhyun; Jang, Tae Su; Kim, Ki Hyun. Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells. J. Ginseng Res. 2018, 42, 562-570.

15. Lee, Tae Kyoung; Park, Jun Yeon; Yu, Jae Sik; Jang, Tae Su; Oh, Seong Taek; Pang, Changhyun; Ko, Yoon-Joo; Kang, Ki Sung; Kim, Ki Hyun. 7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs. Bioorg. Med. Chem. Lett. 2018, 28, 1084-1089.

14. Song, Ji Hoon; Lee, Dahae; Lee, Seoung Rak; Yu, Jae Sik, Jang, Tae Su; Nam, Joo-Won; Kim, Ki Hyun; Kang, Ki Sung. Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells. Mol. Med. Rep. 2018, 17, 5982–5987.

13. Yu, Jae Sik; Lee, Dahae; Lee, Seoung Rak; Lee, Jae Wook; Choi, Chang-Ik; Jang, Tae Su; Kang, Ki Sung; Kim, Ki Hyun. Chemical characterization of cytotoxic indole acetic acid derivative from Mulberry fruit (Morus alba L.) against human cervical cancer. Bioorg. Chem. 2018, 76, 28-36.

12. Yu, Jae Sik; Moon, Eunjung; Kim, Ki Hyun. A new cerebroside from the twigs of Lindera glauca (Sieb. et Zucc.) Blume. Bioorg. Chem. 2017, 74, 122-125.

11. Kim, Sil; So, Hae Min; Roh, Hyun-Soo1 Kim, Jin; Yu, Jae Sik; Lee, Seul; Seok, Soonja; Pang, Changhyun; Baek, Kwan-Hyuck; Kim, Ki Hyun Kim. Vulpinic acid contributes to the cytotoxicity of Pulveroboletus ravenelii to human cancer cells by inducing apoptosis. RSC Adv. 2017, 7, 35297–35304.

10. Yu, Jae Sik; Kim, Jun Ho; Lee, Seulah; Jung, Kiwon; Kim, Ki Hyun; Cho, Jae Youl. Src/Syk-Targeted Anti-Inflammatory Actions of Triterpenoidal Saponins from Gac (Momordica cochinchinensis) Seeds. Am. J. Chinese Med. 2017, 45, 459-473.

9. Yu, Jae Sik; Roh, Hyun-Soo; Lee, Seul; Jung, Kiwon; Baek, Kwan-Hyuck; Kim, Ki Hyun. Antiproliferative effect of Momordica cochinchinensis seeds on human lung cancer cells and isolation of the major constituents. Braz. J. Pharmacog. 2017, 27, 329–333.

8. Lee, Tae Kyoung; Roh, Hyun-Soo; Yu, Jae Sik; Kwon, Dong-Joo; Kim, Sun Young; Baek, Kwan-Hyuck; Kim, Ki Hyun. A novel cytotoxic activity of the fruit of Sorbus commixta against human lung cancer cells and isolation of the major constituents. J. Funct. Foods 2017, 30, 1-7.

7. Lee, Tae Kyoung; Roh, Hyun-Soo; Yu, Jae Sik; Baek, Jiwon; Lee, Seul; Ra, Moonjin; Kim, Sun Young; Baek, Kwan-Hyuck; Kim, Ki Hyun. Pinecone of Pinus koraiensis Inducing Apoptosis in Human Lung Cancer Cells by Activating Caspase-3 and its Chemical Constituents. Chem. Biodivers. 2017, 14, e1600412.

6. Lee, Dahae; Kang, Ki Sung; Yu, Jae Sik; Woo, Jung-Yoon; Hwang, Gwi Seo; Eom, Dae-Woon; Baek, Seung-Hoon; Lee, Hye Lim; Kim, Ki Hyun; Yamabe, Noriko. Protective effect of Korean Red Ginseng against FK-506-induced damage in LLC-PK1 cells. J. Ginseng Res. 2017, 41, 284-289.

5. Yu, Jae Sik; Baek, Jiwon; Park, Hyun Bong; Moon, Eunjung; Kim, Sun Yeou; Choi, Sang Un; Kim, Ki Hyun. A new rearranged eudesmane sesquiterpene and bioactive sesquiterpenes from the twigs of Lindera glauca (Sieb. et Zucc.) Blume. Arch. Pharm. Res. 2016, 39, 1628–1634.

4. Lee, Seoung Rak; Park, Jun Yeon; Yu, Jae Sik; Lee, Sung Ok; Ryu, Ja-Young; Choi, Sang-Zin; Kang, Ki Sung; Yamabe, Noriko; Kim, Ki Hyun. Odisolane, a Novel Oxolane Derivative and Antiangiogenic Constituents from the Fruits of Mulberry (Morus alba L.). J. Agric. Food Chem. 2016, 64, 3804−3809.

3. Yu, Jae Sik; Moon, Eunjung; Choi, Sang Un; Kim, Ki Hyun. Asarotonide, a new phenylpropanoid with a rare natural acetonide group from the rhizomes of Acorus gramineus. Tetrahedron Lett. 2016, 57, 1699-1701.

2. Jung, Kiwon; Lee, Dahae; Yu, Jae Sik; Namgung, Hojin; Kang, Ki Sung; Kim, Ki Hyun. Protective effect and mechanism of action of saponins isolated from the seeds of gac (Momordica cochinchinensis Spreng.) against cisplatin-induced damage in LLC-PK1 kidney cells. Bioorg. Med. Chem. Lett. 2016, 26, 1466–1470.

1. Kim, Ki Hyun; Moon, Eunjung; Cha, Joon Min; Lee, Seulah; Yu, Jae Sik; Kim, Chung Sub; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro. Anti-Neuroinflammatory and Anti-Proliferative Activities of Constituents from Tilia amurensis Rupr. Chem. Pharm. Bull. 2015, 63, 837–842.