Publications

Elbaum L, Yuan W, Seiler J P-H, Blom N, Chan YC, Baig AH, Brose N, Rumpel S, Ziv NE (2024). Revealing Acute Consequences of Rapid Protein Elimination at Individual Synapses using Auxin-Inducible Degron 2 Technology. bioRxiv 2024.10.20.619267; doi: https://doi.org/10.1101/2024.10.20.619267

Kasai H, Ziv NE, Okazaki H, Yagishita S, Toyoizumi T (2021). Spine dynamics in the brain, mental disorders and artificial neural networks.  Nat Rev Neurosci. 22:407-422.

Hazan L, Ziv NE.  (2020) Activity Dependent and Independent Determinants of Synaptic Size Diversity.  J Neurosci. 40:2828-2848.

Ziv NE, Brenner N (2018). Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses.  Trends Neurosci. 41:89-99.

Shomar A, Geyrhofer L, Ziv NE, Brenner N. (2017) Cooperative stochastic binding and unbinding explain synaptic size dynamics and statistics. PLoS Comput Biol. 13:e1005668.

Dvorkin R, Ziv NE. (2016) Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses.  PLoS Biol. 14(10):e1002572.

Rubinski A, Ziv NE. (2015) Remodeling and Tenacity of Inhibitory Synapses: Relationships with Network Activity and Neighboring Excitatory Synapses. PLoS Comput Biol. 11(11):e1004632.

Statman A, Kaufman M, Minerbi A, Ziv NE, Brenner N. (2014) Synaptic Size Dynamics as an Effectively Stochastic Process. PLoS Comput Biol. 10(10):e1003846.

Ziv NE (2013) “Imaging-based measures of synaptic tenacity”, In Nanoscale Imaging of Synapses: New Opportunities and Concepts. Nägerl, V and Triller, A, Editors. Springer.

Fisher-Lavie A, Ziv NE. (2013) Matching dynamics of presynaptic and postsynaptic scaffolds.  J Neurosci. 33:13094-13100.

Zeidan A, Ziv NE. (2012)  Neuroligin-1 loss is associated with reduced tenacity of excitatory synapses. PLoS One. 7(7):e42314.

Fisher-Lavie A, Zeidan A, Stern M, Garner CC, Ziv NE. (2011) Use dependence of presynaptic tenacity.  J Neurosci. 31:16770-80.

Ziv NE. (2010) Hebb and the art of spine remodeling. F1000 Biology Reports 2:69.

Minerbi A, Kahana R, Goldfeld L, Kaufman M, Marom S, Ziv NE. (2009) Long-Term Relationships between Synaptic Tenacity, synaptic remodeling, and network activity. PLoS Biol. 23;7(6) e1000136

Ziv NE, Triller A. (2023) Special issue: Synaptic logistics - Maintenance of synaptic composition, properties and function. Mol Cell Neurosci. 127:103885. 

Cohen LD, Ziv T, Ziv NE. (2022) Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points. Front. Mol. Neurosci. 15:1038614

Cohen LD, Boulos A, Ziv NE. (2020) A Non-Fluorescent HaloTag Blocker for Improved Measurement and Visualization of Protein Synthesis in Living Cells. F1000Res. 9:ISF-302.

Cohen LD, Ziv NE. (2019)  Neuronal and synaptic protein lifetimes. Curr Opin Neurobiol. 57:9-16.

Ziv NE (2018). Maintaining the active zone: Demand, supply and disposal of core active zone proteins. Neurosci Res. 127:70-77.

Cohen LD, Ziv NE. (2017) Recent insights on principles of synaptic protein degradation. F1000Res. 6:675.

Hakim V, Cohen LD, Zuchman R, Ziv T, Ziv NE. (2016) The effects of proteasomal inhibition on synaptic proteostasis. EMBO J. 35:2238-2262.

Rosenberg, T., Gal-Ben-Ari, S., Dieterich, D.C., Kreutz, M.R., Ziv, NE Gundelfinger, E.D., Rosenblum, K.R. (2014) The roles of protein expression in synaptic plasticity and memory consolidation. Frontiers in Molecular Neuroscience 7:86.

Ziv NE, Fisher-Lavie A (2014). Presynaptic and postsynaptic scaffolds: dynamics fast and slow. Neuroscientist. 20(5):439-52.

Cohen LD, Zuchman R, Sorokina O, Müller A, Dieterich DC, Armstrong JD, Ziv T, Ziv NE. (2013) Metabolic turnover of synaptic proteins kinetics, interdependencies and implications for synaptic maintenance. PLoS One. 8(5):e63191.

Ribrault C, Reingruber J, Petkovia M, Galli T, Ziv NE, Holcman D, Triller A.  (2011) Syntaxin1A Lateral Diffusion Reveals Transient and Local SNARE Interactions. J Neurosci. 31:17590-17602.

Tsuriel S, Fisher A, Wittenmayer N, Dresbach T, Garner CC, Ziv NE. (2009) Exchange and redistribution dynamics of the cytoskeleton of the active zone molecule bassoon. J Neurosci.29:351-358.

Kalla S, Stern M, Basu J, Varoqueaux F, Reim K, Rosenmund C, Ziv NE, Brose N. (2006) Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant mice. J Neurosci. 26:13054-13066.

Tsuriel S, Geva R, Zamorano P, Dresbach T, Boeckers T, Gundelfinger ED, Garner CC, Ziv NE. (2006) Local sharing as a predominant determinant of synaptic matrix molecular dynamics. PLoS Biol. 4(9):e271.

Boulos A, Maroun D, Ciechanover A, Ziv NE. (2024) Peripheral sequestration of huntingtin delays neuronal death and depends on N-terminal ubiquitination. Commun Biol 7:1014.

Ziv NE, Ciechanover A. (2020) A possible non-proteolytic role of ubiquitin conjugation in alleviating the pathology of Huntingtin’s aggregation. Cell Death Differ. 28:814-817

Hakim-Eshed V, Boulos A, Cohen-Rosenzweig C, Yu-Taeger L, Ziv T, Kwon YT, Riess O, Phuc Nguyen HH, Ziv NE, Ciechanover A. (2020) Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects. Proc Natl Acad Sci U S A. 117:18661-18669.

Kaufman M, Reinartz S, Ziv NE. (2014) Adaptation to prolonged neuromodulation in cortical cultures: an invariable return to network synchrony. BMC Biol. 12:83.

Kaufman M, Corner MA, Ziv NE. (2012) Long-term Relationships between Cholinergic Tone, Synchronous Bursting and Synaptic Remodeling. PLoS One. 7(7):e40980.

Eytan D, Minerbi A, Ziv N, Marom S. (2004) Dopamine-induced dispersion of correlations between action potentials in networks of cortical neurons. 92:1817-1824.

Hazan H, Ziv NE. (2017) Closed Loop Experiment Manager (CLEM)—An Open and Inexpensive Solution for Multichannel Electrophysiological Recordings and Closed Loop Experiments. Front. Neurosci. 11:579.

Levy O, Ziv NE, Marom S. (2012) Enhancement of neural representation capacity by modular architecture in networks of cortical neurons . Eur J Neurosci. 35:1753-1760.

Ziv NE, Schiller J (2011) Differential Interference Contrast Imaging of Living Cells, In Imaging: A Laboratory Manual (Yuste, R, Editor) Cold Spring Harbor press, New York.

Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, Brambilla R, Turco E, Rosenblum K, Wanker EE, Ziv NE, Menna E, Matteoli M. (2015) Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis. Cell Death Differ. 22:1425-1436.

Maas C, Torres VI, Altrock WD, Leal-Ortiz S. Wagh D, Terry-Lorenzo RT, Fejtova A, Gundelfinger ED, Ziv NE, Garner CC. (2012) Formation of Golgi-derived active zone precursor vesicles J. Neurosci. 32:11095-11108.

Ziv NE, Garner CC (2009) “Synapse Formation and elimination: Presynaptic Development & Active Zones” in "New Encyclopedia of Neuroscience", pp 957-966. Larry R. Squire, Editor(s)-in-Chief. Academic Press, Oxford.

Fejtova A, Davydova D, Bischof,F, Lazarevic V, Altrock WD, Romorini S, Schöne C, Zuschratter W, Kreutz MR, Garner CC, Ziv NE, Gundelfinger ED (2009)  Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. J Cell Biol 185, 341-355 

Garner CC, Waites CL, Ziv NE. (2006) Synapse development: still looking for the forest, still lost in the trees. Cell Tissue Research 326, 249-262. 

Dresbach T, Torres V, Wittenmayer N., Altrock WD, Zamorano P, Zuschratter W, Nawrotzki R, Ziv NE, Garner CC, Gundelfinger ED. (2006) Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment. J Biol Chem 281:6038-6047.

Ziv NE, Garner CC. (2004) Cellular and molecular mechanisms of presynaptic assembly. Nat Rev Neurosci. 5:385-399.

Bresler T, Shapira M, Boeckers T, Dresbach T, Futter M, Garner CC, Rosenblum K, Gundelfinger ED, Ziv NE. (2004) Postsynaptic density assembly is fundamentally different from presynaptic active zone assembly. J Neurosci. 24:1507-1520.

Shapira M, Zhai RG, Dresbach, T, Bresler T, Torres VI, Gundelfinger ED, Ziv NE,  Garner CC.  (2003) Unitary assembly of presynaptic active zones from Piccolo Bassoon transport vesicles. Neuron 38:237-252.

Garner CC, Zhai RG, Gundelfinger ED, Ziv NE (2002). Molecular mechanisms of CNS synaptogenesis. Trends Neurosci. 25:243-251.

Ziv NE, Garner CC (2001). Principles of glutamatergic synapse formation: seeing the forest for the trees. Curr Opin Neurobiol, 11:536-543.

Ziv NE (2001). Recruitment of synaptic molecules during synaptogenesis. Neuroscientist 7:365-370.

Bresler T, Ramati Y, Zamorano PL,  Zhai R, Garner CC and Ziv NE. (2001) The dynamics of SAP90 PSD-95 recruitment to new synaptic junctions. Mol Cell Neurosci. 18:149-167.

Zhai R, Vardinon Friedman H, Cases-Langhoff C, Becker B. Eckart D. Gundelfinger ED, Ziv NE, Garner CC (2001). Assembling the presynaptic active zone: Characterization of an active zone precursor vesicle.  Neuron 29:131-143.

Vardinon Friedman H, Bresler T, Garner CC. and Ziv NE. (2000) Assembly of new individual excitatory synapses: Time course and temporal order of synaptic molecule recruitment. Neuron. 27:57-79.

Ziv NE, Smith SJ (1996) Evidence for a role of dendritic filopodia in synaptogenesis and spine formation. Neuron 17:91-102.

Spira ME, Ziv NE, Oren R, Dormann A, Gitler D (2000). High calcium concentrations, calpain activation and cytoskeleton remodeling in neuronal regeneration after axotomy. In: Calcium: The molecular basis of calcium action in biology and medicine pp. 581-597. (R. Pochet, R. Donato, J. Haiech, C. Heizmann and V. Gerke, Eds). Kluwer Academic Publishers, Nederlands.

Spira ME, Gitler D, Oren R, Ziv NE (1999). The role of calcium in triggering growth cone formation and neuritogenesis after axotomy of cultured Aplysia neurons. In: The Neuron in Tissue Culture (Laurie Haynes, Ed). John Wiley and Sons, Chichester.

Ziv NE, Spira ME (1998) Induction of growth cone formation by transient and localized increases of intracellular proteolytic activity. J Cell Biol 140:223-232.

Ziv NE, Spira ME (1997) Localized and transient elevations of intracellular Ca2+ to sub‑milimolar levels can induce growth cone formation and neuritogenesis. J. Neurosci 17:3568-3579.

Ziv NE, Spira ME (1995) Axotomy induces a transient and localized elevation of the free intracellular calcium concentration to the milimolar range. J Neurophysiol 74:2625-2637.

Ziv, N.E. and Spira, M.E. (1993) Spatiotemporal distribution of calcium following axotomy and throughout the recovery process of cultured Aplysia neurons. Eur J. Neurosci.  5:657-668.

Spira ME, Dormann A, Ashery U, Gabso M, Gitler D, Benbassat D,  Ziv NE (1996) Use of Aplysia neurons for the study of cellular alterations and the resealing of transected axons in vitro. J Neurosci Methods 69:91-102.

Rahman KA, Orlando M, Boulos A, Andrzejak E, Schmitz D, Ziv NE, Prüss H, Garner CC, Ichkova A. (2023) Microglia actively remove NR1 autoantibody-bound NMDA receptors and associated post-synaptic proteins in neuron microglia co-cultures. Glia.  71:1804-1829. 

Andrzejak E, Rabinovitch E, Kreye J, Prüss H, Rosenmund C, Ziv NE, Garner CC, Ackermann F. (2020) Patient-Derived Anti-NMDAR Antibody Disinhibits Cortical Neuronal Networks through Dysfunction of Inhibitory Neuron Output. J Neurosci 42:3253-3270.

Ziv NE, Ahissar E. (2009) New tricks and old spines. Nature 462:859-861.

Bonneh-Barkay D, Ziv NE, Finberg JP (2005) Characterization of the neuroprotective activity of rasagiline in cerebellar granule cells. Neuropharmacology 48, 406-416.

Meiry, G., Reisner, Y., Feld, Y., Goldberg, S., Rosen, M., Ziv, NE, Binah, O. (2001) Evolution of action potential propagation and repolarization in cultured neonatal rat ventricular myocytes. J Cardiovasc Electrophysiol 12, 1269-1277 

Ryan TA, Ziv NE, Smith SJ (1996) Potentiation of evoked synaptic turnover at individually resolved synaptic boutons. Neuron 17:125-134. 

Orwar O, Fishman HA, Ziv NE, Scheller RH, Zare RN.(1995) Single-cell analysis and histochemical localization of 2,3-naphthalenedicarboxaldehyde-labeled glutathione using capillary electrophoresis with laser-induced fluorescence detection and fluorescence microscopy