Research
"Electrical Interrogation of Nervous System"
The electrical interrogation of the brain and neurons is the most direct way to interface with the brain, considering the electrochemical nature of the brain
Brain Interface Devices
Placing a sensor directly on the brain - National Science Foundation (NSF) - YouTube
We have developed multi-thousand channel µECoG technology, which offer high spatial and temporal resolution for mapping brain activity. The grids were tested in rats and humans, providing submillimeter functional organization resolution and fine temporal dynamics resolution. µECoG grids also identified epileptic discharges in a patient undergoing epilepsy surgery. The technology has the potential to revolutionize clinical mapping and research in brain-machine interfaces.
Brain-Gut Axis
The µECoG technology, which provides high spatial and temporal resolution for mapping brain activity, has potential applications in understanding the electrophysiological interaction between the gut-brain axis. Specifically, it can be used for gut-neural interfaces, allowing for a better understanding of how the gut and brain communicate with each other.
Nanoscale Neuron Interface Devices
To better understand the microscopic, individual cell level intracellular activities of the nervous system in an intact brain, we have developed nanoscale probes for intact brain tissue.
Semiconductor Optoelectronics for Brain and Neuron Interfaces
A new neurotechnology has been developed that integrates flexible micro light-emitting diode (μLED) arrays with micro-electrocorticography (μECoG) cortical grids. This LED+ECoG technology provides real-time visual feedback directly from the brain surface, allowing for precise identification of cortical landmarks and lesions. The integration of electrophysiological devices and display technologies has the potential to improve patient outcomes by increasing accuracy, reducing procedure time, and avoiding harm to neurological function. This technology is a significant advancement in neurosurgery and may have broad applications in neuro-oncology.
(Learn more: A Flexible Microdisplay Can Monitor and Visualize Brain Activity in Real-time During Brain Surgery)
Neural Data Processing & Real-Time Decoding
Our lab's focus extends beyond the fabrication of neural interface devices to the analysis of neural data and the development of real-time decoding algorithms. Our aim is to extract meaningful information from neural signals using AI-based algorithms. This information can be utilized for multiple purposes, including gaining a better understanding of the autonomous nervous system and its role in maintaining our health, as well as improving the diagnosis and treatment of neurological diseases. Additionally, our research may lead to new discoveries and insights into basic neuroscientific questions.