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My research work majorly revolves around in the area of bioengineering. It is an interdisciplinary science and I work in area of materials engineering to develop applications for addressing biomedical problems.
We use physical cues from engineered biomaterials that influence biological responses in 3D tissue scaffolds.
Research Interests:
Research Interests:
Organ-on-Chip Systems
In-vitro disease models - Idiopathic Pulmonary Fibrosis, Lung Cancer, Breast cancer
Vascular tissue engineering
4D Bioprinting
Research Project(s):
Research Project(s):
Engineering 3D bioprinted Lungs-on-a-Dish Platform to investigate Pulmonary Fibrosis
Idiopathic Pulmonary fibrosis (IPF) is an interstitial lung disease that results in excessive deposition of ECM collagen in the lung alveoli regions. Current strategies to treat IPF are severely limited, and the drugs proven good in animal are not very successful in human clinical trials. Processes underlying this unusual disease remain poorly understood, owing to the absence of dependable and reproducible models reiterating the tissue pathophysiology. The underlying limitations of such models underscore the development of a clinically relevant 3D in vitro model
We have tried combinations of a few bioinks like Alginate-Gelatin, Alginate-Methylcellulose, and Alginate-GelMA-Methylcellulose for 3D bioprinting parameters optimization at different cell densities and cross-linking time. The cell viability, proliferation, and morphological features in a 3D culture were compared for two weeks.
Our approach aims to create a biomimetic microsystem that reconstitutes the functional alveolar interface of the human lung. It will help us understand the epithelial-to-mesenchymal transition of epithelial cells, how they affect the fibroblasts, and govern them to a fibrotic stage in the co-culture study.
Printed Scaffold - "Lung Waffle"
Printed Scaffold - "Lung Waffle"
Alveolar nodes of 250 µm
Alveolar nodes of 250 µm
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