N E T W O R K     I M M U N O P H Y S I O L O G Y     L A B

To develop a detailed mechanistic understanding of inter-organ dynamics specific to disease.

To help comprehend and overcome the stochastic nature of disease development, progression, and sequelae.

To identify inter-organ-level biomarkers and pharmaceutical targets for the early diagnosis, treatment, and prevention of disease conditions.

Given the liver’s central role in metabolic homeostasis, progressive functional deterioration of the liver has been identified as a founding risk factor in various diseases. Indeed, comorbid conditions associated with chronic liver disease (CLD) range from metabolic syndrome and inflammatory bowel disease (IBD) to psoriasis, pulmonary disease, and neurological disorders,  significantly overlapping with the extra-intestinal manifestations of IBD.

While the causal relationships between these comorbidities remain elusive, the reciprocal crosstalk between the gut and liver appears to constitute a central axis of body integrity.