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Where does the concept of regeneration immunotherapy comes from?
The immune system has been found to be the driving force responsible for tissue repair and regeneration in vertebrate regenerating species such as the zebrafish, the axolotl, the spiny mouse.... These species can regenerate almost every organ with exquisite precision and scar free! Hence comes the hypothesis: is the lack of regenerative capacities of most mammals due to a defect in immune regulation of tissue repair? This hypothesis is the driving idea of my research. If we can understand how the immune system regulates tissue repair in regenerative species, we could apply this knowledge to unlock the human immune system to perform pro-regenerative tasks.
What do we need to learn?
What are the signals that activate immune cells to perform tissue repair/regeneration?
Which immune cell types and states are involved in the different steps of organ regeneration?
What signals do immune cells provide to the damaged tissue to induce tissue re-growth?
Techniques I use to answer these questions:
Live confocal microscopy during organ regeneration in zebrafish: allows to determine the dynamics of each immune cell types as well as their function.
scRNA-sequencing of immune cells during organ regeneration in zebrafish: allows to identify the immune cell types as well as the molecular signals regulating their function
Nanobody engineering: allows for immune cells' specific protein degradation to assess the requirement of specific molecular signals during organ regeneration
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