PUBLICATIONS

Publications (SCIE)

46. S. Son, M. Park, J. Kim, K. Lee*, “ACE mRNA (Additional Chimeric Element incorporated IVT mRNA) for Enhancing Protein Expression by Modulating Immunogenicity”, Advanced Science (IF 14.3, Materials science, multidisciplinary JCR 6.5 %), 2307541, 2024

45. Y. Kim, J. Choi, E. H. Kim, W. Park, H. Jang, Y. Jang, S-G. Chi, D-H. Kweon, K. Lee, S. H. Kim*, Y. Yang*, “Design of PD-L1-Targeted Lipid Nanoparticles to Turn on PTEN for Efficient Cancer Therapy”, Advanced Science (IF 14.3, Materials science, multidisciplinary JCR 6.5 %), e2309917, 2024

44. S. Son, K. Lee*, “Development of mRNA Vaccines/Therapeutics and Their Delivery System”, Molecules and Cells (IF 3.7, Biochemistry & molecular biology JCR 37.9 %), 46(1), 41-47, 2023

43. S. Kwon, M. Kwon, S. E. Im, K. Lee*, H. Lee*, “mRNA vaccines: The most recent clinical applications of synthetic mRNA”, Archives of Pharmacal Research (IF 6.9, Pharmacology & pharmacy JCR 3.5 %), 45, 245-262, 2022 (*co-corresponding authors)

42. B. Jang, H. Jang, H. Kim, M. Kim, M. Jeong, K. Lee*, H. Lee*, “Protein-RNA interaction guided chemical modification of Dicer substrate RNA nanostructures for superior in vivo gene silencing”, Journal of Controlled Release (IF 10.5, Pharmacology & pharmacy JCR 3.2 %), 343, 57-65, 2022 (*co-corresponding authors)

41. I. Noh, K. Lee, Y-S. Rhee*, “Microneedle systems for delivering nucleic acid drugs”, Journal of Pharmaceutical Investigation (IF 5.3, Pharmacology & pharmacy JCR 9.5 %), 52, 273-292, 2022

40. Z. Yu, X. Zhang, X. Pei, W. Cao, J. Ye, J. Wang, L. Sun, F. Yu, J. Wang, N. Li, K. Lee, S. Barth, V. C. Yang, H. He, “Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA”, International Journal of Pharmaceutics (IF 5.3, Pharmacology & pharmacy JCR 9.5 %), 606, 120940, 2021

39. M. Kim, M. Jeong, S. Hur, Y. Cho, J. Park, H. Jung, Y. Seo, H. A. Woo, K. T. Nam, K. Lee, H. Lee, “Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver”, Science Advances (IF 11.7, Multidisciplinary sciences JCR 7.8 %), 7, eabf4398, 2021

38. K. Lee*, T. S. Kim, Y. Seo, S. Y. Kim, H. Lee*, “Combined hybrid structure of siRNA tailed IVT mRNA (ChriST mRNA) for enhancing DC maturation and subsequent anticancer T cell immunity”, Journal of Controlled Release (IF 10.5, Pharmacology & pharmacy JCR 3.2 %), 327, 225-234, 2020 (*co-corresponding authors)

37. H. J. Park, E. K. Bang, J. J. Hong, S. M. Lee, H. L Ko, H. W. Kwak, H. Park, K. W. Kang, R. H. Kim, S. R. Ryu, G. Kim, H. Oh, H. J. Kim, K. Lee, M. Kim, S. Y. Kim, J. O. Kim, K. El-Baz, H. Lee, M. Song, D. G. Jeong, G. Keum J. H. Nam, “Nanoformulated Single-Stranded RNA-Based Adjuvant with a Coordinative Amphiphile as an Effective Stabilizer: Inducing Humoral Immune Response by Activation of Antigen-Presenting Cells”, Angewandte Chemie International Edition (IF 16.1, Chemistry, multidisciplinary JCR 5.4 %), 59, 11540-11549, 2020

36. K. Lee, S. Y. Kim, Y. Seo, M. H. Kim, J. Chang, H. Lee, “Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy”, Biomaterials Science (IF 5.8, Materials science, biomaterials JCR 21.7 %), 8, 1101-1105, 2020

35. K. Lee, S. Y. Kim, Y. Seo, H. Kwon, Y. J. Kwon, H. Lee, “Multicistronic IVT mRNA for simultaneous expression of multiple fluorescent proteins”, Journal of Industrial and Engineering Chemistry (IF 5.9, Engineering, chemical JCR 16.2 %), 80, 770-777, 2019

34. J. E. Lee†, K. Lee†, J. A. Nam, A. Kim, S. Y. Lee, M. S. Lee, N. W. Kim, Y. Yin, J. W. Park, S. Y. Park, J. H. Jeong, “Cellular Delivery of siRNA Using Poly(2-dimethylaminoethyl methacrylate) Functionalized Graphene Oxide Nano-Wrap”, Macromolecular Research (IF 2.8, Polymer science JCR 47.3 %), 26(12), 1115-1122, 2018 (†co-first authors)

33. M. S. Lee†, K. Lee†, M. W. Nam, K. M. Jeong, J. E. Lee, N. W. Kim, Y. Yin, S. Y. Lim, D. E. Yoo, J. Lee, J. H. Jeong, “Natural deep eutectic solvents as a storage medium for human interferon-α2: a green and improved strategy for room-temperature biologics", Journal of Industrial and Engineering Chemistry (IF 5.9, Engineering, chemical JCR 16.2 %), 65, 343-348, 2018 (†co-first authors)

32. K. Lee, M. Kim, Y. Seo, H. Lee, “Development of mRNA vaccines and their prophylactic and therapeutic applications”, Nano Research (IF 9.5, Physics, Applied JCR 10.3 %), 11, 5173-5192, 2018

31. K. Lee, B. Jang, Y. Lee, E. Suh, J. Yoo, M. Lee, J. Lee, H. Lee, “The cutting-edge technologies of siRNA delivery and their application in clinical trials”, Archives of Pharmacal Research (IF 6.9, Pharmacology & pharmacy JCR 3.5 %), 41, 867-874, 2018

30. B. Jang, B. Kim, H. Kim, H. Kwon, M. Kim, Y Seo, M. Colas, H. Jeong, E. H. Jeong, K. Lee, H. Lee*, “Enzymatic Synthesis of Self-assembled Dicer Substrate RNA Nanostructures for Programmable Gene Silencing”, Nano Letters (IF 9.6, Physics, Applied JCR 9.8 %), 18, 4279-4284, 2018

29. H. Kwon, M. Kim, Y. Seo, Y. S. Moon, H. J. Lee, K. Lee*, H. Lee*, “Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine”, Biomaterials (IF 12, Materials science, biomaterials JCR 2.8 %), 156, 172-193, 2018 (*co-corresponding authors)

28. E. H. Jeong, H. Jeong, B. Jang, B. Kim, M. Kim, H. Kwon, K. Lee*, H. Lee*, “Aptamer-incorporated DNA holliday junction for the targeted delivery of siRNA”, Journal of Industrial and Engineering Chemistry (IF 5.9, Engineering, chemical JCR 16.2 %), 56, 55-61, 2017 (*co-corresponding authors)

27. K. Lee, A. E. David, J. Zhang, M. C. Shin, V. C. Yang, “Enhanced accumulation of theranostic nanoparticles in brain tumor by external magnetic field mediated in situ clustering of magnetic nanoparticles”, Journal of Industrial and Engineering Chemistry (IF 5.9, Engineering, chemical JCR 16.2 %), 54, 389-397, 2017

26. I. Y. Jung, J. S. Kim, B. R. Choi, K. Lee*, H. Lee* “Hydrogel Based Biosensors for in vitro diagnostics of Biochemicals, Proteins, and Genes”, Advanced Healthcare Materials (IF 10, Materials Science, Biomaterials JCR 4.7 %), 6, 1601475, 2017 (*co-corresponding authors)

25. I. Y. Jung, J. B. You, B. R. Choi, J. S. Kim, H. K. Kim, B. Jang, H. S. Jeong, K. Lee, S. G. Im, H. Lee, “A highly sensitive molecular detection platform for robust and facile diagnosis of middle east respiratory syndrome (MERS) corona virus”. Advanced Healthcare Materials (IF 10, Materials Science, Biomaterials JCR 4.7 %), 5, 2168-2173, 2016

24. M. C. Shin, J. Zhang, K. A. Min, K. Lee, C. Moon, J. P. Balthasar, V. C. Yang, “Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy.”, Journal of Controlled Release (IF 10.5, Pharmacology & pharmacy JCR 3.2 %), 194, 197-210, 2014

23. M. S. Lee, J. E. Lee, E. Byun, N. W. Kim, K. Lee, H. Lee, S. J. Sim, D. S. Lee, J. H. Jeong, “Target-specific delivery of siRNA by stabilized calcium phosphate nanoparticles using dopa- hyaluronic acid conjugate.”, Journal of Controlled Release (IF 10.5, Pharmacology & pharmacy JCR 3.2 %), 192, 122-130, 2014

22. N. W. Kim, M. S. Lee, K. R. Kim, J. E. Lee, K. Lee, J. S. Park, Y. Matsumoto, D. G. Jo, H. Lee, D. S. Lee, J. H. Jeong, “Polyplex-releasing microneedles for enhanced cutaneous delivery of DNA vaccine”, Journal of Controlled Release (IF 10.5, Pharmacology & pharmacy JCR 3.2 %), 179, 11-17, 2014

21. H. He, J. Ye J, Y. Wang Y, Q. Liu, H. S. Chung, Y. M. Kwon, M. C. Shin, K. Lee, V. C. Yang, “Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application”, Journal of Controlled Release (IF 10.5, Pharmacology & pharmacy JCR 3.2 %), 176, 123-132, 2014

20. J. Zhang, M. C. Shin, A. E. David, J. Zhou, K. Lee, H. He, V. C. Yang, “Long-circulating heparin-functionalized magnetic nanoparticles for potential application as a protein drug delivery platform”, Molecular Pharmaceutics (IF 4.5, Pharmacology & pharmacy JCR 16.8 %), 10, 3892-3902, 2013

19. M. C. Shin, J. Zhang, K. A. Min, K. Lee, Y. Byun, A. E. David, H. He, V. C. Yang, “Cell- penetrating peptides: achievements and challenges in application for cancer treatment”, Journal of Biomedical Materials Research Part A (IF 3.9, Engineering, biomedical JCR 34 %), 102, 575-587, 2014

18. H. Hyun†, K. Lee†, K. H. Min, P. Jeon, K. Kim, S. Y. Jeong, I. C. Kwon, T. G. Park, M. Lee, “Ischemic brain imaging using fluorescent gold nanoprobes sensitive to reactive oxygen species”, Journal of Controlled Release (IF 10.5, Pharmacology & pharmacy JCR 3.2 %), 170, 352-357, 2013, (†co-first authors)

17. M. S. Lee, N. W. Kim, K. Lee, H. Kim, J. H. Jeong, “Enhanced Transfection by Antioxidative Polymeric Gene Carrier that Reduces Polyplex-Mediated Cellular Oxidative Stress”, Pharmaceutical Research (IF 3.5, Pharmacology & pharmacy 28.1 %), 30, 1642-1651, 2013

16. H. He, A. David, B. Chertok, A. Cole, K. Lee, J. Zhang, J. Wang, Y. Huang, V. C. Yang, “Magnetic Nanoparticles for Tumor Imaging and Therapy:A So-Called Theranostic System”, Pharmaceutical Research (IF 3.5, Pharmacology & pharmacy 28.1 %), 30, 2445-2458, 2013

15. K. Lee, M. H. Oh, M. S. Lee, Y. S. Nam, T. G. Park, J. H. Jeong, “Stabilized calcium phosphate nano-aggregates using a dopa-chitosan conjugate for gene delivery”, International Journal of Pharmaceutics (IF 5.3, Pharmacology & pharmacy JCR 9.5 %), 445, 196-202, 2013

14. Y. S. Park, A. E. David, K. M. Park, C. Y. Lin, K. D. Than, K. Lee, J. B. Park, I. Jo, K. D. Park, V. C. Yang, “Controlled Release of Simvastatin from In situ Forming Hydrogel Triggers Bone Formation in MC3T3-E1 Cells”, AAPS Journal (IF 5.0, Pharmacology & pharmacy JCR 12 %), 15, 367-376, 2013

13. Y. L. Jang, U. J. Yun, M. S. Lee, M. G. Kim, S. Son, K. Lee, S. Y. Chae, D. W. Lim, H. T. Kim, S. H. Kim, J. H. Jeong, “Cell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppression”, International Journal of Pharmaceutics (IF 5.3, Pharmacology & pharmacy JCR 9.5 %), 434, 488-493, 2012

12. M. S. Lee, M. G. Kim, Y. L. Jang, K. Lee, T. G. Kim, S. H. Kim, T. G. Park, H. T. Kim, J. H. Jeong, “Polyethyleneimine-g-Poly(lactic-co-glycolic acid) as Non-Toxic Micelle-Type Carrier for Gene Delivery”, Macromolecular Research (IF 2.8, Polymer science JCR 47.3 %), 19, 688-693, 2011

11. S. Y. Chae, H. J. Kim, M. S. Lee, Y. L. Jang, Y. Lee, S. H. Lee, K. Lee, S. H. Kim, H. T. Kim, S. C. Chi, T. G. Park, J. H. Jeong, “Energy-Independent Intracellular Gene Delivery Mediated by Polymeric Biomimetics of Cell-Penetrating Peptides”, Macromolecular Bioscience (IF 4.4, Polymer science JCR 23.9 %), 11, 1169-1174, 2011

10. K. Lee, H. Lee, K. W. Lee, T. G. Park, “Optical imaging of intracellular reactive oxygen species for the assessment of the cytotoxicity of nanoparticles”, Biomaterials (IF 12, Materials science, biomaterials JCR 2.8 %), 32, 2556-2565, 2011

9. K. H. Bae, K. Lee, C. Kim, T. G. Park, “Surface Functionalized Hollow Manganese Oxide Nanoparticles for Cancer Targeted siRNA Delivery and Magnetic Resonance Imaging”, Biomaterials (IF 12, Materials science, biomaterials JCR 2.8 %), 32, 176-184, 2010

8. K. Lee, H. Lee, K. H. Bae, T. G. Park, “Heparin Immobilized Gold Nanoparticles for Targeted Detection and Apoptotic Death of Metastatic Cancer Cells”, Biomaterials (IF 12, Materials science, biomaterials JCR 2.8 %), 31, 6530-6536, 2010

7. K. Lee, K. H. Bae, Y. Lee, S. H. Lee, C-H. Ahn, T. G. Park, “Pluronic/Polyethylenimine Shell Cross-linked Nanocapsules with Embedded Magnetite Nanocrystals for Magnetically Triggered Delivery of siRNA”, Macromolecular Bioscience (IF 2.8, Polymer science JCR 47.3 %), 10, 239-245, 2010

6. J. Lee†, K. Lee†, S. H. Moon, Y. Lee, T. G. Park, J. Cheon, "All-in-one Target Cell-specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery", Angewandte Chemie International Edition (IF 16.1, Chemistry, multidisciplinary JCR 5.4 %), 48, 4174-4179, 2009 (†co-first authors), highlighted in the Chemistry World (Royal Society of Chemistry), Genetic Engineering News, ScienceDaily, Nanowerk, Korea Times, Arirang TV, and many other media.

5. H. Lee, K, Lee, I. K. Lee, T. G. Park, "Fluorescent Gold Nanoprobe Sensitive to Intracellular Reactive Oxygen Species", Advanced Functional Materials (IF 18.5, Chemistry, multidisciplinary JCR 4.1 %), 19, 1884-1890, 2009

4. H. Lee, K. Lee, I. K. Kim, T. G. Park, “Synthesis, Characterization, and In vivo Diagnostic Applications of Hyaluronic Acid Immobilized Gold Nanoprobes”, Biomaterials (IF 12, Materials science, biomaterials JCR 2.8 %), 29, 4709-4718, 2008

3. H, Lee, K. Lee, T. G. Park, “Hyaluronic Acid-Paclitaxel Conjugate Micelles: Synthesis, Characterization, and Anti-tumor Activity”, Bioconjugate Chemistry (IF 4.0, Biochemical research methods JCR 15.9 %), 19, 1319-1325, 2008

2. S. H. Lee, K. H. Bae, S. H. Kim, K. Lee, T. G. Park, “Amine-Functionalized Gold Nanoparticles as Non-cytotoxic and Efficient Intracellular siRNA Delivery Carriers”, International Journal of Pharmaceutics (IF 5.3, Pharmacology & pharmacy JCR 9.5 %), 364, 94-101, 2008

1. K. H. Bae, Y. J. Ha, C. Kim, K. Lee, T. G. Park, “Pluronic/Chitosan Shell Cross-Linked Nanocapsules Encapsulating Magnetic Nanoparticles”, Journal of Biomaterials Science, Polymer Edition (IF 3.6, Polymer science JCR 35.6 %), 12, 1571-1583, 2008