About the Lab
About the Lab
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Our Research
Our Research
The CNU Neurophysiology Lab investigates how the brain works at the cellular and molecular levels. We focus on understanding neural communication, metabolic characteristics of brain tumors, and molecular factors that regulate synaptic function through multiple research approaches.
Research Areas
Research Areas
# Neuron-Astrocyte Interactions
Astrocytes actively participate in synaptic transmission. Using electrophysiology and calcium imaging, our laboratory studies how astrocytes modulate neuronal activity. Bidirectional signaling between neurons and astrocytes can be disrupted in neurological diseases, and understanding these mechanisms is a priority in our work.
# Synaptic Function and Glycosylation
Glycosylation attaches sugar molecules to proteins, which is necessary for many cell surface proteins and signaling pathways. Our studies examine how glycosylation patterns affect synaptic receptors and their role in learning and memory, revealing new mechanisms of synaptic function regulation.
# Glioblastoma and Signaling molecules
Glioblastoma is extremely difficult to treat with poor prognosis. We investigate how gliotransmitters regulate tumor invasion and proliferation. Our research demonstrates that calcium signaling pathways and mechanosensitive channel activation increase proliferation and invasion of GBM by releasing glutamate and ATP and aims to develop new therapeutic strategies.
# Cerebellar Physiology
The cerebellum plays an important role in motor coordination and learning. We study Purkinje cell function and synaptic plasticity in the cerebellar cortex using electrophysiology. Understanding cerebellar circuits will provide important foundations for developing treatments for movement disorders.
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