Publications

Google Scholar : https://scholar.google.com/citations?user=EmRKTH8AAAAJ&hl=ko

2025

• Ma JH, Eo JC, Lee C, Choi J, Hwang I, Yang YJ, Shin SJ, Kim CH, Yu JW.  Type I interferon signaling promotes kainic acid-induced seizures through mTOR activation. Neuropharmacology (2025) 110634. Read paper

• Yoon SH*, Kim CY*, Lee E, Lee C, Lee KS, Lee JH, Park H, Choi B, Hwang I, Kim J, Kim TG, Son J, Hyun YM, Hong S**, Yu JW**. Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice.  Nat Commun (2025) 16, 699. Read paper (*equal contribution, **Co-correspondence)

2024

• Lee KS, Yoon SH, Hwang I, Ma JH, Yang E, Kim RH, Kim E, Yu JW. Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming. J Neuroinflammation (2024) 21, 137. Read paper

• Shim DW, Eo JC, Kim S, Hwang I, Nam BY, Shin JE, Han SH, Yu JW. Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis. Exp Mol Med (2024) 56, 370-382. Read paper

• Oh SJ, Yu JW, Ahn JH, Choi ST, Park H, Yun J, Shin OS. Varicella zoster virus glycoprotein E facilitates PINK1/Parkin-mediated mitophagy to evade STING and MAVS-mediated antiviral innate immunity. Cell Death Dis (2024) 15, 16. Read paper

2023

• Byun DJ, Lee J, Yu JW, Hyun YM. NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain. Immune Netw (2023) 23, e27. Read paper

• Chae BJ, Lee KS, Hwang I, Yu JW. Extracellular Acidification Augments NLRP3-Mediated Inflammasome Signaling in Macrophages. Immune Netw (2023) 23, e23. Read paper

• Choi B, Lee C, Yu JW.  Distinctive role of inflammation in tissue repair and regeneration. Arch Pharm Res (2023) 46, 78-89. Read paper

2022

• Ma JH*, Lee E*, Yoon SH*, Min H*, Oh JH, Hwang I, Sung Y, Ryu JH, Bok J**, Yu JW**. Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model. EBiomedicine (2022) 82, 104184. Read paper (*equal contribution, **Co-correspondence)

• Zuo D, Do N, Hwang I, Ann J, Yu JW, Lee J. Design and synthesis of an N-benzyl 5-(4-sulfamoylbenzylidene-2-thioxothiazolidin-4-one scaffold as a novel NLRP3 inflammasome inhibitor. Bioorg Med Chem Lett (2022) 65, 128693. Read paper

• Jung H, Lee H, Kim D, Cheong E, Hyun YM, Yu JW, Um JW . Differential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice. J Inflamm Res (2022) 15, 3053-3063. Read paper

• Kim ER, Kim SR, Cho W, Lee SG, Kim SH, Kim JH, Choi E, Kim JH, Yu JW, Lee BW, Kang ES, Cha BS, Lee MS, Cho JW, Jeon JY, Lee YH . Short Term Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome Via B-hydroxybutyrate and Fibroblast Growth Factor 21. Front Immunol (2022) 13, 843520. Read paper

• Nam BY, Jhee JH, Park J, Kim S, Kim GR, Park JT, Yoo TH, Kang SW, Yu JW, Han SH.  PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis. Cell Death Dis (2022) 13, 31. Read paper

2021

• Shim DW, Cho HJ, Hwang I, Jung TY, Kim HS, Ryu JH, Yu JW.  Intracellular NAD + Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation. Front Immunol (2021) 12, 765477. Read paper

• Yoon SH, Hwang I, Lee E, Cho HJ, Ryu JH, Kim TG, Yu JW.  Antimicrobial Peptide LL-37 Drives Rosacea-Like Skin Inflammation in an NLRP3-Dependent Manner. J Invest Dermatol (2021) 141, 2885-2894.e5. Read paper

•  Son S, Yoon SH, Chae BJ, Hwang I, Shim DW, Choe YH, Hyun YM, Yu JW.  Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu. Front Immunol (2021) 12, 746032. Read paper

• Lee E, Eo JC, Lee C, Yu JW. Distinct Features of Brain-Resident Macrophages: Microglia and Non-Parenchymal Brain Macrophages. Mol Cells (2021) 445, 281-291. Read paper

• Kwon OC, Song JJ, Yang Y, Kim SH, Kim JY, Seok MJ, Hwang I, Yu JW, Karmacharya J, Maeng HJ, Kim J, Jho EH, Ko SY, Son H, Chang MY, Lee SH. SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models. EMBO Mol Med (2021) 13, e13076. Read paper

2020

• Yang J, Hwang I, Lee E, Shin SJ, Lee EJ, Rhee JH, Yu JW. Bacterial outer membrane vesicle-mediated cytosolic delivery of flagellin triggers host NLRC4 canonical inflammasome signaling. Front Immunol (2020) 11, 581165 (cited 50 times as of 2024-07)

• Kim M, Lee JE, Cho H, Jung HG, Lee W, Seo HY, Lee SH, Ahn DG, Kim SJ, Yu JW, Oh JW. Antiviral efficacy of orally delivered neoagarohexaose, a nonconventional TLR4 agonist, against norovirus infection in mice. Biomaterials (2020) 263; 120391

• Kim SR, Lee SG, Kim SH, Kim JH, Choi E, Cho W, Rim JH, Hwang I, Lee CJ, Lee M, Oh CM, Jeon JY, Gee HY, Kim JH, Lee BW, Kang ES, Cha BS, Lee MS, Yu JW, Cho JW, Kim JS, Lee YH. SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease. Nat Commun (2020) 11, 2127   

• Ahn Y, Seo J, Lee EJ, Kim JY, Park MY, Hwang S, Almurayshid A, Lim BJ, Yu JW, Oh SH. ATP-P2X7-induced inflammasome activation contributes to melanocyte death and CD8+ T-cell trafficking to the skin in vitiligo. J Invest Dermatol (2020) 140; 1794-1804

• Ko YJ, Lee JW, Yang EJ, Jang N, Park J, Jeon YK, Yu JW, Cho NH, Kim HS, Kwon IC. Non-invasive in vivo imaging of caspase-1 activation enables rapid and spatiotemporal detection of acute and chronic inflammatory disorders. Biomaterials (2020) 226; 119543

2019

• Gim E, Shim DW, Hwang I, Shin OS, Yu JW. Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner. Immune Netw (2019) 19(6) e40

• Lee HJ, Kim JH, Hong S, Hwang I, Park SJ, Kim TI, Kim WH, Yu JW, Kim SW, Cheon JH. Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet’s disease. Sci Rep (2019) 9, 11716

• Son S, Shim DW, Hwang I, Park JH, Yu JW. Chemotherapeutic agent paclitaxel mediates priming of NLRP3 inflammasome activation. Front Immunol (2019) 10, 1108

• Lee E, Hwang I, Park S, Hong S, Hwang B, Cho Y, Son J, Yu JW. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell Death Differ (2019) 26, 213-228 (cited 336 times as of 2024-07)

• Hong S, Hwang I, Gim E, Yang J, Park S, Yoon SH, Lee WW, Yu JW. Brefeldin A-sensitive ER-Golgi vesicle trafficking contributes to NLRP3-dependent caspase-1 activation. FASEB J (2019) 33, 4547-4558 (F1000 recommendation)

2018

• Ann SJ, Kim KK, Cheon EJ, Noh HM, Hwang I, Yu JW, Park S, Kang SM, Manabe I, Miller YI, Kim S, Lee SH. Palmitate and minimally-modified low-density lipoprotein cooperatively promote inflammatory responses in macrophages. Plos One (2018) 13, e0193649

• Hong S, Yu JW. Prolonged exposure of lipopolysaccharide induces NLRP3-independent maturation and secretion of interleukin (IL)-1beta in macrophages. J Microbiol Biotechnol (2018) 28, 115-121

2017

• Son S, Hwang I, Han SH, Shin JS, Shin OS, Yu JW. Advanced glycation end products impair NLRP3 inflammasome-mediated immune responses in macrophages. J Biol Chem (2017) 292, 20437-20448 (cited 63 times as of 2024-07)

• Jeon SA, Lee E, Hwang I, Han B, Park S, Son S, Yang J, Hong S, Kim CH, Son J, Yu JW. NLRP3 Inflammasome Contributes to Lipopolysaccharide-induced Depressive-like Behaviors via Indoleamine 2,3-dioxygenase Induction. Int J Neuropsychopharmacol (2017) 20, 896-906 (cited 49 times as of 2024-07)

• Yang J, Lee KM, Park S, Cho Y, Lee E, Park JH, Shin OS, Son J, Yoon SS, Yu JW.Bacterial secretant from Pseudomonas aeruginosa dampens inflammasome activation in a quorum sensing-dependent manner. Front Immunol (2017) 8, 333

• Lee JH, Lee HH, Kim HW, Yu JW, Kim KN, Kim KM. Immunomodulatory/anti-inflammatory effect of ZOE-based dental materials. Dent Mater (2017) 33, e1-e12

2016

• Jang J*, Park S*, Hur HJ, Cho HJ, Hwang I, Kang YP, Im I, Lee H, Lee E, Yang W, Kang HC, Kwon SW, Yu JW**, Kim DW**. 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome activation. Nat Commun  (2016) 7, 13129  (**Co-correspondence) (cited 140 times as of 2024-07)

• Yu JW, Lee MS. Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance. Arch Pharm Res (2016) 39, 1503-1518 (cited 177 times as of 2024-07)

• Kim JH, Park JH, Eisenhut M, Yu JW, Shin JI. Inflammasome activation by cell volume regulation and inflammation-associated hyponatremia: A vicious cycle. Med Hypotheses (2016) 93, 117-121

• Oh JE, Kim B, Chang DH, Kwon M, Lee SY, Kang D, Kim JY, Hwang I, Yu JW, Nakae S, Lee HK. Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa. Proc Natl Acad Sci USA (2016) 113, E762-771

2015

• Hwang I, Lee E, Jeon SA, Yu JW. Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation. Biochem Biophys Res Commun (2015) 467, 973-978 (cited 49 times as of 2024-07)

• Park S, Won JH, Hwang I, Hong S, Lee HK, Yu JW. Defective mitochondrial fission augments NLRP3 inflammasome activation. Sci Rep (2015) 5, 15489 (cited 161 times as of 2024-07)

• Won JH, Park S, Hong S, Son S, Yu JW. Rotenone-induced impairment of mitochondrial electron transport chain confers a selective priming signal for NLRP3 inflammasome activation. J Biol Chem (2015) 290, 27425-27437 (F1000 recommendation) (cited 124 times as of 2024-07)

• Hwang I, Yang J, Hong S, Lee EJ, Lee SH, Fernandes-Alnemri T, Alnemri ES, Yu JW. Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4. Immunol Cell Biol (2015) 93, 591-599 (cited 45 times as of 2024-07)

2013

• Park S, Juliana C, Hong S, Datta P, Hwang I, Fernandes-Alnemri T, Yu JW*, Alnemri ES*. The mitochondrial anti-viral protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol (2013) 191, 4358-4366 (*Co-correspondence) (cited 275 times as of 2024-07)

• Kim EH, Won JH, Hwang I, Yu JW. Cobalt chloride-induced hypoxia ameliorates NLRP3-mediated caspase-1 activation in mixed glial cultures. Immune Netw (2013) 13, 141-147

• Yu JW*, Farias A, Hwang I, Fernandes-Alnemri T, Alnemri ES*. Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome. J Biol Chem (2013) 288, 11378-11383 (*Co-correspondence)

• Hong S, Hwang I, Lee YS, Park S, Lee WK, Fernandes-Alnemri T, Alnemri ES, Kim YS, Yu JW. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death. Cancer Lett. (2013) 331, 183-191

2010-2012

• Hwang I, Park S, Hong S, Kim EH, Yu JW. Salmonella promotes ASC oligomerization-dependent caspase-1 activation. Immune Netw (2012) 12, 284-290

• Hong S, Park S, Yu JW. Pyrin domain (PYD)-containing inflammasome in innate immunity. J Bacteriol Virol (2011) 41,133-146

• Kim JY, Lee JY, Kim DG, Koo GB, Yu JW, Kim YS. TRADD is critical for resistance to TRAIL-induced cell death through NF-kB activation. FEBS Lett (2011) 585, 2144-2150

• Kim KJ, Yu JW, Hwang HS, Choi EJ. CIIA is a regulator of detachment-induced cell death. Cancer Res (2010) 70, 6352-6358

• Yu JW, Yang R, Kim YS. Differential cytoprotective effect of copper- and iron-containing chlorophyllins against oxidative stress-mediated cell death. Free Radic Res (2010) 44, 655-667

• Fernandes-Alnemri T*, Yu JW*, Juliana C, Solorzano L, Kang SW, Wu J, Datta P, McCormick M, Huang L, McDermott E, Eisenlohr L, Landel CP, Alnemri ES. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol (2010) 11, 385-393 (* equal contribution) (cited 846 times as of 2024-07)

• Juliana C, Fernandes-Alnemri T, Wu J, Solorzano L, Datta P, Yu JW, Meng R, Quong AA, Latz E, Scott CP, Alnemri ES. Anti-inflammatory compounds parthenolide and Bay 11-7802 are direct inhibitors of the inflammasome. J Biol Chem (2010) 285, 9792-9802 (cited 618 times as of 2024-07)

Before 2010

• Fernandes-Alnemri T*, Yu JW*, Wu J, Datta P, Alnemri ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature (2009) 458, 509-513 (* equal contribution) (cited 2073 times as of 2024-07)

• Jéru I, Duquesnoy P, Fernandes-Alnemri T, Cochet E, Yu JW, Lackmy-Port-Lis M, Grimprel E, Landman-Parker J, Hentgen V, Marlin S, McElreavey K, Sarkisian T, Grateau G, Alnemri ES, Amselem S. Mutations in NALP12 cause hereditary periodic fever syndromes. Proc Natl Acad Sci USA (2008) 105, 1614-1619 (cited 433 times as of 2024-07)

• Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, McCormick M, Zhang Z, Alnemri ES. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Molecular Cell (2007) 28, 214-227 (cited 333 times as of 2024-07)

• T Fernandes-Alnemri, J Wu, J-W Yu, P Datta, B Miller, W Janchowski, S Rosenberg, J Zhang, ES Alnemri. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ (2007) 14(9): 1590-1604 (cited 1176 times as of 2024-07)

• J-W Yu*, J Wu*, Z Zhang, P Datta, I Ibrahimi, S Taniguchi, J Sagara, T Fernandes-Alnemri, ES Alnemri.  Cryopyrin and pyrin activate caspase-1, but not NF-kB, via ASC oligomerization. Cell Death Differ (2006) 13(2): 236-249 (cited 458 times as of 2024-07)

• Park HS*, Yu JW*, Cho JH*, Kim MS*, Huh SH, Ryoo K, Choi EJ. Inhibition of Apoptosis-Signaling Kinase 1 (ASK1) by nitric oxide through a thiol-redox mechanism. J Biol Chem (2004) 279(9): 7584-7590 (*equal contribution) (cited 129 times as of 2024-07)

• Yu JW, Yoon SS, Yang R. Iron chlorin e6 scavenges hydroxyl radical and protects human endothelial cells against hydrogen peroxide toxicity. Biol Pharm Bull (2001) 24(9): 1053-1059