Turnkey Hardware for Neuromodulation by Focused Ultrasound

Introducing the NeuroFUS™ CTX and DPX Systems from Integrated Sonic Technologies (IST).

NeuroFUS CTX and NeuroFUS DPX Systems provide turnkey delivery of Focused Ultrasound (FUS) for Noninvasive Neuromodulation research. The NeuroFUS CTX and DPX Systems deliver pulsed focused ultrasound neuromodulation waveforms to targeted brain regions and nerve structures from a phased array ultrasound transducer powered by a multi-channel amplifier.

NeuroFUS Hardware

The NeuroFUS CTX System includes a 4-channel amplifier and annular phased array transducer that provides Z-axis positioning capabilities for delivering FUS neuromodulation beams to different depths or distances away from the transducer. The NeuroFUS Beam produced by the CTX system is a radially symmetrical ellipsoid (width 3 mm x length 21 mm). The focal length can be adjusted in real-time and the NeuroFUS Beam can be positioned +/- 25 mm from the geometric focus in 0.1 mm increments up to a maximum focal length (depth) of 80 mm.

The NeuroFUS DPX System includes a 64-channel amplifier and phased array transducer. The DPX provides users with 3D Spatial Control over the placement of FUS neuromodulation beams using XYZ beam modulation and steering methods. The NeuroFUS Beam produced by the DPX is a radially symmetrical ellipsoid with a width of 3.1 mm and a length of 23.1 mm. The Z-axis range is +/- 28 mm with +/- 10.5 mm XY-axis lateral positioning capability in 0.1 mm increments from a geometric focus of 50 mm.

NeuroFUS Commander

Using the NeuroFUS Commander USB interface and NeuroFUS SDK users can conduct the ultrasonic neuromodulation of cortical and subcortical brain regions using widely reported transcranial focused ultrasound neuromodulation methods. Preset FUS Neuromodulation Waveforms provide users with out-of-the-box implementation requiring little setup time. The NeuroFUS SDK and Matlab tools provide advanced users with more liberal control over ultrasonic neuromodulation waveform parameters like acoustic power, pulse repetition frequency, pulse length, duty cycle, ultrasound acoustic frequency and others.

NeuroFUS™ CTX System Component Specifications

4-Channel Transducer Power Output (TPO™) Phased Amplifier• Amplifier Control System • Operating band: 0.1 to 1.0 MHz• Peak acoustic intensity output is software limited to 100 W/cm². • Housing: 35.5 x 34.5 x 19.0 cm, < 35 lbs • Font panel, includes: Treatment 'Start' and 'Stop' Switch • Touch sensitive front panel display inputs: • Frequency: 0.1 to 1.0 MHz, 10 kHz resolution• Peak Acoustic Intensity: 100 W/cm²• Pulse width: 10 usec to 100 msec• Pulse repetition rate: up to 100% duty cycle• Rear panel, includes:• System On/Off switch, power to wall 120 VAC mains• Transducer Output BNC (f) connector, 3 each• Gated External Trigger on rising edge, BNC (f)• Sync, BNC (f)• Source impedance: 50 Ohms per channel• Input power: Power supply (provided), 100 – 240 VAC, 2.3A, 47-63 Hz• USB input port for software control using SDK and Matlab example scripts available upon request, i.e. steering, frequency modulation, amplitude modulation. 0.5 MHz 4-Element Annular Array, 64.0 mm f/1.0 NeuroFUS CTX Transducer • Broadband ultrasound producing multiple power peaks across the FUS neuromodulation spectrum.• +/- 25 mm axial focal steering about geometric focal plane.• 3.0 x 21.0 mm ellipsoidal focus down -6 dB.• Axial focal distance: 30 - 80 mm from the exit plane of the transducer in 0.1 mm increments.• Cables and Connectors Include:• 2.0 meter hi-power / low loss cables for each channel.• 50 Ohm matching networks housed in an RF shielded metal enclosure for direct plug into the Transducer Power Output (TPO™) Amplifier.

NeuroFUS™ DPX System Component Specifications

64-Channel Transducer Power Output (TPO™) Phased Amplifier • Amplifier Control System• Operating band: 0.1 to 1.0 MHz• Housing: 53 x 53 x 19 cm, < 35 lbs.• Font panel, includes: Treatment 'Start' and 'Stop' Switch;• Touch sensitive front panel display Inputs: • Frequency: 0.1 to 1.0 MHz, 10 kHz resolution• Peak Acoustic Intensity: 150 W/cm² • Pulse width: 10 usec to 100 msec• Pulse repetition rate: Up to 100% duty cycle• X -Y- Z Positioning: Per transducer focal steering range, in 0.1 mm increments• Rear panel, includes:• System On/Off switch, power to wall 120 VAC mains• Transducer Output Connector for direct plug to H-314• Gated External Trigger on rising edge, BNC (f)• Sync, BNC (f)• Source impedance: 50 Ohms per channel•Input power: Power supply (provided), 100 – 240 VAC, 2.3A, 47-63 Hz• USB input port for software control using SDK and Matlab example scripts available upon request, i.e. steering, frequency modulation, amplitude modulation. 64-Element 0.5 MHz Random Array 150.0 mm f/1.0 NeuroFUS Transducer (41.0 mm I.D.)• Broadband ultrasound with multiple power peaks across FUS neuromodulation spectrum.• 3.1 x 23.1 mm ellipsoidal focus down -6 dB• +/- 28 mm axial focal steering about geometric focal plane• +/- 10.5 mm lateral (radial) focal steering about the central axis• Cables and Connectors Include:• 2.0 meter hi-power / low loss cables for each channel• 50 Ohms matching networks housed in an RF shielded metal enclosure for direct plug into the Transducer Power Output (TPO™) Amplifier.

Unprecedented Spatial Resolutions and Superior Control with NeuroFUS

Dynamic Modulation of CTX NeuroFUS Beams Enable Control of Focal Depth.

The acoustic intensity field maps illustrate software-controlled spatial modulation of NeuroFUS Beams focused at 30 mm (top right), 40 mm (bottom left), and 75 mm (bottom right) depths. Acoustic intensity data collected from a needle (1 mm) hydrophone are shown across the XZ planes of acoustic fields and displayed using a linear voltage scale.

DPX Systems Enable Dynamic 3D Spatial Control of NeuroFUS for Axial and Lateral Beam Positioning and Steering.

As shown above data examples of the beam steering capacity for DPX-64-05M NeuroFUS transducer arrays.

Our CTX and DPX NeuroFUS Systems enable users to readily conduct High Resolution (Millimeter Scale) Transcranial Focused Ultrasound Neuromodulation or Peripheral Nerve Modulation using Low-Intensity, Low-Frequency Pulsed Ultrasound. Both the CTX and DPX Systems offer user-friendly interfaces for achieving the real-time spatial modulation of NeuroFUS™ beams. Dynamic NeuroFUS™ beam modulation enables the control of acoustic power and intensity, as well as the focusing, blurring, and steering of ultrasonic neuromodulation waveforms through a USB interface. The NeuroFUS™ Commander Interface combined with conventional TTL triggering methods provide plug-and-play integration with many laboratory and clinical neurophysiological recording and stimulating devices, such as electroencephalography (EEG) and transcranial magnetic stimulation (TMS).

State-of-the-Art Neuroscience methods are electromagnetically and mechanically compatible with NeuroFUS. These compatible neurotechnology methods include: EEG, AR/VR immersion or stimulation, peripheral nerve stimulation including VNS, fNIRS, tES, tDCS, tACS, TMS, and others.

MR-compatible NeuroFUS systems are available upon request.

Investigational System. The system is not an FDA-evaluated Medical Device. The system is not intended for the treatment of any medical disorder or condition.

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Internationally Distributed in Partnership with Brainbox.

Patents: USA Patent Numbers 9403038, 8858440, and 8591419; EU EPO Patent Numbers 2310094 and EPO 2496307; China Patent Number ZL2009 8 0135241.4; Japan Patent Numbers 6061678, 5879402, and 5597198; and Israeli Patent Numbers 210642 and 219584. Other USA and International Patents Pending.

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