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CONTACTS
CONTACTS
Researcher at Istituto dei Sisitemi Complessi- Consiglio Nazionale delle Ricerche
Dipartimento Di Fisica- Università di Roma La Sapienza
Piazzale Aldo Moro 5, 00185-Rome, Italy
Fermi Building - Room 410
Interests: Microlasers, Biosensing, Random photonics, Nonlinear Optics
Highlights:
This work reports, for the first time, the ultrametric structure of the state space in random lasers, as predicted by the Parisi Ansatz. Above the lasing threshold, the increasing number of states forming isosceles triangles reveals a hierarchical organization, which can be represented by a genealogical tree. This structure also provides direct evidence of a complex energy landscape and ergodicity breaking in the glassy regime.
We developed and experimentally validated PHISA, a highly sensitive free-space microlaser biosensor for the specific, label-free detection of antigens. The sensor can detect IFN-γ concentrations as low as 10 pg mL⁻¹ in a 2 μL sample, without the need for tagging and multi-step procedures. By monitoring the laser resonance shift and its temporal growth rate, PHISA provides quantitative measurements comparable to standard ELISA assays, making it a promising platform for real-time protein monitoring and liquid biopsy applications.
We successfully use polymeric whispering gallery microlasers as biosensors for detecting small amounts of proteins, down to 400 pg. They have the advantage of working in free space without any need for waveguiding for input excitation or output signal detection. The photonic microsensors can be easily patterned on microscope slides and operate in air and solution. We estimate the limit of detection up to 148 nm/RIU for three different protein dispersions. In addition, the sensing ability of passive spherical resonators in the presence of dielectric nanoparticles that mimic proteins is described by massive ab initio numerical simulations.
We highlight the impressing experiments by Tivedi et al. on thermally reconfigurable random lasers. Janus micro-colloids act as heat reservoirs and attract titania particles due to the Soret effect. Thanks to their accumulation around patterns of "hot colloids" and under pumping programmable random laser action is nicely demonstated.
We realize flexible smart photonic labels made of doped liquid droplets encapsulated in polymeric matrix. The innovative hybrid whispering gallery and random lasing emission offers a multitude of spectroscopic encoding schemes for the realization of photonic barcodes and labels to be employed in anticounterfeiting applications and multiplexed bioassays.
Statistical mechanics analysis of fluorescence imaging provides new insights into the complex entrapment of light in disordered heterostructures. Heterogeneous random lasers made of ribbon-like and highly porous fibers show laser action from separated micrometric domains that alternatively switch on and off by tuning the pumping light intensity.
We demonstrate that the configuration of random laser lines is uniquely dependent on the structure of porous materials at micrometric scale. Differently from other spectroscopic techniques that provide mainly and accurately the chemical composition, RL spectra can be used to identify the micro- scopic structure and the aggregation state of the compounds.
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