PUBLICATIONS 

Refereed Journal Publications 

35. Kyle J. Hackney, Vidura Jayasooriya , Nathaniel Johnson , Adam Bradley, Christopher Kotarsky , Lizzy Jepng’etich , Daniel Friesner , Sherri Stastny1 , and Dharmakeerthi Nawarathna, c-miRs 140 and 935 are associated with fat loss with 6 weeks of diet and exercise, 2022, sensors

34.  Velmanickam, L., Jayasooriya, V., Madhava. V., Tida, U.R., Nawarathna, D., Recent Advances in Dielectrophoresis Toward Biomarker Detection: A Summary of Studies Published between 2014 and 2021, Electrophoresis, 2021, In-press

33. V. D. Jayasooriya, B. Ringwelski, G. Dorsam and D. Nawarathna, mRNA-based CAR T-cells Manufactured by Miniaturized Two-step Electroporation Produce Selective Cytotoxicity Toward Target Cancer Cells, Lab Chip, 2021, DOI: 10.1039/D1LC00219H.  

32. Velmanickam, L., Jayasooriya V., and  Nawarathna, D.  (2021), Integrated Dielectrophoretic and Impedimetric Biosensor Provides a Template for Universal Biomarker Sensing in Clinical Samples, Electrophoresis, 42(9-10), 1060-1069.

31. Ringwelski, B., Jayasooriya, V., and Nawarathna, D., (2020), Dielectrophoretic High Purity Isolation of Primary T-cells in Samples Contaminated with Leukemia Cells, for Biomanufacturing of Therapeutic CAR T-cells, Journal  of  Physics D: Applied Physics, 54(6), pp.065402

30. Oh, M., Jayasooriya V., Woo, S. O., Nawarathna D., and Choi Y., (2020). Selective Manipulation of Biomolecules with Insulator-Based Dielectrophoretic Tweezers. ACS Applied Nano Materials, 3(1), pp.797-805

29. Gudagunti, F.D., Velmanickam, L., Nawarathna, D. and Lima Jr, I.T., (2020). Nucleotide Identification in DNA Using Dielectrophoresis Spectroscopy. Micromachines, 11(1), p.39

28. Gudagunti, F.D., Jayasooriya, V., Afrose, S., Nawarathna, D. and Lima Jr, I.T., (2019). Biosensor for the Characterization of Gene Expression in Cells. Chemosensors, 7(4), p.60.

27. Jayasooriya, V. and Nawarathna, D., (2019). Label-free purification of viable human T-lymphocyte cells from a mixture of viable and non-viable cells after transfection by electroporation. Journal of Physics D: Applied Physics, 52, 36LT01 (7pp)

26. Velmanickam, M. Baines, M. Fondakowski, G. Dorsam and D. Nawarathna, (2018). iLluminate-miRNA: Paradigm for high-throughput, low-cost, and sensitive miRNA detection in serum samples at point-of-care, Journal of Physics D., 52 (5), pp. 055401

25. Dackson Gudagunti, F.; Velmanickam, L.; Nawarathna, D.; Lima, I.T., Jr., (2018), Label-Free Biosensing Method for the Detection of a Pancreatic Cancer Biomarker Based on Dielectrophoresis Spectroscopy. Chemosensors, 6, pp.33. 

24. Vemlanickam L., Fondakowski M. and Nawarathna D. (2018), "Integrated dielectrophoretic and fluorescence based biomarker protein detection and quantification", Journal of Biomedical Physics and Engineering Express, 4(2), pp.025018.

23. Velmanickam L., Fondakowski M., Lima Jr. I.T., Nawarathna D., (2017), “Integrated dielectrophoretic and surface plasmonic platform for million-fold improvement in the detection of fluorescent events”, Biomicrofluidics, pp. 044115.

22. Froberg J., Jayasooriya V., You S., Nawarathna D., and Choi Y., (2017), "Quantitative measurements of dielectrophoresis in a nanoscale electrode array with an atomic force microscopy", Applied physics letters, pp. 203701.

21. Kirmani, S.A.M., Gudagunti, F.D., Velmanickam, L., Nawarathna, D. and Lima, I.T., (2017), Negative dielectrophoresis spectroscopy for rare analyte quantification in biological samples, 2017, Journal of Biomedical Optics, 22(3), pp. 037006-037006.

20. Velmanickam L. and Nawarathna D., (2017), “Design & fabrication of a dielectrophoretic cell trap array”, Advances in Science, Technology and Engineering Systems Journal, 2(1), pp. 84-89.

19. Velmanickam L., Laudenbach D. and Nawarathna D., (2016), “Dielectrophoretic label-free immunoassay for rare-analyte quantification in biological samples”, Physical Review E, vol. 94, pp.042408. 

18. Jayasooriya, V. and Nawarathna, D., (2016), Design of Micro-interdigitated Electrodes and Detailed Impedance Data Analysis for Label-free Biomarker Quantification. Electro analysis, pp. 201600364.

17. Shuja, S., Srinivasan, S.K., Jabeen, S. and Nawarathna, D., (2015), A formal verification methodology for DDD mode pacemaker control programs. Journal of Electrical and Computer Engineering, 2015, pp.57.

16. D. Nawarathna et al., (2013), Shrink-Induced Microfluidic Sorting using Integrated Nanoscale Magnetic Traps, Applied Physics Letters, 102(6), pp.63504-4

15. D. Nawarathna, R. Chang, E. Nelson and H. Kumar Wickramasinghe, (2010) Targeted mRNA Profiling of Transfected Breast Cancer Gene in a Living Cell, Analytical Biochemistry, 408(2), pp. 342-344

14. D. Nawarathna, T. Turan and H. Kumar Wickramasinghe, (2009), selective probing of mRNA expression levels within single living cell, Applied Physics Letters, 95(8), pp.083117-3  

13. D. Nawarathna, K. Unal and H. Kumar Wickramasinghe, (2008), Localized electroporation and molecular delivery into single living cells by atomic force microscopy, Applied Physics Letters, 93(15), pp. 153111-3

12. M.S. Pommer, Y. Zhang, Nawarathna Keerthi, D. Chen, J. A. Thomsom, C. Meinhart and H. T. Soh, (2008), Dielectrophoretic Separation of Platelets from Diluted Whole Blood in Microfluidic Channels, Electrophoresis, 29, pp. 1213-1218

11. D. Nawarathna, J.R. Claycomb, G. Cardenas, V. Vajrala, D.Warmflash, J. Gardner, W. R. Widger and J.H. Miller Jr. (2006), SQUID-base biosensor for probing ion transporters in cell suspensions and tissue, IEEE Transactions on Applied Superconductivity, 17 (2), pp. 812- 815

10. D. Nawarathna, J.H. Miller Jr., J.R. Claycomb, G. Cardenas and D. Warmflash, (2006), Harmonic generation by yeast cells in response to low frequency electric fields, Physical Review E, 73, pp. 051914

9. K.S. Martirosyan, D. Nawarathna, J.H. Miller Jr., and D. Luss, (2006), Complex dielectric behavior during the formation of BaTiO3 by combustion synthesis, Journal of Physics D: Applied Physics, 39, pp. 3689-3694

8. D. Nawarathna, J.H. Miller Jr., J.R. Claycomb, G. Cardenas and D. Warmflash, (2005), Harmonic response of cellular memebrane pumps to low frequency electric fields, Physical Review Letters, 95, pp. 158103- 158107

7. D. Nawarathna, J. R.Claycomb, J. H. Miller and M. J. Benedik, (2005), Nonlinear dielectric spectroscopy of live cells using superconducting quantum interference device, Applied Physics Letters, 86, (1), pp. 023902-023905

6. V. Vajrala, D. Nawarathna, J. R. Claycomb and J.H. Miller Jr., (2005) high-Tc SQUID-Based Impedance Magnetocardiography, IEEE Transactions on Applied Superconductivity, 15(2), pp. 679-683

5. J.R. Claycomb, D. Nawarathna, V. Vajrala and J.H. Miller Jr., (2005), Power law behavior in chemical reactions, Journal of Chemical Physics, 122(1), pp. 12428-12430

4. J.H. Miller Jr., D. Nawarathna, V. Vajrala, G. Gardner and W. Widger, (2005), Electromagnetic probes of molecular motors in the electron transport chains of mitochondria and chloroplasts, Journal of Physics, IV, 131, pp. 363-366

3. J.H. Miller Jr., D. Nawarathna, D. Warmflash, F. Pereira and W. Brownell, (2005), Dielectric Properties of Yeast Cells Expressed With the Motor Protein Prestin, Journal of Biological Physics, 31(3-4), pp. 465-475

2. J. R. Claycomb, V. Vajrala, D. Nawarathna and J. H. Miller Jr, (2004), Impedance Magnetocardiography Experiments and Modeling, Journal of Applied Physics, 96(12), pp. 7650-7654

1. J.R. Claycomb, C. Prodan, D. Nawarathna and J.H. Miller Jr., (2002), Nonlinear dielectric spectroscopy of living cell suspensions, IEEE Transactions on Biomedical Engineering Proceedings, 2, pp. 1669-1670

 Refereed Conference Proceeding Papers (selected)

53. S. Lakshan and D. Nawarathna, Label-free Biomarker Detection Using Dielectrophoresis and Localized Surface Plasmonic Resonance, 2022, IEEE Research and Applications of Photonics in Defense Conference (RAPID), Miramar Beach, FL, USA, 2022  

52.  L. Velmanickam, D. Chang, G. Ganepola and D. Nawarathna, Low-cost and Rapid micro-RNA Assay for Identification of Pancreatic Cancer, 2021, IEEE Research and Applications of Photonics in Defense Conference (RAPID), Miramar Beach, FL, USA, 2021.   

51.  K. Nellermoe, S. Lakshan and D. Nawarathna, 2021,  Integrated Dielectrophoresis and Fluorescence Enhancement for Detection of Biomarker Molecules, MicroTAS -2021. 

50. K. Nellermoe and D. Nawarathna, (2020), “AC Electric Fields Enhance The Intensity of Fluorophore Molecules”, Annual Conference of Sustainable Nanotechnology Organization (virtual conference), 11/12 -11/13.

49. V. Jayasooriya et al., "MiRNA Testing to Identify Candidates for Individualized Weight Loss," 2020 IEEE Research and Applications of Photonics in Defense Conference (RAPID), Miramar Beach, FL, USA, 2020, pp. 1-2, doi: 10.1109/RAPID49481.2020.9195688.

48. L. Velmanickam, V. Jayasooriya, M. S. Vemuri, U. R. Tida and D. Nawarathna, "Universal Biosensor for Multiple Biomarker Detection for Medical Applications," 2020 IEEE Research and Applications of Photonics in Defense Conference (RAPID), Miramar Beach, FL, USA, 2020, pp. 1-2, doi: 10.1109/RAPID49481.2020.9195702.

47. F. D. Gudagunti, P. Mulinti, S. G. Gundlakunta, D. Nawarathna, A. E. Brooks and I. T. Lima, "Dielectrophoresis Based Sensor for Heparin Detection," 2020 IEEE Research and Applications of Photonics in Defense Conference (RAPID), Miramar Beach, FL, USA, 2020, pp. 1-2, doi: 10.1109/RAPID49481.2020.9195677.

46. L. Velmanickam, I. T. Lima and D. Nawarathna, "Achieving over million-fold fluorescence enhancement for biosensing applications," 2020 IEEE Research and Applications of Photonics in Defense Conference (RAPID), Miramar Beach, FL, USA, 2020, pp. 1-2, doi: 10.1109/RAPID49481.2020.9195707.

45.  Velmanickam, L., Pokharel, R., Lima, I., and Nawarathna, D.,  Label free microRNA biomarker detection in serum samples for diagnosis applications at point-of care, IEEE RAPID virtual conference, 2020 (accepted).   

44. Fleming Gudatunti, Sharmin Afrose, Julian Thrash, Dharmakeerthi Nawarathna, and  Ivan Lima, " Quantification of Pancreatic Cancer Antigen CA 242 Using Dielectrophoresis", 2019, Annual Biomedical Engineering Society meeting (accepted). 

43. Rounak Pokharel, Logeeshan Velmanickam and Dharmakeerthi Nawarathna, "MicroRNA biomarker detection in serum samples for potential diagnosis applications at point-of-care settings", 2019,  Annual Biomedical Engineering Society meeting (accepted).

42. Beth Ringwelski, Vidura Jayasooriya, and Dharmakeerthi Nawarathna, "Label-free Cell Purification after Electroporation",  2019,  Annual Biomedical Engineering Society meeting (accepted).

41. Vidura Jayasooriya and Dharmakeerthi Nawarathna, "Miniaturized Device for Engineering Safe CAR T-cells for Immunotherapy", 2019,  Annual Biomedical Engineering Society meeting (accepted).

40. Gudagunti F. D., Velmanickam L., Thrash III  J. E., Nawarathna D., and Lima Jr. I. T.,“Accurate method to measure concentration of CA 19-9 using dielectrophoresis”, 55thAnnual Rocky Mountain Biengineering Symposium, An International Society of Automation Symposium, Fargo, North Dakota, USA, April 13-14, 2018.

39. Gudagunti F. D., Velmanickam L., Nawarathna D., and Lima Jr. I. T., “Spectroscopy Method for the Quantification of Pancreatic Cancer Antigen in Serum Using Dielectrophoresis” 2018 Biomedical Engineering Society Annual Meeting (BMES 2018), Georgia, Atlanta, USA, October 17-20, 2018.

38. Velmanickam L., Bains M., Dorsam G.P. and Nawarathna D., “Target miRNA detection in serum samples at point-of-care settings”, 2018 Biomedical Engineering Society Annual Meeting (BMES 2018), Georgia, Atlanta, USA, October 17-20, 2018.

37. Velmanickam L., Fondakowski M., Lima Jr. I.T., Nawarathna D., “High sensitive integrated dielectrophoretic and LSPR sensor for biomarker detection” 2018 Biomedical Engineering Society Annual Meeting (BMES 2018), Georgia, Atlanta, USA, October 17-20, 2018.

36. Logeeshan Velmanickam ; Dharmakeerthi Nawarathna, High Throughput and Low-Cost Detection of Short Nucleic Acid Biomarkers in Serum using Dielectrophoretic Biosensor, 2018 IEEE Research and Applications of Photonics In Defense Conference (RAPID), 1-3.

35. Vidura Jayasooriya ; Dharmakeerthi Nawarathna, Interdigitated Micro Electrode Array Dielectrophoretic System for Label-free Multi-Parameter-based Cell Detection, 2018 IEEE Research and Applications of Photonics In Defense Conference (RAPID), 1-4.

34. Fleming Dackson Gudagunti ; Logeeshan Velmanickam ; Dharmakeerthi Nawarathna ; Ivan T. Lima, Biosensor for Pancreatic Cancer Biomarker Based on Dielectrophoresis and Image Processing, 2018 IEEE Research and Applications of Photonics In Defense Conference (RAPID), 1-2.

33. Sharma, S., Can, O.T., Hammed, M., Nawarathna, D. and Simsek, H., 2018, March. Organic pollutant removal from edible oil process wastewater using electrocoagulation. In IOP Conference Series: Earth and Environmental Science (Vol. 142, No. 1, p. 012079). IOP Publishing.  

32. Vidura Jayasooriya and Dharmakeerthi Nawarathna, Simulation of molecular transport in an electroporated cell using COMSOL Multiphysics, Annual Comsol conference, Boston, MA, 2017

31.  Velmanickam L., Fondakowski M., and Nawarathna D., “Detection of DNA molecules at point-of-care settings without PCR”, Biomedical Engineering Conference, Phoenix, AZ, 2017

30. Logeeshan Velmanickam and Dharmakeerthi Nawarathna, “Design of a Biosensor Using COMSOL Multiphysics® for Cancer Detection”, Annual Comsol conference, Boston, MA, 2017 

29. Velmanickam L., Fondakowski M., and Nawarathna D., “Detecting antigens in biological samples without ELISA” Biomedical Engineering Conference, Phoenix, AZ, 2017 

28. Vidura Jayasooriya and Dharmakeerthi Nawarathna, Simulation of molecular transport in an electroporated cell using COMSOL Multiphysics, Annual Comsol conference, Boston, MA, 2017 

27. Velmanickam L., Fondakowski M., and Nawarathna D. "Detection of extremely low level of bio-markers by utilizing integrated dielectrophoretic and surface plasmonic platform" IEEE Red River Valley Conference & Poster Competition, Fargo, ND USA, 2017.

26.  Gudagunti F.D., Velmanickam L., Kirmani S. A .M, Nawarathna D., Lima  I.T. Jr.  "Negative Dielectrophoresis Spectroscopy for Detecting and Quantification of Rare Molecules in Biological Samples" IEEE Red River Valley Conference & Poster Competition, Fargo, ND USA, 2017.

25.  Velmanickam L., and Nawarathna D., “Dielectrophoretic cell isolation in microfluidics channels for high-throughput biomedical applications”, IEEE International Conference on Electro Information Technology (EIT), Grand folks, ND, USA, 2016. 

24.   Velmanickam L. and Nawarathna D., “Design of Dielectrophoretic Cell Traps in Microfluidics Devices Using Comsol Multiphysics® Software” COMSOL Conference in Boston, 2016. 

23.  Kirmani S.A.M., Velmanickam L., Nawarathna D., Sherif S.S. and Lima Jr. I.T., “ Simulation of Diffuse Optical Tomography using COMSOL Multiphysics®”, COMSOL Conference in Boston, 2016. 

22. Lima Jr. I.T., Velmanickam L., Fondakowski M. and Nawarathna D., “Quantification of Fluorescence Enhancement Due to Dielectrophoresis and Plasmonic Effect Using Time-Resolved Fluorescence”, Frontiers in Optics Conference, 2016. 

21.   Kirmani S.A.M., Gudagunti F.D., Velmanickam L., Nawarathna D., and Lima Jr. I.T., “Dielectrophoretic Spectroscopy Using a Microscopic Electrode Array” Photonics West Conference, 2017. 

20.  Velmanickam L., Fondakowski M., Lima Jr. I.T., and Nawarathna D., “ Rare Biomarker Quantification Through Integrated Dielectrophoretic and Plasmonic Based Fluorescence Enhancement”, Biomedical Engineering Society Conference, Minneapolis, USA, 2016.

19.  Denielle D., Vidura J., Velmanickam L., and Nawarathna D., “Single Stranded DNA Separation using Dielectrophoresis”, ND EPSCoR Regional Conference, Grand folks, ND, USA, 2016.

18.   Velmanickam L. and Nawarathna D., “Dielectrophoretic cell isolation in microfluidics channels for high-throughput biomedical applications”, IEEE International Conference on Electro Information Technology (EIT), Grand folks, ND, USA, 2016. 

17.  Velmanickam L., Fondakowski M., Ivan T.L.Jr. and Nawarathna D., “ Rare Biomarker Quantification Through Integrated Dielectrophoretic and Plasmonic Based Fluorescence Enhancement”, Biomedical Engineering Society Conference, Minneapolis, USA, 2016.

16.  Danielson D., Velmanickam L., Jayasooriya V. and Nawarathna D., “Single Stranded DNA Separation using Dielectrophoresis”, ND EPSCoR Regional Conference, Grand folks, ND, USA, 2016.

15. D.Nawarathna, K. Unal and H. Kumar Wickramasinghe, 2008, Localized electroporation and molecular delivery into single living cells by atomic force microscopy, Virtual Journal of Biological Physics Research, Vol.  16, Issue 8

14. G. Cardenas, D. Nawarathna, J. Fang, S.Y. Hsu, J. Gardner, S. Maric, V. Vajrala, W. R. Widger and J. H. Miller, 2007, Electromagnetic assays of enzymatic activity in live cells, Biophysical Journal, 142A-142A

13. Claycomb, J.R., Nawarathna, D., Cardenas, G., Vajrala, V., Gardner, J., Widger, W.R., and Miller, Jr., J.H., 2007, Harmonic generation by ion transporters in cell membranes. 24th Annual Houston Conference on Biomedical Engineering Research, Houston Society for Engineering in Medicine and Biology (HSEMB-2007), Houston, TX

12. Miller, Jr., J. H., Cardenas, G., Fang, J., Vajrala, V., Maric, S., Nawarathna, D., Gardner, J., Widger, W.R., and Claycomb, J.R, 2007, Noninvasive sensors of bioenergetic processes. 24th Annual Houston Conference on Biomedical Engineering Research, Houston Society for Engineering in Medicine and Biology (HSEMB-2007), Houston, TX

11. Miller, Jr., J.H., Nawarathna, D., Gardner, J., Cardenas, G., Claycomb, J.R., and Widger, W.R, 2006, Electromagnetic probing of mitochondria and chloroplasts reveals unique harmonics due to specific components of the electron transport chain, Gordon Conference on Molecular and Cellular Bioenergetics, Proctor Academy, Andover, NH

10. J. H. Miller, Jr., D. Nawarathna, H. Sanabria, V. Vajrala, and J. R. Claycomb, 2006,Nonlinear Harmonic Responses of Live Cells Using High-Tc Superconducting Quantum Interference Devices, AIP Conference Proceedings, 850, 1685-1686

9. J. H. Miller Jr., D. Warmflash, D. Nawarathna, J. Gardner, G. Cardenas and W. R. Widger, 2006, Low-frequency electromagnetic probes of live organisms, American Geophysical Union Spring Meeting, 87(36), NS34A-02(Invited) 

8. D.Nawarathna, J.R.Claycomb, H. Sanabria, D. Warmflash and J.H.Miller, 2005, High frequency non-linear dielectric spectroscopy of eukaryotic cells, Biophysical Journal, 88(1), 590A-590A

7.  H. Sanabria, D. Nawarathna, A. Mershin, J.H. Miller, D.V. Nanopoulos, 2005, Dielectric spectroscopy of live cells and proteins, Biophysical Journal, 88(1), 171A-171A  

6.   D.Nawarathna, J.R.Claycomb, J.H.Miller and M.J.Benedik, 2005, Non-linear dielectric spectroscopy of live cells using superconducting quantum interference device, Virtual Journal of Biological Physics Research, Vol. 9, Issue 2

5.   D.Nawarathna, J.R.Claycomb, J.H.Miller and M.J.Benedik, 2005, Non-linear dielectric spectroscopy of live cells using superconducting quantum interference device, Virtual Journal of Applications of Superconductivity, Vol. 8, Issue 2

4.   J. H. Miller Jr., W.R. Widger, D. Nawarathna, 2005, Electromagnetic probes of biological molecular motors, Institute for Space Systems Operation Y2005 Annual Report, 75

3.   J.H. Miller Jr., J. Wosik, D.S. McKay, J. A. Jones, F. Karouia, D. Warmflash and D. Nawarathna, 2005, Martial soil biosensors based on dielectric spectroscopy, Institute for Space Systems Operation Y2005 Report, 33

2. D. Nawarathna, J. R. Claycomb, and J. H. Miller, Jr., 2004 Electrical impedance spectroscopy of biological cells,  Bulletin of  the American  Physical Society 49, 451

1. V. Vajrala, D. Nawarathna, J. R. Claycomb, and J. H. Miller, Jr. Nested sphere model for SQUID-based impedance magnetocardiography, 2004, Bulletin of the American Physical Society 49,1128 

 Patent Applications and Invention Disclosures 

•  2 US Patent applications (biomanufacturing and molecular sensing) 

•  2 Inventor Disclosures 

Issued US Patents

(1) D.Nawarathna and H. Kumar Wickramasinghe, Quantitative analysis of mRNA and protein expression levels within single cells, US20120131703A1, US patent pending

(2) D.Nawarathna, K.Unal and H.Kumar Wickramasinghe, A device for localized electroporation of single cells, University of California Irvine, 2008, Invention disclosure 

(3) S.H. Oh, A.K. Singh, D. Nawarathna, U.Kim, B.S.Ferguson, P.Daugherty and H.T.Soh, Continuous flow microfluidic magnetic separation device, 2006, US patent numbers 7,807,454 and 8,071,054

Books

(1) J. Froberg, M. Oh, V. Jayasooriya, D. Nawarathna, and Y. Choi, (2018), Atomic Force Microscopy in Dielectrophoresis Applications: Principles, Developments and Applications, Nova Publishers, pp. 21-46.

(2) A.Mershin, H.Sanabria, J.H Miller Jr., D.Nawarathna et al, 2005, Towards Experimental Tests of Quantum Effects in Cytoskeletal Proteins, The Emerging Physics of Consciousness, chapter12

(3) D. Nawarathna, 2005, Nonlinear electromagnetic responses of active protein complexes in living cells and organelles, PhD Thesis, University of Houston, Houston, TX 

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