Publications

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2026

Split prism-assisted optical aptasensor for ultrasensitive and reliable detection of SARS-CoV-2

Hyun Mo Cho, Won Chegal, Sae Chae Jeoung, Jung Hyun Choi, Jiyoon Bu*, Dong Hyung Kim*

Sensors and Actuators B: Chemical 2026, 430, 139185

Synovial Exosomal Type II Collagen as a Biomarker for Osteoarthritis Progression: From Molecular Evaluation to AI-Powered SERS-based Diagnosis

Dongjun Shin†, Jung Hyun Choi†, Myeong Jin Jeon†, Sunwoo Hong, Hosu Lee, Samuel Jaeyoon Won, Dong Hyung Kim, Jiyoon Bu*, Dong Jin Ryu*, Jong Uk Lee*

Biosensors & Bioelectronics 2026, 293, 118180

2025

Ultrasensitive Detection of PD-L1-Expressing Extracellular Vesicles via Reflection-Mediated Ellipsometry: From Nanoscale Optical Modeling to Immunotherapy Response Prediction

Jung Hyun Choi†, Hyun Mo Cho†, Jun Hyeok Lim†, Wook Choi, Dongjun Shin, Chae Yeon Son, Hyun Sung Park, Sunwoo Hong, Lucia Kim, Il Doh, Jiyoon Bu*, Dong Hyung Kim*

Small 2025, Online ahead of print, e07372

Aptamer-Engineered Ellipsometry for Clinical Detection of BALF-Derived Exosomes: Multi-level Engineering for Prognostic Evaluation of Immunotherapy Responses
Euna Jeong†, Jung Hyun Choi†, Minyoung Lee†, Jun Hyoek Lim†, Seokho Jung, Yeeun Woo, Joo-young Kim, Jaehyeon Ok, Lucia Kim, Woo-jin Jeong, Won Chegal, Hyun Mo Cho, Chulhwan Park, Jiyoon Bu*, Dong Hyung Kim*, Taek Lee*

Advanced Science 2025, Online ahead of print, e15247

Development of a high-sensitivity interleukin-6 biosensor by combining nanobody engineering and solution-immersed silicon ellipsometry
Chandana S. Talwar†, Jung Hyun Choi†, Salsabilla Izzah Nurheibah, Kwang-Hyun Park, Woo-Chan Ahn, Seong-Ryeong Go, Jin Young Kim, ChaeHo Shin, Jiyoon Bu, Dong Hyung Kim*, Eui-Jeon Woo*

Chemical Engineering Journal 2025, 525, 170017

Cell-Free DNA Versus Circulating Tumor Cells: A Pilot Study of Alpha-Fetoprotein Analysis for Diagnosis and Treatment Monitoring in Hepatocellular Carcinoma
Ga Young Moon†, Hyun Sung Park†, Ha Neul Kim†, Hei-Gwon Choi, Yonghan Han, Hyuk Soo Eun*, Tae Hee Lee*, Jiyoon Bu*

Biosensors 2025, 15, 579

In silico fragment-based peptide design targeting undruggable proteins for enhanced detection of circulating tumor cells
Joo-young Kim†, Hyun Sung Park†, Hanbit Kang†, Chae Yeon Son, Ha Kyeong Kim, Jung Hyun Choi, Lucia Kim, Sung chan Choi, Yongju Kim, Seungpyo Hong, Dong Hyung Kim, Jun Hyeok Lim, Jiyoon Bu*, Woo-jin Jeong*

Chemical Engineering Journal 2025, 522, 167447

Avidity‐Based Capture of PD‐L1‐Expressing Exosomes via Dendrimer–Peptide Conjugates: A Nanoengineered Platform for Enhanced Prediction of Immunotherapy Response
Jiah Lee†, Dongjun Shin†, Chae Yeon Son†, Hanbit Kang†, Jung Hyun Choi, Hyun Sung Park, Seha Bang, Lucia Kim, Tae Hee Lee, Hyuk Soo Eun, Michael J Poellmann, Woo-jin Jeong*, Dong Hyung Kim*, Jun Hyeok Lim*, Seungpyo Hong*, Jiyoon Bu*

Advanced Science 2025, 12, e09270

Liquid biopsy for cancer immunotherapy: Biomarkers to predict and monitor response upon immune checkpoint blockade

Chae Yeon Son†, Deborah Lee†, Hyun Sung Park, Jung Hyun Choi, Dong Hyung Kim, Il Doh, Lifeng Kang, Jiyoon Bu*, Sun Min Kim*, Tae-Joon Jeon*

Coordination Chemistry Reviews 2025, 539, 216767

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Mohit J Mehta†, Dongjun Shin†, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim*, Seungpyo Hong*, Jiyoon Bu*

Small Methods 2025, 9, 2402058

Dual Biomarker Strategies for Liquid Biopsy: Integrating Circulating Tumor Cells and Circulating Tumor DNA for Enhanced Tumor Monitoring
Ga Young Moon†, Basak Dalkiran†, Hyun Sung Park†, Dongjun Shin, Chaeyeon Son, Jung Hyun Choi, Seha Bang, Hosu Lee, Il Doh, Dong Hyung Kim, Woo-jin Jeong*, Jiyoon Bu*

Biosensors 2025, 15, 74

2024

Carcinoembryonic antigen-positive circulating epithelial cells as a biomarker for the diagnosis and prognosis of colorectal cancer
Hong Jae Jeon†, Jin hyuk Seo†, Euna Jeong†, Chae Yeon Son†, Piper A Rawding, Yuri Hwang, Seha Bang, Tae min Jang, Luke J Kubiatowicz, Sung Hee Hyun, Seungpyo Hong, Ik-Chan Song, Tae Hee Lee, Jiyoon Bu*, Hyuk Soo Eun*

Biotechnology and Bioprocess Engineering 2024, 29, 877

Programmed Death 1 and Cytotoxic T-Lymphocyte-Associated Protein 4 Gene Expression in Peripheral Blood Mononuclear Cells Can Serve as Prognostic Biomarkers for Hepatocellular Carcinoma
Ji Ah Lee†, Hei-Gwon Choi†, Hyuk Soo Eun, Jiyoon Bu, Tae Min Jang, Jeongdong Lee, Chae Yeon Son, Min Seok Kim, Woo Sun Rou, Seok Hyun Kim, Byung Seok Lee, Ha Neul Kim, Tae Hee Lee, Hong Jae Jeon

Cancers 2024, 16, 1493

2023

Prospective characterization of circulating tumor cell kinetics in patients with oligometastatic disease receiving definitive intent radiation therapy
Shivani Sud, Michael J Poellmann, Jacob Hall, Xianming Tan, Jiyoon Bu, Ja Hye Myung, Andrew Z Wang, Seungpyo Hong, Dana L Casey*

JCO Precision Oncology 2023, 7, e2300303

Circulating tumor cell abundance in head and neck squamous cell carcinoma decreases with successful chemoradiation and cetuximab treatment
Michael J Poellmann, Jiyoon Bu, DaWon Kim, Mari Iida, Heejoo Hong, Andrew Z Wang, Deric L Wheeler, Randall J Kimple, Seungpyo Hong*

Cancer letters 2023, 562, 216187

A high-sensitivity cfDNA capture enables to detect the BRAF V600E mutation in papillary thyroid carcinoma
Tae Hee Lee†, Hong Jae Jeon†, Jung Hyun Choi†, Young Jun Kim, Pil-Neo Hwangbo, Hyun Sung Park, Chae Yeon Son, Hei-Gwon Choi, Ha Neul Kim, Jae Won Chang, Jiyoon Bu*, Hyuk Soo Eun*

Korean Journal of Chemical Engineering 2023, 40, 429

Nanotechnology and machine learning enable circulating tumor cells as a reliable biomarker for radiotherapy responses of gastrointestinal cancer patients
Michael J Poellmann, Jiyoon Bu, Stanley Liu, Andrew Z Wang, Steven N Seyedin, Chandrikha Chandrasekharan, Heejoo Hong, YoungSoo Kim, Joseph M Caster, Seungpyo Hong

Biosensors and Bioelectronics 2023, 226, 115117

Recent advances in microfluidic approaches for the isolation and detection of exosomes
Krishan Kumar, Eunsu Kim, Munirah Alhammadi, Umapathi Reddicherla, Sheik Aliya, Jitendra N Tiwari, Hyun Sung Park, Jung Hyun Choi, Chae Yeon Son, AT Ezhil Vilian, Young-Kyu Han, Jiyoon Bu*, Yun Suk Huh*

TrAC Trends in Analytical Chemistry 2023, 159, 116912

2022

Dendrimer-peptide conjugates for effective blockade of the interactions between SARS-CoV-2 spike protein and human ACE2 receptor
Woo-jin Jeong†, Jiyoon Bu†, Philip Mickel, Yanxiao Han, Piper A Rawding, Jianxin Wang, Hanbit Kang, Heejoo Hong, Petr Král, Seungpyo Hong

Biomacromolecules 2022, 24, 141

Bimodal liquid biopsy for cancer immunotherapy based on peptide engineering and nanoscale analysis
Jiyoon Bu†, Woo-jin Jeong†, Roya Jafari, Luke J Kubiatowicz, Ashita Nair, Michael J Poellmann, Rachel S Hong, Elizabeth W Liu, Randall H Owen, Piper A Rawding, Caroline M Hopkins, DaWon Kim, Daniel J George, Andrew J Armstrong, Petr Král, Andrew Z Wang, Justine Bruce, Tian Zhang, Randall J Kimple, Seungpyo Hong*

Biosensors and Bioelectronics 2022, 213, 114445

Machine-Learning-Based Clinical Biomarker Using Cell-Free DNA for Hepatocellular Carcinoma (HCC)
Taehee Lee†, Piper A Rawding†, Jiyoon Bu†, Sunghee Hyun, Woosun Rou, Hongjae Jeon, Seokhyun Kim, Byungseok Lee, Luke J Kubiatowicz, Dawon Kim, Seungpyo Hong*, Hyuksoo Eun*

Cancers 2022, 14, 2061

Branched, dendritic, and hyperbranched polymers in liquid biopsy device design
Michael J Poellmann, Piper Rawding, DaWon Kim, Jiyoon Bu, YoungSoo Kim, Seungpyo Hong*

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2022, 14, e1770

Dendrimers for cancer immunotherapy: Avidity‐based drug delivery vehicles for effective anti‐tumor immune response
Piper A Rawding†, Jiyoon Bu†, Jianxin Wang, Da Won Kim, Adam J Drelich, Youngsoo Kim, Seungpyo Hong*

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2022, 14, e1752

Hierarchically Multivalent Peptide–Nanoparticle Architectures: A Systematic Approach to Engineer Surface Adhesion
Woo‐jin Jeong†, Jiyoon Bu†, Roya Jafari, Pavel Rehak, Luke J Kubiatowicz, Adam J Drelich, Randall H Owen, Ashita Nair, Piper A Rawding, Michael J Poellmann, Caroline M Hopkins, Petr Král, Seungpyo Hong*

Advanced Science 2022, 9, 2103098

Cytochalasin B Treatment and Osmotic Pressure Enhance the Production of Extracellular Vesicles (EVs) with Improved Drug Loading Capacity
Ashita Nair†, Jiyoon Bu†, Piper A Rawding, Steven C Do, Hangpeng Li, Seungpyo Hong*

Nanomaterials 2022, 12, 3

~2021

Chemically and biologically engineered bacteria‐based delivery systems for emerging diagnosis and advanced therapy
Zhaoting Li, Yixin Wang, Jun Liu, Piper Rawding, Jiyoon Bu, Seungpyo Hong, Quanyin Hu*

Advanced Materials 2021, 33, 2102580

Tri‐modal liquid biopsy: Combinational analysis of circulating tumor cells, exosomes, and cell‐free DNA using machine learning algorithm
Jiyoon Bu†, Tae Hee Lee†, Michael J Poellmann, Piper A Rawding, Woo‐Jin Jeong, Rachel S Hong, Sung Hee Hyun, Hyuk Soo Eun, Seungpyo Hong*

Clinical and Translational Medicine 2021, 11 (8), e499

Size-dependent drug loading, gene complexation, cell uptake, and transfection of a novel dendron-lipid nanoparticle for drug/gene co-delivery
Ashita Nair†, Jiyoon Bu†, Jason Bugno, Piper A Rawding, Luke J Kubiatowicz, Woo-jin Jeong, Seungpyo Hong

Biomacromolecules 2021, 22, 3746

Enhanced detection of cell-free DNA (cfDNA) enables its use as a reliable biomarker for diagnosis and prognosis of gastric cancer
Jiyoon Bu, Tae Hee Lee, Woo-jin Jeong, Michael J Poellmann, Kara Mudd, Hyuk Soo Eun, Elizabeth W Liu, Seungpyo Hong, Sung Hee Hyun

PLoS One 2020, 15, e0242145

Viable and high-throughput isolation of heterogeneous circulating tumor cells using tapered-slit filters
Jae-Eul Shim, Jiyoon Bu, Mi-Kyung Lee, Young-Ho Cho, Tae-Ha Kim, Jong-Uk Bu, Sae-Won Han, Young-Ho Cho*

Sensors and Actuators B: Chemical 2020, 321, 128369

Surface engineering for efficient capture of circulating tumor cells in renal cell carcinoma: From nanoscale analysis to clinical application
Jiyoon Bu, Ashita Nair, Luke J Kubiatowicz, Michael J Poellmann, Woo-jin Jeong, Marco Reyes-Martinez, Andrew J Armstrong, Daniel J George, Andrew Z Wang, Tian Zhang, Seungpyo Hong*

Biosensors and Bioelectronics 2020, 162, 112250

An Avidity-based PD-L1 Antagonist Using Nanoparticle-Antibody Conjugates for Enhanced Immunotherapy
Jiyoon Bu, Ashita Nair, Mari Iida, Woo-jin Jeong, Michael J Poellmann, Kara Mudd, Luke J Kubiatowicz, Elizabeth W Liu, Deric L Wheeler, Seungpyo Hong*

Nano Letters 2020, 20, 4901

Immunoavidity-based capture of tumor exosomes using poly (amidoamine) dendrimer surfaces
Michael J Poellmann, Ashita Nair, Jiyoon Bu, Jack KH Kim, Randall J Kimple, Seungpyo Hong*

Nano letters 2020, 20, 5686

Nanoparticle conjugation stabilizes and multimerizes β-hairpin peptides to effectively target PD-1/PD-L1 β-sheet-rich interfaces
Woo-jin Jeong, Jiyoon Bu, Yanxiao Han, Adam J Drelich, Ashita Nair, Petr Král, Seungpyo Hong*

Journal of the American Chemical Society 2020, 142, 1832

Multi-modal liquid biopsy platform for cancer screening: screening both cancer-associated rare cells and cancer cell-derived vesicles on the fabric filters for a reliable liquid biopsy analysis
Jiyoon Bu, Jae-Eul Shim, Tae Hee Lee, Young-Ho Cho*

Nano Convergence 2019, 6, 39

Post-debulking circulating tumor cell as a poor prognostic marker in advanced stage ovarian cancer: A prospective observational study
Miseon Kim, Dong Hoon Suh, Jin Young Choi, Jiyoon Bu, Yoon-Tae Kang, Kidong Kim, Jae Hong No, Yong Beom Kim, Young-Ho Cho*

Medicine 2019, 98, e15354

Sub-lethal hyperthermia promotes epithelial-to-mesenchymal-like transition of breast cancer cells: implication of the synergy between hyperthermia and chemotherapy
Tae Hee Lee†, Jiyoon Bu†, Byoung Hyuck Kim, Michael J Poellmann, Seungpyo Hong*, Sung Hee Hyun*

RSC Advances 2019, 9, 52

Peptide–nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?
Woo-jin Jeong†, Jiyoon Bu†, Luke J Kubiatowicz, Stephanie S Chen, YoungSoo Kim, Seungpyo Hong*

Nano Convergence 2018, 5, 38

Would antioxidant-loaded nanoparticles present an effective treatment for ischemic stroke?
Michael J Poellmann, Jiyoon Bu, Seungpyo Hong*

Nanomedicine 2018, 13, 2327

Epithelial and mesenchymal circulating tumor cell isolation and discrimination using dual-immunopatterned device with newly-developed anti-63B6 and anti-EpCAM
Yoon-Tae Kang, Young Jun Kim, Jiyoon Bu, Shilin Chen, Young-Ho Cho*, Hyun Min Lee*, Chun Jeih Ryu*, Yoojoo Lim*, Sae-Won Han*

Sensors and Actuators B: Chemical 2018, 260, 320

Enhancement of isolation sensitivity for the viable heterogeneous circulating tumor cells swelled by hypo-osmotic pressure
Jiyoon Bu, Young-Ho Cho, Sae-Won Han

RSC Advances 2017, 7, 49684

Circulating tumor cells in the differential diagnosis of adnexal masses
Dong Hoon Suh, Miseon Kim, Jin Young Choi, Jiyoon Bu, Yoon-Tae Kang, Byung Su Kwon, Banghyun Lee, Kidong Kim, Jae Hong No, Yong-Beom Kim, Young-Ho Cho

Oncotarget 2017, 8, 77195

Microfluidic-based mechanical phenotyping of cells for the validation of epithelial-to-mesenchymal-like transition caused by insufficient heat treatment
Jiyoon Bu, Tae Hee Lee, In Sik Kim, Young-Ho Cho

Sensors and Actuators B: Chemical 2017, 244, 591

A multi-staining chip using hydrophobic valves for exfoliative cytology in cancer
Tae Hee Lee†, Jiyoon Bu†, Jung Eun Moon, Young Jun Kim, Yoon-Tae Kang, Young-Ho Cho, In Sik Kim

Journal of Micromechanics and Microengineering 2017, 27, 075022

Polyester fabric sheet layers functionalized with graphene oxide for sensitive isolation of circulating tumor cells
Jiyoon Bu†, Young Jun Kim†, Yoon-Tae Kang, Tae Hee Lee, Jeongsuk Kim, Young-Ho Cho, Sae-Won Han

Biomaterials 2017, 27, 075022

Lab on a fabric: Mass producible and low-cost fabric filters for the high-throughput viable isolation of circulating tumor cells
Jiyoon Bu, Yoon-Tae Kang, Yong-Seok Lee, Jeongsuk Kim, Young-Ho Cho*, Byung-In Moon*

Biosensors and Bioelectronics 2017, 91, 747

Frequency-Dependent Impedance Analysis for Discriminating Cancer and Normal Cells Using Microchamber Array
YoonHee Chang, Jiyoon Bu, Young-Ho Cho*

Sensors & Materials 2017, 29,3

A viable circulating tumor cell isolation device with high retrieval efficiency using a reversibly deformable membrane barrier
Yoonji Kim, Jiyoon Bu, Young-Ho Cho*, Il Tae Son*, Sung-Bum Kang*