Publications
Fiore PF, Forcelloni S, Moretta L, Assenza MR, Orecchia P, Bilotta MT, Machwirth M, Shpati T, Sanvi LW, Haas D, Vitozzi S, Giansanti M, Nazio F, Tumino N, Caruana I, Vacca P. Multifunctional-engineered NK cells overcome tumor immunosuppression by combining PD-L1 and HLA-E targeting and endogenous IL15 production. Signal Transduct Target Ther. 2026 Jul 10;11(1):269. doi: 10.1038/s41392-026-02827-w.
Milletti G, Cadeddu G, Adelantado-Rubio A, Ferraina C, Keuper K, Munk SHN, De Stefanis C, Quacquarini D, Rossi S, Mastronuzzi A, Locatelli F, Grumati P, Cianfanelli V, Nazio F, Bartek J, Maya-Mendoza A, Cecconi F. Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress. Nucleic Acids Res. 2026 Jun 22;54(12):gkag595. doi: 10.1093/nar/gkag595.
Fiore PF, Forcelloni S, Vitozzi S, Tumino N, Theinert T, Sanvi LW, Nazio F, D'Oria V, Martini S, Reichert M, Moretta L, Caruana I, Vacca P. Autophagy supports the storage of lytic granules in human NK cells. Cell Death Dis. 2026 Jun 1. doi: 10.1038/s41419-026-08937-1.
Marini A, Pitolli C, Ciccone S, Pieraccioli M, Robil N, Naro C, Palluzzi F, Giansanti M, Tamburrini G, Giacò L, de la Grange P, Nazio F, Bielli P, Sette C, Pagliarini V. HnRNP C binding to inverted Aluelements protects the transcriptome from pre-mRNA circularization. Sci Adv. 2026 May;12(18):eaea2351. doi: 10.1126/sciadv.aea2351.
Genah S, Pellegrino M, Giansanti M, Mancusi A, Taviani A, Cardinale A, Rosichini M, Flamini S, Catanoso ML, Giorda E, Volpe G, Piccione M, Nazio F, Dudakov JA, van den Brink MRM, de Billy E, Locatelli F, Velardi E. Proteasome inhibition promotes Foxn1 expression in thymic epithelial cells and induces thymic regeneration in mice. Cell Death Differ. 2026 Mar 26. doi: 10.1038/s41418-026-01724-7.
De Mitri F, Giansanti M, Melaiu O, Haas D, Ebert S, Tumino N, Vulpis E, Gatto F, Martuscelli B, Antonioli M, Sangiuliano E, Caruso S, Marco S, De Stefanis C, Marabitti V, Campello S, Fruci D, Vacca P, Caruana I, Nazio F. Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma. J Exp Clin Cancer Res. 2025 Jul 3;44(1):185. doi: 10.1186/s13046-025-03453-0.
Foti A, Allia F, Briglia M, Malaguarnera R, Tamburrini G, Cecconi F, Pagliarini V, Nazio F, Graziano ACE. Medulloblastoma: Molecular Targets and Innovative Theranostic Approaches. Pharmaceutics. 2025 Jun 4;17(6):736. doi: 10.3390/pharmaceutics17060736.
Marabitti V, Vulpis E, Nazio F*, Campello S*. Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness:Current Insights and Future Directions. Pharmacol Res. 2024 Oct;208:107382. doi: 10.1016/j.phrs.2024.107382.
Ciccone R, Quintarelli C, Camera A, Pezzella M, Caruso S, Manni S, Ottaviani A, Guercio M, Del Bufalo F, Quadraccia MC, Orlando D, Di Cecca S, Sinibaldi M, Aurigemma M, Iaffaldano L, Sarcinelli A, D'Amore ML, Ceccarelli M, Nazio F, Marabitti V, Giorda E, Pezzullo M, De Stefanis C, Carai A, Rossi S, Alaggio R, Del Baldo G, Becilli M, Mastronuzzi A, De Angelis B, Locatelli F. GD2-Targeting CAR T-cell Therapy for Patients with GD2+ Medulloblastoma. Clin Cancer Res. 2024 Jun 3;30(11):2545-2557. doi: 10.1158/1078-0432.CCR-23-1880.
Salvatori I, Nesci V, Spalloni A, Marabitti V, Muzzi M, Zenuni H, Scaricamazza S, Rosina M, Fenili G, Goglia M, Boffa L, Massa R, Moreno S, Mercuri NB, Nazio F, Longone P, Ferri A, Valle C. Trimetazidine Improves Mitochondrial Dysfunction in SOD1G93A Cellular Models of Amyotrophic Lateral Sclerosis through Autophagy Activation. Int J Mol Sci. 2024 Mar 13;25(6):3251. doi: 10.3390/ijms25063251.
Giansanti M, Theinert T, Boeing SK, Haas D, Schlegel PG, Vacca P, Nazio F*, Caruana I*. Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies. Mol Cancer. 2023 Dec 9;22(1):201. doi: 10.1186/s12943-023-01893-w.
Pagliara D, Ciolfi A, Pedace L, Haghshenas S, Ferilli M, Levy MA, Miele E, Nardini C, Cappelletti C, Relator R, Pitisci A, De Vito R, Pizzi S, Kerkhof J, McConkey H, Nazio F, Kant SG, Di Donato M, Agolini E, Matraxia M, Pasini B, Pelle A, Galluccio T, Novelli A, Barakat TS, Andreani M, Rossi F, Mecucci C, Savoia A, Sadikovic B, Locatelli F, Tartaglia M. Identification of a robust DNA methylation signature for Fanconi anemia. Am J Hum Genet. 2023 Nov 2;110(11):1938-1949. doi: 10.1016/j.ajhg.2023.09.014.
Marabitti V, Caruana I, Nazio F. Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade. Mol Cancer. 2023 Sep 7;22(1):149. doi: 10.1186/s12943-023-01851-6.
Pitolli C, Marini A, Guerra M, Pieraccioli M, Marabitti V, Palluzzi F, Giacò L, Tamburrini G, Cecconi F, Nazio F, Sette C, Pagliarini V. MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma. J Exp Clin Cancer Res. 2023 Aug 21;42(1):214. doi: 10.1186/s13046-023-02790-2..
Marabitti V, Giansanti M, De Mitri F, Gatto F, Mastronuzzi A, Nazio F. Pathological implications of metabolic reprogramming and its therapeutic potential in medulloblastoma. Front Cell Dev Biol. 2022 Oct 19;10:1007641. doi: 10.3389/fcell.2022.1007641.